Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
May-2019 Volume 54 Issue 5

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2019 Volume 54 Issue 5

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Interferon-β sensitizes human malignant melanoma cells to temozolomide-induced apoptosis and autophagy

  • Authors:
    • Kotaro Makita
    • Hiroyuki Hara
    • Emiko Sano
    • Yutaka Okamoto
    • Yushi Ochiai
    • Tomonori Harada
    • Takuya Ueda
    • Tomohiro Nakayama
    • Shin Aizawa
    • Atsuo Yoshino
  • View Affiliations / Copyright

    Affiliations: Division of Neurosurgery, Department of Neurological Surgery, Nihon University School of Medicine, Tokyo 173-8610, Japan, Division of Anatomical Science, Department of Functional Morphology, Nihon University School of Medicine, Tokyo 173-8610, Japan, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo 277-8562, Japan, Japan Agency for Medical Research and Development, Tokyo 100-0004, Japan, Division of Companion Diagnostics, Department of Pathology and Microbiology, Nihon University of School of Medicine, Tokyo 173-8610, Japan
  • Pages: 1864-1874
    |
    Published online on: March 7, 2019
       https://doi.org/10.3892/ijo.2019.4743
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Malignant melanoma is a highly aggressive skin cancer that is highly resistant to chemotherapy. Adjuvant therapy is administered to patients with melanoma that possess no microscopic metastases or have a high risk of developing microscopic metastases. Methylating agents, including dacarbazine (DTIC) and temozolomide (TMZ), pegylated interferon (IFN)‑α2b and interleukin‑2 have been approved for adjuvant immuno‑chemotherapy; however, unsatisfactory results have been reported following the administration of methylating agents. IFN‑β has been considered to be a signaling molecule with an important therapeutic potential in cancer. The aim of the present study was to elucidate whether antitumor effects could be augmented by the combination of TMZ and IFN‑β in malignant melanoma. We evaluated the efficacy of TMZ and IFN‑β by comparing O6‑methylguanine‑DNA transferase (MGMT)‑proficient and ‑deficient cells, as MGMT has been reported to be associated with the resistance to methylating agents. Cell viability was determined by counting living cells with a Coulter counter, and apoptosis was analyzed by dual staining with Annexin V Alexa Fluor® 488 and propidium iodide. The expression of proteins involved in the cell cycle, apoptosis and autophagy was evaluated by western blot analysis. The combined treatment with TMZ and IFN‑β suppressed cell proliferation and induced cell cycle arrest. We also demonstrated that a combination of TMZ and IFN‑β enhanced apoptosis and autophagy more efficiently compared with TMZ treatment alone. These findings suggest that antitumor activity may be potentiated by IFN‑β in combination with TMZ.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Cancer Facts and Figures 2009. American Cancer Society; Atlanta: 2009

2 

Coit DG, Andtbacka R, Anker CJ, Bichakjian CK, Carson WE III, Daud A, Dimaio D, Fleming MD, Guild V, Halpern AC, et al: Melanoma, version 2.2013: featured updates to the NCCN guidelines. J Natl Compr Canc Netw. 11:395–407. 2013.

3 

Kainthla R, Kim KB and Falchook GS: Dabrafenib for treatment of BRAF-mutant melanoma. Pharmgenomics Pers Med. 7:21–29. 2013.

4 

Jang S and Atkins MB: Which drug, and when, for patients with BRAF-mutant melanoma? Lancet Oncol. 14:e60–e69. 2013.

5 

Jang S and Atkins MB: Treatment of BRAF-mutant melanoma: The role of vemurafenib and other therapies. Clin Pharmacol Ther. 95:24–31. 2014.

6 

Homet B and Ribas A: New drug targets in metastatic melanoma. J Pathol. 232:134–141. 2014.

7 

Nihal M, Wu J and Wood GS: Methotrexate inhibits the viability of human melanoma cell lines and enhances Fas/Fas-ligand expression, apoptosis and response to interferon-alpha: Rationale for its use in combination therapy. Arch Biochem Biophys. 563:101–107. 2014.

8 

Yoshino A, Tashiro S, Ogino A, Yachi K, Ohta T, Fukushima T, Watanabe T, Katayama Y, Okamoto Y, Sano E, et al: Gene expression profiles predicting the response to IFN-β and a combination of temozolomide and IFN-β in malignant gliomas. Int J Oncol. 39:529–542. 2011.

9 

Li RH, Hou XY, Yang CS, Liu WL, Tang JQ, Liu YQ and Jiang G: Temozolomide for treating malignant melanoma. J Coll Physicians Surg Pak. 25:680–688. 2015.

10 

Harries M, Malvehy J, Lebbe C, Heron L, Amelio J, Szabo Z and Schadendorf D: Treatment patterns of advanced malignant melanoma (stage III-IV) - A review of current standards in Europe. Eur J Cancer. 60:179–189. 2016.

11 

Losa M, Mazza E, Terreni MR, McCormack A, Gill AJ, Motta M, Cangi MG, Talarico A, Mortini P and Reni M: Salvage therapy with temozolomide in patients with aggressive or metastatic pituitary adenomas: Experience in six cases. Eur J Endocrinol. 163:843–851. 2010.

12 

Zuhur SS, Tanik C, Karaman Ö, Velet S, Çil E, Öztürk FY, Özkayalar H, Müslüman AM and Altuntaş Y: MGMT immu-noexpression in growth hormone-secreting pituitary adenomas and its correlation with Ki-67 labeling index and cytokeratin distribution pattern. Endocrine. 40:222–227. 2011.

13 

Bush ZM, Longtine JA, Cunningham T, Schiff D, Jane JA Jr, Vance ML, Thorner MO, Laws ER Jr and Lopes MB: Temozolomide treatment for aggressive pituitary tumors: Correlation of clinical outcome with O(6)-methylguanine meth-yltransferase (MGMT) promoter methylation and expression. J Clin Endocrinol Metab. 95:E280–E290. 2010.

14 

Raverot G, Sturm N, de Fraipont F, Muller M, Salenave S, Caron P, Chabre O, Chanson P, Cortet-Rudelli C, Assaker R, et al: Temozolomide treatment in aggressive pituitary tumors and pituitary carcinomas: A French multicenter experience. J Clin Endocrinol Metab. 95:4592–4599. 2010.

15 

Roos WP, Jöst E, Belohlavek C, Nagel G, Fritz G and Kaina B: Intrinsic anticancer drug resistance of malignant melanoma cells is abrogated by IFN-β and valproic acid. Cancer Res. 71:4150–4160. 2011.

16 

Sano E, Tashiro S, Tadakuma H, Takei T, Ueda T and Tsumoto K: Type 1 IFN inhibits the growth factor deprived apoptosis of cultured human aortic endothelial cells and protects the cells from chemically induced oxidative cytotoxicity. J Cell Biochem. 113:3823–3834. 2012.

17 

Herndon TM, Demko SG, Jiang X, He K, Gootenberg JE, Cohen MH, Keegan P and Pazdur R: U.S. food and drug administration of patients with melanoma. Oncologist. 17:1323–1328. 2012.

18 

Baron S, Tyring SK, Fleischmann WR Jr, Coppenhaver DH, Niesel DW, Klimpel GR, Stanton GJ and Hughes TK: The interferons Mechanisms of action and clinical applications. JAMA. 266:1375–1383. 1991.

19 

Yoshida J, Kajita Y, Wakabayashi T and Sugita K: Long-term follow-up results of 175 patients with malignant glioma: Importance of radical tumour resection and postoperative adjuvant therapy with interferon, ACNU and radiation. Acta Neurochir (Wien). 127:55–59. 1994.

20 

Chawla-Sarkar M, Leaman DW and Borden EC: Preferential induction of apoptosis by interferon (IFN)-beta compared with IFN-alpha2: Correlation with TRAIL/Apo2L induction in melanoma cell lines. Clin Cancer Res. 7:1821–1831. 2001.

21 

García M, del Muro XG, Tres A, Crespo C, Valladares M, López JJ, Rifà J, Pérez X, Filipovich E and Germà-Lluch JR: Phase II multicentre study of temozolomide in combination with interferon alpha-2b in metastatic malignant melanoma. Melanoma Res. 16:365–370. 2006.

22 

Hwu WJ, Panageas KS, Menell JH, Lamb LA, Aird S, Krown SE, Williams LJ, Chapman PB, Livingston PO, Wolchok JD, et al: Phase II study of temozolomide plus pegylated interferon-alpha-2b for metastatic melanoma. Cancer. 106:2445–2451. 2006.

23 

Quirt I, Verma S, Petrella T, Bak K and Charette M: Temozolomide for the treatment of metastatic melanoma: A systematic review. Oncologist. 12:1114–1123. 2007.

24 

Guillot B, Khamari A, Cupissol D, Delaunay M, Bedane C, Dreno B, Picot MC and Dereure O: Temozolomide associated with PEG-interferon in patients with metastatic melanoma: A multicenter prospective phase I/II study. Melanoma Res. 18:141–146. 2008.

25 

Spieth K, Kaufmann R, Dummer R, Garbe C, Becker JC, Hauschild A, Tilgen W, Ugurel S, Beyeler M, Bröcker EB, et al: Temozolomide plus pegylated interferon alfa-2b as first-line treatment for stage IV melanoma: A multicenter phase II trial of the Dermatologic Cooperative Oncology Group (DeCOG). Ann Oncol. 19:801–806. 2008.

26 

Ridolfi R, Romanini A, Sileni VC, Michiara M, Guida M, Biasco G, Poletti P, Amaducci L, Leoni M and Ravaioli A: Temozolomide and interferon-alpha in metastatic melanoma: A phase II study of the Italian Melanoma Intergroup. Melanoma Res. 14:295–299. 2004.

27 

Yoshino A, Ogino A, Yachi K, Ohta T, Fukushima T, Watanabe T, Katayama Y, Okamoto Y, Naruse N and Sano E: Effect of IFN-beta on human glioma cell lines with temozolomide resistance. Int J Oncol. 35:139–148. 2009.

28 

Tanaka S, Oka H, Fujii K, Watanabe K, Nagao K and Kakimoto A: Quantitation of O6-methylguanine-DNA methyltransferase gene messenger RNA in gliomas by means of real-time RT-PCR and clinical response to nitrosoureas. Cell Mol Neurobiol. 25:1067–1071. 2005.

29 

Tanaka S, Kobayashi I, Utsuki S, Oka H, Fujii K, Watanabe T, Nagashima T and Hori T: O6-methylguanine-DNA methyl-transpherase gene expression in gliomas by means of real-time quantitative RT-PCR and clinical response to nitrosoureas. Int J Cancer. 103:67–72. 2003.

30 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.

31 

Ostermann S, Csajka C, Buclin T, Leyvraz S, Lejeune F, Decosterd LA and Stupp R: Plasma and cerebrospinal fluid population pharmacokinetics of temozolomide in malignant glioma patients. Clin Cancer Res. 10:3728–3736. 2004.

32 

Higuchi Y and Hashida M: Pharmacokinetics of interferon. Clin All-Round. 52:2499–2505. 2003.In Japanese.

33 

Naumann SC, Roos WP, Jöst E, Belohlavek C, Lennerz V, Schmidt CW, Christmann M and Kaina B: Temozolomide- and fotemustine-induced apoptosis in human malignant melanoma cells: Response related to MGMT, MMR, DSBs, and p53. Br J Cancer. 100:322–333. 2009.

34 

Friedman HS, Keir S, Pegg AE, Houghton PJ, Colvin OM, Moschel RC, Bigner DD and Dolan ME: O6-benzylguanine-mediated enhancement of chemotherapy. Mol Cancer Ther. 1:943–948. 2002.

35 

Kaina B, Fritz G, Mitra S and Coquerelle T: Transfection and expression of human O6-methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: The role of MGMT in protection against the genotoxic effects of alkylating agents. Carcinogenesis. 12:1857–1867. 1991.

36 

Chen JM, Zhang YP, Wang C, Sun Y, Fujimoto J and Ikenaga M: O6-methylguanine-DNA methyltransferase activity in human tumors. Carcinogenesis. 13:1503–1507. 1992.

37 

Kaina B, Ziouta A, Ochs K and Coquerelle T: Chromosomal instability, reproductive cell death and apoptosis induced by O6-methylguanine in Mex−, Mex+ and methylation-tolerant mismatch repair compromised cells: Facts and models. Mutat Res. 381:227–241. 1997.

38 

Liu L, Markowitz S and Gerson SL: Mismatch repair mutations override alkyltransferase in conferring resistance to temozolomide but not to 1,3-bis(2-chloroethyl)nitrosourea. Cancer Res. 56:5375–5379. 1996.

39 

Hirose Y, Berger MS and Pieper RO: p53 effects both the duration of G2/M arrest and the fate of temozolomide-treated human glioblastoma cells. Cancer Res. 61:1957–1963. 2001.

40 

Beaumont KA, Hill DS, Daignault SM, Lui GYL, Sharp DM, Gabrielli B, Weninger W and Haass NK: Cell cycle phase-specific drug resistance as an escape mechanism of melanoma cells. J Invest Dermatol. 136:1479–1489. 2016.

41 

Natsume A, Ishii D, Wakabayashi T, Tsuno T, Hatano H, Mizuno M and Yoshida J: IFN-beta down-regulates the expression of DNA repair gene MGMT and sensitizes resistant glioma cells to temozolomide. Cancer Res. 65:7573–7579. 2005.

42 

Levine AJ: p53, the cellular gatekeeper for growth and division. Cell. 88:323–331. 1997.

43 

Takaoka A, Hayakawa S, Yanai H, Stoiber D, Negishi H, Kikuchi H, Sasaki S, Imai K, Shibue T, Honda K, et al: Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence. Nature. 424:516–523. 2003.

44 

Zhang X, Fang P, Zhao Z, Ding X, Xie F, Wang Y and Li C: Antitumorigenic effect of damnacanthal on melanoma cell viability through p53 and NF-κB/caspase-3 signaling pathways. Oncol Lett. 16:6039–6044. 2018.

45 

el-Deiry WS, Harper JW, O’Connor PM, Velculescu VE, Canman CE, Jackman J, Pietenpol JA, Burrell M, Hill DE, Wang Y, et al: WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res. 54:1169–1174. 1994.

46 

Giandomenico V, Vaccari G, Fiorucci G, Percario Z, Vannuchi S, Matarrese P, Malorni W, Romeo G and Affabris GR: Apoptosis and growth inhibition of squamous carcinoma cells treated with interferon-alpha, IFN-beta and retinoic acid are associated with induction of the cyclin-dependent kinase inhibitor p21. Eur Cytokine Netw. 9:619–631. 1998.

47 

Miyashita T and Reed JC: Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell. 80:293–299. 1995.

48 

Wittnebel S, Jalil A, Thiery J, DaRocha S, Viey E, Escudier B, Chouaib S and Caignard A: The sensitivity of renal cell carcinoma cells to interferon alpha correlates with p53-induction and involves Bax. Eur Cytokine Netw. 16:123–127. 2005.

49 

Florean C, Song S, Dicato M and Diederich M: Redox biology of regulated cell death in cancer: A focus on necroptosis and ferroptosis. Free Radic Biol Med. 134:177–189. 2019.

50 

Peter ME, Kischkel FC, Hellbardt S, Chinnaiyan AM, Krammer PH and Dixit VM: CD95 (APO-1/Fas)-associating signalling proteins. Cell Death Differ. 3:161–170. 1996.

51 

Nagata S: Apoptosis by death factor. Cell. 88:355–365. 1997.

52 

Tominaga Y, Tsuzuki T, Shiraishi A, Kawate H and Sekiguchi M: Alkylation-induced apoptosis of embryonic stem cells in which the gene for DNA-repair, methyltransferase, had been disrupted by gene targeting. Carcinogenesis. 18:889–896. 1997.

53 

Meikrantz W, Bergom MA, Memisoglu A and Samson L: O6-alkylguanine DNA lesions trigger apoptosis. Carcinogenesis. 19:369–372. 1998.

54 

Kanzawa T, Germano IM, Komata T, Ito H, Kondo Y and Kondo S: Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells. Cell Death Differ. 11:448–457. 2004.

55 

Ling YH, Aracil M, Zou Y, Yuan Z, Lu B, Jimeno J, Cuervo AM and Perez-Soler R: PM02734 (elisidepsin) induces caspase-independent cell death associated with features of autophagy, inhibition of the Akt/mTOR signaling pathway, and activation of death-associated protein kinase. Clin Cancer Res. 17:5353–5366. 2011.

56 

Chen WL, Pan L, Kinghorn AD, Swanson SM and Burdette JE: Silvestrol induces early autophagy and apoptosis in human melanoma cells. BMC Cancer. 167:172016.

57 

Koga S, Hirohata S, Kondo Y, Komata T, Takakura M, Inoue M, Kyo S and Kondo S: A novel telomerase-specific gene therapy: Gene transfer of caspase-8 utilizing the human telomerase catalytic subunit gene promoter. Hum Gene Ther. 11:1397–1406. 2000.

58 

Hou W, Han J, Lu C, Goldstein LA and Rabinowich H: Autophagic degradation of active caspase-8: A crosstalk mechanism between autophagy and apoptosis. Autophagy. 6:891–900. 2010.

59 

Sistigu A, Yamazaki T, Vacchelli E, Chaba K, Enot DP, Adam J, Vitale I, Goubar A, Baracco EE, Remédios C, et al: Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy. Nat Med. 20:1301–1309. 2014.

60 

Johns TG, Mackay IR, Callister KA, Hertzog PJ, Devenish RJ and Linnane AW: Antiproliferative potencies of interferons on melanoma cell lines and xenografts: Higher efficacy of interferon beta. J Natl Cancer Inst. 84:1185–1190. 1992.

61 

Horikoshi T, Fukuzawa K, Hanada N, Ezoe K, Eguchi H, Hamaoka S, Tsujiya H and Tsukamoto T: In vitro comparative study of the antitumor effects of human interferon-alpha, beta and gamma on the growth and invasive potential of human melanoma cells. J Dermatol. 22:631–636. 1995.

62 

Köpf J, Hanson C, Delle U, Weimarck A and Stierner U: Action of interferon alpha and beta on four human melanoma cell lines in vitro. Anticancer Res. 16:791–798. 1996.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Makita K, Hara H, Sano E, Okamoto Y, Ochiai Y, Harada T, Ueda T, Nakayama T, Aizawa S, Yoshino A, Yoshino A, et al: Interferon-β sensitizes human malignant melanoma cells to temozolomide-induced apoptosis and autophagy. Int J Oncol 54: 1864-1874, 2019.
APA
Makita, K., Hara, H., Sano, E., Okamoto, Y., Ochiai, Y., Harada, T. ... Yoshino, A. (2019). Interferon-β sensitizes human malignant melanoma cells to temozolomide-induced apoptosis and autophagy. International Journal of Oncology, 54, 1864-1874. https://doi.org/10.3892/ijo.2019.4743
MLA
Makita, K., Hara, H., Sano, E., Okamoto, Y., Ochiai, Y., Harada, T., Ueda, T., Nakayama, T., Aizawa, S., Yoshino, A."Interferon-β sensitizes human malignant melanoma cells to temozolomide-induced apoptosis and autophagy". International Journal of Oncology 54.5 (2019): 1864-1874.
Chicago
Makita, K., Hara, H., Sano, E., Okamoto, Y., Ochiai, Y., Harada, T., Ueda, T., Nakayama, T., Aizawa, S., Yoshino, A."Interferon-β sensitizes human malignant melanoma cells to temozolomide-induced apoptosis and autophagy". International Journal of Oncology 54, no. 5 (2019): 1864-1874. https://doi.org/10.3892/ijo.2019.4743
Copy and paste a formatted citation
x
Spandidos Publications style
Makita K, Hara H, Sano E, Okamoto Y, Ochiai Y, Harada T, Ueda T, Nakayama T, Aizawa S, Yoshino A, Yoshino A, et al: Interferon-β sensitizes human malignant melanoma cells to temozolomide-induced apoptosis and autophagy. Int J Oncol 54: 1864-1874, 2019.
APA
Makita, K., Hara, H., Sano, E., Okamoto, Y., Ochiai, Y., Harada, T. ... Yoshino, A. (2019). Interferon-β sensitizes human malignant melanoma cells to temozolomide-induced apoptosis and autophagy. International Journal of Oncology, 54, 1864-1874. https://doi.org/10.3892/ijo.2019.4743
MLA
Makita, K., Hara, H., Sano, E., Okamoto, Y., Ochiai, Y., Harada, T., Ueda, T., Nakayama, T., Aizawa, S., Yoshino, A."Interferon-β sensitizes human malignant melanoma cells to temozolomide-induced apoptosis and autophagy". International Journal of Oncology 54.5 (2019): 1864-1874.
Chicago
Makita, K., Hara, H., Sano, E., Okamoto, Y., Ochiai, Y., Harada, T., Ueda, T., Nakayama, T., Aizawa, S., Yoshino, A."Interferon-β sensitizes human malignant melanoma cells to temozolomide-induced apoptosis and autophagy". International Journal of Oncology 54, no. 5 (2019): 1864-1874. https://doi.org/10.3892/ijo.2019.4743
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team