|
1
|
Jemal A, Bray F, Center MM, Ferlay J, Ward
E and Forman D: Global cancer statistics. CA Cancer J Clin.
61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Center MM, Jemal A, Smith RA and Ward E:
Worldwide variations in colorectal cancer. CA Cancer J Clin.
59:366–378. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Siegel R, Desantis C and Jemal A:
Colorectal cancer statistics, 2014. CA Cancer J Clin. 64:104–117.
2014. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Koehler BC, Jäger D and Schulze-Bergkamen
H: Targeting cell death signaling in colorectal cancer: Current
strategies and future perspectives. World J Gastroenterol.
20:1923–1934. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Green DR and Llambi F: Cell death
signaling. Cold Spring Harb Perspect Biol. 7:a0060802015.
View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Kroemer G, Galluzzi L, Vandenabeele P,
Abrams J, Alnemri ES, Baehrecke EH, Blagosklonny MV, El-Deiry WS,
Golstein P, Green DR, et al: Nomenclature Committee on Cell Death
2009: Classification of cell death: Recommendations of the
Nomenclature Committee on Cell Death 2009. Cell Death Differ.
16:3–11. 2009. View Article : Google Scholar
|
|
7
|
Shintani T and Klionsky DJ: Autophagy in
health and disease: A double-edged sword. Science. 306:990–995.
2004. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Ng G and Huang J: The significance of
autophagy in cancer. Mol Carcinog. 43:183–187. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Codogno P and Meijer AJ: Autophagy and
signaling: Their role in cell survival and cell death. Cell Death
Differ. 12(Suppl 2): 1509–1518. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Su M, Mei Y and Sinha S: Role of the
crosstalk between autophagy and apoptosis in cancer. J Oncol.
2013:1027352013. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Ouyang L, Shi Z, Zhao S, Wang FT, Zhou TT,
Liu B and Bao JK: Programmed cell death pathways in cancer: A
review of apoptosis, autophagy and programmed necrosis. Cell
Prolif. 45:487–498. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Ou L, Lin S, Song B, Liu J, Lai R and Shao
L: The mechanisms of graphene-based materials-induced programmed
cell death: A review of apoptosis, autophagy, and programmed
necrosis. Int J Nanomedicine. 12:6633–6646. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Qian HR, Shi ZQ, Zhu HP, Gu LH, Wang XF
and Yang Y: Interplay between apoptosis and autophagy in colorectal
cancer. Oncotarget. 8:62759–62768. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Reczek CR and Chandel NS: ROS-dependent
signal transduction. Curr Opin Cell Biol. 33:8–13. 2015. View Article : Google Scholar :
|
|
15
|
Marchi S, Giorgi C, Suski JM, Agnoletto C,
Bononi A, Bonora M, De Marchi E, Missiroli S, Patergnani S, Poletti
F, et al: Mitochondria-ros crosstalk in the control of cell death
and aging. J Signal Transduct. 2012:3296352012. View Article : Google Scholar
|
|
16
|
Na AR, Chung YM, Lee SB, Park SH, Lee MS
and Yoo YD: A critical role for Romo1-derived ROS in cell
proliferation. Biochem Biophys Res Commun. 369:672–678. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Li L, Tan J, Miao Y, Lei P and Zhang Q:
ROS and autophagy: Interactions and molecular regulatory
mechanisms. Cell Mol Neurobiol. 35:615–621. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Scherz-Shouval R and Elazar Z: Regulation
of autophagy by ROS: Physiology and pathology. Trends Biochem Sci.
36:30–38. 2011. View Article : Google Scholar
|
|
19
|
Xie J, Xu Y, Huang X, Chen Y, Fu J, Xi M
and Wang L: Berberine-induced apoptosis in human breast cancer
cells is mediated by reactive oxygen species generation and
mitochondrial-related apoptotic pathway. Tumour Biol. 36:1279–1288.
2015. View Article : Google Scholar
|
|
20
|
Li GH, Lin XL, Zhang H, Li S, He XL, Zhang
K, Peng J, Tang YL, Zeng JF, Zhao Y, et al: Ox-Lp(a) transiently
induces HUVEC autophagy via an ROS-dependent PAPR-1-LKB1-AMPK-mTOR
pathway. Atherosclerosis. 243:223–235. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Lee MS, Tsai CW, Wang CP, Chen JH and Lin
HH: Anti-prostate cancer potential of gossypetin via inducing
apoptotic and autophagic cell death. Mol Carcinog. 56:2578–2592.
2017. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Sun ZL, Dong JL and Wu J: Juglanin induces
apoptosis and autophagy in human breast cancer progression via
ROS/JNK promotion. Biomed Pharmacother. 85:303–312. 2017.
View Article : Google Scholar
|
|
23
|
Sun D, Shen W, Zhang F, Fan H, Tan J1, Li
L, Xu C, Zhang H, Yang Y and Cheng H: α-Hederin arrests cell cycle
at G2/M checkpoint and promotes mitochondrial apoptosis by blocking
nuclear factor-B signaling in colon cancer cells. BioMed Res Int.
2548378:20182018.
|
|
24
|
Gumushan-Aktas H and Altun S: Effects of
Hedera helix L. extracts on rat prostate cancer cell proliferation
and motility. Oncol Lett. 12:2985–2991. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Claereboudt EJS, Eeckhaut I, Lins L and
Deleu M: How different sterols contribute to saponin tolerant
plasma membranes in sea cucumbers. Sci Rep. 8:108452018. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Li J, Wu DD, Zhang JX, Wang J, Ma JJ, Hu X
and Dong WG: Mitochondrial pathway mediated by reactive oxygen
species involvement in α-hederin-induced apoptosis in
hepatocellular carcinoma cells. World J Gastroenterol.
24:1901–1910. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Lorent JH, Léonard C, Abouzi M, Akabi F,
Quetin-Leclercq J and Mingeot-Leclercq MP: α-Hederin induces
apoptosis, membrane permeabilization and morphologic changes in two
cancer cell lines through a cholesterol-dependent mechanism. Planta
Med. 82:1532–1539. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Sun D, Shen W, Zhang F, Fan H, Xu C, Li L,
Tan J, Miao Y, Zhang Yang Y, et al: α-Hederin inhibits interleukin
6-induced epithelial-to-mesenchymal transition associated with
disruption of JAK2/STAT3 signaling in colon cancer cells. Biomed
Pharmacother. 101:107–114. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Sun J, Liu T and Xu J: Improving the
anticancer activity of α-hederin by physically encapsulating it
with targeted micelles assembled from amphiphilic block copolymers.
J Drug Deliv Sci Technol. 35:252–259. 2016. View Article : Google Scholar
|
|
30
|
Sun J, Xu K, Qiu Y, Gao H, Xu J, Tang Q
and Yin P: Bufalin reverses acquired drug resistance by inhibiting
stemness in colorectal cancer cells. Oncol Rep. 38:1420–1430. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Zhu R, Zhang CG, Liu Y, Yuan ZQ, Chen WL,
Yang SD, Li JZ, Zhu WJ, Zhou XF, You BG, et al: CD147 monoclonal
antibody mediated by chitosan nanoparticles loaded with α-hederin
enhances antineoplastic activity and cellular uptake in liver
cancer cells. Sci Rep. 5:179042015. View Article : Google Scholar
|
|
32
|
Cheng L, Xia TS, Wang YF, Zhou W, Liang
XQ, Xue JQ, Shi L, Wang Y, Ding Q and Wang M: The anticancer effect
and mechanism of α-hederin on breast cancer cells. Int J Oncol.
45:757–763. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Cheng L, Xia TS, Wang YF, Zhou W, Liang
XQ, Xue JQ, Shi L, Wang Y and Ding Q: The apoptotic effect of D
Rhamnose β-hederin, a novel oleanane-type triterpenoid saponin on
breast cancer cells. PLoS One. 9:e908482014. View Article : Google Scholar
|
|
34
|
Randhawa MA and Alghamdi MS: Anticancer
activity of Nigella sativa (black seed) - a review. Am J Chin Med.
39:1075–1091. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Rooney S and Ryan MF: Effects of
alpha-hederin and thymoquinone, constituents of Nigella sativa, on
human cancer cell lines. Anticancer Res. 25:2199–2204.
2005.PubMed/NCBI
|
|
36
|
Rooney S and Ryan MF: Modes of action of
alpha-hederin and thymoquinone, active constituents of Nigella
sativa, against HEp-2 cancer cells. Anticancer Res. 25:4255–4259.
2005.PubMed/NCBI
|
|
37
|
Swamy SM and Huat BT: Intracellular
glutathione depletion and reactive oxygen species generation are
important in alpha-hederin-induced apoptosis of P388 cells. Mol
Cell Biochem. 245:127–139. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Suen DF, Norris KL and Youle RJ:
Mitochondrial dynamics and apoptosis. Genes Dev. 22:1577–1590.
2008. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Gump JM, Staskiewicz L, Morgan MJ, Bamberg
A, Riches DW and Thorburn A: Autophagy variation within a cell
population determines cell fate through selective degradation of
Fap-1. Nat Cell Biol. 16:47–54. 2014. View Article : Google Scholar
|
|
40
|
Dunlop EA and Tee AR: mTOR and autophagy:
A dynamic relationship governed by nutrients and energy. Semin Cell
Dev Biol. 36:121–129. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Tanida I, Ueno T and Kominami E: LC3 and
Autophagy. Methods Mol Biol. 445:77–88. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Kou B, Liu W, Xu X, Yang Y, Yi Q, Guo F,
Li J, Zhou J and Kou Q: Autophagy induction enhances
tetrandrine-induced apoptosis via the AMPK/mTOR pathway in human
bladder cancer cells. Oncol Rep. 38:3137–3143. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Zha QB, Zhang XY, Lin QR, Xu LH, Zhao GX,
Pan H, Zhou D, Ouyang DY, Liu ZH and He XH: Cucurbitacin E induces
autophagy via downregulating mTORC1 signaling and upregulating AMPK
activity. PLoS One. 10:e01243552015. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Zhan Y, Wang K, Li Q, Zou Y, Chen B, Gong
Q, Ho HI, Yin T, Zhang F, Lu Y, et al: The novel autophagy
inhibitor alpha-hederin promoted paclitaxel cytotoxicity by
increasing reactive oxygen species accumulation in non-small cell
lung cancer cells. Int J Mol Sci. 19:32212018. View Article : Google Scholar :
|
|
45
|
Wu AG, Zeng W, Wong VK, Zhu YZ, Lo AC, Liu
L and Law BY: Hederagenin and α-hederin promote degradation of
proteins in neurodegenerative diseases and improve motor deficits
in MPTP-mice. Pharmacol Res. 115:25–44. 2017. View Article : Google Scholar
|
|
46
|
Roach PJ: AMPK -> ULK1 -> autophagy.
Mol Cell Biol. 31:3082–3084. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Mao X, Yu CR, Li WH and Li WX: Induction
of apoptosis by shikonin through a ROS/JNK-mediated process in
Bcr/Abl-positive chronic myelogenous leukemia (CML) cells. Cell
Res. 18:879–888. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Ghavami S, Eshragi M, Ande SR, Chazin WJ,
Klonisch T, Halayko AJ, McNeill KD, Hashemi M, Kerkhoff C and Los
M: S100A8/A9 induces autophagy and apoptosis via ROS-mediated
cross-talk between mitochondria and lysosomes that involves BNIP3.
Cell Res. 20:314–331. 2010. View Article : Google Scholar
|
|
49
|
Chen S, Rehman SK, Zhang W, Wen A, Yao L
and Zhang J: Autophagy is a therapeutic target in anticancer drug
resistance. Biochim Biophys Acta. 1806:220–229. 2010.PubMed/NCBI
|
|
50
|
Xu L, Qu XJ, Liu YP, Xu YY, Liu J, Hou KZ
and Zhang Y: Protective autophagy antagonizes oxaliplatin-induced
apoptosis in gastric cancer cells. Chin J Cancer. 30:490–496. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Wang N, Feng Y, Zhu M, Tsang CM, Man K,
Tong Y and Tsao SW: Berberine induces autophagic cell death and
mitochondrial apoptosis in liver cancer cells: The cellular
mechanism. J Cell Biochem. 111:1426–1436. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Kanzawa T, Zhang L, Xiao L, Germano IM,
Kondo Y and Kondo S: Arsenic trioxide induces autophagic cell death
in malignant glioma cells by upregulation of mitochondrial cell
death protein BNIP3. Oncogene. 24:980–991. 2005. View Article : Google Scholar
|
|
53
|
Zhai B, Hu F, Jiang X, Xu J, Zhao D, Liu
B, Pan S, Dong X, Tan G, Wei Z, et al: Inhibition of Akt reverses
the acquired resistance to sorafenib by switching protective
autophagy to autophagic cell death in hepatocellular carcinoma. Mol
Cancer Ther. 13:1589–1598. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Bang SC, Seo HH, Shin HR, Lee KC, Hoang TA
and Jung SH: A convenient preparation of a disaccharide motif and
its role in the cytotoxicity of the triterpenoid saponin,
alpha-hederin. Arch Pharm Res. 31:555–561. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Jeong HG and Park HY: The prevention of
carbon tetrachloride-induced hepatotoxicity in mice by
alpha-hederin: Inhibiton of cytochrome P450 2E1 expression. Biochem
Mol Biol Int. 45:163–170. 1998.PubMed/NCBI
|
|
56
|
Gaillard Y, Blaise P, Darré A, Barbier T
and Pépin G: An unusual case of death: Suffocation caused by leaves
of common ivy (Hedera helix). Detection of hederacoside C,
α-hederin, and hederagenin by LC-EI/MS-MS. J Anal Toxicol.
27:257–262. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Delmas F, Di Giorgio C, Elias R, Gasquet
M, Azas N, Mshvildadze V, Dekanosidze G, Kemertelidze E and
Timon-David P: Antileishmanial activity of three saponins isolated
from ivy, alpha-hederin, beta-hederin and hederacolchiside A1, as
compared to their action on mammalian cells cultured in vitro.
Planta Med. 66:343–347. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Danloy S, Quetin-Leclercq J, Coucke P, De
Pauw-Gillet MC, Elias R, Balansard G, Angenot L and Bassleer R:
Effects of alpha-hederin, a saponin extracted from Hedera helix, on
cells cultured in vitro. Planta Med. 60:45–49. 1994. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Takechi M and Yasuo T: Structure-activity
relationships of the saponin α-hederin. Phytochemistry. 29:451–452.
1990. View Article : Google Scholar
|
