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Article Open Access

lncRNA PLAC2 activated by H3K27 acetylation promotes cell proliferation and invasion via the activation of Wnt/β‑catenin pathway in oral squamous cell carcinoma

Retraction in: /10.3892/ijo.2025.5743
  • Authors:
    • Fubo Chen
    • Shengcai Qi
    • Xu Zhang
    • Jinjin Wu
    • Xi Yang
    • Raorao Wang
  • View Affiliations / Copyright

    Affiliations: Department of Stomatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China, Department of Oral and Maxillofacial Head and Neck Oncology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1183-1194
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    Published online on: February 1, 2019
       https://doi.org/10.3892/ijo.2019.4707
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Abstract

As a new group of important effector molecules involved in multiple cancer types, including breast cancer, lung cancer and oral squamous cell carcinoma, long noncoding RNAs (lncRNAs) have attracted considerable attention recently. However, the underlying cause that induces the dysregulated lncRNAs in cancer remains poorly understood. In the present study, the regulatory model of the lncRNA placenta‑specific protein 2 (PLAC2) upregulation in oral squamous cell carcinoma (OSCC) was investigated and its biological functions in OSCC malignant progression was identified. A reverse transcription‑quantitative polymerase chain reaction assay identified that PLAC2 is upregulated in OSCC cell lines and primary tissue samples. Furthermore, bioinformatic analysis followed by chromatin immunoprecipitation verified an enriched histone H3 on lysine 27 (H3K27) acetylation (H3K27ac) at the promoter region of the PLAC2 gene. Knockdown of cAMP‑response element binding protein‑binding protein (CBP) significantly reduced the enrichment level of H3K27ac, and thereby induced a decreased expression of PLAC2. Functionally, overexpression of PLAC2 promotes OSCC cell proliferation, migration and invasion, whereas knockdown of PLAC2 exerted an opposite effect. Furthermore, the Wnt/β‑catenin signaling pathway was activated by PLAC2 and mediated the PLAC2‑induced malignant progress of OSCC. In conclusion, the present results indicated that lncRNA PLAC2 is transcriptionally activated by H3K27ac modification at the promoter region in OSCC, and promotes cell growth and metastasis via activating Wnt/β‑catenin signaling pathway. Therefore, PLAC2 may serve as a promising biomarker for OSCC prognosis and therapy.
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View References

1 

Binmadi NO and Basile JR: Perineural invasion in oral squamous cell carcinoma: A discussion of significance and review of the literature. Oral Oncol. 47:1005–1010. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Yan L, Chen F, Liu F, Qiu Y, Wang J, Wu J, Bao X, Hu Z, Peng X, Lin X, et al: Differences in modifiable factors of oral squamous cell carcinoma in the upper and lower of oral fissure. Oncotarget. 8:75094–75101. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Glazer CA, Chang SS, Ha PK and Califano JA: Applying the molecular biology and epigenetics of head and neck cancer in everyday clinical practice. Oral Oncol. 45:440–446. 2009. View Article : Google Scholar

4 

Loewen G, Jayawickramarajah J, Zhuo Y and Shan B: Functions of lncRNA HOTAIR in lung cancer. J Hematol Oncol. 7:902014. View Article : Google Scholar : PubMed/NCBI

5 

Nishizawa Y, Konno M, Asai A, Koseki J, Kawamoto K, Miyoshi N, Takahashi H, Nishida N, Haraguchi N, Sakai D, et al: Hypoxia stimulates the cytoplasmic localization of oncogenic long noncoding RNA LINC00152 in colorectal cancer. Int J Oncol. 52:453–460. 2018.PubMed/NCBI

6 

Zhang W, Cai X, Yu J, Lu X, Qian Q and Qian W: Exosome-mediated transfer of lncRNA RP11 838N2.4 promotes erlotinib resistance in non-small cell lung cancer. Int J Oncol. 53:527–538. 2018.PubMed/NCBI

7 

Zhang X, Feng W, Zhang J, Ge L, Zhang Y, Jiang X, Peng W, Wang D, Gong A and Xu M: Long non coding RNA PVT1 promotes epithelial mesenchymal transition via the TGF β/Smad pathway in pancreatic cancer cells. Oncol Rep. 40:1093–1102. 2018.PubMed/NCBI

8 

Han P, Li JW, Zhang BM, Lv JC, Li YM, Gu XY, Yu ZW, Jia YH, Bai XF, Li L, et al: The lncRNA CRNDE promotes colorectal cancer cell proliferation and chemoresistance via miR-181a-5p-mediated regulation of Wnt/β-catenin signaling. Mol Cancer. 16:92017. View Article : Google Scholar

9 

Bassett AR, Akhtar A, Barlow DP, Bird AP, Brockdorff N, Duboule D, Ephrussi A, Ferguson-Smith AC, Gingeras TR, Haerty W, et al: Considerations when investigating lncRNA function in vivo. eLife. 3:e030582014. View Article : Google Scholar : PubMed/NCBI

10 

Wapinski O and Chang HY: Long noncoding RNAs and human disease. Trends Cell Biol. 21:354–361. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Hu YW, Kang CM, Zhao JJ, Nie Y, Zheng L, Li HX, Li X, Wang Q and Qiu YR: LncRNA PLAC2 down-regulates RPL36 expression and blocks cell cycle progression in glioma through a mechanism involving STAT1. J Cell Mol Med. 22:497–510. 2018. View Article : Google Scholar

12 

Kretz M: TINCR, staufen1, and cellular differentiation. RNA Biol. 10:1597–1601. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Wang S, Zang C, Xiao T, Fan J, Mei S, Qin Q, Wu Q, Li X, Xu K, He HH, et al: Modeling cis-regulation with a compendium of genome-wide histone H3K27ac profiles. Genome Res. 26:1417–1429. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Zubritskiy A and Medvedeva YA: DNA sequence features in the establishing of H3K27ac. F1000 Res. 7:1652018. View Article : Google Scholar

15 

Creyghton MP, Cheng AW, Welstead GG, Kooistra T, Carey BW, Steine EJ, Hanna J, Lodato MA, Frampton GM, Sharp PA, et al: Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proc Natl Acad Sci USA. 107:21931–21936. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Ding G, Li W, Liu J, Zeng Y, Mao C, Kang Y and Shang J: LncRNA GHET1 activated by H3K27 acetylation promotes cell tumorigenesis through regulating ATF1 in hepatocellular carcinoma. Biomed Pharmacother. 94:326–331. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Tuomi JM, Voorbraak F, Jones DL and Ruijter JM: Bias in the Cq value observed with hydrolysis probe based quantitative PCR can be corrected with the estimated PCR efficiency value. Methods. 50:313–322. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Minn AJ, Gupta GP, Siegel PM, Bos PD, Shu W, Giri DD, Viale A, Olshen AB, Gerald WL and Massagué J: Genes that mediate breast cancer metastasis to lung. Nature. 436:518–524. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Jain AK, Xi Y, McCarthy R, Allton K, Akdemir KC, Patel LR, Aronow B, Lin C, Li W, Yang L, et al: LncPRESS1 Is a p53-Regulated LncRNA that Safeguards Pluripotency by Disrupting SIRT6-Mediated De-acetylation of Histone H3K56. Mol Cell. 64:967–981. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Bose DA, Donahue G, Reinberg D, Shiekhattar R, Bonasio R and Berger SL: RNA Binding to CBP Stimulates Histone Acetylation and Transcription. Cell. 168:135–149.e22. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Miller I, Min M, Yang C, Tian C, Gookin S, Carter D and Spencer SL: Ki67 is a Graded Rather than a Binary Marker of Proliferation versus Quiescence. Cell Reports. 24:1105–1112.e5. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Arensman MD, Telesca D, Lay AR, Kershaw KM, Wu N, Donahue TR and Dawson DW: The CREB-binding protein inhibitor ICG-001 suppresses pancreatic cancer growth. Mol Cancer Ther. 13:2303–2314. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Han F, Xu Q, Zhao J, Xiong P and Liu J: ERO1L promotes pancreatic cancer cell progression through activating the Wnt/catenin pathway. J Cell Biochem. 119:8996–9005. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Tian T, Wang M, Lin S, Guo Y, Dai Z, Liu K, Yang P, Dai C, Zhu Y, Zheng Y, et al: The Impact of lncRNA Dysregulation on Clinicopathology and Survival of Breast Cancer: A Systematic Review and Meta-analysis. Mol Ther Nucleic Acids. 12:359–369. 2018. View Article : Google Scholar : PubMed/NCBI

25 

Chang SM and Hu WW: Long non-coding RNA MALAT1 promotes oral squamous cell carcinoma development via microRNA-125b/STAT3 axis. J Cell Physiol. 233:3384–3396. 2018. View Article : Google Scholar

26 

Zhang Wu Y, Zhang L, Wang L, Li Y, Ren H, Wei X, Yu F, Liu W, Wang TX, et al: Long non-coding RNA HOTAIR promotes tumor cell invasion and metastasis by recruiting EZH2 and repressing E-cadherin in oral squamous cell carcinoma. Int J Oncol. 46:2586–2594. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Sun CC, Zhang L, Li G, Li SJ, Chen ZL, Fu YF, Gong FY, Bai T, Zhang DY, Wu QM, et al: The lncRNA PDIA3P Interacts with miR-185-5p-to Modulate Oral Squamous Cell Carcinoma Progression by Targeting Cyclin D2. Mol Ther Nucleic Acids. 9:100–110. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Piunti A and Pasini D: Epigenetic factors in cancer development: Polycomb group proteins. Future Oncol. 7:57–75. 2011. View Article : Google Scholar

29 

Suka N, Suka Y, Carmen AA, Wu J and Grunstein M: Highly specific antibodies determine histone acetylation site usage in yeast heterochromatin and euchromatin. Mol Cell. 8:473–479. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Tie F, Banerjee R, Conrad PA, Scacheri PC and Harte PJ: Histone demethylase UTX and chromatin remodeler BRM bind directly to CBP and modulate acetylation of histone H3 lysine 27. Mol Cell Biol. 32:2323–2334. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Tak YG, Hung Y, Yao L, Grimmer MR, Do A, Bhakta MS, O'Geen H, Segal DJ and Farnham PJ: Effects on the transcriptome upon deletion of a distal element cannot be predicted by the size of the H3K27Ac peak in human cells. Nucleic Acids Res. 44:4123–4133. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Kouzarides T: Chromatin modifications and their function. Cell. 128:693–705. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Benton CB, Fiskus W and Bhalla KN: Targeting Histone Acetylation: Readers and Writers in Leukemia and Cancer. Cancer J. 23:286–291. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Pradeepa MM, Grimes GR, Kumar Y, Olley G, Taylor GC, Schneider R and Bickmore WA: Histone H3 globular domain acetylation identifies a new class of enhancers. Nat Genet. 48:681–686. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Gräff J and Tsai LH: Histone acetylation: Molecular mnemonics on the chromatin. Nat Rev Neurosci. 14:97–111. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Hamzaoui H, Rizk-Rabin M, Gordon J, Offutt C, Bertherat J and Bouizar Z: PTHrP P3 p romoter activity in breast cancer cell lines: Role of Ets1 and CBP (CREB binding protein). Mol Cell Endocrinol. 268:75–84. 2007. View Article : Google Scholar : PubMed/NCBI

37 

Tang Z, Yu W, Zhang C, Zhao S, Yu Z, Xiao X, Tang R, Xuan Y, Yang W, Hao J, et al: CREB-binding protein regulates lung cancer growth by targeting MAPK and CPSF4 signaling pathway. Mol Oncol. 10:317–329. 2016. View Article : Google Scholar

38 

Hsu CH, Chang MD, Tai KY, Yang YT, Wang PS, Chen CJ, Wang YH, Lee SC, Wu CW and Juan LJ: HCMV IE2-mediated inhibition of HAT activity downregulates p53 function. EMBO J. 23:2269–2280. 2004. View Article : Google Scholar : PubMed/NCBI

39 

Xu TP, Wang YF, Xiong WL, Ma P, Wang WY, Chen WM, Huang MD, Xia R, Wang R, Zhang EB, et al: E2F1 induces TINCR transcriptional activity and accelerates gastric cancer progression via activation of TINCR/STAU1/CDKN2B signaling axis. Cell Death Dis. 8:e28372017. View Article : Google Scholar : PubMed/NCBI

40 

Liu Y, Du Y, Hu X, Zhao L and Xia W: Up-regulation of ceRNA TINCR by SP1 contributes to tumorigenesis in breast cancer. BMC Cancer. 18:3672018. View Article : Google Scholar : PubMed/NCBI

41 

Tian F, Xu J, Xue F, Guan E and Xu X: TINCR expression is associated with unfavorable prognosis in patients with hepato-cellular carcinoma. Biosci Rep. 37:372017. View Article : Google Scholar

42 

Zheng Y, Yang C, Tong S, Ding Y, Deng W, Song D and Xiao K: Genetic variation of long non-coding RNA TINCR contribute to the susceptibility and progression of colorectal cancer. Oncotarget. 8:33536–33543. 2017.PubMed/NCBI

43 

Zhu ZJ and He JK: TINCR facilitates non-small cell lung cancer progression through BRAF-activated MAPK pathway. Biochem Biophys Res Commun. 497:971–977. 2018. View Article : Google Scholar : PubMed/NCBI

44 

Zhang ZY, Lu YX, Zhang ZY, Chang YY, Zheng L, Yuan L, Zhang F, Hu YH, Zhang WJ and Li XN: Loss of TINCR expression promotes proliferation, metastasis through activating EpCAM cleavage in colorectal cancer. Oncotarget. 7:22639–22649. 2016.PubMed/NCBI

45 

Liu X, Ma J, Xu F and Li L: TINCR suppresses proliferation and invasion through regulating miR-544a/FBXW7 axis in lung cancer. Biomed Pharmacother. 99:9–17. 2018. View Article : Google Scholar : PubMed/NCBI

46 

Pollaers K, Hinton-Bayre A, Friedland PL and Farah CS: AJCC 8th Edition oral cavity squamous cell carcinoma staging - Is it an improvement on the AJCC 7th Edition? Oral Oncol. 82:23–28. 2018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chen F, Qi S, Zhang X, Wu J, Yang X and Wang R: lncRNA PLAC2 activated by H3K27 acetylation promotes cell proliferation and invasion via the activation of Wnt/β‑catenin pathway in oral squamous cell carcinoma Retraction in /10.3892/ijo.2025.5743. Int J Oncol 54: 1183-1194, 2019.
APA
Chen, F., Qi, S., Zhang, X., Wu, J., Yang, X., & Wang, R. (2019). lncRNA PLAC2 activated by H3K27 acetylation promotes cell proliferation and invasion via the activation of Wnt/β‑catenin pathway in oral squamous cell carcinoma Retraction in /10.3892/ijo.2025.5743. International Journal of Oncology, 54, 1183-1194. https://doi.org/10.3892/ijo.2019.4707
MLA
Chen, F., Qi, S., Zhang, X., Wu, J., Yang, X., Wang, R."lncRNA PLAC2 activated by H3K27 acetylation promotes cell proliferation and invasion via the activation of Wnt/β‑catenin pathway in oral squamous cell carcinoma Retraction in /10.3892/ijo.2025.5743". International Journal of Oncology 54.4 (2019): 1183-1194.
Chicago
Chen, F., Qi, S., Zhang, X., Wu, J., Yang, X., Wang, R."lncRNA PLAC2 activated by H3K27 acetylation promotes cell proliferation and invasion via the activation of Wnt/β‑catenin pathway in oral squamous cell carcinoma Retraction in /10.3892/ijo.2025.5743". International Journal of Oncology 54, no. 4 (2019): 1183-1194. https://doi.org/10.3892/ijo.2019.4707
Copy and paste a formatted citation
x
Spandidos Publications style
Chen F, Qi S, Zhang X, Wu J, Yang X and Wang R: lncRNA PLAC2 activated by H3K27 acetylation promotes cell proliferation and invasion via the activation of Wnt/β‑catenin pathway in oral squamous cell carcinoma Retraction in /10.3892/ijo.2025.5743. Int J Oncol 54: 1183-1194, 2019.
APA
Chen, F., Qi, S., Zhang, X., Wu, J., Yang, X., & Wang, R. (2019). lncRNA PLAC2 activated by H3K27 acetylation promotes cell proliferation and invasion via the activation of Wnt/β‑catenin pathway in oral squamous cell carcinoma Retraction in /10.3892/ijo.2025.5743. International Journal of Oncology, 54, 1183-1194. https://doi.org/10.3892/ijo.2019.4707
MLA
Chen, F., Qi, S., Zhang, X., Wu, J., Yang, X., Wang, R."lncRNA PLAC2 activated by H3K27 acetylation promotes cell proliferation and invasion via the activation of Wnt/β‑catenin pathway in oral squamous cell carcinoma Retraction in /10.3892/ijo.2025.5743". International Journal of Oncology 54.4 (2019): 1183-1194.
Chicago
Chen, F., Qi, S., Zhang, X., Wu, J., Yang, X., Wang, R."lncRNA PLAC2 activated by H3K27 acetylation promotes cell proliferation and invasion via the activation of Wnt/β‑catenin pathway in oral squamous cell carcinoma Retraction in /10.3892/ijo.2025.5743". International Journal of Oncology 54, no. 4 (2019): 1183-1194. https://doi.org/10.3892/ijo.2019.4707
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