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Review

Role of primary cilium in pancreatic ductal adenocarcinoma (Review)

  • Authors:
    • Berina Sabanovic
    • Matteo Giulietti
    • Francesco Piva
  • View Affiliations / Copyright

    Affiliations: Department of Specialistic Clinical and Odontostomatological Sciences, Polytechnic University of Marche, I‑60131 Ancona, Italy
  • Pages: 1095-1102
    |
    Published online on: September 14, 2020
       https://doi.org/10.3892/ijo.2020.5121
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Abstract

The primary cilium is a non‑motile cellular structure extending from the apical membrane of epithelial cells that is involved in several processes due to its ability to receive and elaborate different signals. Ciliogenesis and its obliteration are essential for proliferating cells, and several signalling pathways are responsible for their regulation. In fact, the primary cilium is a central hub for numerous signalling pathways implicated in a variety of biological processes, such as the Hedgehog, mammalian target of rapamycin and Wnt pathways. Loss of primary cilia has been recently correlated with different types of tumours, including pancreatic ductal adenocarcinoma (PDAC). K‑Ras and HDAC2 were recently identified as possible ciliogenesis regulators in PDAC, likely acting through Aurora A kinase (AURKA) which, in turn, controls inositol polyphosphate‑5‑phosphatase E. However, the exact molecular mechanisms underlying this regulatory effect remain to be fully elucidated. In the present study, the regulation of the main genes involved in primary cilia assembly/resorption was reconstructed showing the links with the Hedgehog and phosphoinositide 3‑kinase/AKT pathways. Finally, by analysing gene expression databases, the regulatory genes that have high probability to be associated with prognosis, histological grade and pathological stage in patients with PDAC have been highlighted. However, further experimental studies are required to reach definitive conclusions on the roles of these genes. Improving our understating of ciliogenesis and its regulators may help develop ciliotherapies using histone deacetylase and AURKA inhibitors, which may induce re‑differentiation of tumour cells into normal cells by reducing tumour growth or inducing apoptosis of cancer cells.
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1 

Higgins M, Obaidi I and McMorrow T: Primary cilia and their role in cancer. Oncol Lett. 17:3041–3047. 2019.PubMed/NCBI

2 

Pala R, Alomari N and Nauli SM: Primary Cilium-dependent signaling mechanisms. Int J Mol Sci. 18:22722017. View Article : Google Scholar :

3 

Malicki JJ and Johnson CA: The Cilium: Cellular antenna and central processing unit. Trends Cell Biol. 27:126–140. 2017. View Article : Google Scholar :

4 

Sorokin SP: Reconstructions of centriole formation and ciliogenesis in mammalian lungs. J Cell Sci. 3:207–230. 1968.PubMed/NCBI

5 

Wheway G, Nazlamova L and Hancock JT: Signaling through the primary cilium. Front Cell Dev Biol. 6:82018. View Article : Google Scholar : PubMed/NCBI

6 

Izawa I, Goto H, Kasahara K and Inagaki M: Current topics of functional links between primary cilia and cell cycle. Cilia. 4:122015. View Article : Google Scholar

7 

Jonassen JA, San Agustin J, Follit JA and Pazour GJ: Deletion of IFT20 in the mouse kidney causes misorientation of the mitotic spindle and cystic kidney disease. J Cell Biol. 183:377–384. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Pugacheva EN, Jablonski SA, Hartman TR, Henske EP and Golemis EA: HEF1-dependent Aurora A activation induces disassembly of the primary cilium. Cell. 129:1351–1363. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Tucker RW, Pardee AB and Fujiwara K: Centriole ciliation is related to quiescence and DNA synthesis in 3T3 cells. Cell. 17:527–535. 1979. View Article : Google Scholar : PubMed/NCBI

10 

Li A, Saito M, Chuang J, Tseng Y, Dedesma C, Tomizawa K, Kaitsuka T and Sung C: Ciliary transition zone activation of phosphorylated Tctex-1 controls ciliary resorption, S-phase entry and fate of neural progenitors. Nat Cell Biol. 13:402–411. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Breslin L, Prosser SL, Cuffe S and Morrison CG: Ciliary abnormalities in senescent human fibroblasts impair proliferative capacity. Cell Cycle. 13:2773–2779. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Spalluto C, Wilson DI and Hearn T: Nek2 localises to the distal portion of the mother centriole/basal body and is required for timely cilium disassembly at the G2/M transition. Eur J Cell Biol. 91:675–686. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Kim S, Lee K, Choi J, Ringstad N and Dynlacht BD: Nek2 activation of Kif24 ensures cilium disassembly during the cell cycle. Nat Commun. 6:80872015. View Article : Google Scholar : PubMed/NCBI

14 

Moser JJ, Fritzler MJ and Rattner JB: Primary ciliogenesis defects are associated with human astrocytoma/glioblastoma cells. BMC Cancer. 9:4482009. View Article : Google Scholar : PubMed/NCBI

15 

Seeley ES, Carrière C, Goetze T, Longnecker DS and Korc M: Pancreatic cancer and precursor pancreatic intraepithelial neoplasia lesions are devoid of primary cilia. Cancer Res. 69:422–430. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Gherman A, Davis EE and Katsanis N: The ciliary proteome database: An integrated community resource for the genetic and functional dissection of cilia. Nat Genet. 38:961–962. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Gradilone SA, Pisarello MJL and LaRusso NF: Primary cilia in tumor biology: The primary cilium as a therapeutic target in cholangiocarcinoma. Curr Drug Targets. 18:958–963. 2017. View Article : Google Scholar :

18 

Gradilone SA, Radtke BN, Bogert PS, Huang BQ, Gajdos GB and LaRusso NF: HDAC6 inhibition restores ciliary expression and decreases tumor growth. Cancer Res. 73:2259–2270. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Kim J, Dabiri S and Seeley ES: Primary cilium depletion typifies cutaneous melanoma in situ and malignant melanoma. PLoS One. 6:e274102011. View Article : Google Scholar : PubMed/NCBI

20 

Hassounah NB, Nagle R, Saboda K, Roe DJ, Dalkin BL and McDermott KM: Primary cilia are lost in preinvasive and invasive prostate cancer. PLoS One. 8:e685212013. View Article : Google Scholar : PubMed/NCBI

21 

Yuan K, Frolova N, Xie Y, Wang D, Cook L, Kwon YJ, Steg AD, Serra R and Frost AR: Primary cilia are decreased in breast cancer: Analysis of a collection of human breast cancer cell lines and tissues. J Histochem Cytochem. 58:857–870. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Ho L, Ali SA, Al-Jazrawe M, Kandel R, Wunder JS and Alman BA: Primary cilia attenuate hedgehog signalling in neoplastic chondrocytes. Oncogene. 32:5388–5396. 2013. View Article : Google Scholar

23 

Egeberg DL, Lethan M, Manguso R, Schneider L, Awan A, Jprgensen TS, Byskov AG, Pedersen LB and Christensen ST: Primary cilia and aberrant cell signaling in epithelial ovarian cancer. Cilia. 1:152012. View Article : Google Scholar

24 

Dere R, Perkins AL, Bawa-Khalfe T, Jonasch D and Walker CL: p-catenin links von Hippel-Lindau to aurora kinase A and loss of primary cilia in renal cell carcinoma. J Am Soc Nephrol. 26:553–564. 2015. View Article : Google Scholar

25 

Kobayashi T and Itoh H: Loss of a primary cilium in PDAC. Cell Cycle. 16:817–818. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Quilichini E, Fabre M, Dirami T, Stedman A, De Vas M, Ozguc O, Pasek RC, Cereghini S, Morillon L, Guerra C, et al: Pancreatic ductal deletion of Hnf1b disrupts exocrine homeostasis, leads to pancreatitis, and facilitates tumorigenesis. Cell Mol Gastroenterol Hepatol. 8:487–511. 2019. View Article : Google Scholar : PubMed/NCBI

27 

Schimmack S, Kneller S, Dadabaeva N, Bergmann F, Taylor A, Hackert T, Werner J and Strobel O: Epithelial to stromal Re-distribution of primary cilia during pancreatic carcinogenesis. PLoS One. 11:e01642312016. View Article : Google Scholar : PubMed/NCBI

28 

Kobayashi T, Nakazono K, Tokuda M, Mashima Y, Dynlacht BD and Itoh H: HDAC2 promotes loss of primary cilia in pancreatic ductal adenocarcinoma. EMBO Rep. 18:334–343. 2017. View Article : Google Scholar :

29 

Li D, Zhu J, Firozi PF, Abbruzzese JL, Evans DB, Cleary K, Friess H and Sen S: Overexpression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic cancer. Clin Cancer Res. 9:991–997. 2003.PubMed/NCBI

30 

Plotnikova OV, Nikonova AS, Loskutov YV, Kozyulina PY, Pugacheva EN and Golemis EA: Calmodulin activation of Aurora-A kinase (AURKA) is required during ciliary disassembly and in mitosis. Mol Biol Cell. 23:2658–2670. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Plotnikova OV, Seo S, Cottle DL, Conduit S, Hakim S, Dyson JM, Mitchell CA and Smyth IM: lNPP5E interacts with aurka, linking phosphoinositide signaling to primary cilium stability. J Cell Sci. 128:364–372. 2015. View Article : Google Scholar :

32 

Garcia-Gonzalo FR, Phua SC, Roberson EC, Garcia G, Abedin M, Schurmans S, Inoue T and Reiter JF: Phosphoinositides regulate ciliary protein trafficking to modulate hedgehog signaling. Dev Cell. 34:400–409. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Kisseleva MV, Wilson MP and Majerus PW: The isolation and characterization of a cDNA encoding phospholipid-specific inositol polyphosphate 5-phosphatase. J Biol Chem. 275:20110–20116. 2000. View Article : Google Scholar : PubMed/NCBI

34 

Bielas SL, Silhavy JL, Brancati F, Kisseleva MV, Al-Gazali L, Sztriha L, Bayoumi RA, Zaki MS, Abdel-Aleem A, Rosti RO, et al: Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies. Nat Genet. 41:1032–1036. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Kisseleva MV, Cao L and Majerus PW: Phosphoinositide-specific inositol polyphosphate 5-phosphatase IV inhibits Akt/protein kinase B phosphorylation and leads to apoptotic cell death. J Biol Chem. 277:6266–6272. 2002. View Article : Google Scholar

36 

Phua SC, Chiba S, Suzuki M, Su E, Roberson EC, Pusapati GV, Schurmans S, Setou M, Rohatgi R, Reiter JF, et al: Dynamic remodeling of membrane composition drives cell cycle through primary cilia excision. Cell. 168:264–279.e15. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Mukhopadhyay S, Wen X, Ratti N, Loktev A, Rangell L, Scales SJ and Jackson PK: The ciliary G-protein-coupled receptor Gpr161 negatively regulates the sonic hedgehog pathway via cAMP signaling. Cell. 152:210–223. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Chavez M, Ena S, Van Sande J, de Kerchove d'Exaerde A, Schurmans S and Schiffmann SN: Modulation of ciliary phosphoinositide content regulates trafficking and sonic hedgehog signaling output. Dev Cell. 34:338–350. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Emoto K, Masugi Y, Yamazaki K, Effendi K, Tsujikawa H, Tanabe M, Kitagawa Y and Sakamoto M: Presence of primary cilia in cancer cells correlates with prognosis of pancreatic ductal adenocarcinoma. Hum Pathol. 45:817–825. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Thayer SP, di Magliano MP, Heiser PW, Nielsen CM, Roberts DJ, Lauwers GY, Qi YP, Gysin S, Fernandez-del Castillo C, Yajnik V, et al: Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature. 425:851–856. 2003. View Article : Google Scholar : PubMed/NCBI

41 

Bailey J, Mohr A and Hollingsworth M: Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer. Oncogene. 28:3513–3525. 2009. View Article : Google Scholar : PubMed/NCBI

42 

Deng YZ, Cai Z, Shi S, Jiang H, Shang YR, Ma N, Wang JJ, Guan DX, Chen TW, Rong YF, et al: Cilia loss sensitizes cells to transformation by activating the mevalonate pathway. J Exp Med. 215:177–195. 2018. View Article : Google Scholar :

43 

Bangs FK, Miller P and O'Neill E: Ciliogenesis and Hedgehog signalling are suppressed downstream of KRAS during Acinar-ductal metaplasia in mouse. Dis Model Mech. 13:dmm0442892020. View Article : Google Scholar : PubMed/NCBI

44 

Baretti M, Ahuja N and Azad NS: Targeting the epigenome of pancreatic cancer for therapy: Challenges and opportunities. Ann Pancreat Cancer. 2:182019. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Sabanovic B, Giulietti M and Piva F: Role of primary cilium in pancreatic ductal adenocarcinoma (Review). Int J Oncol 57: 1095-1102, 2020.
APA
Sabanovic, B., Giulietti, M., & Piva, F. (2020). Role of primary cilium in pancreatic ductal adenocarcinoma (Review). International Journal of Oncology, 57, 1095-1102. https://doi.org/10.3892/ijo.2020.5121
MLA
Sabanovic, B., Giulietti, M., Piva, F."Role of primary cilium in pancreatic ductal adenocarcinoma (Review)". International Journal of Oncology 57.5 (2020): 1095-1102.
Chicago
Sabanovic, B., Giulietti, M., Piva, F."Role of primary cilium in pancreatic ductal adenocarcinoma (Review)". International Journal of Oncology 57, no. 5 (2020): 1095-1102. https://doi.org/10.3892/ijo.2020.5121
Copy and paste a formatted citation
x
Spandidos Publications style
Sabanovic B, Giulietti M and Piva F: Role of primary cilium in pancreatic ductal adenocarcinoma (Review). Int J Oncol 57: 1095-1102, 2020.
APA
Sabanovic, B., Giulietti, M., & Piva, F. (2020). Role of primary cilium in pancreatic ductal adenocarcinoma (Review). International Journal of Oncology, 57, 1095-1102. https://doi.org/10.3892/ijo.2020.5121
MLA
Sabanovic, B., Giulietti, M., Piva, F."Role of primary cilium in pancreatic ductal adenocarcinoma (Review)". International Journal of Oncology 57.5 (2020): 1095-1102.
Chicago
Sabanovic, B., Giulietti, M., Piva, F."Role of primary cilium in pancreatic ductal adenocarcinoma (Review)". International Journal of Oncology 57, no. 5 (2020): 1095-1102. https://doi.org/10.3892/ijo.2020.5121
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