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CircRNA hsa_circ_0070934 functions as a competitive endogenous RNA to regulate HOXB7 expression by sponging miR‑1236‑3p in cutaneous squamous cell carcinoma

  • Authors:
    • Da‑Wei Zhang
    • Hai‑Yan Wu
    • Chuan‑Rong Zhu
    • Dong‑Dong Wu
  • View Affiliations / Copyright

    Affiliations: Department of Burn and Plastic Surgery, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huaian, Jiangsu 223300, P.R. China, Department of Surgery, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huaian, Jiangsu 223300, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 478-487
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    Published online on: May 14, 2020
       https://doi.org/10.3892/ijo.2020.5066
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Abstract

Circular ribonucleic acids (circRNAs) serve a vital role in the pathological processes of a number of diseases. Previous microarray results of circRNA expression revealed that hsa_circ_0070933 and hsa_circ_0070934, two circRNAs associated with the La ribonucleoprotein 1B gene, were highly expressed in cutaneous squamous cell carcinoma (CSCC). The present study aimed to explore the specific role of these circRNAs in CSCC. Through reverse transcription‑quantitative PCR, hsa_circ_0070933 and hsa_circ_0070934 expression levels in CSCC cell lines and a human keratinocyte cell line were detected. Additionally, direct interactions between miR‑1236‑3p and HOXB7 or circ‑0070934 were identified using RNA binding protein immunoprecipitation assays and dual‑luciferase reporter assays. Cell Counting Kit‑8, 5‑ethynyl‑2'‑deoxyuridine, Transwell invasion and flow cytometry assays were used to assess the roles of miR‑1236‑3p or circ‑0070934 in cell invasion, proliferation and apoptosis. Subsequently, in vivo tumor formation assays were used to verify the role of circ‑0070934 in CSCC. The results demonstrated that the expression of circ‑0070934 was stably upregulated in a number of CSCC cell lines compared with that in normal human keratinocytes. Knockdown of circ‑0070934 inhibited the invasive and proliferative potential of CSCC cells and promoted apoptosis both in vivo and in vitro. In addition, circ‑0070934 modulated HOXB7 expression through competitive binding with miR‑1236‑3p. In conclusion, the results of the present study demonstrated the effects of the circ‑0070934/miR‑1236‑3p/HOXB7 regulatory axis on CSCC and provided a novel insight for the pathogenesis of CSCC.
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1 

Apalla Z, Lallas A, Sotiriou E, Lazaridou E and Ioannides D: Epidemiological trends in skin cancer. Dermatol Pract Concept. 7:1–6. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Leiter U, Eigentler T and Garbe C: Epidemiology of skin cancer. Adv Exp Med Biol. 810:120–140. 2014.PubMed/NCBI

3 

Newlands C, Currie R, Memon A, Whitaker S and Woolford T: Non-melanoma skin cancer: United Kingdom National Multidisciplinary Guidelines. J Laryngol Otol. 130(Suppl 2): pp. S125–S132. 2016, View Article : Google Scholar : PubMed/NCBI

4 

Satgunaseelan L, Chia N, Suh H, Virk S, Ashford B, Lum T, Ranson M, Clark J and Gupta R: p16 expression in cutaneous squamous cell carcinoma of the head and neck is not associated with integration of high risk HPV DNA or prognosis. Pathology. 49:494–498. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Chen H, Takahara M, Xie L, Takeuchi S, Tu Y, Nakahara T, Uchi H, Moroi Y and Furue M: Levels of the EMT-related protein Snail/Slug are not correlated with p53/p63 in cutaneous squamous cell carcinoma. J Cutan Pathol. 40:651–656. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Hu X, Liu Y, Ai P, He S, Liu L, Chen C, Tan Y and Wang T: MicroRNA-186 promotes cell proliferation and inhibits cell apoptosis in cutaneous squamous cell carcinoma by targeting RETREG1. Exp Ther Med. 17:1930–1938. 2019.PubMed/NCBI

7 

Mei XL and Zhong S: Long noncoding RNA LINC00520 prevents the progression of cutaneous squamous cell carcinoma through the inactivation of the PI3K/Akt signaling pathway by downregulating EGFR. Chin Med J (Engl). 132:454–465. 2019. View Article : Google Scholar

8 

Hausser J and Zavolan M: Identification and consequences of miRNA-target interactions - beyond repression of gene expression. Nat Rev Genet. 15:599–612. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Rupaimoole R, Calin GA, Lopez-Berestein G and Sood AK: miRNA Deregulation in Cancer Cells and the Tumor Microenvironment. Cancer Discov. 6:235–246. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Hubé F, Ulveling D, Sureau A, Forveille S and Francastel C: Short intron-derived ncRNAs. Nucleic Acids Res. 45:4768–4781. 2017.PubMed/NCBI

11 

Leisegang MS, Fork C, Josipovic I, Richter FM, Preussner J, Hu J, Miller MJ, Epah J, Hofmann P, Günther S, et al: Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function. Circulation. 136:65–79. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Kim J, Piao HL, Kim BJ, Yao F, Han Z, Wang Y, Xiao Z, Siverly AN, Lawhon SE, Ton BN, et al: Long noncoding RNA MALAT1 suppresses breast cancer metastasis. Nat Genet. 50:1705–1715. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Zhu LP, He YJ, Hou JC, Chen X, Zhou SY, Yang SJ, Li J, Zhang HD, Hu JH, Zhong SL, et al: The role of circRNAs in cancers. Biosci Rep. 37:BSR201707502017. View Article : Google Scholar : PubMed/NCBI

14 

Andreeva K and Cooper NG: MicroRNAs in the Neural Retina. Int J Genomics. 2014:1658972014. View Article : Google Scholar : PubMed/NCBI

15 

Patop IL and Kadener S: circRNAs in Cancer. Curr Opin Genet Dev. 48:121–127. 2018. View Article : Google Scholar :

16 

Greene J, Baird AM, Brady L, Lim M, Gray SG, McDermott R and Finn SP: Circular RNAs: Biogenesis, Function and Role in Human Diseases. Front Mol Biosci. 4:382017. View Article : Google Scholar : PubMed/NCBI

17 

Fan X, Weng X, Zhao Y, Chen W, Gan T and Xu D: Circular RNAs in Cardiovascular Disease: An Overview. BioMed Res Int. 2017:51357812017. View Article : Google Scholar : PubMed/NCBI

18 

Sheng JQ, Liu L, Wang MR and Li PY: Circular RNAs in digestive system cancer: Potential biomarkers and therapeutic targets. Am J Cancer Res. 8:1142–1156. 2018.PubMed/NCBI

19 

Su H, Tao T, Yang Z, Kang X, Zhang X, Kang D, Wu S and Li C: Circular RNA cTFRC acts as the sponge of MicroRNA-107 to promote bladder carcinoma progression. Mol Cancer. 18:272019. View Article : Google Scholar : PubMed/NCBI

20 

Sand M, Bechara FG, Gambichler T, Sand D, Bromba M, Hahn SA, Stockfleth E and Hessam S: Circular RNA expression in cutaneous squamous cell carcinoma. J Dermatol Sci. 83:210–218. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Schmittgen TD and Livak KJ: Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc. 3:1101–1108. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Bi W, Huang J, Nie C, Liu B, He G, Han J, Pang R, Ding Z, Xu J and Zhang J: CircRNA circRNA_102171 promotes papillary thyroid cancer progression through modulating CTNNBIP1-dependent activation of β-catenin pathway. J Exp Clin Cancer Res. 37:2752018. View Article : Google Scholar

23 

Su Y, Xu C, Liu Y, Hu Y and Wu H: Circular RNA hsa_circ_0001649 inhibits hepatocellular carcinoma progression via multiple miRNAs sponge. Aging (Albany NY). 11:3362–3375. 2019.

24 

Towler BP, Jones CI and Newbury SF: Mechanisms of regulation of mature miRNAs. Biochem Soc Trans. 43:1208–1214. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Conte F, Fiscon G, Chiara M, Colombo T, Farina L and Paci P: Role of the long non-coding RNA PVT1 in the dysregulation of the ceRNA-ceRNA network in human breast cancer. PLoS One. 12:pp. e01716612017, View Article : Google Scholar : PubMed/NCBI

26 

Chen G, Shi Y, Zhang Y and Sun J: CircRNA_100782 regulates pancreatic carcinoma proliferation through the IL6-STAT3 pathway. OncoTargets Ther. 10:5783–5794. 2017. View Article : Google Scholar

27 

Chen L, Zhang S, Wu J, Cui J, Zhong L, Zeng L and Ge S: circRNA_100290 plays a role in oral cancer by functioning as a sponge of the miR-29 family. Oncogene. 36:4551–4561. 2017. View Article : Google Scholar : PubMed/NCBI

28 

He JH, Li YG, Han ZP, Zhou JB, Chen WM, Lv YB, He ML, Zuo JD and Zheng L: The CircRNA-ACAP2/Hsa-miR-21-5p/ Tiam1 Regulatory Feedback Circuit Affects the Proliferation, Migration, and Invasion of Colon Cancer SW480 Cells. Cell Physiol Biochem. 49:1539–1550. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Ma HB, Yao YN, Yu JJ, Chen XX and Li HF: Extensive profiling of circular RNAs and the potential regulatory role of circRNA-000284 in cell proliferation and invasion of cervical cancer via sponging miR-506. Am J Transl Res. 10:592–604. 2018.PubMed/NCBI

30 

Bian T, Jiang D, Liu J, Yuan X, Feng J, Li Q, Zhang Q, Li X, Liu Y and Zhang J: miR-1236-3p suppresses the migration and invasion by targeting KLF8 in lung adenocarcinoma A549 cells. Biochem Biophys Res Commun. 492:461–467. 2017. View Article : Google Scholar : PubMed/NCBI

31 

An JX, Ma MH, Zhang CD, Shao S, Zhou NM and Dai DQ: miR-1236-3p inhibits invasion and metastasis in gastric cancer by targeting MTA2. Cancer Cell Int. 18:662018. View Article : Google Scholar : PubMed/NCBI

32 

Manthei U, Nickells MW, Barnes SH, Ballard LL, Cui WY and Atkinson JP: Identification of a C3b/iC3 binding protein of rabbit platelets and leukocytes. A CR1-like candidate for the immune adherence receptor. J Immunol. 140:1228–1235. 1988.PubMed/NCBI

33 

Wang Y, Yan S, Liu X, Zhang W, Li Y, Dong R, Zhang Q, Yang Q, Yuan C, Shen K, et al: miR-1236-3p represses the cell migration and invasion abilities by targeting ZEB1 in high-grade serous ovarian carcinoma. Oncol Rep. 31:1905–1910. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Miksiunas R, Mobasheri A and Bironaite D: Homeobox Genes and Homeodomain Proteins: New Insights into Cardiac Development, Degeneration and Regeneration. Adv Exp Med Biol. 1212:155–178. 2020. View Article : Google Scholar

35 

Carrera M, Bitu CC, de Oliveira CE, Cervigne NK, Graner E, Manninen A, Salo T and Coletta RD: HOXA10 controls proliferation, migration and invasion in oral squamous cell carcinoma. Int J Clin Exp Pathol. 8:3613–3623. 2015.PubMed/NCBI

36 

Hur H, Lee JY, Yun HJ, Park BW and Kim MH: Analysis of HOX gene expression patterns in human breast cancer. Mol Biotechnol. 56:64–71. 2014. View Article : Google Scholar

37 

Holland PW: Evolution of homeobox genes. Wiley Interdiscip Rev Dev Biol. 2:31–45. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Joo MK, Park JJ, Yoo HS, Lee BJ, Chun HJ, Lee SW and Bak YT: The roles of HOXB7 in promoting migration, invasion, and anti-apoptosis in gastric cancer. J Gastroenterol Hepatol. 31:1717–1726. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Tsuboi M, Taniuchi K, Shimizu T, Saito M and Saibara T: The transcription factor HOXB7 regulates ERK kinase activity and thereby stimulates the motility and invasiveness of pancreatic cancer cells. J Biol Chem. 292:17681–17702. 2017. View Article : Google Scholar : PubMed/NCBI

40 

Monterisi S, Lo Riso P, Russo K, Bertalot G, Vecchi M, Testa G, Di Fiore PP and Bianchi F: HOXB7 overexpression in lung cancer is a hallmark of acquired stem-like phenotype. Oncogene. 37:3575–3588. 2018. View Article : Google Scholar : PubMed/NCBI

41 

Wang K, Jin J, Ma T and Zhai H: MiR-376c-3p regulates the proliferation, invasion, migration, cell cycle and apoptosis of human oral squamous cancer cells by suppressing HOXB7. Biomed Pharmacother. 91:517–525. 2017. View Article : Google Scholar : PubMed/NCBI

42 

Heinonen H, Lepikhova T, Sahu B, Pehkonen H, Pihlajamaa P, Louhimo R, Gao P, Wei GH, Hautaniemi S, Jänne OA, et al: Identification of several potential chromatin binding sites of HOXB7 and its downstream target genes in breast cancer. Int J Cancer. 137:2374–2383. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Tu W, Zhu X, Han Y, Wen Y, Qiu G and Zhou C: Overexpression of HOXB7 is associated with a poor prognosis in patients with gastric cancer. Oncol Lett. 10:2967–2973. 2015. View Article : Google Scholar

44 

Gao D and Chen HQ: Specific knockdown of HOXB7 inhibits cutaneous squamous cell carcinoma cell migration and invasion while inducing apoptosis via the Wnt/beta-catenin signaling pathway. Am J Physiol Cell Physiol. 315:C675–C86. 2018. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Zhang DW, Wu HY, Zhu CR and Wu DD: CircRNA hsa_circ_0070934 functions as a competitive endogenous RNA to regulate HOXB7 expression by sponging miR‑1236‑3p in cutaneous squamous cell carcinoma. Int J Oncol 57: 478-487, 2020.
APA
Zhang, D., Wu, H., Zhu, C., & Wu, D. (2020). CircRNA hsa_circ_0070934 functions as a competitive endogenous RNA to regulate HOXB7 expression by sponging miR‑1236‑3p in cutaneous squamous cell carcinoma. International Journal of Oncology, 57, 478-487. https://doi.org/10.3892/ijo.2020.5066
MLA
Zhang, D., Wu, H., Zhu, C., Wu, D."CircRNA hsa_circ_0070934 functions as a competitive endogenous RNA to regulate HOXB7 expression by sponging miR‑1236‑3p in cutaneous squamous cell carcinoma". International Journal of Oncology 57.2 (2020): 478-487.
Chicago
Zhang, D., Wu, H., Zhu, C., Wu, D."CircRNA hsa_circ_0070934 functions as a competitive endogenous RNA to regulate HOXB7 expression by sponging miR‑1236‑3p in cutaneous squamous cell carcinoma". International Journal of Oncology 57, no. 2 (2020): 478-487. https://doi.org/10.3892/ijo.2020.5066
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang DW, Wu HY, Zhu CR and Wu DD: CircRNA hsa_circ_0070934 functions as a competitive endogenous RNA to regulate HOXB7 expression by sponging miR‑1236‑3p in cutaneous squamous cell carcinoma. Int J Oncol 57: 478-487, 2020.
APA
Zhang, D., Wu, H., Zhu, C., & Wu, D. (2020). CircRNA hsa_circ_0070934 functions as a competitive endogenous RNA to regulate HOXB7 expression by sponging miR‑1236‑3p in cutaneous squamous cell carcinoma. International Journal of Oncology, 57, 478-487. https://doi.org/10.3892/ijo.2020.5066
MLA
Zhang, D., Wu, H., Zhu, C., Wu, D."CircRNA hsa_circ_0070934 functions as a competitive endogenous RNA to regulate HOXB7 expression by sponging miR‑1236‑3p in cutaneous squamous cell carcinoma". International Journal of Oncology 57.2 (2020): 478-487.
Chicago
Zhang, D., Wu, H., Zhu, C., Wu, D."CircRNA hsa_circ_0070934 functions as a competitive endogenous RNA to regulate HOXB7 expression by sponging miR‑1236‑3p in cutaneous squamous cell carcinoma". International Journal of Oncology 57, no. 2 (2020): 478-487. https://doi.org/10.3892/ijo.2020.5066
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