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International Journal of Oncology
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Article

Long non-coding RNA TUG1 recruits miR‑29c‑3p from its target gene RGS1 to promote proliferation and metastasis of melanoma cells

  • Authors:
    • Yanqian Wang
    • Gang Liu
    • Lin Ren
    • Kun Wang
    • Aimin Liu
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, Xinxiang Central Hospital, Xinxiang, Henan 45300, P.R. China, Department of Dermatology, Jiaozuo People's Hospital, Jiaozuo, Henan 454001, P.R. China, Wound Diagnosis and Treatment Center, Xinxiang Central Hospital, Xinxiang, Henan 45300, P.R. China, Department of Dermatology, Jiaozuo Second People's Hospital, Jiaozuo, Henan 454000, P.R. China, Department of Dermatology, Henan Traditional Chinese Medicine Hospital, Zhengzhou, Henan 450002, P.R. China
  • Pages: 1317-1326
    |
    Published online on: January 28, 2019
       https://doi.org/10.3892/ijo.2019.4699
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Abstract

Melanoma is an aggressive type of skin cancer, characterized by high mortality rates worldwide. Therefore, the identification of new diagnostic markers and therapeutic targets for melanoma is imperative. Accumulating evidence has demonstrated that long non-coding RNAs (lncRNAs) play important roles in tumor initiation and progression. It was recently reported that the expression of lncRNA taurine upregulated 1 (TUG1) was relatively higher in cancer compared with that in normal cells, and that TUG1 promoted the progression of various cancers. However, the pattern of expression and mechanism of action of TUG1 in melanoma remain unclear. The aim of the present study was to investigate whether TUG1 expression is relatively higher in melanoma tissues and whether this expression is correlated with poor overall survival. Knockdown of TUG1 was found to suppress melanoma cell growth and metastasis and induce cell apoptosis. By contrast, the overexpression of TUG1 promoted the growth and metastasis of melanoma cells, and inhibited their apoptosis. In addition, the results of the present study indicated that TUG1 sequestered endogenous miR‑29c‑3p and that it was able to suppress its expression. Furthermore, it was observed that miR‑29c‑3p could reverse the promoting effect of TUG1 on melanoma progression, which may be associated with the positive regulation of regulator of G-protein signaling 1 (RGS1), a target gene of miR‑29c‑3p. Taken together, the data of the present study demonstrated that TUG1 promoted proliferation and invasion and suppressed apoptosis in melanoma cells by regulating miR‑29c‑3p and its target gene, RGS1. Therefore, lncRNA TUG1 appears to be a promising diagnostic marker for melanoma patients.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Liu G, Ren L, Wang K and Liu A: Long non-coding RNA TUG1 recruits miR‑29c‑3p from its target gene RGS1 to promote proliferation and metastasis of melanoma cells. Int J Oncol 54: 1317-1326, 2019.
APA
Wang, Y., Liu, G., Ren, L., Wang, K., & Liu, A. (2019). Long non-coding RNA TUG1 recruits miR‑29c‑3p from its target gene RGS1 to promote proliferation and metastasis of melanoma cells. International Journal of Oncology, 54, 1317-1326. https://doi.org/10.3892/ijo.2019.4699
MLA
Wang, Y., Liu, G., Ren, L., Wang, K., Liu, A."Long non-coding RNA TUG1 recruits miR‑29c‑3p from its target gene RGS1 to promote proliferation and metastasis of melanoma cells". International Journal of Oncology 54.4 (2019): 1317-1326.
Chicago
Wang, Y., Liu, G., Ren, L., Wang, K., Liu, A."Long non-coding RNA TUG1 recruits miR‑29c‑3p from its target gene RGS1 to promote proliferation and metastasis of melanoma cells". International Journal of Oncology 54, no. 4 (2019): 1317-1326. https://doi.org/10.3892/ijo.2019.4699
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Liu G, Ren L, Wang K and Liu A: Long non-coding RNA TUG1 recruits miR‑29c‑3p from its target gene RGS1 to promote proliferation and metastasis of melanoma cells. Int J Oncol 54: 1317-1326, 2019.
APA
Wang, Y., Liu, G., Ren, L., Wang, K., & Liu, A. (2019). Long non-coding RNA TUG1 recruits miR‑29c‑3p from its target gene RGS1 to promote proliferation and metastasis of melanoma cells. International Journal of Oncology, 54, 1317-1326. https://doi.org/10.3892/ijo.2019.4699
MLA
Wang, Y., Liu, G., Ren, L., Wang, K., Liu, A."Long non-coding RNA TUG1 recruits miR‑29c‑3p from its target gene RGS1 to promote proliferation and metastasis of melanoma cells". International Journal of Oncology 54.4 (2019): 1317-1326.
Chicago
Wang, Y., Liu, G., Ren, L., Wang, K., Liu, A."Long non-coding RNA TUG1 recruits miR‑29c‑3p from its target gene RGS1 to promote proliferation and metastasis of melanoma cells". International Journal of Oncology 54, no. 4 (2019): 1317-1326. https://doi.org/10.3892/ijo.2019.4699
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