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Review Open Access

Research status and prospects of biomarkers for nasopharyngeal carcinoma in the era of high‑throughput omics (Review)

  • Authors:
    • Shan-Qiang Zhang
    • Su-Ming Pan
    • Si-Xian Liang
    • Yu-Shuai Han
    • Hai-Bin Chen
    • Ji-Cheng Li
  • View Affiliations / Copyright

    Affiliations: Medical Research Center, Yue Bei People's Hospital, Shantou University Medical College, Wujiang, Shaoguan, Guangdong 512025, P.R. China, Department of Radiotherapy, Yue Bei People's Hospital, Shantou University Medical College, Wujiang, Shaoguan, Guangdong 512025, P.R. China, Institute of Cell Biology, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, P.R. China, Department of Histology and Embryology, Shantou University Medical College, Shantou, Guangdong 515041, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 9
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    Published online on: February 15, 2021
       https://doi.org/10.3892/ijo.2021.5188
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Abstract

As a malignant tumor type, nasopharyngeal carcinoma (NPC) is characterized by distinct geographical, ethnic and genetic differences; presenting a major threat to human health in many countries, especially in Southern China. At present, no accurate and effective methods are available for the early diagnosis, efficacious evaluation or prognosis prediction for NPC. As such, a large number of patients have locoregionally advanced NPC at the time of initial diagnosis. Many patients show toxic reactions to overtreatment and have risks of cancer recurrence and distant metastasis owing to insufficient treatment. To solve these clinical problems, high‑throughput ‘‑omics’ technologies are being used to screen and identify specific molecular biomarkers for NPC. Because of the lack of comprehensive descriptions regarding NPC biomarkers, the present study summarized the research progress that has been made in recent years to discover NPC biomarkers, highlighting the existing problems that require exploration. In view of the lack of authoritative reports at present, study design factors that affect the screening of biomarkers are also discussed here and prospects for future research are proposed to provide references for follow‑up studies of NPC biomarkers.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang S, Pan S, Liang S, Han Y, Chen H and Li J: Research status and prospects of biomarkers for nasopharyngeal carcinoma in the era of high‑throughput omics (Review). Int J Oncol 58: 9, 2021.
APA
Zhang, S., Pan, S., Liang, S., Han, Y., Chen, H., & Li, J. (2021). Research status and prospects of biomarkers for nasopharyngeal carcinoma in the era of high‑throughput omics (Review). International Journal of Oncology, 58, 9. https://doi.org/10.3892/ijo.2021.5188
MLA
Zhang, S., Pan, S., Liang, S., Han, Y., Chen, H., Li, J."Research status and prospects of biomarkers for nasopharyngeal carcinoma in the era of high‑throughput omics (Review)". International Journal of Oncology 58.4 (2021): 9.
Chicago
Zhang, S., Pan, S., Liang, S., Han, Y., Chen, H., Li, J."Research status and prospects of biomarkers for nasopharyngeal carcinoma in the era of high‑throughput omics (Review)". International Journal of Oncology 58, no. 4 (2021): 9. https://doi.org/10.3892/ijo.2021.5188
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang S, Pan S, Liang S, Han Y, Chen H and Li J: Research status and prospects of biomarkers for nasopharyngeal carcinoma in the era of high‑throughput omics (Review). Int J Oncol 58: 9, 2021.
APA
Zhang, S., Pan, S., Liang, S., Han, Y., Chen, H., & Li, J. (2021). Research status and prospects of biomarkers for nasopharyngeal carcinoma in the era of high‑throughput omics (Review). International Journal of Oncology, 58, 9. https://doi.org/10.3892/ijo.2021.5188
MLA
Zhang, S., Pan, S., Liang, S., Han, Y., Chen, H., Li, J."Research status and prospects of biomarkers for nasopharyngeal carcinoma in the era of high‑throughput omics (Review)". International Journal of Oncology 58.4 (2021): 9.
Chicago
Zhang, S., Pan, S., Liang, S., Han, Y., Chen, H., Li, J."Research status and prospects of biomarkers for nasopharyngeal carcinoma in the era of high‑throughput omics (Review)". International Journal of Oncology 58, no. 4 (2021): 9. https://doi.org/10.3892/ijo.2021.5188
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