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Bladder cancer cells interact with vascular endothelial cells triggering EGFR signals to promote tumor progression

  • Authors:
    • Zhixin Huang
    • Mengzhao Zhang
    • Guanqiu Chen
    • Weiyi Wang
    • Pu Zhang
    • Yangyang Yue
    • Zhenfeng Guan
    • Xinyang Wang
    • Jinhai Fan
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China, Department of Urology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 710068, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1555-1566
    |
    Published online on: February 27, 2019
       https://doi.org/10.3892/ijo.2019.4729
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Abstract

Although important progress has been made in elucidating the role of the tumor microenvironment in the development of bladder cancer, little is currently known regarding the interactions with vascular endothelial cells (ECs) that promote cancer progression. In the present study, it is reported that epidermal growth factor receptor ligands induced by the upregulation of vascular endothelial growth factor (VEGF)‑A and VEGF‑C via the VEGF receptor (R)2/nuclear factor‑κB signaling pathway in ECs, may trigger EGFR signaling in bladder cancer cells and promote bladder cancer progression. Furthermore, the interaction between bladder cancer cells and ECs enhanced EC recruitment though the CXCL1/CXCL5/CXCL8‑CXCR2 pathway. Western blotting was used to evaluate the presence of VEGFR, EGFR and nuclear factor‑κB, and reverse transcription‑quantitative polymerase chain reaction was used to evaluate the expression of VEGFR ligands and EGFR ligands. The present results indicate the mechanism by which the indirect interplay between bladder cancer cells and vascular ECs promotes cancer progression, through the VEGFR2 signaling pathway in vascular ECs and through the EGFR signaling pathway in bladder cancer cells.
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Copy and paste a formatted citation
Spandidos Publications style
Huang Z, Zhang M, Chen G, Wang W, Zhang P, Yue Y, Guan Z, Wang X and Fan J: Bladder cancer cells interact with vascular endothelial cells triggering EGFR signals to promote tumor progression. Int J Oncol 54: 1555-1566, 2019.
APA
Huang, Z., Zhang, M., Chen, G., Wang, W., Zhang, P., Yue, Y. ... Fan, J. (2019). Bladder cancer cells interact with vascular endothelial cells triggering EGFR signals to promote tumor progression. International Journal of Oncology, 54, 1555-1566. https://doi.org/10.3892/ijo.2019.4729
MLA
Huang, Z., Zhang, M., Chen, G., Wang, W., Zhang, P., Yue, Y., Guan, Z., Wang, X., Fan, J."Bladder cancer cells interact with vascular endothelial cells triggering EGFR signals to promote tumor progression". International Journal of Oncology 54.5 (2019): 1555-1566.
Chicago
Huang, Z., Zhang, M., Chen, G., Wang, W., Zhang, P., Yue, Y., Guan, Z., Wang, X., Fan, J."Bladder cancer cells interact with vascular endothelial cells triggering EGFR signals to promote tumor progression". International Journal of Oncology 54, no. 5 (2019): 1555-1566. https://doi.org/10.3892/ijo.2019.4729
Copy and paste a formatted citation
x
Spandidos Publications style
Huang Z, Zhang M, Chen G, Wang W, Zhang P, Yue Y, Guan Z, Wang X and Fan J: Bladder cancer cells interact with vascular endothelial cells triggering EGFR signals to promote tumor progression. Int J Oncol 54: 1555-1566, 2019.
APA
Huang, Z., Zhang, M., Chen, G., Wang, W., Zhang, P., Yue, Y. ... Fan, J. (2019). Bladder cancer cells interact with vascular endothelial cells triggering EGFR signals to promote tumor progression. International Journal of Oncology, 54, 1555-1566. https://doi.org/10.3892/ijo.2019.4729
MLA
Huang, Z., Zhang, M., Chen, G., Wang, W., Zhang, P., Yue, Y., Guan, Z., Wang, X., Fan, J."Bladder cancer cells interact with vascular endothelial cells triggering EGFR signals to promote tumor progression". International Journal of Oncology 54.5 (2019): 1555-1566.
Chicago
Huang, Z., Zhang, M., Chen, G., Wang, W., Zhang, P., Yue, Y., Guan, Z., Wang, X., Fan, J."Bladder cancer cells interact with vascular endothelial cells triggering EGFR signals to promote tumor progression". International Journal of Oncology 54, no. 5 (2019): 1555-1566. https://doi.org/10.3892/ijo.2019.4729
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