Open Access

Oral mucosal mesenchymal stem cell‑derived exosomes: A potential therapeutic target in oral premalignant lesions

  • Authors:
    • Wenwen Li
    • Ying Han
    • Zhongfang Zhao
    • Xiaoli Ji
    • Xing Wang
    • Jianqiu Jin
    • Qian Wang
    • Xiang Guo
    • Zhe Cheng
    • Mingxing Lu
    • Guodong Wang
    • Yixiang Wang
    • Hongwei Liu
  • View Affiliations

  • Published online on: March 19, 2019     https://doi.org/10.3892/ijo.2019.4756
  • Pages: 1567-1578
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Emerging evidence indicates that mesenchymal stem cells (MSCs) serve an indispensable role in the tumor microenvironment. However, whether MSCs participate in the development of oral carcinogenesis remains unclear. The present study isolated MSCs from clinical tissues and investigated the differences of MSCs derived from normal oral mucosa (N‑MSC), oral leukoplakia with dysplasia (LK‑MSC) and oral carcinoma (Ca‑MSC). The results revealed that the LK‑MSCs exhibited reduced proliferation and migration, compared with the N‑MSCs and Ca‑MSCs. Furthermore, it was demonstrated that the exosomes secreted by LK‑MSCs have significant roles in promoting proliferation, migration and invasion in vitro, which was similar to the Ca‑MSC‑derived exosomes. The promoting effect was also demonstrated in a 3D coculture model. When the secretion of exosomes was blocked, the promoting effect of LK‑MSCs was reversed. Based on a microarray analysis of MSC‑derived exosomes, microRNA‑8485 (miR‑8485) was identified to be ectopically expressed. The exosomal miR‑8485 was capable of promoting the proliferation, migration and invasion of tumor cells. Therefore, the present study highlights the significance of MSC‑derived exosomes and exosomal miR‑8485 in premalignant lesions and carcinogenesis. Intervention with the secretion of MSC‑derived‑exosomes may be an innovative strategy to retard the carcinogenesis.
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May-2019
Volume 54 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Li W, Han Y, Zhao Z, Ji X, Wang X, Jin J, Wang Q, Guo X, Cheng Z, Lu M, Lu M, et al: Oral mucosal mesenchymal stem cell‑derived exosomes: A potential therapeutic target in oral premalignant lesions. Int J Oncol 54: 1567-1578, 2019
APA
Li, W., Han, Y., Zhao, Z., Ji, X., Wang, X., Jin, J. ... Liu, H. (2019). Oral mucosal mesenchymal stem cell‑derived exosomes: A potential therapeutic target in oral premalignant lesions. International Journal of Oncology, 54, 1567-1578. https://doi.org/10.3892/ijo.2019.4756
MLA
Li, W., Han, Y., Zhao, Z., Ji, X., Wang, X., Jin, J., Wang, Q., Guo, X., Cheng, Z., Lu, M., Wang, G., Wang, Y., Liu, H."Oral mucosal mesenchymal stem cell‑derived exosomes: A potential therapeutic target in oral premalignant lesions". International Journal of Oncology 54.5 (2019): 1567-1578.
Chicago
Li, W., Han, Y., Zhao, Z., Ji, X., Wang, X., Jin, J., Wang, Q., Guo, X., Cheng, Z., Lu, M., Wang, G., Wang, Y., Liu, H."Oral mucosal mesenchymal stem cell‑derived exosomes: A potential therapeutic target in oral premalignant lesions". International Journal of Oncology 54, no. 5 (2019): 1567-1578. https://doi.org/10.3892/ijo.2019.4756