Open Access

Glioma cells are resistant to inflammation‑induced alterations of mitochondrial dynamics

  • Authors:
    • Wange Fan
    • Yanan Song
    • Zongyao Ren
    • Xiaoli Cheng
    • Pu Li
    • Huiling Song
    • Liyun Jia
  • View Affiliations

  • Published online on: October 15, 2020     https://doi.org/10.3892/ijo.2020.5134
  • Copyright: © Fan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Accumulating evidence suggests that inflammation is present in solid tumors. However, it is poorly understood whether inflammation exists in glioma and how it affects the metabolic signature of glioma. By analyzing immunohistochemical data and gene expression data downloaded from bioinformatic datasets, the present study revealed an accumulation of inflammatory cells in glioma, activation of microglia, upregulation of proinflammatory factors (including IL‑6, IL‑8, hypoxia‑inducible factor‑1α, STAT3, NF‑κB1 and NF‑κB2), destruction of mitochondrial structure and altered expression levels of electron transfer chain complexes and metabolic enzymes. By monitoring glioma cells following proinflammatory stimulation, the current study observed a remodeling of their mitochondrial network via mitochondrial fission. More than half of the mitochondria presented ring‑shaped or spherical morphologies. Transmission electron microscopic analyses revealed mitochondrial swelling with partial or total cristolysis. Furthermore, proinflammatory stimuli resulted in increased generation of reactive oxygen species, decreased mitochondrial membrane potential and reprogrammed metabolism. The defective mitochondria were not eliminated via mitophagy. However, cell viability was not affected, and apoptosis was decreased in glioma cells after proinflammatory stimuli. Overall, the present findings suggested that inflammation may be present in glioma and that glioma cells may be resistant to inflammation‑induced mitochondrial dysfunction.

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Copy and paste a formatted citation
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Spandidos Publications style
Fan W, Song Y, Ren Z, Cheng X, Li P, Song H and Jia L: Glioma cells are resistant to inflammation‑induced alterations of mitochondrial dynamics. Int J Oncol 0: 0-0, 1899
APA
Fan, W., Song, Y., Ren, Z., Cheng, X., Li, P., Song, H., & Jia, L. (1899). Glioma cells are resistant to inflammation‑induced alterations of mitochondrial dynamics. International Journal of Oncology, 0, 0-0. https://doi.org/10.3892/ijo.2020.5134
MLA
Fan, W., Song, Y., Ren, Z., Cheng, X., Li, P., Song, H., Jia, L."Glioma cells are resistant to inflammation‑induced alterations of mitochondrial dynamics". International Journal of Oncology 0.0 (1899): 0-0.
Chicago
Fan, W., Song, Y., Ren, Z., Cheng, X., Li, P., Song, H., Jia, L."Glioma cells are resistant to inflammation‑induced alterations of mitochondrial dynamics". International Journal of Oncology 0, no. 0 (1899): 0-0. https://doi.org/10.3892/ijo.2020.5134