Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
December-2020 Volume 57 Issue 6

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2020 Volume 57 Issue 6

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

Update on uveal melanoma: Translational research from biology to clinical practice (Review)

  • Authors:
    • Miguel A. Ortega
    • Oscar Fraile‑Martínez
    • Natalio García‑Honduvilla
    • Santiago Coca
    • Melchor Álvarez‑Mon
    • Julia Buján
    • Miguel A. Teus
  • View Affiliations / Copyright

    Affiliations: Department of Medicine and Medical Specialties, Faculty of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares, 28871 Madrid, Spain, Department of Surgery, Medical and Social Sciences, Faculty of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares, 28871 Madrid, Spain
    Copyright: © Ortega et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1262-1279
    |
    Published online on: October 22, 2020
       https://doi.org/10.3892/ijo.2020.5140
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Uveal melanoma is the most common type of intraocular cancer with a low mean annual incidence of 5‑10 cases per million. Tumours are located in the choroid (90%), ciliary body (6%) or iris (4%) and of 85% are primary tumours. As in cutaneous melanoma, tumours arise in melanocytes; however, the characteristics of uveal melanoma differ, accounting for 3‑5% of melanocytic cancers. Among the numerous risk factors are age, sex, genetic and phenotypic predisposition, the work environment and dermatological conditions. Management is usually multidisciplinary, including several specialists such as ophthalmologists, oncologists and maxillofacial surgeons, who participate in the diagnosis, treatment and complex follow‑up of these patients, without excluding the management of the immense emotional burden. Clinically, uveal melanoma generates symptoms that depend as much on the affected ocular globe site as on the tumour size. The anatomopathological study of uveal melanoma has recently benefited from developments in molecular biology. In effect, disease classification or staging according to molecular profile is proving useful for the assessment of this type of tumour. Further, the improved knowledge of tumour biology is giving rise to a more targeted approach to diagnosis, prognosis and treatment development; for example, epigenetics driven by microRNAs as a target for disease control. In the present study, the main epidemiological, clinical, physiopathological and molecular features of this disease are reviewed, and the associations among all these factors are discussed.
View Figures

Figure 1

Figure 2

View References

1 

Andreoli MT, Mieler WF and Leiderman YI: Epidemiological trends in uveal melanoma. Br J Ophthalmol. 99:1550–1553. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Maheshwari A and Finger PT: Cancers of the eye. Cancer Metastasis Rev. 37:677–690. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Carvajal RD, Schwartz GK, Tezel T, Marr B, Francis JH and Nathan PD: Metastatic disease from uveal melanoma: Treatment options and future prospects. Br J Ophthalmol. 101:38–44. 2017. View Article : Google Scholar :

4 

Krantz BA, Dave N, Komatsubara KM, Marr BP and Carvajal RD: Uveal melanoma: Epidemiology, etiology, and treatment of primary disease. Clin Ophthalmol. 11:279–289. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Seedor RS, Eschelman DJ, Gonsalves CF, Adamo RD, Orloff M, Amjad A, Sharpe-Mills E, Chervoneva I, Shields CL, Shields JA, et al: An Outcome assessment of a single Institution's longitudinal experience with Uveal melanoma patients with liver metastasis. Cancers (Basel). 12:1172020. View Article : Google Scholar

6 

Shields CL, Manalac J, Das C, Ferguson K and Shields JA: Choroidal melanoma: Clinical features, classification, and top 10 pseudomelanomas. Curr Opin Ophthalmol. 25:177–185. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Shields CL, Kaliki S, Furuta M, Mashayekhi A and Shields JA: Clinical spectrum and prognosis of uveal melanoma based on age at presentation in 8,033 cases. Retina. 32:1363–1372. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Virgili G, Gatta G, Ciccolallo L, Capocaccia R, Biggeri A, Crocetti E, Lutz JM and Paci E; EUROCARE Working Group: Incidence of uveal melanoma in europe. Ophthalmology. 114:2309–2315. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Park SJ, Oh CM, Kim BW, Woo SJ, Cho H and Park KH: Nationwide incidence of ocular melanoma in South Korea by using the national cancer registry database (1999-2011). Invest Ophthalmol Vis Sci. 56:4719–4724. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Singh N, Seregard S and Singh AD: Uveal melanoma: Epidemiologic aspects. Clin Ophthalmic Oncol. 53–69. 2019. View Article : Google Scholar

11 

Nichols EE, Richmond A and Daniels AB: Disparities in uveal melanoma: Patient characteristics. Semin Ophthalmol. 31:296–303. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Nayman T, Bostan C, Logan P and Burnier MN Jr: Uveal melanoma risk Factors: A systematic review of Meta-analyses. Curr Eye Res. 42:1085–1093. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Kaliki S, Shields CL and Shields JA: Uveal melanoma: Estimating prognosis. Indian J Ophthalmol. 63:93–102. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Al-Jamal RT and Kivelä T: Uveal melanoma among Finnish children and young adults. J AAPOS. 18:61–66. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Mallet JD, Gendron SP, Drigeard Desgarnier MC and Rochette PJ: Implication of ultraviolet light in the etiology of uveal melanoma: A review. Photochem Photobiol. 90:15–21. 2014. View Article : Google Scholar

16 

Mishra S and Bharagava RN: Toxic and genotoxic effects of hexavalent chromium in environment and its bioremediation strategies. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 34:1–32. 2016. View Article : Google Scholar

17 

Velazquez N and Jones IS: Ocular and oculodermal melanocytosis associated with Uveal melanoma. Ophthalmology. 90:1472–1476. 1983. View Article : Google Scholar : PubMed/NCBI

18 

Plateroti AM, Scavella V, Abdolrahimzadeh B, Plateroti R and Rahimi S: An update on oculodermal melanocytosis and rare associated conditions. Semin Ophthalmol. 32:524–528. 2017. View Article : Google Scholar

19 

Shields CL, Kaliki S, Hutchinson A, Nickerson S, Patel J, Kancherla S, Peshtani A, Nakhoda S, Kocher K, Kolbus E, et al: Iris nevus growth into melanoma: Analysis of 1611 consecutive eyes: The ABCDEF guide. Ophthalmology. 120:766–772. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Chien JL, Sioufi K, Surakiatchanukul T, Shields JA and Shields CL: Choroidal nevus: A review of prevalence, features, genetics, risks, and outcomes. Curr Opin Ophthalmol. 28:228–237. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Rodríguez A, Dueñas-Gonzalez A and Delgado-Pelayo S: Clinical presentation and management of uveal melanoma. Mol Clin Oncol. 5:675–677. 2016. View Article : Google Scholar

22 

Nezu N, Goto H, Umazume K, Ueda S and Shibata M: Clinical analysis of uveal melanoma. Nippon Ganka Gakkai Zasshi. 121:413–418. 2017.In Japanese. PubMed/NCBI

23 

Callender GR: Malignant melanotic tumors of the eye. A study of histologic types in 111 cases. Trans Am Acad Ophthalmol Otolaryngol. 36:131–140. 1931.

24 

McLean IW, Foster WD, Zimmerman LE and Gamel JW: Modifications of Callender's classification of uveal melanoma at the armed forces institute of pathology. Am J Ophthalmol. 96:502–509. 1983. View Article : Google Scholar : PubMed/NCBI

25 

Seddon JM, Polivogianis L, Hsieh CC, Albert DM, Gamel JW and Gragoudas ES: Death from uveal melanoma. Number of epithelioid cells and inverse SD of nucleolar area as prognostic factors. Arch Ophthalmol. 105:801–806. 1987. View Article : Google Scholar : PubMed/NCBI

26 

Seregard S and Kock E: Prognostic indicators following enucleation for posterior uveal melanoma. A multivariate analysis of Long-term survival with minimized loss to Follow-up. Acta Ophthalmol Scand. 73:340–344. 1995. View Article : Google Scholar : PubMed/NCBI

27 

Folberg R, Pe'er J, Gruman LM, Woolson RF, Jeng G, Montague PR, Moninger TO, Yi H and Moore KC: The morpho-logic characteristics of tumor blood vessels as a marker of tumor progression in primary human uveal melanoma: A matched Case-control study. Hum Pathol. 23:1298–1305. 1992. View Article : Google Scholar : PubMed/NCBI

28 

Al-Jamal RT, Mäkitie T and Kivelä T: Nucleolar diameter and microvascular factors as independent predictors of mortality from malignant melanoma of the choroid and ciliary body. Invest Ophthalmol Vis Sci. 44:2381–2389. 2003. View Article : Google Scholar : PubMed/NCBI

29 

Moshari A and McLean IW: Uveal melanoma: Mean of the longest nucleoli measured on Silver-stained sections. Invest Ophthalmol Vis Sci. 42:1160–1163. 2001.PubMed/NCBI

30 

All-Ericsson C, Girnita L, Seregard S, Bartolazzi A, Jager MJ and Larsson O: Insulin-like growth Factor-1 receptor in uveal melanoma: A predictor for metastatic disease and a potential therapeutic target. Invest Ophthalmol Vis Sci. 43:1–8. 2002.PubMed/NCBI

31 

Karlsson M, Boeryd B, Carstensen J, Frånlund B, Gustafsson B, Kågedal B, Sun XF and Wingren S: Correlations of Ki-67 and PCNA to DNA ploidy, S-phase fraction and survival in uveal melanoma. Eur J Cancer. 32A:357–362. 1996. View Article : Google Scholar : PubMed/NCBI

32 

Bronkhorst IH, Ly LV, Jordanova ES, Vrolijk J, Versluis M, Luyten GP and Jager MJ: Detection of M2-macrophages in uveal melanoma and relation with survival. Invest Ophthalmol Vis Sci. 52:643–650. 2011. View Article : Google Scholar

33 

Bronkhorst IH and Jager MJ: Uveal melanoma: The inflammatory microenvironment. J Innate Immun. 4:454–462. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Blom DJ, Luyten GP, Mooy C, Kerkvliet S, Zwinderman AH and Jager MJ: Human leukocyte antigen class I expression. Marker of poor prognosis in uveal melanoma. Invest Ophthalmol Vis Sci. 38:1865–1872. 1997.PubMed/NCBI

35 

Onken MD, Worley LA, Ehlers JP and Harbour JW: Gene expression profiling in uveal melanoma reveals two molecular classes and predicts metastatic death. Cancer Res. 64:7205–7209. 2004. View Article : Google Scholar : PubMed/NCBI

36 

Robertson AG, Shih J, Yau C, Gibb EA, Oba J, Mungall KL, Hess JM, Uzunangelov V, Walter V, Danilova L, et al: Integrative analysis identifies four molecular and clinical subsets in uveal melanoma. Cancer Cell. 32:204–220.e15. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Reichstein D: New concepts in the molecular understanding of uveal melanoma. Curr Opin Ophthalmol. 28:219–227. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Field MG, Decatur CL, Kurtenbach S, Gezgin G, van der Velden PA, Jager MJ, Kozak KN and Harbour JW: PRAME as an independent biomarker for metastasis in uveal melanoma. Clin Cancer Res. 22:1234–1242. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Field MG, Durante MA, Decatur CL, Tarlan B, Oelschlager KM, Stone JF, Kuznetsov J, Bowcock AM, Kurtenbach S and Harbour JW: Epigenetic reprogramming and aberrant expression of PRAME are associated with increased metastatic risk in class 1 and class 2 uveal melanomas. Oncotarget. 7:59209–59219. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Decatur CL, Ong E, Garg N, Anbunathan H, Bowcock AM, Field MG and Harbour JW: Driver mutations in uveal melanoma: Associations with gene expression profile and patient outcomes. JAMA Ophthalmol. 134:728–733. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Diener-West M, Reynolds SM, Agugliaro DJ, Caldwell R, Cumming K, Earle JD, Hawkins BS, Hayman JA, Jaiyesimi I, Jampol LM, et al: Development of metastatic disease after enrolment in the COMS trials for treatment of choroidal melanoma: Collaborative ocular melanoma study group report no 26. Arch Ophthalmol. 123:1639–1643. 2005. View Article : Google Scholar : PubMed/NCBI

42 

Ramaiya KJ and Harbour JW: Current management of uveal melanoma. Expert Rev Ophthalmol. 2:939–946. 2007. View Article : Google Scholar

43 

Pandiani C, Béranger GE, Leclerc J, Ballotti R and Bertolotto C: Focus on cutaneous and uveal melanoma specificities. Genes Dev. 31:724–743. 2017. View Article : Google Scholar : PubMed/NCBI

44 

Ny L, Nyakas M, Hernberg M, Koivunen J, Oddershede L, Yoon MR, Wang X, Guyot P and Geisler J: BRAF mutation as a prognostic marker for survival in malignant melanoma: A systematic review and meta-analysis. J Clin Oncol. 36:e215662018. View Article : Google Scholar

45 

Wu J, Brunner G and Celebi JT: A melanoma subtype: Uveal melanoma. J Am Acad Dermatol. 64:1185–1186. 2011. View Article : Google Scholar : PubMed/NCBI

46 

Saldanha G, Purnell D, Fletcher A, Potter L, Gillies A and Pringle JH: High BRAF mutation frequency does not characterize all melanocytic tumor types. Int J Cancer. 111:705–710. 2004. View Article : Google Scholar : PubMed/NCBI

47 

Van Raamsdonk CD, Griewank KG, Crosby MB, Garrido MC, Vemula S, Wiesner T, Obenauf AC, Wackernagel W, Green G, Bouvier N, et al: Mutations in GNA11 in uveal melanoma. N Engl J Med. 363:2191–2199. 2010. View Article : Google Scholar : PubMed/NCBI

48 

Van der Kooij MK, Speetjens FM, van der Burg SH and Kapiteijn E: Uveal versus cutaneous melanoma; Same origin, very distinct tumor types. Cancers (Basel). 11:8452019. View Article : Google Scholar

49 

Moore AR, Ceraudo E, Sher JJ, Guan Y, Shoushtari AN, Chang MT, Zhang JQ, Walczak EG, Kazmi MA, Taylor BS, et al: Recurrent activating mutations of G-Protein-coupled receptor CYSLTR2 in uveal melanoma. Nat Genet. 48:675–680. 2016. View Article : Google Scholar : PubMed/NCBI

50 

Johansson P, Aoude LG, Wadt K, Glasson WJ, Warrier SK, Hewitt AW, Kiilgaard JF, Heegaard S, Isaacs T, Franchina M, et al: Deep sequencing of uveal melanoma identifies a recurrent mutation in PLCB4. Oncotarget. 7:4624–4631. 2016. View Article : Google Scholar

51 

Dono M, Angelini G, Cecconi M, Amaro A, Esposito AI, Mirisola V, Maric I, Lanza F, Nasciuti F, Viaggi S, et al: Mutation frequencies of GNAQ, GNA11, BAP1, SF3B1, EIF1AX and TERT in uveal melanoma: Detection of an activating mutation in the TERT gene promoter in a single case of uveal melanoma. Br J Cancer. 110:1058–1065. 2014. View Article : Google Scholar : PubMed/NCBI

52 

Horn S, Figl A, Rachakonda PS, Fischer C, Sucker A, Gast A, Kadel S, Moll I, Nagore E, Hemminki K, et al: TERT promoter mutations in familial and sporadic melanoma. Science. 339:959–961. 2013. View Article : Google Scholar : PubMed/NCBI

53 

Griewank KG, Murali R, Schilling B, Scholz S, Sucker A, Song M, Süsskind D, Grabellus F, Zimmer L, Hillen U, et al: TERT promoter mutations in ocular melanoma distinguish between conjunctival and uveal tumours. Br J Cancer. 109:497–501. 2013. View Article : Google Scholar : PubMed/NCBI

54 

Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI

55 

Bronkhorst IH and Jager MJ: Inflammation in uveal melanoma. Eye (Lond). 27:217–223. 2013. View Article : Google Scholar

56 

Maat W, Ly LV, Jordanova ES, Wolff-Rouendaal D, Schalij-Delfos NE and Jager MJ: Monosomy of chromosome 3 and an inflammatory phenotype occur together in uveal melanoma. Invest Ophthalmol Vis Sci. 49:505–510. 2008. View Article : Google Scholar : PubMed/NCBI

57 

Mahoney KM, Freeman GJ and McDermott DF: The next immune-checkpoint inhibitors: PD-1/PD-L1 blockade in melanoma. Clin Ther. 37:764–782. 2015. View Article : Google Scholar : PubMed/NCBI

58 

Yun S, Vincelette ND, Green MR, Wahner Hendrickson AE and Abraham I: Targeting immune checkpoints in unresectable metastatic cutaneous melanoma: A systematic review and Meta-analysis of anti-CTLA-4 and anti-PD-1 agents trials. Cancer Med. 5:1481–1491. 2016. View Article : Google Scholar : PubMed/NCBI

59 

Javed A, Arguello D, Johnston C, Gatalica Z, Terai M, Weight RM, Orloff M, Mastrangelo MJ and Sato T: PD-L1 expression in tumor metastasis is different between uveal melanoma and cutaneous melanoma. Immunotherapy. 9:1323–1330. 2017. View Article : Google Scholar : PubMed/NCBI

60 

Mougiakakos D, Johansson CC, Trocme E, All-Ericsson C, Economou MA, Larsson O, Seregard S and Kiessling R: Intratumoral forkhead box P3-positive regulatory T cells predict poor survival in cyclooxygenase-2-positive uveal melanoma. Cancer. 116:2224–2233. 2010.PubMed/NCBI

61 

Lagouros E, Salomao D, Thorland E, Hodge DO, Vile R and Pulido JS: Infiltrative T regulatory cells in enucleated uveal melanomas. Trans Am Ophthalmol Soc. 107:223–228. 2009.

62 

Bronkhorst IH, Vu TH, Jordanova ES, Luyten GP, Burg SH and Jager MJ: Different subsets of tumor-infiltrating lymphocytes correlate with macrophage influx and monosomy 3 in uveal melanoma. Invest Ophthalmol Vis Sci. 53:5370–5378. 2012. View Article : Google Scholar : PubMed/NCBI

63 

Petralia MC, Mazzon E, Fagone P, Russo A, Longo A, Avitabile T, Nicoletti F, Reibaldi M and Basile MS: Characterization of the pathophysiological role of CD47 in Uveal melanoma. Molecules. 24:24502019. View Article : Google Scholar :

64 

Basile MS, Mazzon E, Russo A, Mammana S, Longo A, Bonfiglio V, Fallico M, Caltabiano R, Fagone P, Nicoletti F, et al: Differential modulation and prognostic values of immune-escape genes in uveal melanoma. PLoS One. 14:e02102762019. View Article : Google Scholar : PubMed/NCBI

65 

Ding L, Lu S and Li Y: Regulation of PD-1/PD-L1 pathway in cancer by noncoding RNAs. Pathol Oncol Res. 26:651–663. 2020. View Article : Google Scholar

66 

Javed A, Arguello D, Johnston C, Gatalica Z, Terai M, Weight RM, Orloff M, Mastrangelo MJ and Sato T: PD-L1 expression in tumor metastasis is different between uveal melanoma and cutaneous melanoma. Immunotherapy. 9:1323–1330. 2017. View Article : Google Scholar : PubMed/NCBI

67 

Durante MA, Rodriguez DA, Kurtenbach S, Kuznetsov JN, Sanchez MI, Decatur CL, Snyder H, Feun LG, Livingstone AS and Harbour JW: Single-cell analysis reveals new evolutionary complexity in uveal melanoma. Nat Commun. 11(496)2020. View Article : Google Scholar : PubMed/NCBI

68 

Babchia N, Landreville S, Clément B, Coulouarn C and Mouriaux F: The bidirectional crosstalk between metastatic uveal melanoma cells and hepatic stellate cells engenders an inflammatory microenvironment. Exp Eye Res. 181:213–222. 2019. View Article : Google Scholar : PubMed/NCBI

69 

Giulietti M, Vivenzio V, Piva F, Principato G, Bellantuono C and Nardi B: How much do we know about the coupling of G-proteins to serotonin receptors? Mol Brain. 7:492014. View Article : Google Scholar : PubMed/NCBI

70 

Tschentscher F, Hüsing J, Holter T, Kruse E, Dresen IG, Jöckel KH, Anastassiou G, Schilling H, Bornfeld N, Horsthemke B, et al: Tumor classification based on gene expression profiling shows that uveal melanomas with and without monosomy 3 represent two distinct entities. Cancer Res. 63:2578–2584. 2003.PubMed/NCBI

71 

Bakalian S, Marshall JC, Logan P, Faingold D, Maloney S, Di Cesare S, Martins C, Fernandes BF and Burnier MN Jr: Molecular pathways mediating liver metastasis in patients with uveal melanoma. Clin Cancer Res. 14:951–956. 2008. View Article : Google Scholar : PubMed/NCBI

72 

O'Hayre M, Degese MS and Gutkind JS: Novel insights into G protein and G Protein-coupled receptor signaling in cancer. Curr Opin Cell Biol. 27:126–135. 2014. View Article : Google Scholar : PubMed/NCBI

73 

Liu H, Lei C, Long K, Yang X, Zhu Z, Zhang L and Liu J: Mutant GNAQ promotes cell viability and migration of uveal melanoma cells through the activation of Notch signaling. Oncol Rep. 34:295–301. 2015. View Article : Google Scholar : PubMed/NCBI

74 

Feng X, Degese MS, Iglesias-Bartolome R, Vaque JP, Molinolo AA, Rodrigues M, Zaidi MR, Ksander BR, Merlino G, Sodhi A, et al: Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry. Cancer Cell. 25:831–845. 2014. View Article : Google Scholar : PubMed/NCBI

75 

Harbour JW, Onken MD, Roberson ED, Duan S, Cao L, Worley LA, Council ML, Matatall KA, Helms C and Bowcock AM: Frequent mutation of BAP1 in metastasizing uveal melanomas. Science. 330:1410–1413. 2010. View Article : Google Scholar : PubMed/NCBI

76 

Coupland SE, Lake SL, Zeschnigk M and Damato BE: Molecular pathology of uveal melanoma. Eye (Lond). 27:230–242. 2013. View Article : Google Scholar

77 

Abdel-Rahman MH, Pilarski R, Cebulla CM, Massengill JB, Christopher BN, Boru G, Hovland P and Davidorf FH: Germline BAP1 mutation predisposes to uveal melanoma, lung adenocarcinoma, meningioma, and other cancers. J Med Genet. 48:856–859. 2011. View Article : Google Scholar : PubMed/NCBI

78 

Scheuermann JC, de Ayala Alonso AG, Oktaba K, Ly-Hartig N, McGinty RK, Fraterman S, Wilm M, Muir TW and Müller J: Histone H2A deubiquitinase activity of the polycomb repressive complex PR-DUB. Nature. 465:243–247. 2010. View Article : Google Scholar : PubMed/NCBI

79 

Eletr ZM and Wilkinson KD: An emerging model for BAP1's role in regulating cell cycle progression. Cell Biochem Biophys. 60:3–11. 2001. View Article : Google Scholar

80 

He M, Chaurushiya MS, Webster JD, Kummerfeld S, Reja R, Chaudhuri S, Chen YJ, Modrusan Z, Haley B, Dugger DL, et al: Intrinsic apoptosis shapes the tumor spectrum linked to inactivation of the deubiquitinase BAP1. Science. 364:283–285. 2019.PubMed/NCBI

81 

Park JJ, Diefenbach RJ, Joshua AM, Kefford RF, Carlino MS and Rizos H: Oncogenic signaling in uveal melanoma. Pigment Cell Melanoma Res. 31:661–672. 2018. View Article : Google Scholar : PubMed/NCBI

82 

Matatall KA, Agapova OA, Onken MD, Worley LA, Bowcock AM and Harbour JW: BAP1 deficiency causes loss of melanocytic cell identity in uveal melanoma. BMC Cancer. 13:3712013. View Article : Google Scholar : PubMed/NCBI

83 

Oliva M, Rullan AJ and Piulats JM: Uveal melanoma as a target for Immune therapy. Ann Transl Med. 4:1722016. View Article : Google Scholar

84 

Szalai E, Wells JR, Ward L and Grossniklaus HE: Uveal melanoma nuclear BRCA1-associated Protein-1 immunoreactivity is an indicator of metastasis. Ophthalmology. 125:203–209. 2018. View Article : Google Scholar

85 

Furney SJ, Pedersen M, Gentien D, Dumont AG, Rapinat A, Desjardins L, Turajlic S, Piperno-Neumann S, de la Grange P, Roman-Roman S, et al: SF3B1 mutations are associated with alternative splicing in uveal melanoma. Cancer Discov. 3:1122–1129. 2013. View Article : Google Scholar : PubMed/NCBI

86 

Amaro A, Gangemi R, Piaggio F, Angelini G, Barisione G, Ferrini S and Pfeffer U: The biology of uveal melanoma. Cancer Metastasis Rev. 36:109–140. 2017. View Article : Google Scholar : PubMed/NCBI

87 

Yavuzyigitoglu S, Koopmans AE, Verdijk RM, Vaarwater J, Eussen B, van Bodegom A, Paridaens D, Kiliç E and de Klein A; Rotterdam Ocular Melanoma Study Group: Uveal melanomas with SF3B1 mutations: A distinct subclass associated with Late-onset metastases. Ophthalmology. 123:1118–1128. 2016. View Article : Google Scholar : PubMed/NCBI

88 

Coltri PP, Dos Santos MGP and da Silva GHG: Splicing and cancer: Challenges and opportunities. Wiley Interdiscip Rev RNA. 10:e15272019. View Article : Google Scholar : PubMed/NCBI

89 

Alsafadi S, Mobuchon L, Rodrigues M and Stern MH: Uveal melanoma, a model disease for splicing alterations and oncogenesis. Med Sci (Paris). 34:155–160. 2018.In French. View Article : Google Scholar

90 

Tanaka A, Kobayashi S, Xiao M and Inoue D: Understanding and therapeutic targeting of aberrant mRNA splicing mechanisms in oncogenesis. Rinsho Ketsueki. 61:643–650. 2020.In Japanese.

91 

Freemantle SJ, Spinella MJ and Dmitrovsky E: Retinoids in cancer therapy and chemoprevention: Promise meets resistance. Oncogene. 22:7305–7315. 2003. View Article : Google Scholar : PubMed/NCBI

92 

Epping MT, Wang L, Edel MJ, Carlee L, Hernandez M and Bernards R: The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling. Cell. 122:835–847. 2005. View Article : Google Scholar : PubMed/NCBI

93 

Etemadmoghadam D, Azar WJ, Lei Y, Moujaber T, Garsed DW, Kennedy CJ, Fereday S, Mitchell C, Chiew YE, Hendley J, et al: EIF1AX and NRAS Mutations Co-occur and Cooperate in Low-grade serous ovarian carcinomas. Cancer Res. 77:4268–4278. 2017. View Article : Google Scholar : PubMed/NCBI

94 

Krishnamoorthy GP, Davidson NR, Leach SD, Zhao Z, Lowe SW, Lee G, Landa I, Nagarajah J, Saqcena M, Singh K, et al: EIF1AX and RAS mutations cooperate to drive thyroid tumorigenesis through ATF4 and C-MYC. Cancer Discov. 9:264–281. 2019. View Article : Google Scholar :

95 

Bagnato A and Rosanò L: The endothelin axis in cancer. Int J Biochem Cell Biol. 40:1443–1451. 2008. View Article : Google Scholar : PubMed/NCBI

96 

Davenport AP, Hyndman KA, Dhaun N, Southan C, Kohan DE, Pollock JS, Pollock DM, Webb DJ and Maguire JJ: Endothelin. Pharmacol Rev. 68:357–418. 2016. View Article : Google Scholar : PubMed/NCBI

97 

Pla P, Alberti C, Solov'eva O, Pasdar M, Kunisada T and Larue L: Ednrb2 orients cell migration towards the dorsolateral neural crest pathway and promotes melanocyte differentiation. Pigment Cell Res. 18:181–187. 2005. View Article : Google Scholar : PubMed/NCBI

98 

Smith SL, Damato BE, Scholes AG, Nunn J, Field JK and Heighway J: Decreased endothelin receptor B expression in large primary uveal melanomas is associated with early clinical metastasis and short survival. Br J Cancer. 87:1308–1313. 2002. View Article : Google Scholar : PubMed/NCBI

99 

Urtatiz O and Van Raamsdonk CD: Gnaq and Gna11 in the endothelin signaling pathway and melanoma. Front Genet. 7:592016. View Article : Google Scholar : PubMed/NCBI

100 

Mallikarjuna K, Pushparaj V, Biswas J and Krishnakumar S: Expression of epidermal growth factor receptor, ezrin, hepatocyte growth factor, and c-Met in uveal melanoma: An immunohistochemical study. Curr Eye Res. 32:281–290. 2007. View Article : Google Scholar : PubMed/NCBI

101 

Franco R, Botti G, Mascolo M, Loquercio G, Liguori G, Ilardi G, Losito S, La Mura A, Calemma R, Ierano C, et al: CXCR4-CXCL12 and VEGF correlate to uveal melanoma progression. Front Biosci (Elite Ed). 2:13–21. 2010. View Article : Google Scholar

102 

Vivet-Noguer R, Tarin M, Roman-Roman S and Alsafadi S: Emerging therapeutic opportunities based on current knowledge of uveal melanoma Biology. Cancers (Basel). 11:10192019. View Article : Google Scholar

103 

Cheng H, Chua V, Liao C, Purwin TJ, Terai M, Kageyama K, Davies MA, Sato T and Aplin AE: Co-targeting HGF-CMET Signaling with MEK inhibitors in metastatic uveal melanoma. Mol Cancer Ther. 116:516–528. 2017. View Article : Google Scholar

104 

Abdel-Rahman MH, Yang Y, Zhou XP, Craig EL, Davidorf FH and Eng C: High frequency of submicroscopic hemizygous deletion is a major mechanism of loss of expression of PTEN in uveal melanoma. J Clin Oncol. 24:288–295. 2006. View Article : Google Scholar

105 

Walsh JC, Lebedev A, Aten E, Madsen K, Marciano L and Kolb HC: The clinical importance of assessing tumor hypoxia: Relationship of tumor hypoxia to prognosis and therapeutic opportunities. Antioxid Redox Signal. 21:1516–1554. 2014. View Article : Google Scholar : PubMed/NCBI

106 

Semenza GL: HIF-1: Upstream and downstream of cancer metabolism. Curr Opin Genet Dev. 20:51–56. 2010. View Article : Google Scholar :

107 

Burroughs SK, Kaluz S, Wang D, Wang K, Van Meir EG and Wang B: Hypoxia inducible factor pathway inhibitors as anti-cancer therapeutics. Future Med Chem. 5:553–572. 2013. View Article : Google Scholar : PubMed/NCBI

108 

Luke JJ, Triozzi PL, McKenna KC, Van Meir EG, Gershenwald JE, Bastian BC, Gutkind JS, Bowcock AM, Streicher HZ, Patel PM, et al: Biology of advanced uveal melanoma and next steps for clinical therapeutics. Pigment Cell Melanoma Res. 28:135–147. 2015. View Article : Google Scholar :

109 

Keith B, Johnson RS and Simon MC: HIF1α and HIF2α: Sibling rivalry in hypoxic tumour growth and progression. Nat Rev Cancer. 12:9–22. 2011. View Article : Google Scholar : PubMed/NCBI

110 

Asnaghi L, Lin MH, Lim KS, Lim KJ, Tripathy A, Wendeborn M, Merbs SL, Handa JT, Sodhi A, Bar EE and Eberhart CG: Hypoxia promotes uveal melanoma invasion through enhanced Notch and MAPK activation. PLoS One. 9:e1053722014. View Article : Google Scholar : PubMed/NCBI

111 

Mouriaux F, Sanschagrin F, Diorio C, Landreville S, Comoz F, Petit E, Bernaudin M, Rousseau AP, Bergeron D and Morcos M: Increased HIF-1α expression correlates with cell proliferation and vascular markers CD31 and VEGF-A in uveal melanoma. Invest Ophthalmol Vis Sci. 55:1277–1283. 2014. View Article : Google Scholar : PubMed/NCBI

112 

Hu K, Babapoor-Farrokhran S, Rodrigues M, Deshpande M, Puchner B, Kashiwabuchi F, Hassan SJ, Asnaghi L, Handa JT, Merbs S, et al: Hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanoma. Oncotarget. 7:7816–7828. 2016. View Article : Google Scholar : PubMed/NCBI

113 

Dong L, You S, Zhang Q, Osuka S, Devi NS, Kaluz S, Ferguson JH, Yang H, Chen G, Wang B, et al: Arylsulfonamide 64B inhibits Hypoxia/HIF-induced expression of c-Met and CXCR4 and reduces primary tumor growth and metastasis of uveal melanoma. Clin Cancer Res. 25:2206–2218. 2019. View Article : Google Scholar :

114 

Brouwer NJ, Gezgin G, Wierenga APA, Bronkhorst IHG, Marinkovic M, Luyten GPM, Versluis M, Kroes WGM, van der Velden PA, Verdijk RM and Jager MJ: Tumour angiogenesis in uveal melanoma is related to genetic evolution. Cancers (Basel). 11:9792019. View Article : Google Scholar

115 

Brouwer NJ, Wierenga APA, Gezgin G, Marinkovic M, Luyten GPM, Kroes WGM, Versluis M, van der Velden PA, Verdijk RM and Jager MJ: Ischemia is related to tumour genetics in uveal melanoma. Cancers (Basel). 11:10042019. View Article : Google Scholar

116 

Spector A: Review: Oxidative stress and disease. J Ocul Pharmacol Ther. 16:193–201. 2000. View Article : Google Scholar : PubMed/NCBI

117 

Di Meo S, Reed TT, Venditti P and Victor VM: Role of ROS and RNS sources in physiological and pathological conditions. Oxid Med Cell Longev. 2016:12450492016. View Article : Google Scholar : PubMed/NCBI

118 

Mitra D, Luo X, Morgan A, Wang J, Hoang MP, Lo J, Guerrero CR, Lennerz JK, Mihm MC, Wargo JA, et al: An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background. Nature. 491:449–453. 2012. View Article : Google Scholar : PubMed/NCBI

119 

Reuter S, Gupta SC, Chaturvedi MM and Aggarwal BB: Oxidative stress, inflammation, and cancer: How are they linked? Free Radic Biol Med. 49:1603–1616. 2010. View Article : Google Scholar : PubMed/NCBI

120 

Andrisic L, Dudzik D, Barbas C, Milkovic L, Grune T and Zarkovic N: Short overview on metabolomics approach to study pathophysiology of oxidative stress in cancer. Redox Biol. 14:47–58. 2018. View Article : Google Scholar

121 

Piskounova E, Agathocleous M, Murphy MM, Hu Z, Huddlestun SE, Zhao Z, Leitch AM, Johnson TM, DeBerardinis RJ and Morrison SJ: Oxidative stress inhibits distant metastasis by human melanoma cells. Nature. 527:186–1891. 2015. View Article : Google Scholar : PubMed/NCBI

122 

Dithmer M, Kirsch AM, Gräfenstein L, Wang F, Schmidt H, Coupland SE, Fuchs S, Roider J and Klettner AK: Uveal melanoma cell under oxidative Stress-influence of VEGF and VEGF-inhibitors. Klin Monbl Augenheilkd. 236:295–307. 2019.In German. View Article : Google Scholar

123 

Costa FF: Epigenomics in cancer management. Cancer Manag Res. 2:255–265. 2010. View Article : Google Scholar : PubMed/NCBI

124 

Yang X, Gao L and Zhang S: Comparative Pan-cancer DNA methylation analysis reveals cancer common and specific patterns. Brief Bioinform. 18:761–773. 2017.

125 

Maat W, van der Velden PA, Out-Luiting C, Plug M, Dirks- Mulder A, Jager MJ and Gruis NA: Epigenetic inactivation of RASSF1a in uveal melanoma. Invest Ophthalmol Vis Sci. 48:486–490. 2007. View Article : Google Scholar : PubMed/NCBI

126 

Dammann RH, Richter AM, Jiménez AP, Woods M, Küster M and Witharana C: Impact of natural compounds on DNA methylation levels of the tumor suppressor Gene RASSF1A in cancer. Int J Mol Sci. 18:21602017. View Article : Google Scholar :

127 

Maat W, Beiboer SH, Jager MJ, Luyten GP, Gruis NA and van der Velden PA: Epigenetic regulation identifies RASEF as a Tumor-suppressor gene in uveal melanoma. Invest Ophthalmol Vis Sci. 49:1291–1298. 2008. View Article : Google Scholar : PubMed/NCBI

128 

Venza M, Visalli M, Biondo C, Lentini M, Catalano T, Teti D and Venza I: Epigenetic regulation of p14ARF and p16INK4A expression in cutaneous and uveal melanoma. Biochim Biophys Acta. 1849:247–256. 2015. View Article : Google Scholar

129 

Venza M, Visalli M, Catalano T, Fortunato C, Oteri R, Teti D and Venza I: Impact of DNA methyltransferases on the epigenetic regulation of tumor necrosis Factor-related Apoptosis-inducing ligand (TRAIL) receptor expression in malignant melanoma. Biochem Biophys Res Commun. 441:743–750. 2013. View Article : Google Scholar : PubMed/NCBI

130 

Van der Veiden PA, Metzelaar-Blok JA, Bergman W, Hurks H, Frants RR, Gruis NA and Jager MJ: Promoter Hypermethylation: A common cause of reduced P16(INK4a) expression in uveal melanoma. Cancer Res. 61:5303–5306. 2001.

131 

Li Y, Jia R and Ge S: Role of Epigenetics in Uveal Melanoma. Int J Biol Sci. 13:426–4332. 2017. View Article : Google Scholar : PubMed/NCBI

132 

Yang ZK, Yang JY, Xu ZZ and Yu WH: DNA Methylation and uveal melanoma. Chin Med J (Engl). 131:845–851. 2018. View Article : Google Scholar

133 

Audia JE and Campbell RM: Histone modifications and cancer. Cold Spring Harb Perspect Biol. 8:a0195212016. View Article : Google Scholar : PubMed/NCBI

134 

Ding X, Wang X, Lin M, Xing Y, Ge S, Jia R, Zhang H, Fan X and Li J: PAUPAR lncRNA suppresses tumourigenesis by H3K4 demethylation in uveal melanoma. FEBS Lett. 590:1729–1738. 2016. View Article : Google Scholar : PubMed/NCBI

135 

Dong R, Liu J, Sun W and Ping W: Comprehensive analysis of aberrantly expressed profiles of lncRNAs and miRNAs with associated ceRNA Network in lung adenocarcinoma and lung squamous cell carcinoma. Pathol Oncol Res. 26:1935–1945. 2020. View Article : Google Scholar : PubMed/NCBI

136 

Catalanotto C, Cogoni C and Zardo G: MicroRNA in control of gene expression: An overview of nuclear functions. Int J Mol Sci. 17:17122016. View Article : Google Scholar :

137 

Rupaimoole R and Slack FJ: MicroRNA therapeutics: Towards a new era for the management of cancer and other diseases. Nat Rev Drug Discov. 16:203–222. 2017. View Article : Google Scholar : PubMed/NCBI

138 

Mishra S, Yadav T and Rani V: Exploring miRNA based approaches in cancer diagnostics and therapeutics. Crit Rev Oncol Hematol. 98:12–23. 2016. View Article : Google Scholar

139 

Lopez-Rincon A, Martinez-Archundia M, Martinez-Ruiz GU, Schoenhuth A and Tonda A: Automatic discovery of 100-miRNA signature for cancer classification using ensemble feature selection. BMC Bioinformatics. 20:4802019. View Article : Google Scholar : PubMed/NCBI

140 

Li Z, Yu X, Shen J and Jiang Y: MicroRNA dysregulation in uveal melanoma: A new player enters the game. Oncotarget. 6:4562–458. 2015. View Article : Google Scholar : PubMed/NCBI

141 

Yang C and Wei W: The miRNA expression profile of the uveal melanoma. Sci China Life Sci. 54:351–358. 2011. View Article : Google Scholar : PubMed/NCBI

142 

Wang YC, Yang X, Wei WB and Xu XL: Role of microRNA-21 in uveal melanoma cell invasion and metastasis by regulating p53 and its downstream protein. Int J Ophthalmol. 11:1258–1268. 2018.

143 

Radhakrishnan A, Badhrinarayanan N, Biswas J and Krishnakumar S: Analysis of chromosomal aberration (1, 3, and 8) and association of microRNAs in uveal melanoma. Mol Vis. 15:2146–2154. 2009.PubMed/NCBI

144 

Peng J, Liu H and Liu C: MiR-155 Promotes uveal melanoma cell proliferation and invasion by regulating NDFIP1 expression. Technol Cancer Res Treat. 16:1160–1167. 2017. View Article : Google Scholar

145 

Li Y, Huang Q, Shi X, Jin X, Shen L, Xu X and Wei W: MicroRNA 145 may play an important role in uveal melanoma cell growth by potentially targeting insulin receptor substrate 1. Chin Med J (Engl). 127:1410–1416. 2014.

146 

Yan D, Zhou X, Chen X, Hu DN, Dong XD, Wang J, Lu F, Tu L and Qu J: MicroRNA-34a inhibits uveal melanoma cell proliferation and migration through downregulation of c-Met. Invest Ophthalmol Vis Sci. 50:1559–1565. 2009. View Article : Google Scholar

147 

Dong F and Lou D: MicroRNA-34b/c suppresses uveal melanoma cell proliferation and migration through multiple targets. Mol Vis. 18:537–546. 2012.PubMed/NCBI

148 

Serocki M, Bartoszewska S, Janaszak-Jasiecka A, Ochocka RJ, Collawn JF and Bartoszewski R: miRNAs regulate the HIF switch during hypoxia: A novel therapeutic target. Angiogenesis. 21:183–202. 2018. View Article : Google Scholar : PubMed/NCBI

149 

Sun L, Wang Q, Gao X, Shi D, Mi S and Han Q: MicroRNA-454 functions as an oncogene by regulating PTEN in uveal melanoma. FEBS Lett. 589:2791–2796. 2015. View Article : Google Scholar : PubMed/NCBI

150 

Ling J, Lu P, Zhang Y, Jiang S and Zhang Z: MiR-367 promotes uveal melanoma cell proliferation and migration by regulating PTEN. Genet Mol Res. 16:gmr160390672017. View Article : Google Scholar

151 

Liu Y, Huo Y, Wang D, Tai Y, Li J, Pang D, Zhang Y, Zhao W, Du N and Huang Y: MiR-216a-5p/Hexokinase 2 axis regulates uveal melanoma growth through modulation of Warburg effect. Biochem Biophys Res Commun. 50:885–892. 2018. View Article : Google Scholar

152 

Singh AD, Turell ME and Topham AK: Uveal melanoma: Trends in incidence, treatment, and survival. Ophthalmology. 118:1881–1885. 2011. View Article : Google Scholar : PubMed/NCBI

153 

Kaliki S and Shields CL: Uveal melanoma: Relatively rare but deadly cancer. Eye (Lond). 31:241–257. 2017. View Article : Google Scholar

154 

Triozzi PL and Singh AD: Blood biomarkers for uveal melanoma. Future Oncol. 8:205–215. 2012. View Article : Google Scholar : PubMed/NCBI

155 

Cabel L, Proudhon C, Gortais H, Loirat D, Coussy F, Pierga JY and Bidard FC: Circulating tumor cells: Clinical validity and utility. Int J Clin Oncol. 22:421–430. 2017. View Article : Google Scholar : PubMed/NCBI

156 

Valpione S, Gremel G, Mundra P, Middlehurst P, Galvani E, Girotti MR, Lee RJ, Garner G, Dhomen N, Lorigan PC and Marais R: Plasma total Cell-free DNA (cfDNA) is a surrogate biomarker for tumour burden and a prognostic biomarker for survival in metastatic melanoma patients. Eur J Cancer. 88:1–9. 2018. View Article : Google Scholar :

157 

Terai M, Mu Z, Eschelman DJ, Gonsalves CF, Kageyama K, Chervoneva I, Orloff M, Weight R, Mastrangelo MJ, Cristofanilli M and Sato T: Arterial blood, rather than venous blood, is a better source for circulating melanoma cells. EBioMedicine. 2:1821–1826. 2015. View Article : Google Scholar

158 

Bidard FC, Madic J, Mariani P, Piperno-Neumann S, Rampanou A, Servois V, Cassoux N, Desjardins L, Milder M, Vaucher I, et al: Detection rate and prognostic value of circulating tumor cells and circulating tumor DNA in metastatic uveal melanoma. Int J Cancer. 134:1207–1213. 2014. View Article : Google Scholar

159 

Schuster R, Bechrakis NE, Stroux A, Busse A, Schmittel A, Thiel E, Foerster MH and Keilholz U: Prognostic relevance of circulating tumor cells in metastatic uveal melanoma. Oncology. 80:57–62. 2011. View Article : Google Scholar : PubMed/NCBI

160 

Tura A, Merz H, Reinsberg M, Lüke M, Jager MJ, Grisanti S and Lüke J: Analysis of monosomy-3 in immunomagnetically-isolated circulating melanoma cells in uveal melanoma patients. Pigment Cell Melanoma Res. 29:583–589. 2016. View Article : Google Scholar : PubMed/NCBI

161 

Achberger S, Aldrich W, Tubbs R, Crabb JW, Singh AD and Triozzi PL: Circulating immune cell and microRNA in patients with uveal melanoma developing metastatic disease. Mol Immunol. 58:182–186. 2014. View Article : Google Scholar :

162 

Russo A, Caltabiano R, Longo A, Avitabile T, Franco LM, Bonfiglio V, Puzzo L and Reibaldi M: Increased levels of miRNA-146a in serum and histologic samples of patients with uveal melanoma. Front Pharmacol. 7:4242016. View Article : Google Scholar : PubMed/NCBI

163 

Eldh M, Olofsson Bagge R, Lässer C, Svanvik J, Sjöstrand M, Mattsson J, Lindnér P, Choi DS, Gho YS and Lötvall J: MicroRNA in exosomes isolated directly from the liver circulation in patients with metastatic uveal melanoma. BMC Cancer. 14:9622014. View Article : Google Scholar : PubMed/NCBI

164 

Stark MS, Gray ES, Isaacs T, Chen FK, Millward M, McEvoy A, Zaenker P, Ziman M, Soyer HP, Glasson WJ, et al: Panel of Circulating MicroRNAs detects uveal melanoma with high precision. Transl Vis Sci Technol. 8:122019. View Article : Google Scholar

165 

Peng L, Cantor DI, Huang C, Wang K, Baker MS and Nice EC: Tissue and plasma proteomics for early stage cancer detection. Mol Omics. 14:405–423. 2018. View Article : Google Scholar : PubMed/NCBI

166 

Karimi P, Shahrokni A and Ranjbar MR: Implementation of proteomics for cancer research: Past, present, and future. Asian Pac J Cancer Prev. 15:2433–2438. 2014. View Article : Google Scholar : PubMed/NCBI

167 

Reiniger IW, Schaller UC, Haritoglou C, Hein R, Bosserhoff AK, Kampik A and Mueller AJ: 'Melanoma inhibitory activity' (MIA): A promising serological tumour marker in metastatic uveal melanoma. Graefes Arch Clin Exp Ophthalmol. 243:1161–1166. 2005. View Article : Google Scholar : PubMed/NCBI

168 

Haritoglou I, Wolf A, Maier T, Haritoglou C, Hein R and Schaller UC: Osteopontin and 'melanoma inhibitory activity': Comparison of two serological tumor markers in metastatic uveal melanoma patients. Ophthalmologica. 223:239–243. 2009. View Article : Google Scholar : PubMed/NCBI

169 

Barak V, Frenkel S, Kalickman I, Maniotis AJ, Folberg R and Pe'er J: Serum markers to detect metastatic uveal melanoma. Anticancer Res. 27:1897–1900. 2007.PubMed/NCBI

170 

Missotten GS, Tang NE, Korse CM, Hurks HM, de Wolff-Rouendaal D, Keunen JE, Jager MJ and Bonfrer JM: Prognostic value of S-100-beta serum concentration in patients with uveal melanoma. Arch Ophthalmol. 121:1117–1119. 2003. View Article : Google Scholar : PubMed/NCBI

171 

Strobel K, Bode B, Dummer R, Veit-Haibach P, Fischer DR, Imhof L, Goldinger S, Steinert HC and von Schulthess GK: Limited value of 18F-FDG PET/CT and S-100B tumour marker in the detection of liver metastases from uveal melanoma compared to liver metastases from cutaneous melanoma. Eur J Nucl Med Mol Imaging. 36:1774–1782. 2009. View Article : Google Scholar : PubMed/NCBI

172 

Suesskind D, Schatz A, Schnichels S, Coupland SE, Lake SL, Wissinger B, Bartz-Schmidt KU and Henke-Fahle S: GDF-15: A novel serum marker for metastases in uveal melanoma patients. Graefes Arch Clin Exp Ophthalmol. 250:887–895. 2012. View Article : Google Scholar

173 

Bande MF, Santiago M, Blanco MJ, Mera P, Capeans C, Rodríguez-Alvarez MX, Pardo M and Piñeiro A: Serum DJ-1/PARK 7 is a potential biomarker of choroidal nevi transformation. Invest Ophthalmol Vis Sci. 53:62–67. 2012. View Article : Google Scholar

174 

Bande MF, Santiago M, Mera P, Piulats JM, Blanco MJ, Rodríguez-Álvarez MX, Capeans C, Piñeiro A and Pardo M: ME20-S as a potential biomarker for the evaluation of uveal melanoma. Invest Ophthalmol Vis Sci. 56:7007–7011. 2015. View Article : Google Scholar : PubMed/NCBI

175 

Barisione G, Fabbi M, Gino A, Queirolo P, Orgiano L, Spano L, Picasso V, Pfeffer U, Mosci C, Jager MJ, et al: Potential Role of Soluble c-Met as a New candidate biomarker of metastatic uveal melanoma. JAMA Ophthalmol. 133:1013–1021. 2015. View Article : Google Scholar : PubMed/NCBI

176 

Angi M, Kalirai H, Prendergast S, Simpson D, Hammond DE, Madigan MC, Beynon RJ and Coupland SE: In-depth proteomic profiling of the uveal melanoma secretome. Oncotarget. 7:49623–49635. 2016. View Article : Google Scholar : PubMed/NCBI

177 

Crabb JW, Hu B, Crabb JS, Triozzi P, Saunthararajah Y, Tubbs R and Singh AD: iTRAQ quantitative proteomic comparison of metastatic and non-metastatic uveal melanoma tumors. PLoS One. 10:e01355432015. View Article : Google Scholar : PubMed/NCBI

178 

Shi XY, Li Q, Wei WB and Tao LM: Peptidome profiling of human serum of uveal melanoma patients based on magnetic bead fractionation and mass spectrometry. Int J Ophthalmol. 10:939–947. 2017.PubMed/NCBI

179 

Song J, Merbs SL, Sokoll LJ, Chan DW and Zhang Z: A multi-plex immunoassay of serum biomarkers for the detection of uveal melanoma. Clin Proteomics. 16:102019. View Article : Google Scholar

180 

Corrêa ZM: Assessing prognosis in uveal melanoma. Cancer Control. 23:93–98. 2016. View Article : Google Scholar : PubMed/NCBI

181 

Balasubramanya R, Selvarajan SK, Cox M, Joshi G, Deshmukh S, Mitchell DG and O'Kane P: Imaging of ocular melanoma metastasis. Br J Radiol. 89:201600922016. View Article : Google Scholar : PubMed/NCBI

182 

Smit KN, Jager MJ, de Klein A and Kiliç E: Uveal melanoma: Towards a molecular understanding. Prog Retin Eye Res. 75:1008002020. View Article : Google Scholar

183 

Schopper VJ and Correa ZM: Clinical application of genetic testing for posterior uveal melanoma. Int J Retina Vitreous. 2:42016. View Article : Google Scholar : PubMed/NCBI

184 

Damato B, Dopierala JA and Coupland SE: Genotypic profiling of 452 choroidal melanomas with multiplex Ligation-dependent probe amplification. Clin Cancer Res. 16:6083–6092. 2010. View Article : Google Scholar : PubMed/NCBI

185 

Dogrusöz M, Jager MJ and Damato B: Uveal melanoma treatment and prognostication. Asia Pac J Ophthalmol (Phila). 6:186–196. 2017.

186 

Onken MD, Worley LA, Char DH, Augsburger JJ, Correa ZM, Nudleman E, Aaberg TM Jr, Altaweel MM, Bardenstein DS, Finger PT, et al: Collaborative Ocular Oncology Group report number 1: Prospective validation of a Multi-gene prognostic assay in uveal melanoma. Ophthalmology. 119:1596–1603. 2012. View Article : Google Scholar : PubMed/NCBI

187 

Royer-Bertrand B, Torsello M, Rimoldi D, El Zaoui I, Cisarova K, Pescini-Gobert R, Raynaud F, Zografos L, Schalenbourg A, Speiser D, et al: Comprehensive genetic landscape of uveal melanoma by whole-genome sequencing. Am J Hum Genet. 99:1190–1198. 2016. View Article : Google Scholar : PubMed/NCBI

188 

Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE and Patel SP: Uveal melanoma: From diagnosis to treatment and the science in between. Cancer. 122:2299–2312. 2016. View Article : Google Scholar : PubMed/NCBI

189 

Frizziero L, Midena E, Trainiti S, Londei D, Bonaldi L, Bini S and Parrozzani R: Uveal melanoma biopsy: A review. Cancers (Basel). 11:10752019. View Article : Google Scholar

190 

Erim Y, Scheel J, Breidenstein A, Metz CH, Lohmann D, Friederich HC and Tagay SP: Psychosocial impact of prognostic genetic testing in the care of uveal melanoma patients: Protocol of a controlled prospective clinical observational. BMC Cancer. 16:4082016. View Article : Google Scholar

191 

Damato B and Coupland SE: Translating uveal melanoma cytogenetics into clinical care. Arch Ophthalmol. 127:423–429. 2009. View Article : Google Scholar : PubMed/NCBI

192 

Harbour JW: Molecular prognostic testing and individualized patient care in uveal melanoma. Am J Ophthalmol. 148:823–829.e1. 2009. View Article : Google Scholar : PubMed/NCBI

193 

Aaberg TM Jr, Cook RW, Oelschlager K, Maetzold D, Rao PK and Mason JO III: Current clinical practice: Differential management of uveal melanoma in the era of molecular tumor analyses. Clin Ophthalmol. 8:2449–2460. 2014. View Article : Google Scholar

194 

Schoenfield L, Pettay J, Tubbs RR and Singh AD: Variation of monosomy 3 status within uveal melanoma. Arch Pathol Lab Med. 133:1219–1222. 2009.PubMed/NCBI

195 

Nathan P, Cohen V, Coupland S, Curtis K, Damato B, Evans J, Fenwick S, Kirkpatrick L, Li O, Marshall E, et al: Uveal melanoma UK national guidelines. Eur J Cancer. 51:2404–2412. 2015. View Article : Google Scholar : PubMed/NCBI

196 

Álvarez-Rodríguez B, Latorre A, Posch C and Somoza Á: Recent advances in uveal melanoma treatment. Med Res Rev. 37:1350–1372. 2017. View Article : Google Scholar : PubMed/NCBI

197 

Damato BE, Dukes J, Goodall H and Carvajal RD: Tebentafusp: T cell redirection for the treatment of metastatic uveal melanoma. Cancers (Basel). 11:9712019. View Article : Google Scholar

198 

Schank TE and Hassel JC: Immunotherapies for the treatment of uveal melanoma-history and future. Cancers (Basel). 11:10482019. View Article : Google Scholar

199 

Bol K, van den Bosch T, Schreibelt G, Punt C, Figdor C, Paridaens D and de Vries J: Adjuvant dendritic cell vaccination in high-risk uveal melanoma patients. J Immuno Ther Cancer:. 3:2015.

200 

Thota R, Johnson DB and Sosman JA: Trametinib in the treatment of melanoma. Expert Opin Biol Ther. 15:735–747. 2015. View Article : Google Scholar : PubMed/NCBI

201 

Carvajal RD, Piperno-Neumann S, Kapiteijn E, Chapman PB, Frank S, Joshua AM, Piulats JM, Wolter P, Cocquyt V, Chmielowski B, et al: Selumetinib in combination with dacarbazine in patients with metastatic uveal melanoma: A Phase III, Multicenter, randomized trial (SUMIT). J Clin Oncol. 36:1232–1239. 2018. View Article : Google Scholar : PubMed/NCBI

202 

Brighton HE, Angus SP, Bo T, Roques J, Tagliatela AC, Darr DB, Karagoz K, Sciaky N, Gatza ML, Sharpless NE, et al: New mechanisms of resistance to MEK inhibitors in melanoma revealed by intravital imaging. Cancer Res. 78:542–557. 2018. View Article : Google Scholar :

203 

Cheng H, Chua V, Liao C, Purwin TJ, Terai M, Kageyama K, Davies MA, Sato T and Aplin AE: Co-targeting HGF/cMET Signaling with MEK inhibitors in metastatic uveal melanoma. Mol Cancer Ther. 16:516–528. 2017. View Article : Google Scholar : PubMed/NCBI

204 

Faião-Flores F, Emmons MF, Durante MA, Kinose F, Saha B, Fang B, Koomen JM, Chellappan SP, Maria-Engler SS, Rix U, et al: HDAC inhibition enhances the in vivo efficacy of MEK inhibitor therapy in uveal melanoma. Clin Cancer Res. 25:5686–5701. 2019. View Article : Google Scholar

205 

Landreville S, Agapova OA, Matatall KA, Kneass ZT, Onken MD, Lee RS, Bowcock AM and Harbour JW: Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma. Clin Cancer Res. 18:408–416. 2012. View Article : Google Scholar :

206 

Bonnal S, Vigevani L and Valcárcel J: The spliceosome as a target of novel antitumour drugs. Nat Rev Drug Dis. 11:847–859. 2012. View Article : Google Scholar

207 

Yoshimoto R, Kaida D, Furuno M, Burroughs AM, Noma S, Suzuki H, Kawamura Y, Hayashizaki Y, Mayeda A and Yoshida M: Global analysis of pre-mRNA subcellular localization following splicing inhibition by spliceostatin A. RNA. 23:47–57. 2017. View Article : Google Scholar :

208 

Wu G, Fan L, Edmonson MN, Shaw T, Boggs K, Easton J, Rusch MC, Webb TR, Zhang J and Potter PM: Inhibition of SF3B1 by molecules targeting the spliceosome results in massive aberrant exon skipping. RNA. 24:1056–1066. 2018. View Article : Google Scholar : PubMed/NCBI

209 

Zhou Z, Gong Q, Wang Y, Li M, Wang L, Ding H and Li P: The biological function and clinical significance of SF3B1 mutations in cancer. Biomarker Res. 8(38)2020. View Article : Google Scholar

210 

García M, Moreno R, Gil-Martin M, Cascallò M, de Olza MO, Cuadra C, Piulats JM, Navarro V, Domenech M, Alemany R and Salazar R: A Phase 1 Trial of Oncolytic adenovirus ICOVIR-5 administered intravenously to cutaneous and uveal melanoma patients. Hum Gene Ther. 30:352–364. 2019. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ortega MA, Fraile‑Martínez O, García‑Honduvilla N, Coca S, Álvarez‑Mon M, Buján J and Teus MA: Update on uveal melanoma: Translational research from biology to clinical practice (Review). Int J Oncol 57: 1262-1279, 2020.
APA
Ortega, M.A., Fraile‑Martínez, O., García‑Honduvilla, N., Coca, S., Álvarez‑Mon, M., Buján, J., & Teus, M.A. (2020). Update on uveal melanoma: Translational research from biology to clinical practice (Review). International Journal of Oncology, 57, 1262-1279. https://doi.org/10.3892/ijo.2020.5140
MLA
Ortega, M. A., Fraile‑Martínez, O., García‑Honduvilla, N., Coca, S., Álvarez‑Mon, M., Buján, J., Teus, M. A."Update on uveal melanoma: Translational research from biology to clinical practice (Review)". International Journal of Oncology 57.6 (2020): 1262-1279.
Chicago
Ortega, M. A., Fraile‑Martínez, O., García‑Honduvilla, N., Coca, S., Álvarez‑Mon, M., Buján, J., Teus, M. A."Update on uveal melanoma: Translational research from biology to clinical practice (Review)". International Journal of Oncology 57, no. 6 (2020): 1262-1279. https://doi.org/10.3892/ijo.2020.5140
Copy and paste a formatted citation
x
Spandidos Publications style
Ortega MA, Fraile‑Martínez O, García‑Honduvilla N, Coca S, Álvarez‑Mon M, Buján J and Teus MA: Update on uveal melanoma: Translational research from biology to clinical practice (Review). Int J Oncol 57: 1262-1279, 2020.
APA
Ortega, M.A., Fraile‑Martínez, O., García‑Honduvilla, N., Coca, S., Álvarez‑Mon, M., Buján, J., & Teus, M.A. (2020). Update on uveal melanoma: Translational research from biology to clinical practice (Review). International Journal of Oncology, 57, 1262-1279. https://doi.org/10.3892/ijo.2020.5140
MLA
Ortega, M. A., Fraile‑Martínez, O., García‑Honduvilla, N., Coca, S., Álvarez‑Mon, M., Buján, J., Teus, M. A."Update on uveal melanoma: Translational research from biology to clinical practice (Review)". International Journal of Oncology 57.6 (2020): 1262-1279.
Chicago
Ortega, M. A., Fraile‑Martínez, O., García‑Honduvilla, N., Coca, S., Álvarez‑Mon, M., Buján, J., Teus, M. A."Update on uveal melanoma: Translational research from biology to clinical practice (Review)". International Journal of Oncology 57, no. 6 (2020): 1262-1279. https://doi.org/10.3892/ijo.2020.5140
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team