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Review

CircRNAs: From anonymity to novel regulators of gene expression in cancer (Review)

  • Authors:
    • Katherine L. Harper
    • Euan Mcdonnell
    • Adrian Whitehouse
  • View Affiliations / Copyright

    Affiliations: School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK
  • Pages: 1183-1193
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    Published online on: October 24, 2019
       https://doi.org/10.3892/ijo.2019.4904
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Abstract

Circular RNAs (circRNAs) are a group of non‑coding RNAs, formed mostly through a unique backsplicing mechanism. Originally proposed to be a by‑product from errors in splicing, recent studies have shown they exhibit a range of roles in regulating gene expression, including sponging of microRNAs (miRNAs), interactions with RNA‑binding proteins and regulation of transcription. Though research is still in its infancy, evidence suggests circRNA levels are tightly regulated in the cell, reinforced by dysregulated circRNAs levels being implicated in a range of diseases, including cancer and viral infection. There is growing interest in circRNAs playing specific roles in cancers, either oncogenic or as tumour suppressors, with particular focus on their potential as novel biomarkers. This review will provide an overview of circRNA biogenesis and regulation, and their potential roles in the cell, with a focus on their dysregulation in cancer.
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1 

Salzman J: Circular RNA expression: Its potential regulation and function. Trends Genet. 32:309–316. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Ebbesen KK, Hansen TB and Kjems J: Insights into circular RNA biology. RNA Biol. 14:1035–1045. 2017. View Article : Google Scholar :

3 

Taylor JM: Host RNA circles and the origin of hepatitis delta virus. World J Gastroenterol. 20:2971–2978. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Nigro JM, Cho KR, Fearon ER, Kern SE, Ruppert JM, Oliner JD, Kinzler KW and Vogelstein B: Scrambled exons. Cell. 64:607–613. 1991. View Article : Google Scholar : PubMed/NCBI

5 

Jeck WR and Sharpless NE: Detecting and characterizing circular RNAs. Nat Biotechnol. 32:453–461. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Hansen TB, Jensen TI, Clausen BH, Bramsen JB, Finsen B, Damgaard CK and Kjems J: Natural RNA circles function as efficient microRNA sponges. Nature. 495:384–388. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Kristensen LS, Hansen TB, Venø MT and Kjems J: Circular RNAs in cancer: Opportunities and challenges in the field. Oncogene. 37:555–565. 2018. View Article : Google Scholar :

8 

Chen LL and Yang L: Regulation of circRNA biogenesis. RNA Biol. 12:381–388. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Holdt LM, Kohlmaier A and Teupser D: Molecular roles and function of circular RNAs in eukaryotic cells. Cell Mol Life Sci. 75:1071–1098. 2018. View Article : Google Scholar :

10 

Barrett SP and Salzman J: Circular RNAs: Analysis, expression and potential functions. Development. 143:1838–1847. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Liang D and Wilusz JE: Short intronic repeat sequences facilitate circular RNA production. Genes Dev. 28:2233–2247. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Xu S, Zhou L, Ponnusamy M, Zhang L, Dong Y, Zhang Y, Wang Q, Liu J and Wang K: A comprehensive review of circRNA: From purification and identification to disease marker potential. PeerJ. 6:e55032018. View Article : Google Scholar : PubMed/NCBI

13 

Chen I, Chen CY and Chuang TJ: Biogenesis, identification, and function of exonic circular RNAs. Wiley Interdiscip Rev RNA. 6:563–579. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Wang J, Zhu M, Pan J, Chen C, Xia S and Song Y: Circular RNAs: A rising star in respiratory diseases. Respir Res. 20:32019. View Article : Google Scholar : PubMed/NCBI

15 

Zhang Y, Zhang XO, Chen T, Xiang JF, Yin QF, Xing YH, Zhu S, Yang L and Chen LL: Circular intronic long noncoding RNAs. Mol Cell. 51:792–806. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Huang S, Yang B, Chen BJ, Bliim N, Ueberham U, Arendt T and Janitz M: The emerging role of circular RNAs in transcriptome regulation. Genomics. 109:401–407. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Conn SJ, Pillman KA, Toubia J, Conn VM, Salmanidis M, Phillips CA, Roslan S, Schreiber AW, Gregory PA and Goodall GJ: The RNA binding protein quaking regulates formation of circRNAs. Cell. 160:1125–1134. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Huang C, Liang D, Tatomer DC and Wilusz JE: A length-dependent evolutionarily conserved pathway controls nuclear export of circular RNAs. Genes Dev. 32:639–644. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Schumann S, Jackson BR, Yule I, Whitehead SK, Revill C, Foster R and Whitehouse A: Targeting the ATP-dependent formation of herpesvirus ribonucleoprotein particle assembly as an antiviral approach. Nat Microbiol. 2:162012016. View Article : Google Scholar : PubMed/NCBI

20 

Ivanov A, Memczak S, Wyler E, Torti F, Porath HT, Orejuela MR, Piechotta M, Levanon EY, Landthaler M, Dieterich C and Rajewsky N: Analysis of intron sequences reveals hallmarks of circular RNA biogenesis in animals. Cell Rep. 10:170–177. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Aktaş T, Avşar Ilık İ, Maticzka D, Bhardwaj V, Pessoa Rodrigues C, Mittler G, Manke T, Backofen R and Akhtar A: DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome. Nature. 544:115–119. 2017. View Article : Google Scholar

22 

Chen D, Lu X, Yang F and Xing N: Circular RNA circHIPK3 promotes cell proliferation and invasion of prostate cancer by sponging miR-193a-3p and regulating MCL1 expression. Cancer Manag Res. 11:1415–1423. 2019. View Article : Google Scholar : PubMed/NCBI

23 

Chen Y, Yang F, Fang E, Xiao W, Mei H, Li H, Li D, Song H, Wang J, Hong M, et al: Circular RNA circAGO2 drives cancer progression through facilitating HuR-repressed functions of AGO2-miRNA complexes. Cell Death Differ. 26:1346–1364. 2019. View Article : Google Scholar

24 

Deng L, Liu G, Zheng C, Zhang L, Kang Y and Yang F: Circ-LAMP1 promotes T-cell lymphoblastic lymphoma progression via acting as a ceRNA for miR-615-5p to regulate DDR2 expression. Gene. 701:146–151. 2019. View Article : Google Scholar : PubMed/NCBI

25 

Yang G, Wang X, Liu B, Lu Z, Xu Z, Xiu P, Liu Z and Li J: circ-BIRC6, a circular RNA, promotes hepatocellular carcinoma progression by targeting the miR-3918/Bcl2 axis. Cell Cycle. 18:976–989. 2019. View Article : Google Scholar : PubMed/NCBI

26 

Wu Q, Li P, Wu M and Liu Q: Deregulation of circular RNAs in cancer from the perspectives of aberrant biogenesis, transport and removal. Front Genet. 10:162019. View Article : Google Scholar : PubMed/NCBI

27 

Wang C, Zou J, Ma X, Wang E and Peng G: Mechanisms and implications of ADAR-mediated RNA editing in cancer. Cancer Lett. 411:27–34. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Lee T and Pelletier J: The biology of DHX9 and its potential as a therapeutic target. Oncotarget. 7:42716–42739. 2016.PubMed/NCBI

29 

Goehe RW, Shultz JC, Murudkar C, Usanovic S, Lamour NF, Massey DH, Zhang L, Camidge DR, Shay JW, Minna JD and Chalfant CE: hnRNP L regulates the tumorigenic capacity of lung cancer xenografts in mice via caspase-9 pre-mRNA processing. J Clin Invest. 120:3923–3939. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Gou Q, Wu K, Zhou JK, Xie Y, Liu L and Peng Y: Profiling and bioinformatic analysis of circular RNA expression regulated by c-Myc. Oncotarget. 8:71587–71596. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Panda AC: Circular RNAs act as miRNA sponges. Adv Exp Med Biol. 1087:67–79. 2018. View Article : Google Scholar : PubMed/NCBI

32 

O'Brien J, Hayder H, Zayed Y and Peng C: Overview of MicroRNA biogenesis, mechanisms of actions, and circulation. Front Endocrinol (Lausanne). 9:4022018. View Article : Google Scholar

33 

Rong D, Sun H, Li Z, Liu S, Dong C, Fu K, Tang W and Cao H: An emerging function of circRNA-miRNAs-mRNA axis in human diseases. Oncotarget. 8:73271–73281. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Mitra A, Pfeifer K and Park KS: Circular RNAs and competing endogenous RNA (ceRNA) networks. Transl Cancer Res. 7(Suppl 5): S624–S628. 2018. View Article : Google Scholar : PubMed/NCBI

35 

Liu L, Wang J, Khanabdali R, Kalionis B, Tai X and Xia S: Circular RNAs: Isolation, characterization and their potential role in diseases. RNA Biol. 14:1715–1721. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Leggio L, Vivarelli S, L'Episcopo F, Tirolo C, Caniglia S, Testa N, Marchetti B and Iraci N: microRNAs in Parkinson's disease: From pathogenesis to novel diagnostic and therapeutic approaches. Int J Mol Sci. 18:E26982017. View Article : Google Scholar : PubMed/NCBI

37 

Rothman A, Restrepo H, Sarukhanov V, Evans WN, Wiencek RG Jr, Williams R, Hamburger N, Anderson K, Balsara J and Mann D: Assessment of microRNA and gene dysregulation in pulmonary hypertension by endoarterial biopsy. Pulm Circ. 7:455–464. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Girardi E, López P and Pfeffer S: On the importance of Host MicroRNAs during viral infection. Front Genet. 9:4392018. View Article : Google Scholar : PubMed/NCBI

39 

Ragan C, Goodall GJ, Shirokikh NE and Preiss T: Insights into the biogenesis and potential functions of exonic circular RNA. Sci Rep. 9:20482019. View Article : Google Scholar : PubMed/NCBI

40 

Wilusz JE: A 360° view of circular RNAs: From biogenesis to functions. Wiley Interdiscip Rev RNA. 9:e14782018. View Article : Google Scholar

41 

Quan G and Li J: Circular RNAs: Biogenesis, expression and their potential roles in reproduction. J Ovarian Res. 11:92018. View Article : Google Scholar : PubMed/NCBI

42 

Kulcheski FR, Christoff AP and Margis R: Circular RNAs are miRNA sponges and can be used as a new class of biomarker. J Biotechnol. 238:42–51. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Pratt AJ and MacRae IJ: The RNA-induced silencing complex: A versatile gene-silencing machine. J Biol Chem. 284:17897–17901. 2009. View Article : Google Scholar : PubMed/NCBI

44 

Kluiver J, Gibcus JH, Hettinga C, Adema A, Richter MK, Halsema N, Slezak-Prochazka I, Ding Y, Kroesen BJ and van den Berg A: Rapid generation of microRNA sponges for microRNA inhibition. PLoS One. 7:e292752012. View Article : Google Scholar : PubMed/NCBI

45 

Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, et al: Circular RNAs are a large class of animal RNAs with regulatory potency. Nature. 495:333–338. 2013. View Article : Google Scholar : PubMed/NCBI

46 

Peng L, Yuan XQ and Li GC: The emerging landscape of circular RNA ciRS-7 in cancer (Review). Oncol Rep. 33:2669–2674. 2015. View Article : Google Scholar : PubMed/NCBI

47 

Liu L, Liu FB, Huang M, Xie K, Xie QS, Liu CH, Shen MJ and Huang Q: Circular RNA ciRS-7 promotes the proliferation and metastasis of pancreatic cancer by regulating miR-7-mediated EGFR/STAT3 signaling pathway. Hepatobiliary Pancreat Dis Int. Mar 9;S1499-3872(19)30039-6. 2019.Epub ahead of print. View Article : Google Scholar

48 

Zheng Q, Bao C, Guo W, Li S, Chen J, Chen B, Luo Y, Lyu D, Li Y, Shi G, et al: Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs. Nat Commun. 7:112152016. View Article : Google Scholar : PubMed/NCBI

49 

Zeng K, Chen X, Xu M, Liu X, Hu X, Xu T, Sun H, Pan Y, He B and Wang S: CircHIPK3 promotes colorectal cancer growth and metastasis by sponging miR-7. Cell Death Dis. 9:4172018. View Article : Google Scholar : PubMed/NCBI

50 

Chen G, Shi Y, Liu M and Sun J: circHIPK3 regulates cell proliferation and migration by sponging miR-124 and regulating AQP3 expression in hepatocellular carcinoma. Cell Death Dis. 9:1752018. View Article : Google Scholar : PubMed/NCBI

51 

Yu H, Chen Y and Jiang P: Circular RNA HIPK3 exerts oncogenic properties through suppression of miR-124 in lung cancer. Biochem Biophys Res Commun. 506:455–462. 2018. View Article : Google Scholar : PubMed/NCBI

52 

Morgan EL, Wasson CW, Hanson L, Kealy D, Pentland I, McGuire V, Scarpini C, Coleman N, Arthur JSC, Parish JL, et al: STAT3 activation by E6 is essential for the differentiation-dependent HPV18 life cycle. PLoS Pathog. 14:e10069752018. View Article : Google Scholar : PubMed/NCBI

53 

Cheng J, Zhuo H, Xu M, Wang L, Xu H, Peng J, Hou J, Lin L and Cai J: Regulatory network of circRNA-miRNA-mRNA contributes to the histological classification and disease progression in gastric cancer. J Transl Med. 16:2162018. View Article : Google Scholar : PubMed/NCBI

54 

Zhang J, Liu H, Hou L, Wang G, Zhang R, Huang Y, Chen X and Zhu J: Circular RNA_LARP4 inhibits cell proliferation and invasion of gastric cancer by sponging miR-424-5p and regulating LATS1 expression. Mol Cancer. 16:1512017. View Article : Google Scholar : PubMed/NCBI

55 

Chen Z, Zuo X, Pu L, Zhang Y, Han G, Zhang L, Wu J and Wang X: circLARP4 induces cellular senescence through regulating miR-761/RUNX3/p53/p21 signaling in hepatocellular carcinoma. Cancer Sci. 110:568–581. 2019. View Article : Google Scholar :

56 

Levanon D, Bernstein Y, Negreanu V, Bone KR, Pozner A, Eilam R, Lotem J, Brenner O and Groner Y: Absence of Runx3 expression in normal gastrointestinal epithelium calls into question its tumour suppressor function. EMBO Mol Med. 3:593–604. 2011. View Article : Google Scholar : PubMed/NCBI

57 

Wan L, Zhang L, Fan K, Cheng ZX, Sun QC and Wang JJ: Circular RNA-ITCH suppresses lung cancer proliferation via inhibiting the Wnt/β-catenin pathway. Biomed Res Int. 2016:15794902016. View Article : Google Scholar

58 

Yang C, Yuan W, Yang X, Li P, Wang J, Han J, Tao J, Li P, Yang H, Lv Q and Zhang W: Circular RNA circ-ITCH inhibits bladder cancer progression by sponging miR-17/miR-224 and regulating p21, PTEN expression. Mol Cancer. 17:192018. View Article : Google Scholar : PubMed/NCBI

59 

Huang X, Li Z, Zhang Q, Wang W, Li B, Wang L, Xu Z, Zeng A, Zhang X, Zhang X, et al: Circular RNA AKT3 upregulates PIK3R1 to enhance cisplatin resistance in gastric cancer via miR-198 suppression. Mol Cancer. 18:712019. View Article : Google Scholar : PubMed/NCBI

60 

Zhao ZJ and Shen J: Circular RNA participates in the carcinogenesis and the malignant behavior of cancer. RNA Biol. 14:514–521. 2017. View Article : Google Scholar :

61 

Panda AC, Grammatikakis I, Kim KM, De S, Martindale JL, Munk R, Yang X, Abdelmohsen K and Gorospe M: Identification of senescence-associated circular RNAs (SAC-RNAs) reveals senescence suppressor CircPVT1. Nucleic Acids Res. 45:4021–4035. 2017. View Article : Google Scholar :

62 

Li X, Zhang Z, Jiang H, Li Q, Wang R, Pan H, Niu Y, Liu F, Gu H, Fan X and Gao J: Circular RNA circPVT1 promotes proliferation and invasion through sponging miR-125b and activating E2F2 signaling in non-small cell lung cancer. Cell Physiol Biochem. 51:2324–2340. 2018. View Article : Google Scholar : PubMed/NCBI

63 

Wu Z, Huang W, Wang X, Wang T, Chen Y, Chen B, Liu R, Bai P and Xing J: Circular RNA CEP128 acts as a sponge of miR-145-5p in promoting the bladder cancer progression via regulating SOX11. Mol Med. 24:402018. View Article : Google Scholar : PubMed/NCBI

64 

Zhang H, Wang G, Ding C, Liu P, Wang R, Ding W, Tong D, Wu D, Li C, Wei Q, et al: Increased circular RNA UBAP2 acts as a sponge of miR-143 to promote osteosarcoma progression. Oncotarget. 8:61687–61697. 2017.PubMed/NCBI

65 

Zhang J, Hou L, Liang R, Chen X, Zhang R, Chen W and Zhu J: CircDLST promotes the tumorigenesis and metastasis of gastric cancer by sponging miR-502-5p and activating the NRAS/MEK1/ERK1/2 signaling. Mol Cancer. 18:802019. View Article : Google Scholar : PubMed/NCBI

66 

Li Z, Huang C, Bao C, Chen L, Lin M, Wang X, Zhong G, Yu B, Hu W, Dai L, et al: Exon-intron circular RNAs regulate transcription in the nucleus. Nat Struct Mol Biol. 22:256–264. 2015. View Article : Google Scholar : PubMed/NCBI

67 

Holdt LM, Kohlmaier A and Teupser D: Molecular functions and specific roles of circRNAs in the cardiovascular system. Noncoding RNA Res. 3:75–98. 2018. View Article : Google Scholar : PubMed/NCBI

68 

Qin M, Wei G and Sun X: Circ-UBR5: An exonic circular RNA and novel small nuclear RNA involved in RNA splicing. Biochem Biophys Res Commun. 503:1027–1034. 2018. View Article : Google Scholar : PubMed/NCBI

69 

Abdelmohsen K, Panda AC, Munk R, Grammatikakis I, Dudekula DB, De S, Kim J, Noh JH, Kim KM, Martindale JL and Gorospe M: Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1. RNA Biol. 14:361–369. 2017. View Article : Google Scholar : PubMed/NCBI

70 

Holdt LM, Stahringer A, Sass K, Pichler G, Kulak NA, Wilfert W, Kohlmaier A, Herbst A, Northoff BH, Nicolaou A, et al: Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans. Nat Commun. 7:124292016. View Article : Google Scholar : PubMed/NCBI

71 

Banerjee A, Apponi LH, Pavlath GK and Corbett AH: PABPN1: Molecular function and muscle disease. FEBS J. 280:4230–4250. 2013. View Article : Google Scholar : PubMed/NCBI

72 

Lapik YR, Fernandes CJ, Lau LF and Pestov DG: Physical and functional interaction between Pes1 and Bop1 in mammalian ribosome biogenesis. Mol Cell. 15:17–29. 2004. View Article : Google Scholar : PubMed/NCBI

73 

Du WW, Yang W, Chen Y, Wu ZK, Foster FS, Yang Z, Li X and Yang BB: Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses. Eur Heart J. 38:1402–1412. 2017.

74 

Du WW, Yang W, Liu E, Yang Z, Dhaliwal P and Yang BB: Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2. Nucleic Acids Res. 44:2846–2858. 2016. View Article : Google Scholar : PubMed/NCBI

75 

Lu WY: Roles of the circular RNA circ-Foxo3 in breast cancer progression. Cell Cycle. 16:589–590. 2017. View Article : Google Scholar : PubMed/NCBI

76 

Du WW, Fang L, Yang W, Wu N, Awan FM, Yang Z and Yang BB: Induction of tumor apoptosis through a circular RNA enhancing Foxo3 activity. Cell Death Differ. 24:357–370. 2017. View Article : Google Scholar :

77 

Pamudurti NR, Bartok O, Jens M, Ashwal-Fluss R, Stottmeister C, Ruhe L, Hanan M, Wyler E, Perez-Hernandez D, Ramberger E, et al: Translation of CircRNAs. Mol Cell. 66:9–21.e7. 2017. View Article : Google Scholar : PubMed/NCBI

78 

Wesselhoeft RA, Kowalski PS and Anderson DG: Engineering circular RNA for potent and stable translation in eukaryotic cells. Nat Commun. 9:26292018. View Article : Google Scholar : PubMed/NCBI

79 

Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, et al: Circ-ZNF609 is a circular RNA that can be translated and functions in myogenesis. Mol Cell. 66:22–37.e9. 2017. View Article : Google Scholar : PubMed/NCBI

80 

Floor SN and Doudna JA: Tunable protein synthesis by transcript isoforms in human cells. Elife. 5:e109212016. View Article : Google Scholar : PubMed/NCBI

81 

Zhou C, Molinie B, Daneshvar K, Pondick JV, Wang J, Van Wittenberghe N, Xing Y, Giallourakis CC and Mullen AC: Genome-wide maps of m6A circRNAs identify widespread and cell-type-specific methylation patterns that are distinct from mRNAs. Cell Rep. 20:2262–2276. 2017. View Article : Google Scholar : PubMed/NCBI

82 

Arnaiz E, Sole C, Manterola L, Iparraguirre L, Otaegui D and Lawrie CH: CircRNAs and cancer: Biomarkers and master regulators. Semin Cancer Biol. S1044-579X(18)30099-3. 2018.PubMed/NCBI

83 

Luo GG and Ou JH: Oncogenic viruses and cancer. Virol Sin. 30:83–84. 2015. View Article : Google Scholar : PubMed/NCBI

84 

Toptan T, Abere B, Nalesnik MA, Swerdlow SH, Ranganathan S, Lee N, Shair KH, Moore PS and Chang Y: Circular DNA tumor viruses make circular RNAs. Proc Natl Acad Sci USA. 115:E8737–E8745. 2018. View Article : Google Scholar : PubMed/NCBI

85 

Ungerleider NA, Jain V, Wang Y, Maness NJ, Blair RV, Alvarez X, Midkiff C, Kolson D, Bai S, Roberts C, et al: Comparative analysis of gammaherpesvirus circular RNA repertoires: Conserved and unique viral circular RNAs. J Virol. 93:e01952–18. 2019.

86 

Wang M, Yu F, Wu W, Wang Y, Ding H and Qian L: Epstein-Barr virus-encoded microRNAs as regulators in host immune responses. Int J Biol Sci. 14:565–576. 2018. View Article : Google Scholar : PubMed/NCBI

87 

Qin Z, Jakymiw A, Findlay V and Parsons C: KSHV-encoded MicroRNAs: Lessons for viral cancer pathogenesis and emerging concepts. Int J Cell Biol. 2012:6039612012. View Article : Google Scholar : PubMed/NCBI

88 

Ungerleider N, Concha M, Lin Z, Roberts C, Wang X, Cao S, Baddoo M, Moss WN, Yu Y, Seddon M, et al: The Epstein Barr virus circRNAome. PLoS Pathog. 14:e10072062018. View Article : Google Scholar : PubMed/NCBI

89 

Tagawa T, Gao S, Koparde VN, Gonzalez M, Spouge JL, Serquiña AP, Lurain K, Ramaswami R, Uldrick TS, Yarchoan R and Ziegelbauer JM: Discovery of Kaposi's sarcoma herpesvirus-encoded circular RNAs and a human antiviral circular RNA. Proc Natl Acad Sci USA. 115:12805–12810. 2018. View Article : Google Scholar : PubMed/NCBI

90 

Shi J, Hu N, Li J, Zeng Z, Mo L, Sun J, Wu M and Hu Y: Unique expression signatures of circular RNAs in response to DNA tumor virus SV40 infection. Oncotarget. 8:98609–98622. 2017. View Article : Google Scholar : PubMed/NCBI

91 

Zhang X, Yan Y, Lin W, Li A, Zhang H, Lei X, Dai Z, Li X, Li H, Chen W, et al: Circular RNA Vav3 sponges gga-miR-375 to promote epithelial-mesenchymal transition. RNA Biol. 16:118–132. 2019. View Article : Google Scholar : PubMed/NCBI

92 

Zhang X, Yan Y, Lei X, Li A, Zhang H, Dai Z, Li X, Chen W, Lin W, Chen F, et al: Circular RNA alterations are involved in resistance to avian leukosis virus subgroup-J-induced tumor formation in chickens. Oncotarget. 8:34961–34970. 2017.PubMed/NCBI

93 

Zhang Y, Zhang H, An M, Zhao B, Ding H, Zhang Z, He Y, Shang H and Han X: Crosstalk in competing endogenous RNA networks reveals new circular RNAs involved in the pathogenesis of early HIV infection. J Transl Med. 16:3322018. View Article : Google Scholar : PubMed/NCBI

94 

Wang ZY, Guo ZD, Li JM, Zhao ZZ, Fu YY, Zhang CM, Zhang Y and Liu LN, Qian J and Liu LN: Genome-wide search for competing endogenous RNAs responsible for the effects induced by Ebola virus replication and transcription using a trVLP system. Front Cell Infect Microbiol. 7:4792017. View Article : Google Scholar : PubMed/NCBI

95 

Shi J, Hu N, Mo L, Zeng Z, Sun J and Hu Y: Deep RNA sequencing reveals a repertoire of human fibroblast circular RNAs associated with cellular responses to Herpes simplex virus 1 infection. Cell Physiol Biochem. 47:2031–2045. 2018. View Article : Google Scholar : PubMed/NCBI

96 

Tung KH, Ernstoff MS, Allen C and Shu S: A review of exosomes and their role in the tumor microenvironment and host-tumor 'Macroenvironment'. J Immunol Sci. 3:4–8. 2019. View Article : Google Scholar :

97 

Zheng H, Zhan Y, Liu S, Lu J, Luo J, Feng J and Fan S: The roles of tumor-derived exosomes in non-small cell lung cancer and their clinical implications. J Exp Clin Cancer Res. 37:2262018. View Article : Google Scholar : PubMed/NCBI

98 

Tai YL, Chen KC, Hsieh JT and Shen TL: Exosomes in cancer development and clinical applications. Cancer Sci. 109:2364–2374. 2018. View Article : Google Scholar : PubMed/NCBI

99 

Li Y, Zheng Q, Bao C, Li S, Guo W, Zhao J, Chen D, Gu J, He X and Huang S: Circular RNA is enriched and stable in exosomes: A promising biomarker for cancer diagnosis. Cell Res. 25:981–984. 2015. View Article : Google Scholar : PubMed/NCBI

100 

Wang J, Zhang Q, Zhou S, Xu H, Wang D, Feng J, Zhao J and Zhong S: Circular RNA expression in exosomes derived from breast cancer cells and patients. Epigenomics. 11:411–421. 2019. View Article : Google Scholar : PubMed/NCBI

101 

Bai H, Lei K, Huang F, Jiang Z and Zhou X: Exo-circRNAs: A new paradigm for anticancer therapy. Mol Cancer. 18:562019. View Article : Google Scholar : PubMed/NCBI

102 

Li Z, Yanfang W, Li J, Jiang P, Peng T, Chen K, Zhao X, Zhang Y, Zhen P, Zhu J and Li X: Tumor-released exosomal circular RNA PDE8A promotes invasive growth via the miR-338/MACC1/MET pathway in pancreatic cancer. Cancer Lett. 432:237–250. 2018. View Article : Google Scholar : PubMed/NCBI

103 

Zhang Z, Yang T and Xiao J: Circular RNAs: Promising biomarkers for human diseases. EBioMedicine. 34:267–274. 2018. View Article : Google Scholar : PubMed/NCBI

104 

Wang M, Yu F and Li P: Circular RNAs: Characteristics, function and clinical significance in hepatocellular carcinoma. Cancers (Basel). 10:E2582018. View Article : Google Scholar

105 

Huang Z, Su R, Qing C, Peng Y, Luo Q and Li J: Plasma circular RNAs hsa_circ_0001953 and hsa_circ_0009024 as diagnostic biomarkers for active tuberculosis. Front Microbiol. 9:20102018. View Article : Google Scholar : PubMed/NCBI

106 

De Braekeleer E, Douet-Guilbert N and De Braekeleer M: RARA fusion genes in acute promyelocytic leukemia: A review. Expert Rev Hematol. 7:347–357. 2014. View Article : Google Scholar : PubMed/NCBI

107 

Dal Molin A, Bresolin S, Gaffo E, Tretti C, Boldrin E, Meyer LH, Guglielmelli P, Vannucchi AM, Te Kronnie G and Bortoluzzi S: CircRNAs are here to stay: A perspective on the MLL recombinome. Front Genet. 10:882019. View Article : Google Scholar :

108 

Babin L, Piganeau M, Renouf B, Lamribet K, Thirant C, Deriano L, Mercher T, Giovannangeli C and Brunet EC: Chromosomal translocation formation is sufficient to produce fusion circular RNAs specific to patient tumor cells. iScience. 5:19–29. 2018. View Article : Google Scholar : PubMed/NCBI

109 

Guarnerio J, Bezzi M, Jeong JC, Paffenholz SV, Berry K, Naldini MM, Lo-Coco F, Tay Y, Beck AH and Pandolfi PP: Oncogenic role of Fusion-circRNAs derived from cancer-associated chromosomal translocations. Cell. 166:1055–1056. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Harper KL, Mcdonnell E and Whitehouse A: CircRNAs: From anonymity to novel regulators of gene expression in cancer (Review). Int J Oncol 55: 1183-1193, 2019.
APA
Harper, K.L., Mcdonnell, E., & Whitehouse, A. (2019). CircRNAs: From anonymity to novel regulators of gene expression in cancer (Review). International Journal of Oncology, 55, 1183-1193. https://doi.org/10.3892/ijo.2019.4904
MLA
Harper, K. L., Mcdonnell, E., Whitehouse, A."CircRNAs: From anonymity to novel regulators of gene expression in cancer (Review)". International Journal of Oncology 55.6 (2019): 1183-1193.
Chicago
Harper, K. L., Mcdonnell, E., Whitehouse, A."CircRNAs: From anonymity to novel regulators of gene expression in cancer (Review)". International Journal of Oncology 55, no. 6 (2019): 1183-1193. https://doi.org/10.3892/ijo.2019.4904
Copy and paste a formatted citation
x
Spandidos Publications style
Harper KL, Mcdonnell E and Whitehouse A: CircRNAs: From anonymity to novel regulators of gene expression in cancer (Review). Int J Oncol 55: 1183-1193, 2019.
APA
Harper, K.L., Mcdonnell, E., & Whitehouse, A. (2019). CircRNAs: From anonymity to novel regulators of gene expression in cancer (Review). International Journal of Oncology, 55, 1183-1193. https://doi.org/10.3892/ijo.2019.4904
MLA
Harper, K. L., Mcdonnell, E., Whitehouse, A."CircRNAs: From anonymity to novel regulators of gene expression in cancer (Review)". International Journal of Oncology 55.6 (2019): 1183-1193.
Chicago
Harper, K. L., Mcdonnell, E., Whitehouse, A."CircRNAs: From anonymity to novel regulators of gene expression in cancer (Review)". International Journal of Oncology 55, no. 6 (2019): 1183-1193. https://doi.org/10.3892/ijo.2019.4904
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