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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
April-2019 Volume 54 Issue 4

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Journal Metrics

Impact Factor: 7.3

CiteScore: 10.2

CiteScore Rank: Q1: #51/428 Oncology

Source Normalized Impact per Paper (SNIP): 0.955

SCImago Journal Rank (SJR): 1226.0

Review

Iron metabolism and its contribution to cancer (Review)

Ying Chen, Zhimin Fan, Ye Yang, Chunyan Gu
Pages: 1143-1154
Published online on: 20 February 2019

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Review

Mitochondrial calcium: Transport and modulation of cellular processes in homeostasis and cancer (Review)

Susana Romero-Garcia, Heriberto Prado-Garcia
Pages: 1155-1167
Published online on: 28 January 2019

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Article Open Access

Diverse and cancer type‑specific roles of the p53 R248Q gain‑of‑function mutation in cancer migration and invasiveness

Maciej Boleslaw Olszewski, Magdalena Pruszko, Ewa Snaar‑Jagalska, Alicja Zylicz, Maciej Zylicz
Pages: 1168-1182
Published online on: 22 February 2019

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Article Open Access

lncRNA PLAC2 activated by H3K27 acetylation promotes cell proliferation and invasion via the activation of Wnt/β‑catenin pathway in oral squamous cell carcinoma Retraction in /10.3892/ijo.2025.5743

Fubo Chen, Shengcai Qi, Xu Zhang, Jinjin Wu, Xi Yang, Raorao Wang
Pages: 1183-1194
Published online on: 01 February 2019

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Article Open Access

Silencing of COPB2 inhibits the proliferation of gastric cancer cells and induces apoptosis via suppression of the RTK signaling pathway

Caixia An, Hailong Li, Xueyan Zhang, Jing Wang, Yi Qiang, Xinhua Ye, Qiang Li, Quanlin Guan, Yongning Zhou
Pages: 1195-1208
Published online on: 18 February 2019

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Article Open Access

Comparison of tumor‑targeting properties of directly and indirectly radioiodinated designed ankyrin repeat protein (DARPin) G3 variants for molecular imaging of HER2

Anzhelika Vorobyeva, Alexey Sсhulga, Elena Konovalova, Rezan Güler, Bogdan Mitran, Javad Garousi, Sara Rinne, John Löfblom, Anna Orlova, Sergey Deyev, Vladimir Tolmachev
Pages: 1209-1220
Published online on: 11 February 2019

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Article Open Access

FABP5 regulates the proliferation of clear cell renal cell carcinoma cells via the PI3K/AKT signaling pathway

Qi Lv, Gangmin Wang, Yinan Zhang, Xiao Han, Haoming Li, Wei Le, Minguang Zhang, Chunhui Ma, Peijun Wang, Qiang Ding
Pages: 1221-1232
Published online on: 22 February 2019

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Article Open Access

Cathepsin B defines leader cells during the collective invasion of salivary adenoid cystic carcinoma

Jia‑Shun Wu, Zhu‑Feng Li, Hao‑Fan Wang, Xiang‑Hua Yu, Xin Pang, Jing‑Biao Wu, Sha‑Sha Wang, Mei Zhang, Xiao Yang, Ming‑Xin Cao, Ya‑Jie Tang, Xin‑Hua Liang, Min Zheng, Ya‑Ling Tang
Pages: 1233-1244
Published online on: 22 February 2019

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Article Open Access

Upregulation of microRNA‑194‑5p inhibits hypopharyngeal carcinoma cell proliferation, migration and invasion by targeting SMURF1 via the mTOR signaling pathway

Shan Xu, Lian Hui, Ning Yang, Yan Wang, Ning Zhao, Xue‑Jun Jiang
Pages: 1245-1255
Published online on: 04 February 2019

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Article Open Access

A novel mechanism for the anticancer activity of aspirin and salicylates

Asma'u I.J. Bashir, Chandra S. Kankipati, Sarah Jones, Robert M. Newman, Stephen T. Safrany, Christopher J. Perry, Iain D. Nicholl
Pages: 1256-1270
Published online on: 29 January 2019

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Article Open Access

Metformin triggers the intrinsic apoptotic response in human AGS gastric adenocarcinoma cells by activating AMPK and suppressing mTOR/AKT signaling

Chi-Cheng Lu, Jo-Hua Chiang, Fuu-Jen Tsai, Yuan-Man Hsu, Yu-Ning Juan, Jai-Sing Yang, Hong-Yi Chiu
Pages: 1271-1281
Published online on: 30 January 2019

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Article Open Access

miR‑300 regulates tumor proliferation and metastasis by targeting lymphoid enhancer‑binding factor 1 in hepatocellular carcinoma

Yufo Chen, Yuanyuan Guo, Yawei Li, Jingwen Yang, Jing Liu, Qiong Wu, Rui Wang
Pages: 1282-1294
Published online on: 13 February 2019

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Article Open Access

CGK062, a small chemical molecule, inhibits cancer upregulated gene 2‑induced oncogenesis through NEK2 and β‑catenin

Sirichat Kaowinn, Sangtaek Oh, Jeong Moon, Ah Young Yoo, Ho Young Kang, Mi Rim Lee, Ji Eun Kim, Dae Youn Hwang, So Eun Youn, Sang Seok Koh, Young‑Hwa Chung
Pages: 1295-1305
Published online on: 22 February 2019

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Article

Triacetyl resveratrol upregulates miRNA‑200 and suppresses the Shh pathway in pancreatic cancer: A potential therapeutic agent

Junsheng Fu, Anju Shrivastava, Sushant K. Shrivastava, Rakesh K. Srivastava, Sharmila Shankar
Pages: 1306-1316
Published online on: 28 January 2019

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Article

Long non-coding RNA TUG1 recruits miR‑29c‑3p from its target gene RGS1 to promote proliferation and metastasis of melanoma cells

Yanqian Wang, Gang Liu, Lin Ren, Kun Wang, Aimin Liu
Pages: 1317-1326
Published online on: 28 January 2019

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Article

Runx3 inhibits endothelial progenitor cell differentiation and function via suppression of HIF-1α activity

So-Yun Choo, Soo-Hyun Yoon, Dong-Jin Lee, Sun Hee Lee, Kang Li, In Hye Koo, Wooin Lee, Suk-Chul Bae, You Mie Lee
Pages: 1327-1336
Published online on: 11 February 2019

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Article

COUP‑TFII promotes epithelial‑mesenchymal transition by inhibiting miR‑34a expression in colorectal cancer

Ying Bao, Yongliang Lu, Wenming Feng, Hongbin Yu, Huihui  Guo, Yulong Tao, Qian Shi, Wei Chen, Xiang Wang
Pages: 1337-1344
Published online on: 18 February 2019

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Article

Partial agonistic effect of cetuximab on epidermal growth factor receptor and Src kinase activation in triple‑negative breast cancer cell lines

Hakan Gurdal, Matilda Merve Tuglu, Saber Yari Bostanabad, Başak Dalkiliç
Pages: 1345-1356
Published online on: 28 January 2019

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Article

The proteasome inhibitor, bortezomib, induces prostate cancer cell death by suppressing the expression of prostate-specific membrane antigen, as well as androgen receptor

Kenji Kuroda, He Liu
Pages: 1357-1366
Published online on: 01 February 2019

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Article

MACC1 overexpression in carcinoma‑associated fibroblasts induces the invasion of lung adenocarcinoma cells via paracrine signaling

Zhuoshi Li, Tao Guo, Lei Fang, Nan Li, Xiaochao Wang, Peng Wang, Shilei Zhao, Fengzhou Li, Yanwei Cui, Xin Shu, Lei Zhao, Jinxiu Li, Chundong Gu
Pages: 1367-1375
Published online on: 30 January 2019

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Article

Protective effect of curcumin against irinotecan‑induced intestinal mucosal injury via attenuation of NF‑κB activation, oxidative stress and endoplasmic reticulum stress

Manzhao Ouyang, Zhentao Luo, Weijie Zhang, Dajian Zhu, Yan Lu, Jinhao Wu, Xueqing Yao
Pages: 1376-1386
Published online on: 11 February 2019

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Article

RBM3 upregulates ARPC2 by binding the 3'UTR and contributes to breast cancer progression

Ping Chen, Xiaoli Yue, Hongbing Xiong, Xiaohong Lu, Zhenling Ji
Pages: 1387-1397
Published online on: 28 January 2019

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Article

Lysyl oxidase assists tumor‑initiating cells to enhance angiogenesis in hepatocellular carcinoma

Min Yang, Jingtao Liu, Fei Wang, Zhihua Tian, Bo Ma, Zhongwu Li, Boqing Wang, Wei Zhao
Pages: 1398-1408
Published online on: 31 January 2019

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Article

Downregulation of protein disulfide‑isomerase A3 expression inhibits cell proliferation and induces apoptosis through STAT3 signaling in hepatocellular carcinoma

Ryota Kondo, Kousuke Ishino, Ryuichi Wada, Hideyuki Takata, Wei‑Xia Peng, Mitsuhiro Kudo, Shoko Kure, Yohei Kaneya, Nobuhiko Taniai, Hiroshi Yoshida, Zenya Naito
Pages: 1409-1421
Published online on: 04 February 2019

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Article

2,3,7,8‑tetrachlorodibenzo‑p‑dioxin suppresses the growth of human colorectal cancer cells in vitro: Implication of the aryl hydrocarbon receptor signaling

Masayoshi Yamaguchi, Oliver Hankinson
Pages: 1422-1432
Published online on: 30 January 2019

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Article

Efficacy of aflibercept with FOLFOX and maintenance with fluoropyrimidine as first‑line therapy for metastatic colorectal cancer: GERCOR VELVET phase II study

Benoist Chibaudel, Jean‑Baptiste Bachet, Thierry André, Dominique Auby, Jérôme Desramé, Gaël Deplanque, Cédric Lecaille, Christophe Louvet, Christophe Tournigand, Valérie Lebrun‑Ly, Jérôme Dauba, Gérard Lledo, Marie‑Line Garcia, Olivier Dubreuil, Nabil Baba Hamed, Aurélia Meurisse, Annette K. Larsen, Annemilaï Tijeras‑Raballand, Franck Bonnetain, Aimery De Gramont
Pages: 1433-1445
Published online on: 01 February 2019

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Article

Glyceryl trinitrate‑induced cytotoxicity of docetaxel‑resistant prostatic cancer cells is associated with differential regulation of clusterin

Sarra Bouaouiche, Lea Magadoux, Lucile Dondaine, Sylvie Reveneau, Nicolas Isambert, Ali Bettaieb, Jean‑François Jeannin, Veronique Laurens, Stephanie Plenchette
Pages: 1446-1456
Published online on: 01 February 2019

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Article

Netrin‑1 interference potentiates epithelial‑to‑mesenchymal transition through the PI3K/AKT pathway under the hypoxic microenvironment conditions of non‑small cell lung cancer

Xiayun Jin, Heqi Luan, Hua Chai, Lina Yan, Jing Zhang, Qi Wang, Lihua Cao
Pages: 1457-1465
Published online on: 15 February 2019

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Article

Adaptive EGF expression sensitizes pancreatic cancer cells to ionizing radiation through activation of the cyclin D1/P53/PARP pathway

Xiaoxing Liu, Haiyan Chen, Yanli Hou, Xiumei Ma, Ming Ye, Renhua Huang, Bin Hu, Hongbin Cao, Lei Xu, Mengyao Liu, Linfeng Li, Jianxin Gao, Yongrui Bai
Pages: 1466-1480
Published online on: 19 February 2019

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Article

Vitamin D and its low calcemic analogs modulate the anticancer properties of cisplatin and dacarbazine in the human melanoma A375 cell line

Anna Piotrowska, Justyna Wierzbicka, Agnieszka Rybarczyk, Robert C. Tuckey, Andrzej T. Slominski, Michał A. Żmijewski
Pages: 1481-1495
Published online on: 25 February 2019

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Correction Open Access

[Corrigendum] miR‑122 promotes proliferation and invasion of clear cell renal cell carcinoma by suppressing Forkhead box O3

Wenyuan Nie, Dong Ni, Xin Ma, Yu Zhang, Yu Gao, Cheng Peng, Xu Zhang
Pages: 1496-1496
Published online on: 23 January 2019

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Journal Cover
October-2026 Volume 69 Issue 4

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Journal Metrics

Impact Factor: 7.3

CiteScore: 10.2

CiteScore Rank: Q1: #51/428 Oncology

Source Normalized Impact per Paper (SNIP): 0.955

SCImago Journal Rank (SJR): 1226.0

Review Open Access

MicroRNA regulation of macrophage polarization in lung cancer: Regulatory networks and therapeutic potential (Review)

Zhao Yiming, Li Jie
Article Number: 121
Published online on: 02 September 2026

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Article Open Access

Effect of xeroderma pigmentosum group C on the characteristics and regulatory mechanisms of lung cancer stem cells

Ben Yang, Yang Yang, Weiyu Wang, Yubing Wang, Huaijie Wang, Liya Qin, Yongming Wang, Sipeng Sun, Shubo Wang, Meihua Qu
Article Number: 120
Published online on: 01 September 2026

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Review Open Access

Post‑translational modification‑governed immune states in cancer immunity: Biomarker implications for checkpoint competence, tumor visibility and immunotherapy resistance (Review)

Jinghao Pan, Boyang Li, Ruonan Lin, Chenlu Fang, Lucy Yue Lau, Zehao Hong, Yi Chen
Article Number: 119
Published online on: 21 August 2026

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Correction Open Access

[Corrigendum] Sulforaphane reduces molecular response to hypoxia in ovarian tumor cells independently of their resistance to chemotherapy

Michal Pastorek, Veronika Simko, Martina Takacova, Monika Barathova, Maria Bartosova, Luba Hunakova, Olga Sedlakova, Sona Hudecova, Olga Krizanova, Franck Dequiedt, Silvia Pastorekova, Jan Sedlak
Article Number: 118
Published online on: 20 August 2026

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Article Open Access

Single in situ intratumoral low‑dose shikonin hydrogel plus mild photothermal therapy elicits systemic antitumor immunity in immune‑cold triple‑negative breast cancer

Tao Pan, Zujian Feng, Ting Shang, Jun Jiang, Fang Zhang
Article Number: 117
Published online on: 19 August 2026

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Article Open Access

KIAA1429 knockdown alleviates osteosarcoma  progression by destabilizing SLC7A11 mRNA via m6A methylation to promote ferroptosis

Hui Zeng, Yunyan Zhong, Dingbiao Zeng, Shiliang Xiao, Song Zou
Article Number: 116
Published online on: 17 August 2026

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Correction Open Access

[Corrigendum] Tanshinone I effectively induces apoptosis in estrogen receptor‑positive (MCF‑7) and estrogen receptor‑negative (MDA‑MB‑231) breast cancer cells

Irina Tsoy Nizamutdinova, Gyeong Won Lee, Kun Ho Son, Su Jin Jeon, Sam Sik Kang, Yeong Shik Kim, Jae Heun Lee, Han Geuk Seo, Ki Churl Chang, Hye Jung Kim
Article Number: 115
Published online on: 12 August 2026

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Review Open Access

Signaling pathways and targeted therapy in high‑risk refractory thyroid cancer: From bench to bedside (Review)

Jian Wang, Zhi Liu, Qing Zhang, Wei Sun
Article Number: 114
Published online on: 11 August 2026

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Retraction Open Access

[Retracted] Downmodulation of dimethyl transferase activity enhances tumor necrosis factor‑related apoptosis‑inducing ligand‑ induced apoptosis in prostate cancer cells

Claudio Festuccia, Giovanni Luca Gravina, Anna Maria D'Alessandro, Danilo Millimaggi, Cristiana Di Rocco, Vincenza Dolo, Enrico Ricevuto, Carlo Vicentini, Mauro Bologna
Article Number: 113
Published online on: 10 August 2026

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Review Open Access

The pivotal role of SCD1 in digestive cancers: Bridging lipid metabolic reprogramming and programmed cell death (Review)

Yangxi Fu, Zheng Wang, Lin Liu, Xudong Tang
Article Number: 112
Published online on: 07 August 2026

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Article Open Access

piR‑164552 promotes malignant progression in head and neck squamous cell carcinoma via the RBM4/EIF4E2 signaling axis: Insights from multi‑omics and functional analyses

Shan Yang, Zhen Shang, Shunxian Xia, Hongbo Liu, Yanhan Dong, Xiaomin Wang, Wenhua Xu, Haijun Lu
Article Number: 111
Published online on: 07 August 2026

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Correction Open Access

[Corrigendum] Influence of doxorubicin on apoptosis and oxidative stress in breast cancer cell lines

Nesstor Pilco‑Ferreto, Gloria   M. Calaf
Article Number: 110
Published online on: 20 July 2026

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Article Open Access

Evaluation of Punicalagin as a multi‑targeted therapeutic agent against endometrial cancer

Zeeshan Ahmad Bhutta, Dohee Ahn, Hong Kyu Lee, Kyung-Chul Choi
Article Number: 109
Published online on: 17 July 2026

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Journal Cover
November-2026 Volume 69 Issue 5

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Journal Metrics

Impact Factor: 7.3

CiteScore: 10.2

CiteScore Rank: Q1: #51/428 Oncology

Source Normalized Impact per Paper (SNIP): 0.955

SCImago Journal Rank (SJR): 1226.0

Retraction Open Access

[Retracted] In vitro modulation of MMP‑2 and MMP‑9 in adult human sarcoma cell lines by cytokines, inducers and inhibitors

M.W. Roomi, T. Kalinovsky, J.  Monterrey, M. Rath, A. Niedzwiecki
Article Number: 129
Published online on: 21 September 2026

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Review Open Access

Eomesodermin in renal cell carcinoma: Epigenetic and immune crosstalk driving tumor progression (Review)

Zhifei Che, Dongwen Huang, Jiaming Lin, Xincen Wang, Rongjin Feng, Xianping Che, Yubin Wang
Article Number: 128
Published online on: 18 September 2026

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Expression of Concern Open Access

[Expression of Concern] Ultraviolet exposure of melanoma cells induces fibroblast activation protein‑α in fibroblasts: Implications for melanoma invasion

Petra Wäster, Inger Rosdahl, Brendan F.  Gilmore, Oliver Seifert
Article Number: 127
Published online on: 16 September 2026

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Article Open Access

E3 ubiquitin ligase MAGI3‑mediated TAZ ubiquitination suppresses the non‑small cell lung cancer occurrence and development by targeting the Wnt pathway

Ye Liang, Jie Zhuang
Article Number: 126
Published online on: 16 September 2026

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Correction Open Access

[Corrigendum] TIP60 governs the auto‑ubiquitination of UHRF1 through USP7 dissociation from the UHRF1/USP7 complex

Tanveer Ahmad, Waseem Ashraf, Abdulkhaleg Ibrahim, Liliyana Zaayter, Christian D. Muller, Ali Hamiche, Yves Mély, Christian Bronner, Marc Mousli
Article Number: 125
Published online on: 14 September 2026

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Correction Open Access

[Corrigendum] miR‑221/222 promote malignant progression of glioma through activation of the Akt pathway

Junxia Zhang, Lei Han, Youlin Ge, Xuan Zhou, Anling Zhang, Chunzhi Zhang, Yue Zhong, Yongping You, Peiyu Pu, Chunsheng Kang
Article Number: 124
Published online on: 03 September 2026

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Review Open Access

Dendritic cell‑based vaccines for colorectal cancer: Mechanisms, clinical progress and future directions (Review)

Lian Yih Pong, Siti Ayuni Hassanudin, Seng Kong Tham, Ravichandran Manickam, Chee Yin Wong, Keat Seong Poh, Chit Laa Poh
Article Number: 123
Published online on: 03 September 2026

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Retraction Open Access

[Retracted] Pro‑metastatic intracellular signaling of the elaidic trans fatty acid

Kiyomu Fujii, Yi Luo, Rina Fujiwara-tani, Shingo Kishi, Song He, Shuyun Yang, Takamitsu Sasaki, Hitoshi Ohmori, Hiroki Kuniyasu
Article Number: 122
Published online on: 02 September 2026

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