Open Access

Serine, glycine and one‑carbon metabolism in cancer (Review)

  • Authors:
    • Sijing Pan
    • Ming Fan
    • Zhangnan Liu
    • Xia Li
    • Huijuan Wang
  • View Affiliations

  • Published online on: December 11, 2020     https://doi.org/10.3892/ijo.2020.5158
  • Pages: 158-170
  • Copyright: © Pan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Serine/glycine biosynthesis and one‑carbon metabolism are crucial in sustaining cancer cell survival and rapid proliferation, and of high clinical relevance. Excessive activation of serine/glycine biosynthesis drives tumorigenesis and provides a single carbon unit for one‑carbon metabolism. One‑carbon metabolism, which is a complex cyclic metabolic network based on the chemical reaction of folate compounds, provides the necessary proteins, nucleic acids, lipids and other biological macromolecules to support tumor growth. Moreover, one‑carbon metabolism also maintains the redox homeostasis of the tumor microenvironment and provides substrates for the methylation reaction. The present study reviews the role of key enzymes with tumor‑promoting functions and important intermediates that are physiologically relevant to tumorigenesis in serine/glycine/one‑carbon metabolism pathways. The related regulatory mechanisms of action of the key enzymes and important intermediates in tumors are also discussed. It is hoped that investigations into these pathways will provide new translational opportunities for human cancer drug development, dietary interventions, and biomarker identification.

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February-2021
Volume 58 Issue 2

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Copy and paste a formatted citation
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Spandidos Publications style
Pan S, Fan M, Liu Z, Li X and Wang H: Serine, glycine and one‑carbon metabolism in cancer (Review) . Int J Oncol 58: 158-170, 2021
APA
Pan, S., Fan, M., Liu, Z., Li, X., & Wang, H. (2021). Serine, glycine and one‑carbon metabolism in cancer (Review) . International Journal of Oncology, 58, 158-170. https://doi.org/10.3892/ijo.2020.5158
MLA
Pan, S., Fan, M., Liu, Z., Li, X., Wang, H."Serine, glycine and one‑carbon metabolism in cancer (Review) ". International Journal of Oncology 58.2 (2021): 158-170.
Chicago
Pan, S., Fan, M., Liu, Z., Li, X., Wang, H."Serine, glycine and one‑carbon metabolism in cancer (Review) ". International Journal of Oncology 58, no. 2 (2021): 158-170. https://doi.org/10.3892/ijo.2020.5158