CircRNAs: From anonymity to novel regulators of gene expression in cancer (Review)

  • Authors:
    • Katherine L. Harper
    • Euan Mcdonnell
    • Adrian Whitehouse
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  • Published online on: October 24, 2019     https://doi.org/10.3892/ijo.2019.4904
  • Pages: 1183-1193
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Abstract

Circular RNAs (circRNAs) are a group of non‑coding RNAs, formed mostly through a unique backsplicing mechanism. Originally proposed to be a by‑product from errors in splicing, recent studies have shown they exhibit a range of roles in regulating gene expression, including sponging of microRNAs (miRNAs), interactions with RNA‑binding proteins and regulation of transcription. Though research is still in its infancy, evidence suggests circRNA levels are tightly regulated in the cell, reinforced by dysregulated circRNAs levels being implicated in a range of diseases, including cancer and viral infection. There is growing interest in circRNAs playing specific roles in cancers, either oncogenic or as tumour suppressors, with particular focus on their potential as novel biomarkers. This review will provide an overview of circRNA biogenesis and regulation, and their potential roles in the cell, with a focus on their dysregulation in cancer.
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December-2019
Volume 55 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Harper KL, Mcdonnell E and Whitehouse A: CircRNAs: From anonymity to novel regulators of gene expression in cancer (Review). Int J Oncol 55: 1183-1193, 2019.
APA
Harper, K.L., Mcdonnell, E., & Whitehouse, A. (2019). CircRNAs: From anonymity to novel regulators of gene expression in cancer (Review). International Journal of Oncology, 55, 1183-1193. https://doi.org/10.3892/ijo.2019.4904
MLA
Harper, K. L., Mcdonnell, E., Whitehouse, A."CircRNAs: From anonymity to novel regulators of gene expression in cancer (Review)". International Journal of Oncology 55.6 (2019): 1183-1193.
Chicago
Harper, K. L., Mcdonnell, E., Whitehouse, A."CircRNAs: From anonymity to novel regulators of gene expression in cancer (Review)". International Journal of Oncology 55, no. 6 (2019): 1183-1193. https://doi.org/10.3892/ijo.2019.4904