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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
May-2019 Volume 54 Issue 5

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Journal Metrics

Impact Factor: 4.9

CiteScore: 8.9

CiteScore Rank: Q1: #66/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.955

SCImago Journal Rank (SJR): 1226.0

Review Open Access

Human papillomavirus infection and ocular surface disease (Review)

Aikaterini K. Chalkia, Georgios Bontzos, Demetrios A. Spandidos, Efstathios T. Detorakis
Pages: 1503-1510
Published online on: 19 March 2019

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Review Open Access

Induction/reversal of drug resistance in gastric cancer by non-coding RNAs (Review)

Chao Chen, Xiaohuan Tang, Yuanda Liu, Jiaming Zhu, Jingjing Liu
Pages: 1511-1524
Published online on: 18 March 2019

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Review

Role of tumor‑derived extracellular vesicles in cancer progression and their clinical applications (Review)

Fuhao Qiao, Peng Pan, Jiaping Yan, Jing Sun, Yan Zong, Zhiyong Wu, Xiaoqin Lu, Na Chen, Rui Mi, Yongbin Ma, Yuan Ji
Pages: 1525-1533
Published online on: 12 March 2019

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Article Open Access

CDC20 contributes to the development of human cutaneous squamous cell carcinoma through the Wnt/β‑catenin signaling pathway

Zhaowei Chu, Xinyue Zhang, Qingyan Li, Guanglei Hu, Christine Guo Lian, Songmei Geng
Pages: 1534-1544
Published online on: 27 February 2019

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Article Open Access

Solamargine inhibits gastric cancer progression by regulating the expression of lncNEAT1_2 via the MAPK signaling pathway

Runjia Fu, Xiaohong Wang, Ying Hu, Hong Du, Bin Dong, Sheng Ao, Li Zhang, Zhijian Sun, Lianhai Zhang, Guoqing Lv, Jiafu Ji
Pages: 1545-1554
Published online on: 12 March 2019

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Article Open Access

Bladder cancer cells interact with vascular endothelial cells triggering EGFR signals to promote tumor progression

Zhixin Huang, Mengzhao Zhang, Guanqiu Chen, Weiyi Wang, Pu Zhang, Yangyang Yue, Zhenfeng Guan, Xinyang Wang, Jinhai Fan
Pages: 1555-1566
Published online on: 27 February 2019

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Article Open Access

Oral mucosal mesenchymal stem cell‑derived exosomes: A potential therapeutic target in oral premalignant lesions

Wenwen Li, Ying Han, Zhongfang Zhao, Xiaoli Ji, Xing Wang, Jianqiu Jin, Qian Wang, Xiang Guo, Zhe Cheng, Mingxing Lu, Guodong Wang, Yixiang Wang, Hongwei Liu
Pages: 1567-1578
Published online on: 19 March 2019

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Article Open Access

MYB promotes the growth and metastasis of salivary adenoid cystic carcinoma

Li‑Hua Xu, Fei Zhao, Wen‑Wen Yang, Chu‑Wen Chen, Zhi‑Hao Du, Min Fu, Xi‑Yuan Ge, Sheng‑Lin Li
Pages: 1579-1590
Published online on: 18 March 2019

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Article Open Access

Isoforms S and L of MRPL33 from alternative splicing have isoform‑specific roles in the chemoresponse to epirubicin in gastric cancer cells via the PI3K/AKT signaling pathway

Jie Li, Dan Feng, Cuixia Gao, Yingyi Zhang, Jing Xu, Meihong Wu, Xianbao Zhan
Pages: 1591-1600
Published online on: 27 February 2019

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Article Open Access

α-hederin induces autophagic cell death in colorectal cancer cells through reactive oxygen species dependent AMPK/mTOR signaling pathway activation

Jian Sun, Yu Feng, Yan Wang, Qing Ji, Gang Cai, Lei Shi, Yiyi Wang, Yan Huang, Jue Zhang, Qi Li
Pages: 1601-1612
Published online on: 19 March 2019

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Article Open Access

Sodium-coupled monocarboxylate transporter is a target of epigenetic repression in cervical cancer

Jennifer Hernández-Juárez, Orlando Vargas-Sierra, Luis A. Herrera, David Cantú De León, Jorge Fernández-Retana, Carlos Pérez-Plasencia, César López-Camarillo, Patricio Gariglio, José Díaz-Chávez
Pages: 1613-1624
Published online on: 14 March 2019

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Article Open Access

Adrenergic modulation of AMPK‑dependent autophagy by chronic stress enhances cell proliferation and survival in gastric cancer

Xiaofei Zhi, Bowen Li, Zheng Li, Jiaxuan Zhang, Junbo Yu, Lu Zhang, Zekuan Xu
Pages: 1625-1638
Published online on: 18 March 2019

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Article Open Access

Reduction in MnSOD promotes the migration and invasion of squamous carcinoma cells

Jhen‑Jia Fan, Wen‑Hsien Hsu, Hao‑Hsiang Hung, Wei‑Jun Zhang, Yu‑Lin A Lee, Ku‑Chung Chen, Cheng‑Ying Chu, Tzu‑Ping Ko, Ming‑Ting Lee, Cheng‑Wei Lin, Chia‑Hsiung Cheng
Pages: 1639-1650
Published online on: 14 March 2019

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Article Open Access

The expression, significance and function of cancer susceptibility candidate 9 in lung squamous cell carcinoma: A bioinformatics and in vitro investigation

Li Gao, Yi‑Nan Guo, Jiang‑Hui Zeng, Fu‑Chao Ma, Jie Luo, Hua‑Wei Zhu, Shuang Xia, Kang‑Lai Wei, Gang Chen
Pages: 1651-1664
Published online on: 19 March 2019

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Article Open Access

lncRNA CASC9 positively regulates CHK1 to promote breast cancer cell proliferation and survival through sponging the miR‑195/497 cluster

Guoli Shao, Mengchuan Wang, Xulong Fan, Lin Zhong, Zixiang Wang, Pusheng Zhang, Shufeng Ji
Pages: 1665-1675
Published online on: 28 February 2019

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Article Open Access

Silencing of lysyl oxidase‑like 2 inhibits the migration, invasion and epithelial‑to‑mesenchymal transition of renal cell carcinoma cells through the Src/FAK signaling pathway

Xi Hong, Jian‑Jun Yu
Pages: 1676-1690
Published online on: 27 February 2019

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Article Open Access

ZNF692 promotes colon adenocarcinoma cell growth and metastasis by activating the PI3K/AKT pathway

Yanwei Xing, Shuo Ren, Lianjie Ai, Weidong Sun, Zhiwei Zhao, Fengqi Jiang, Yuekun Zhu, Daxun Piao
Pages: 1691-1703
Published online on: 27 February 2019

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Article Open Access

Protein profiling of osteosarcoma tissue and soft callus unveils activation of the unfolded protein response pathway

Parunya Chaiyawat, Patsadakorn Sungngam, Pimpisa Teeyakasem, Nutnicha Sirikaew, Jeerawan Klangjorhor, Jongkolnee Settakorn, Penchatr Diskul‑Na‑Ayudthaya, Daranee Chokchaichamnankit, Chantragan Srisomsap, Jisnuson Svasti, Dumnoensun Pruksakorn
Pages: 1704-1718
Published online on: 28 February 2019

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Article Open Access

Proteomics profiling of plasma exosomes in epithelial ovarian cancer: A potential role in the coagulation cascade, diagnosis and prognosis

Wei Zhang, Xiaoxuan Ou, Xiaohua Wu
Pages: 1719-1733
Published online on: 07 March 2019

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Article Open Access

Autophagy inhibitors regulate TRAIL sensitivity in human malignant cells by targeting the mitochondrial network and calcium dynamics

Asuka Onoe‑Takahashi, Manami Suzuki‑Karasaki, Miki Suzuki‑Karasaki, Toyoko Ochiai, Yoshihiro Suzuki‑Karasaki
Pages: 1734-1746
Published online on: 20 March 2019

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Article

Differential expression and functions of Ehm2 transcript variants in lung adenocarcinoma

Shenglan Li, Jian Ma, Yang Si, Shan Cheng, Mu Hu, Xiuyi Zhi, Baolan Li, Hefen Yu, Wen G. Jiang
Pages: 1747-1758
Published online on: 27 February 2019

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Article

Potential tumor‑suppressive role of microRNA‑99a‑3p in sunitinib‑resistant renal cell carcinoma cells through the regulation of RRM2

Yoichi Osako, Hirofumi Yoshino, Takashi Sakaguchi, Satoshi Sugita, Masaya Yonemori, Masayuki Nakagawa, Hideki Enokida
Pages: 1759-1770
Published online on: 28 February 2019

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Article

MicroRNA let‑7d‑5p rescues ovarian cancer cell apoptosis and restores chemosensitivity by regulating the p53 signaling pathway via HMGA1

Yan‑Nan Chen, Chen‑Chen Ren, Li Yang, Man‑Man Nai, Yi‑Ming Xu, Feng Zhang, Yan Liu
Pages: 1771-1784
Published online on: 27 February 2019

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Article

TOPK is regulated by PP2A and BCR/ABL in leukemia and enhances cell proliferation

Emi Uchida, Shihoko Suwa, Ryoto Yoshimoto, Ken Watanabe, Takeshi Kasama, Osamu Miura, Tetsuya Fukuda
Pages: 1785-1796
Published online on: 05 March 2019

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Article

Tubastatin A, an inhibitor of HDAC6, enhances temozolomide‑induced apoptosis and reverses the malignant phenotype of glioblastoma cells

Alejandro Urdiciain, Elena Erausquin, Bárbara Meléndez, Juan A. Rey, Miguel A. Idoate, Javier S. Castresana
Pages: 1797-1808
Published online on: 01 March 2019

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Article

MicroRNA‑873 targets HOXA9 to inhibit the aggressive phenotype of osteosarcoma by deactivating the Wnt/β‑catenin pathway Retraction in /10.3892/ijo.2022.5420

Yilin Liu, Yuqiang Wang, Hao Yang, Liang Zhao, Ruipeng Song, Hongyu Tan, Limin Wang
Pages: 1809-1820
Published online on: 28 February 2019

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Article

Extracellular vesicle‑delivered miR‑505‑5p, as a diagnostic biomarker of early lung adenocarcinoma, inhibits cell apoptosis by targeting TP53AIP1

Hua Fang, Yutao Liu, Yaohong He, Yang Jiang, Yaping Wei, Han Liu, Yueqing Gong, Guangyu An
Pages: 1821-1832
Published online on: 01 March 2019

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Article

MUL1 E3 ligase regulates the antitumor effects of metformin in chemoresistant ovarian cancer cells via AKT degradation

Junwoo Lee, Sungkwan An, Jin Hyuk Jung, Karam Kim, Ji Yea Kim, In-Sook An, Seunghee Bae
Pages: 1833-1842
Published online on: 27 February 2019

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Article

Mesenchymal stem cell‑derived extracellular vesicles promote the in vitro proliferation and migration of breast cancer cells through the activation of the ERK pathway

Xiaohe Zhou, Tao Li, Yufei Chen, Nannan Zhang, Pengli Wang, Yingying Liang, Melissa Long, Haoran Liu, Jian Mao, Qiuyan Liu, Xiaochun Sun, Huabiao Chen
Pages: 1843-1852
Published online on: 13 March 2019

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Article

Targeting excessive MYCN expression using MLN8237 and JQ1 impairs the growth of hepatoblastoma cells

Corinna Eberherr, Alexander Beck, Christian Vokuhl, Kristina Becker, Beate Häberle, Dietrich Von Schweinitz, Roland Kappler
Pages: 1853-1863
Published online on: 05 March 2019

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Article

Interferon-β sensitizes human malignant melanoma cells to temozolomide-induced apoptosis and autophagy

Kotaro Makita, Hiroyuki Hara, Emiko Sano, Yutaka Okamoto, Yushi Ochiai, Tomonori Harada, Takuya Ueda, Tomohiro Nakayama, Shin Aizawa, Atsuo Yoshino
Pages: 1864-1874
Published online on: 07 March 2019

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Article

Reversine induces cell cycle arrest and apoptosis via upregulation of the Fas and DR5 signaling pathways in human colorectal cancer cells

Young-Lan Park, Sang-Yoon Ha, Sun-Young Park, Jung-Ho Choi, Min-Woo Jung, Dae-Seong Myung, Hyun-Soo Kim, Young-Eun Joo
Pages: 1875-1883
Published online on: 13 March 2019

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Article

MicroRNA-664 targets paired box protein 6 to inhibit the oncogenicity of pancreatic ductal adenocarcinoma Retraction in /10.3892/ijo.2022.5380

Qi Wang, Jiaqi Wang, Songtao Niu, Songsong Wang, Yibin Liu, Xiaoya Wang
Pages: 1884-1896
Published online on: 19 March 2019

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Correction Open Access

[Corrigendum] Lipocalin 2 inversely regulates TRAIL sensitivity through p38 MAPK‑mediated DR5 regulation in colorectal cancer

Se-Lim Kim, In Suk Min, Young Ran Park, Soo Teik Lee, Sang-Wook Kim
Pages: 1897-1897
Published online on: 13 March 2019

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Journal Cover
January-2026 Volume 68 Issue 1

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Journal Metrics

Impact Factor: 4.9

CiteScore: 8.9

CiteScore Rank: Q1: #66/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.955

SCImago Journal Rank (SJR): 1226.0

Article Open Access

c‑Myc‑regulated RPLP0 via the ROS‑mediated JAK2/STAT3 positive feedback loop facilitates hepatocellular carcinoma malignancy progression

Yanqiu Meng, Lebin Yuan, Gangrui Meng, Hongxiang Huang, Xianbin Huang, Xinping Xu, Xiaodong Peng
Article Number: 13
Published online on: 27 November 2025

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Review Open Access

Obesity, chronic breast inflammation and carcinogenesis: Molecular pathways and clinical implications (Review)

Fangying Li, Zhenhua Gao
Article Number: 12
Published online on: 27 November 2025

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Review Open Access

The tumor microenvironment in lung cancer: Heterogeneity, therapeutic resistance and emerging treatment strategies (Review)

Li Liu, Li Yang, Hongmin Li, Tianlu Shang, Lihan Liu
Article Number: 11
Published online on: 26 November 2025

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Article Open Access

Discovery of the late autophagy inhibitor FZU‑0045‑053 and its anti‑breast cancer and immunomodulatory effects

Jinlan Luo, Yi Yang, Lulu Cheng, Fangting Cheng, Huangwenlong Zhuang, Shanshan Chen, Panpan Qiao, Yinbin Liang, Li Chen, Yang Sun, Haijun Chen, Qinying Liu
Article Number: 10
Published online on: 26 November 2025

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Correction Open Access

[Corrigendum] RIPK4/PEBP1 axis promotes pancreatic cancer cell migration and invasion by activating RAF1/MEK/ERK signaling

Zi-Hao Qi, Hua-Xiang Xu, Shi-Rong Zhang, Jin-Zhi Xu, Shuo Li, He-Li Gao, Wei Jin, Wen-Quan Wang, Chun-Tao Wu, Quan-Xing Ni, Xian-Jun Yu, Liang Liu
Article Number: 9
Published online on: 24 November 2025

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Article Open Access

Ephrin‑B2 promotes gastric cancer growth by inhibiting apoptosis and regulating the cell cycle via the Wnt/β‑catenin signaling pathway

Ding Ding, Xiaoshan Wang, Ran Xuan, Rui Li, Yalu Zhang, Zhengguang Wang
Article Number: 8
Published online on: 18 November 2025

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Expression of Concern Open Access

[Expression of Concern] Gene therapy for human colorectal cancer cell lines with recombinant adenovirus 5 based on loss of the insulin‑like growth factor 2 imprinting

Huiling Sun, Yuqin Pan, Bangshun He, Qiwen Deng, Rui Li, Yeqiong Xu, Jie Chen, Tianyi Gao, Houqun Ying, Feng Wang, Xian Liu, Shukui Wang
Article Number: 7
Published online on: 18 November 2025

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Review Open Access

Ferroptosis in biliary tract cancer: Molecular mechanisms and therapeutic applications (Review)

Ruiqi Zou, Yushi Dai, Siqi Yang, Haijie Hu, Fuyu Li, Fei Liu
Article Number: 6
Published online on: 14 November 2025

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Expression of Concern Open Access

[Expression of Concern] Radiosensitization of esophageal carcinoma cells by knockdown of RNF2 expression

Xing-Xiao Yang, Ming Ma, Mei-Xiang Sang, Xue-Xiao Wang, Heng Song, Zhi-Kun Liu, Shu-Chai Zhu
Article Number: 5
Published online on: 10 November 2025

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Review Open Access

Targeting ferroptosis in Helicobacter pylori‑associated gastric cancer development: From molecular mechanisms to application prospects (Review)

Chen-Yi Wang, Meng-Hui Wang, Chuan Xie
Article Number: 4
Published online on: 05 November 2025

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Expression of Concern Open Access

[Expression of Concern] Leptin promotes breast cancer cell migration and invasion via IL‑18 expression and secretion

Kuangfa Li, Lan Wei, Yunxiu Huang, Yang Wu, Min Su, Xueli Pang, Nian Wang, Feihu Ji, Changli Zhong, Tingmei Chen
Article Number: 3
Published online on: 04 November 2025

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Review Open Access

Cancer immunotherapy strategies based on transition‑metal medical materials: Still a long way to go (Review)

Zhefei Du, Zhenyu Cao, Chao Fang, Daihan Xie, Lixin Xie, Chunxia Su, Yu Huo
Article Number: 2
Published online on: 04 November 2025

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Expression of Concern Open Access

[Expression of Concern] Regulation of NADPH oxidase (Nox2) by lipid rafts in breast carcinoma cells

Rama Rao Malla, Hari Raghu, Jasti S. Rao
Article Number: 1
Published online on: 23 October 2025

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Journal Cover
February-2026 Volume 68 Issue 2

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Journal Metrics

Impact Factor: 4.9

CiteScore: 8.9

CiteScore Rank: Q1: #66/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.955

SCImago Journal Rank (SJR): 1226.0

Review

Cancer stem cell heterogeneity‑inspired therapeutics for enhancing tumor treatment outcomes (Review)

Hanning Xu, Qunchao Si, Yongyao Song, Shengping Sun, Xianghong Wei, Hui Long, Xiaomei Wang
Article Number: 18
Published online on: 04 December 2025

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Review Open Access

Roles of interleukins in spasmolytic polypeptide‑expressing metaplasia (Review)

Jiale Ma, Tiancheng Zhan, Xinyuan Zhang, Wang Gao, Shuangmei Zhao, Huizhen Li
Article Number: 17
Published online on: 03 December 2025

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Expression of Concern Open Access

[Expression of Concern] MUC1 is a downstream target of STAT3 and regulates lung cancer cell survival and invasion

Jingchun Gao, Matthew J. Mcconnell, Bin Yu, Jiannong Li, Justin M. Balko, Esther P. Black, Joseph O. Johnson, Mark C. Lloyd, Soner Altiok, Eric B. Haura
Article Number: 16
Published online on: 03 December 2025

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Review Open Access

Emerging biomarkers in prostate cancer diagnosis and treatment: Insights into genetic, RNA and metabolic markers (Review)

Yuanshe Huang, Jingxin Mao, Xiaobing Li
Article Number: 15
Published online on: 03 December 2025

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Retraction Open Access

[Retracted] GDC‑0152 attenuates the malignant progression of osteosarcoma promoted by ANGPTL2 via PI3K/AKT but not p38MAPK signaling pathway

Lin Yang, Taipengfei Shu, Yingjian Liang, Wenguang Gu, Chunlei Wang, Xuanhe Song, Changdong Fan, Wenbo Wang
Article Number: 14
Published online on: 01 December 2025

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