Identification of a multidimensional transcriptome signature predicting tumor regrowth of clinically non‑functioning pituitary adenoma

  • Authors:
    • Sen Cheng
    • Jing Guo
    • Yazhuo Zhang
    • Zhenye Li
    • Chuzhong Li
  • View Affiliations

  • Published online on: June 23, 2020     https://doi.org/10.3892/ijo.2020.5087
  • Pages: 804-812
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Abstract

Clinically non‑functioning pituitary adenoma (NFPA) represents approximately one third of all pituitary adenomas. Tumor regrowth is an important feature of NFPA; however, the effective methods with which to predict this are limited. The present study analyzed the expression of protein‑coding genes and long non‑coding RNA in 66 patients with NFPA. Cox regression analysis was performed to identify genes associated with regrowth or progression‑free survival (PFS). Kaplan‑Meier, random survival forest analysis and receiver operating characteristic curve (ROC) analyses were performed to generate a multi‑protein‑coding gene (PCG) and long non‑coding RNA (lncRNA) signature with a maximum area under the ROC curve (AUC). In total, 1 PCG (CHST12) and 2 lncRNAs (COA6‑AS1 and RP11‑23N2.4) were identified that were significantly associated with tumor regrowth. The multi‑transcriptome signature exhibited a high predictive accuracy for tumor regrowth, with an AUC of 0.869/0.726 in the training/testing set, and the discriminative power of this signature was better than that of age. On the whole, the present study indicates that the combined PCG and lncRNA signature may be beneficial as a marker for the prediction of the prognosis of patients with NFPA.
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September-2020
Volume 57 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Cheng S, Guo J, Zhang Y, Li Z and Li C: Identification of a multidimensional transcriptome signature predicting tumor regrowth of clinically non‑functioning pituitary adenoma. Int J Oncol 57: 804-812, 2020
APA
Cheng, S., Guo, J., Zhang, Y., Li, Z., & Li, C. (2020). Identification of a multidimensional transcriptome signature predicting tumor regrowth of clinically non‑functioning pituitary adenoma. International Journal of Oncology, 57, 804-812. https://doi.org/10.3892/ijo.2020.5087
MLA
Cheng, S., Guo, J., Zhang, Y., Li, Z., Li, C."Identification of a multidimensional transcriptome signature predicting tumor regrowth of clinically non‑functioning pituitary adenoma". International Journal of Oncology 57.3 (2020): 804-812.
Chicago
Cheng, S., Guo, J., Zhang, Y., Li, Z., Li, C."Identification of a multidimensional transcriptome signature predicting tumor regrowth of clinically non‑functioning pituitary adenoma". International Journal of Oncology 57, no. 3 (2020): 804-812. https://doi.org/10.3892/ijo.2020.5087