Advances in circular RNAs and their role in glioma (Review)

Zhang,Yuhao; Lin,Xiaomeng; Geng,Xiuchao; Shi,Liang; Li,Qiang; Liu,Fulin; Fang,Chuan; Wang,Hong

doi:10.3892/ijo.2020.5049

Advances in circular RNAs and their role in glioma (Review)

Authors:
- Yuhao Zhang
- Xiaomeng Lin
- Xiuchao Geng
- Liang Shi
- Qiang Li
- Fulin Liu
- Chuan Fang
- Hong Wang
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Affiliations: Hebei University, School of Medicine, Baoding, Hebei 071000, P.R. China, Department of Breast Surgery, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, P.R. China, Hebei University of Chinese Medicine, Faculty of Integrated Traditional Chinese and Western Medicine, Shijiazhuang, Hebei 050091, P.R. China, Hebei University of Chinese Medicine, Faculty of Acupuncture‑Moxibustion and Tuina, Shijiazhuang, Hebei 050200, P.R. China, Office of Academic Research, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, P.R. China, Department of Neurosurgery, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, P.R. China
Published online on: April 16, 2020 https://doi.org/10.3892/ijo.2020.5049
Pages: 67-79
Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Glioma is the most common primary tumour of the central nervous system, and is associated with a high postoperative recurrence rate and resistance to chemotherapy. High‑grade glioblastoma in particular has a very poor prognosis and poses a serious threat to human health. Related studies have confirmed that the occurrence and development of gliomas are closely associated with the abnormal expression and regulation of genes. Moreover, the number of studies on the association of the expression of non‑coding RNAs [linear RNAs, microRNAs and circular RNAs (circRNAs)] in human cells with glioma has been gradually increasing in recent years. Among those, circRNAs, previously considered to be ‘splicing errors’, have been shown to be highly expressed in eukaryotic cells and regulate the biological behaviour of gliomas. circRNAs are highly abundant and stable, and have become a research hotspot in the field of glioma molecular biology. The aim of the present review was to focus on the research progress regarding the association between circRNA expression and gliomas, and to provide a theoretical basis according to the currently available literature for further exploring this association. The present study may be of value for the early diagnosis, pathological grading, targeted therapy and prognostic evaluation of gliomas.

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