Open Access

Advances in circular RNAs and their role in glioma (Review)

  • Authors:
    • Yuhao Zhang
    • Xiaomeng Lin
    • Xiuchao Geng
    • Liang Shi
    • Qiang Li
    • Fulin Liu
    • Chuan Fang
    • Hong Wang
  • View Affiliations

  • Published online on: April 16, 2020     https://doi.org/10.3892/ijo.2020.5049
  • Pages: 67-79
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Glioma is the most common primary tumour of the central nervous system, and is associated with a high postoperative recurrence rate and resistance to chemotherapy. High‑grade glioblastoma in particular has a very poor prognosis and poses a serious threat to human health. Related studies have confirmed that the occurrence and development of gliomas are closely associated with the abnormal expression and regulation of genes. Moreover, the number of studies on the association of the expression of non‑coding RNAs [linear RNAs, microRNAs and circular RNAs (circRNAs)] in human cells with glioma has been gradually increasing in recent years. Among those, circRNAs, previously considered to be ‘splicing errors’, have been shown to be highly expressed in eukaryotic cells and regulate the biological behaviour of gliomas. circRNAs are highly abundant and stable, and have become a research hotspot in the field of glioma molecular biology. The aim of the present review was to focus on the research progress regarding the association between circRNA expression and gliomas, and to provide a theoretical basis according to the currently available literature for further exploring this association. The present study may be of value for the early diagnosis, pathological grading, targeted therapy and prognostic evaluation of gliomas.

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July 2020
Volume 57 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Zhang, Y., Lin, X., Geng, X., Shi, L., Li, Q., Liu, F. ... Wang, H. (2020). Advances in circular RNAs and their role in glioma (Review). International Journal of Oncology, 57, 67-79. https://doi.org/10.3892/ijo.2020.5049
MLA
Zhang, Y., Lin, X., Geng, X., Shi, L., Li, Q., Liu, F., Fang, C., Wang, H."Advances in circular RNAs and their role in glioma (Review)". International Journal of Oncology 57.1 (2020): 67-79.
Chicago
Zhang, Y., Lin, X., Geng, X., Shi, L., Li, Q., Liu, F., Fang, C., Wang, H."Advances in circular RNAs and their role in glioma (Review)". International Journal of Oncology 57, no. 1 (2020): 67-79. https://doi.org/10.3892/ijo.2020.5049