CAR T‑cell therapy for gastric cancer: Potential and perspective (Review)

  • Authors:
    • Bo Long
    • Long Qin
    • Boya Zhang
    • Qiong Li
    • Long Wang
    • Xiangyan Jiang
    • Huili Ye
    • Genyuan Zhang
    • Zeyuan Yu
    • Zuoyi Jiao
  • View Affiliations

  • Published online on: February 12, 2020     https://doi.org/10.3892/ijo.2020.4982
  • Pages: 889-899
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Abstract

Gastric cancer (GC) is one of the most frequently diagnosed digestive malignancies and is the third leading cause of cancer‑associated death worldwide. Delayed diagnosis and poor prognosis indicate the urgent need for new therapeutic strategies. The success of chimeric antigen receptor (CAR) T‑cell therapy for chemotherapy‑refractory hematological malignancies has inspired the development of a similar strategy for GC treatment. Although using CAR T‑cells against GC is not without difficulty, results from preclinical studies remain encouraging. The current review summarizes relevant preclinical studies and ongoing clinical trials for the use of CAR T‑cells for GC treatment and investigates possible toxicities, as well as current clinical experiences and emerging approaches. With a deeper understanding of the tumor microenvironment, novel target epitopes and scientific‑technical progress, the potential of CAR T‑cell therapy for GC is anticipated in the near future.
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April-2020
Volume 56 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Long B, Qin L, Zhang B, Li Q, Wang L, Jiang X, Ye H, Zhang G, Yu Z, Jiao Z, Jiao Z, et al: CAR T‑cell therapy for gastric cancer: Potential and perspective (Review). Int J Oncol 56: 889-899, 2020
APA
Long, B., Qin, L., Zhang, B., Li, Q., Wang, L., Jiang, X. ... Jiao, Z. (2020). CAR T‑cell therapy for gastric cancer: Potential and perspective (Review). International Journal of Oncology, 56, 889-899. https://doi.org/10.3892/ijo.2020.4982
MLA
Long, B., Qin, L., Zhang, B., Li, Q., Wang, L., Jiang, X., Ye, H., Zhang, G., Yu, Z., Jiao, Z."CAR T‑cell therapy for gastric cancer: Potential and perspective (Review)". International Journal of Oncology 56.4 (2020): 889-899.
Chicago
Long, B., Qin, L., Zhang, B., Li, Q., Wang, L., Jiang, X., Ye, H., Zhang, G., Yu, Z., Jiao, Z."CAR T‑cell therapy for gastric cancer: Potential and perspective (Review)". International Journal of Oncology 56, no. 4 (2020): 889-899. https://doi.org/10.3892/ijo.2020.4982