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Article

Oridonin induces the apoptosis of mucoepidermoid carcinoma cell lines in a myeloid cell leukemia‑1‑dependent manner

  • Authors:
    • Jung‑Min Han
    • Kyoung‑Ok Hong
    • In‑Hyoung Yang
    • Chi‑Hyun  Ahn
    • Bohwan Jin
    • Wonwoo  Lee
    • Yun Chan Jung
    • Kyung‑A Kim
    • Ji‑Ae  Shin
    • Sung‑Dae Cho
    • Seong‑Doo Hong
  • View Affiliations / Copyright

    Affiliations: Department of Oral Pathology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul 03080, Republic of Korea, Cancer Center, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA, Laboratory Animal Center, CHA University, CHA Biocomplex, Seongnam, Gyeonggi 13488, Republic of Korea, Chaon, Seongnam, Gyeonggi 13488, Republic of Korea, Department of Dentistry, School of Medicine, Eulji University, Daejeon 34824, Republic of Korea
  • Pages: 377-385
    |
    Published online on: May 7, 2020
       https://doi.org/10.3892/ijo.2020.5061
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Abstract

Oridonin, an active diterpenoid isolated from Rabdosia rubescens, has been reported to exhibit anticancer activities in several tumors. The aim of the present study was to investigate the anticancer effects and molecular mechanisms of oridonin in mucoepidermoid carcinoma (MEC). Treatment with oridonin induced the apoptosis of MC‑3 and YD‑15 cell and inhibited the expression of myeloid cell leukemia‑1 (MCL‑1) through the regulation of the protein level through post‑translational regulation in these cell lines. Oridonin significantly increased the expression level of truncated Bid (t‑Bid) as a downstream target of MCL‑1 and subsequently decreased the mitochondrial membrane potential. The ectopic expression of MCL‑1 protein was sufficient to reverse the induction of apoptosis and the increased t‑Bid expression induced by oridonin in both cell lines. Taken together, these results suggest that oridonin exerts an apoptotic effect through the modulation of MCL‑1 and t‑Bid in human MEC cell lines and may thus be a potential anticancer drug candidate for the treatment of human MEC.
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Copy and paste a formatted citation
Spandidos Publications style
Han JM, Hong KO, Yang IH, Ahn CH, Jin B, Lee W, Jung Y, Kim KA, Shin JA, Cho SD, Cho SD, et al: Oridonin induces the apoptosis of mucoepidermoid carcinoma cell lines in a myeloid cell leukemia‑1‑dependent manner. Int J Oncol 57: 377-385, 2020.
APA
Han, J., Hong, K., Yang, I., Ahn, C., Jin, B., Lee, W. ... Hong, S. (2020). Oridonin induces the apoptosis of mucoepidermoid carcinoma cell lines in a myeloid cell leukemia‑1‑dependent manner. International Journal of Oncology, 57, 377-385. https://doi.org/10.3892/ijo.2020.5061
MLA
Han, J., Hong, K., Yang, I., Ahn, C., Jin, B., Lee, W., Jung, Y., Kim, K., Shin, J., Cho, S., Hong, S."Oridonin induces the apoptosis of mucoepidermoid carcinoma cell lines in a myeloid cell leukemia‑1‑dependent manner". International Journal of Oncology 57.1 (2020): 377-385.
Chicago
Han, J., Hong, K., Yang, I., Ahn, C., Jin, B., Lee, W., Jung, Y., Kim, K., Shin, J., Cho, S., Hong, S."Oridonin induces the apoptosis of mucoepidermoid carcinoma cell lines in a myeloid cell leukemia‑1‑dependent manner". International Journal of Oncology 57, no. 1 (2020): 377-385. https://doi.org/10.3892/ijo.2020.5061
Copy and paste a formatted citation
x
Spandidos Publications style
Han JM, Hong KO, Yang IH, Ahn CH, Jin B, Lee W, Jung Y, Kim KA, Shin JA, Cho SD, Cho SD, et al: Oridonin induces the apoptosis of mucoepidermoid carcinoma cell lines in a myeloid cell leukemia‑1‑dependent manner. Int J Oncol 57: 377-385, 2020.
APA
Han, J., Hong, K., Yang, I., Ahn, C., Jin, B., Lee, W. ... Hong, S. (2020). Oridonin induces the apoptosis of mucoepidermoid carcinoma cell lines in a myeloid cell leukemia‑1‑dependent manner. International Journal of Oncology, 57, 377-385. https://doi.org/10.3892/ijo.2020.5061
MLA
Han, J., Hong, K., Yang, I., Ahn, C., Jin, B., Lee, W., Jung, Y., Kim, K., Shin, J., Cho, S., Hong, S."Oridonin induces the apoptosis of mucoepidermoid carcinoma cell lines in a myeloid cell leukemia‑1‑dependent manner". International Journal of Oncology 57.1 (2020): 377-385.
Chicago
Han, J., Hong, K., Yang, I., Ahn, C., Jin, B., Lee, W., Jung, Y., Kim, K., Shin, J., Cho, S., Hong, S."Oridonin induces the apoptosis of mucoepidermoid carcinoma cell lines in a myeloid cell leukemia‑1‑dependent manner". International Journal of Oncology 57, no. 1 (2020): 377-385. https://doi.org/10.3892/ijo.2020.5061
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