NUPR1 and its potential role in cancer and pathological conditions (Review)
- Authors:
- Tracey A. Martin
- Amber Xinyu Li
- Andrew J. Sanders
- Lin Ye
- Kathryn Frewer
- Rachel Hargest
- Wen G. Jiang
-
Affiliations: Cardiff China Medical Research Collaborative, Cardiff University School of Medicine, Cardiff CF14 4XN, UK - Published online on: March 16, 2021 https://doi.org/10.3892/ijo.2021.5201
- Article Number: 21
This article is mentioned in:
Abstract
 |
|
Mallo GV, Fiedler F, Calvo EL, Ortiz EM, Vasseur S, Keim V, Morisset J and Iovanna JL: Cloning and expression of the rat p8 cDNA, a new gene activated in pancreas during the acute phase of pancreatitis, pancreatic development, and regeneration, and which promotes cellular growth. J Biol Chem. 272:32360–32369. 1997. View Article : Google Scholar | |
|
Vasseur S, Vidal Mallo G, Fiedler F, Bödeker H, Cánepa E, Moreno S and Iovanna JL: Cloning and expression of the human p8, a nuclear protein with mitogenic activity. Eur J Biochem. 259:670–675. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Ree AH, Tvermyr M, Engebraaten O, Rooman M, Røsok O, Hovig E, Meza-Zepeda LA, Bruland OS and Fodstad O: Expression of a novel factor in human breast cancer cells with metastatic potential. Cancer Res. 59:4675–4680. 1999.PubMed/NCBI | |
|
Quirk CC, Seachrist DD and Nilson JH: Embryonic expression of the luteinizing hormone β gene appears to be coupled to the transient appearance of p8, a high mobility group-related transcription factor. J Biol Chem. 278:1680–1685. 2003. View Article : Google Scholar | |
|
Lopez MB, Garcia MN, Grasso D, Bintz J, Molejon MI, Velez G, Lomberk G, Neira JL, Urrutia R and Iovanna J: Functional characterization of Nupr1L, A Novel p53-regulated isoform of the high-mobility group (HMG)-related protumoral protein Nupr1. J Cell Physiol. 230:2936–2950. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Lan W, Santofimia-Castaño P, Swayden M, Xia Y, Zhou Z, Audebert S, Camoin L, Huang C, Peng L, Jiménez-Alesanco A, et al: ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents. JCI Insight. 5:e1381172020. View Article : Google Scholar | |
|
Santofimia-Castaño P, Rizzuti B, Xia Y, Abian O, Peng L, Velázquez-Campoy A, Iovanna JL and Neira JL: Designing and repurposing drugs to target intrinsically disordered proteins for cancer treatment: Using NUPR1 as a paradigm. Mol Cell Oncol. 6:e16126782019. View Article : Google Scholar : PubMed/NCBI | |
|
Pommier RM, Gout J, Vincent DF, Cano CE, Kaniewski B, Martel S, Rodriguez J, Fourel G, Valcourt U, Marie JC, et al: The human NUPR1/P8 gene is transcriptionally activated by transforming growth factor β via the SMAD signalling pathway. Biochem J. 445:285–293. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Hamidi T, Cano CE, Grasso D, Garcia MN, Sandi MJ, Calvo EL, Dagorn JC, Lomberk G, Urrutia R, Goruppi S, et al: Nupr1-aurora kinase A pathway provides protection against metabolic stress-mediated autophagic-associated cell death. Clin Cancer Res. 18:5234–5246. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Gironella M, Malicet C, Cano C, Sandi MJ, Hamidi T, Tauil RM, Baston M, Valaco P, Moreno S, Lopez F, et al: p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage. J Cell Physiol. 221:594–602. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Carracedo A, Lorente M, Egia A, Blázquez C, García S, Giroux V, Malicet C, Villuendas R, Gironella M, González-Feria L, et al: The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells. Cancer Cell. 9:301–312. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Emma MR, Iovanna JL, Bachvarov D, Puleio R, Loria GR, Augello G, Candido S, Libra M, Gulino A, Cancila V, et al: NUPR1, a new target in liver cancer: Implication in controlling cell growth, migration, invasion and sorafenib resistance. Cell Death Dis. 7:e22692016. View Article : Google Scholar : PubMed/NCBI | |
|
Santofimia-Castaño P, Lan W, Bintz J, Gayet O, Carrier A, Lomberk G, Neira JL, González A, Urrutia R, Soubeyran P and Iovanna J: Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis. Sci Rep. 8:169992018. View Article : Google Scholar : PubMed/NCBI | |
|
Brannon KM, Million Passe CM, White CR, Bade NA, King MW and Quirk CC: Expression of the high mobility group A family member p8 is essential to maintaining tumorigenic potential by promoting cell cycle dysregulation in LbetaT2 cells. Cancer Lett. 254:146–155. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Kong DK, Georgescu SP, Cano C, Aronovitz MJ, Iovanna JL, Patten RD, Kyriakis JM and Goruppi S: Deficiency of the transcriptional regulator p8 results in increased autophagy and apoptosis, and causes impaired heart function. Mol Biol Cell. 21:1335–1349. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Li A, Li X, Chen X, Zeng C, Wang Z, Li Z and Chen J: NUPR1 Silencing induces autophagy-mediated apoptosis in multiple myeloma cells through the PI3K/AKT/mTOR pathway. DNA Cell Biol. 39:368–378. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Mu Y, Yan X, Li D, Zhao D, Wang L, Wang X, Gao D, Yang J, Zhang H, Li Y, et al: NUPR1 maintains autolysosomal efflux by activating SNAP25 transcription in cancer cells. Autophagy. 14:654–670. 2018. View Article : Google Scholar : | |
|
Grasso D, Garcia MN, Hamidi T, Cano C, Calvo E, Lomberk G, Urrutia R and Iovanna JL: Genetic inactivation of the pancreatitis-inducible gene Nupr1 impairs PanIN formation by modulating KrasG12D-induced senescence. Cell Death Differ. 21:1633–1641. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Grasso D, Bintz J, Lomberk G, Molejon MI, Loncle C, Garcia MN, Lopez MB, Urrutia R and Iovanna JL: Pivotal role of the chromatin protein Nupr1 in Kras-induced senescence and transformation. Sci Rep. 5:175492015. View Article : Google Scholar : PubMed/NCBI | |
|
Cai D, Huang E, Luo B, Yang Y, Zhang F, Liu C, Lin Z, Xie WB and Wang H: Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine. Cell Death Dis. 7:e21612016. View Article : Google Scholar : PubMed/NCBI | |
|
Tang B, Li Q, Zhao XH, Wang HG, Li N, Fang Y, Wang K, Jia YP, Zhu P, Gu J, et al: Shiga toxins induce autophagic cell death in intestinal epithelial cells via the endoplasmic reticulum stress pathway. Autophagy. 11:344–354. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Shiraki M, Xu X, Iovanna JL, Kukita T, Hirata H, Kamohara A, Kubota Y, Miyamoto H, Mawatari M and Kukita A: Deficiency of stress-associated gene Nupr1 increases bone volume by attenuating differentiation of osteoclasts and enhancing differentiation of osteoblasts. FASEB J. 33:8836–8852. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Maida A, Zota A, Sjøberg KA, Schumacher J, Sijmonsma TP, Pfenninger A, Christensen MM, Gantert T, Fuhrmeister J, Rothermel U, et al: A liver stress-endocrine nexus promotes metabolic integrity during dietary protein dilution. J Clin Invest. 126:3263–3278. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Hoffmeister A, Ropolo A, Vasseur S, Mallo GV, Bodeker H, Ritz-Laser B, Dressler GR, Vaccaro MI, Dagorn JC, Moreno S and Iovanna JL: The HMG-I/Y-related protein p8 binds to p300 and Pax2 trans-activation domain-interacting protein to regulate the transactivation activity of the Pax2A and Pax2B transcription factors on the glucagon gene promoter. J Biol Chem. 277:22314–22319. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Päth G, Opel A, Knoll A and Seufert J: Nuclear protein p8 is associated with glucose-induced pancreatic beta-cell growth. Diabetes. 53(Suppl 1): S82–S85. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Zhong C, Yu J, Li D, Jiang K, Tang Y, Yang M, Shen H, Fang X, Ding K, Zheng S and Yuan Y: Zyxin as a potential cancer prognostic marker promotes the proliferation and metastasis of colorectal cancer cells. J Cell Physiol. Jan 29–2019.Epub ahead of print. | |
|
Vasseur S, Hoffmeister A, Garcia S, Bagnis C, Dagorn JC and Iovanna JL: p8 is critical for tumour development induced by rasV12 mutated protein and E1A oncogene. EMBO Rep. 3:165–170. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Iovanna JL: Expression of the stress-associated protein p8 is a requisite for tumor development. Int J Gastrointest Cancer. 31:89–98. 2002. View Article : Google Scholar | |
|
Clark DW, Mitra A, Fillmore RA, Jiang WG, Samant RS, Fodstad O and Shevde LA: NUPR1 interacts with p53, transcriptionally regulates p21 and rescues breast epithelial cells from doxorubicin-induced genotoxic stress. Curr Cancer Drug Targets. 8:421–430. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Simpson NE, Lambert WM, Watkins R, Giashuddin S, Huang SJ, Oxelmark E, Arju R, Hochman T, Goldberg JD, Schneider RJ, et al: High levels of Hsp90 cochaperone p23 promote tumor progression and poor prognosis in breast cancer by increasing lymph node metastases and drug resistance. Cancer Res. 70:8446–8456. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Jiang WG, Watkins G, Douglas-Jones A, Mokbel K, Mansel RE and Fodstad O: Expression of Com-1/P8 in human breast cancer and its relevance to clinical outcome and ER status. Int J Cancer. 117:730–737. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Jiang WG, Davies G and Fodstad O: Com-1/P8 in oestrogen regulated growth of breast cancer cells, the ER-beta connection. Biochem Biophys Res Commun. 330:253–262. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Jung SH, Lee A, Yim SH, Hu HJ, Choe C and Chung YJ: Simultaneous copy number gains of NUPR1 and ERBB2 predicting poor prognosis in early-stage breast cancer. BMC Cancer. 12:3822012. View Article : Google Scholar : PubMed/NCBI | |
|
Hollern DP, Honeysett J, Cardiff RD and Andrechek ER: The E2F transcription factors regulate tumor development and metastasis in a mouse model of metastatic breast cancer. Mol Cell Biol. 34:3229–3243. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Jia Q, Zhou W, Yao W, Yang F, Zhang S, Singh R, Chen J, Chen JJ, Zhang Y, Wei F, et al: Downregulation of YAP-dependent Nupr1 promotes tumor-repopulating cell growth in soft matrices. Oncogenesis. 5:e2202016. View Article : Google Scholar : PubMed/NCBI | |
|
Fish L, Zhang S, Yu JX, Culbertson B, Zhou AY, Goga A and Goodarzi H: Cancer cells exploit an orphan RNA to drive meta-static progression. Nat Med. 24:1743–1751. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Matsunaga K, Fujisawa K, Takami T, Burganova G, Sasai N, Matsumoto T, Yamamoto N and Sakaida I: NUPR1 acts as a pro-survival factor in human bone marrow-derived mesenchymal stem cells and is induced by the hypoxia mimetic reagent deferoxamine. J Clin Biochem Nutr. 64:209–216. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Davies ML, Parr C, Sanders AJ, Fodstad O and Jiang WG: The transcript expression and protein distribution pattern in human colorectal carcinoma reveal a pivotal role of COM-1/p8 as a tumour suppressor. Cancer Genomics Proteomics. 7:75–80. 2010.PubMed/NCBI | |
|
Wang L, Jiang F, Xia X and Zhang B: LncRNA FAL1 promotes carcinogenesis by regulation of miR-637/NUPR1 pathway in colorectal cancer. Int J Biochem Cell Biol. 106:46–56. 2019. View Article : Google Scholar | |
|
Li X, Martin TA and Jiang WG: COM-1/p8 acts as a tumour growth enhancer in colorectal cancer cell lines. Anticancer Res. 32:1229–1237. 2012.PubMed/NCBI | |
|
Gao Q, Lei F, Zeng Q, Gao Z, Niu P, Junnan, Ning, Li J and Zhang J: Functional passenger-strand miRNAs in exosomes derived from human colon cancer cells and their heterogeneous paracrine effects. Int J Biol Sci. 16:1044–1058. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Su SB, Motoo Y, Iovanna JL, Berthézène P, Xie MJ, Mouri H, Ohtsubo K, Matsubara F and Sawabu N: Overexpression of p8 is inversely correlated with apoptosis in pancreatic cancer. Clin Cancer Res. 7:1320–1324. 2001.PubMed/NCBI | |
|
Su SB, Motoo Y, Iovanna JL, Xie MJ, Mouri H, Ohtsubo K, Yamaguchi Y, Watanabe H, Okai T, Matsubara F and Sawabu N: Expression of p8 in human pancreatic cancer. Clin Cancer Res. 7:309–313. 2001.PubMed/NCBI | |
|
Hamidi T, Algül H, Cano CE, Sandi MJ, Molejon MI, Riemann M, Calvo EL, Lomberk G, Dagorn JC, Weih F, et al: Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis. J Clin Invest. 122:2092–2103. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Cano CE, Hamidi T, Sandi MJ and Iovanna JL: Nupr1: The Swiss-knife of cancer. J Cell Physiol. 226:1439–1443. 2011. View Article : Google Scholar | |
|
Cano CE, Hamidi T, Garcia MN, Grasso D, Loncle C, Garcia S, Calvo E, Lomberk G, Dusetti N, Bartholin L, et al: Genetic inactivation of Nupr1 acts as a dominant suppressor event in a two-hit model of pancreatic carcinogenesis. Gut. 63:984–995. 2014. View Article : Google Scholar | |
|
Ito Y, Yoshida H, Motoo Y, Miyoshi E, Iovanna JL, Tomoda C, Uruno T, Takamura Y, Miya A, Kobayashi K, et al: Expression and cellular localization of p8 protein in thyroid neoplasms. Cancer Lett. 201:237–244. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Ito Y, Yoshida H, Motoo Y, Iovanna JL, Tomoda C, Uruno T, Takamura Y, Miya A, Kobayashi K, Matsuzuka F, et al: Expression of p8 protein in medullary thyroid carcinoma. Anticancer Res. 25:3419–3423. 2005.PubMed/NCBI | |
|
Jiang WG, Davies G, Martin TA, Kynaston H, Mason MD and Fodstad O: Com-1/p8 acts as a putative tumour suppressor in prostate cancer. Int J Mol Med. 18:981–986. 2006.PubMed/NCBI | |
|
Du P, Ye L, Yang Y and Jiang WG: Candidate of metastasis 1 regulates in vitro growth and invasion of bladder cancer cells. Int J Oncol. 42:1249–1256. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Veerla S, Panagopoulos I, Jin Y, Lindgren D and Höglund M: Promoter analysis of epigenetically controlled genes in bladder cancer. Genes Chromosomes Cancer. 47:368–378. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Guo X, Wang W, Hu J, Feng K, Pan Y, Zhang L and Feng Y: Lentivirus-mediated RNAi knockdown of NUPR1 inhibits human nonsmall cell lung cancer growth in vitro and in vivo. Anat Rec (Hoboken). 295:2114–2121. 2012. View Article : Google Scholar | |
|
Ghandhi SA, Ponnaiya B, Panigrahi SK, Hopkins KM, Cui Q, Hei TK, Amundson SA and Lieberman HB: RAD9 deficiency enhances radiation induced bystander DNA damage and transcriptomal response. Radiat Oncol Lond Engl. 9:2062014. View Article : Google Scholar | |
|
Wu H, Wang W and Xu H: Depletion of C3orf1/TIMMDC1 inhibits migration and proliferation in 95D lung carcinoma cells. Int J Mol Sci. 15:20555–20571. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Frances D, Sharma N, Pofahl R, Maneck M, Behrendt K, Reuter K, Krieg T, Klein CA, Haase I and Niemann C: A role for Rac1 activity in malignant progression of sebaceous skin tumors. Oncogene. 34:5505–5512. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Niessner H, Sinnberg T, Kosnopfel C, Smalley KSM, Beck D, Praetorius C, Mai M, Beissert S, Kulms D, Schaller M, et al: BRAF inhibitors amplify the proapoptotic activity of MEK inhibitors by inducing ER stress in NRAS-mutant melanoma. Clin Cancer Res. 23:6203–6214. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Pedrola N, Devis L, Llauradó M, Campoy I, Martinez-Garcia E, Garcia M, Muinelo-Romay L, Alonso-Alconada L, Abal M, Alameda F, et al: Nidogen 1 and Nuclear Protein 1: Novel targets of ETV5 transcription factor involved in endometrial cancer invasion. Clin Exp Metastasis. 32:467–478. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Di Martino MT, Guzzi PH, Caracciolo D, Agnelli L, Neri A, Walker BA, Morgan GJ, Cannataro M, Tassone P and Tagliaferri P: Integrated analysis of microRNAs, transcription factors and target genes expression discloses a specific molecular architecture of hyperdiploid multiple myeloma. Oncotarget. 6:19132–19147. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Zeng C, Li X, Li A, Yi B, Peng X, Huang X and Chen J: Knockdown of NUPR1 inhibits the growth of U266 and RPMI8226 multiple myeloma cell lines via activating PTEN and caspase activation-dependent apoptosis. Oncol Rep. 40:1487–1494. 2018.PubMed/NCBI | |
|
Kim KS, Jin DI, Yoon S, Baek SY, Kim BS and Oh SO: Expression and roles of NUPR1 in cholangiocarcinoma cells. Anat Cell Biol. 45:17–25. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Seshachalam VP, Sekar K and Hui KM: Insights into the etiology-associated gene regulatory networks in hepatocellular carcinoma from The Cancer Genome Atlas. J Gastroenterol Hepatol. 33:2037–2047. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Lee YK, Jee BA, Kwon SM, Yoon YS, Xu WG, Wang HJ, Wang XW, Thorgeirsson SS, Lee JS, Woo HG and Yoon G: Identification of a mitochondrial defect gene signature reveals NUPR1 as a key regulator of liver cancer progression. Hepatology. 62:1174–1189. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Bak Y and Shin H: Hepatitis B virus X promotes hepatocellular carcinoma development via nuclear protein 1 pathway. Biochem Biophys Res Commun. 466:676–681. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
de Conti A, Dreval K, Tryndyak V, Orisakwe OE, Ross SA, Beland FA and Pogribny IP: Inhibition of the cell death pathway in nonalcoholic steatohepatitis (NASH)-related hepatocarcino-genesis is associated with histone H4 lysine 16 deacetylation. Mol Cancer Res. 15:1163–1172. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Ji Y, Wang Z, Chen H, Zhang L, Zhuo F and Yang Q: Serum from chronic hepatitis B patients promotes growth and proliferation via the IGF-II/IGF-IR/MEK/ERK signaling pathway in hepato-cellular carcinoma cells. Cell Physiol Biochem. 47:39–53. 2018. View Article : Google Scholar | |
|
Chen CY, Wu SM, Lin YH, Chi HC, Lin SL, Yeh CT, Chuang WY and Lin KH: Induction of nuclear protein-1 by thyroid hormone enhances platelet-derived growth factor A mediated angiogen-esis in liver cancer. Theranostics. 9:2361–2379. 2019. View Article : Google Scholar : | |
|
Zhou C, Xu J, Lin J, Lin R, Chen K, Kong J and Shui X: Long non-coding RNA FEZF1-AS1 promotes osteosarcoma progression by regulating miR-4443/NUPR1 axis. Oncol Res. 26:1335–1343. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Li J, Ren S, Liu Y, Lian Z, Dong B, Yao Y and Xu Y: Knockdown of NUPR1 inhibits the proliferation of glioblastoma cells via ERK1/2, p38 MAPK and caspase-3. J Neurooncol. 132:15–26. 2017. View Article : Google Scholar | |
|
Li J, Lian ZG, Xu YH, Liu RY, Wei ZQ, Li T, Lv HT, Zhao YS, Liu YJ, Dong B and Fu X: Downregulation of nuclear protein-1 induces cell cycle arrest in G0/G1 phase in glioma cells in vivo and in vitro via P27. Neoplasma. 67:843–850. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Mohammad HP, Seachrist DD, Quirk CC and Nilson JH: Reexpression of p8 contributes to tumorigenic properties of pituitary cells and appears in a subset of prolactinomas in transgenic mice that hypersecrete luteinizing hormone. Mol Endocrinol. 18:2583–2593. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Passe CM, Cooper G and Quirk CC: The murine p8 gene promoter is activated by activating transcription factor 4 (ATF4) in the gonadotrope-derived LbetaT2 cell line. Endocrine. 30:81–91. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Jin HO, Seo SK, Woo SH, Choe TB, Hong SI, Kim JI and Park IC: Nuclear protein 1 induced by ATF4 in response to various stressors acts as a positive regulator on the transcriptional activation of ATF4. IUBMB Life. 61:1153–1158. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Averous J, Lambert-Langlais S, Cherasse Y, Carraro V, Parry L, B'chir W, Jousse C, Maurin AC, Bruhat A and Fafournoux P: Amino acid deprivation regulates the stress-inducible gene p8 via the GCN2/ATF4 pathway. Biochem Biophys Res Commun. 413:24–29. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Sárvári M, Kalló I, Hrabovszky E, Solymosi N, Tóth K, Likó I, Molnár B, Tihanyi K and Liposits Z: Estradiol replacement alters expression of genes related to neurotransmission and immune surveillance in the frontal cortex of middle-aged, ovariectomized rats. Endocrinology. 151:3847–3862. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Xu X, Huang E, Tai Y, Zhao X, Chen X, Chen C, Chen R, Liu C, Lin Z, Wang H and Xie WB: Nupr1 modulates methamphet-amine-induced dopaminergic neuronal apoptosis and autophagy through CHOP-Trib3-mediated endoplasmic reticulum stress signaling pathway. Front Mol Neurosci. 10:2032017. View Article : Google Scholar | |
|
Goruppi S, Patten RD, Force T and Kyriakis JM: Helix-loop-helix protein p8, a transcriptional regulator required for cardiomyocyte hypertrophy and cardiac fibroblast matrix metalloprotease induction. Mol Cell Biol. 27:993–1006. 2007. View Article : Google Scholar : | |
|
Sambasivan R, Cheedipudi S, Pasupuleti N, Saleh A, Pavlath GK and Dhawan J: The small chromatin-binding protein p8 coordinates the association of anti-proliferative and pro-myogenic proteins at the myogenin promoter. J Cell Sci. 122:3481–3491. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Taïeb D, Malicet C, Garcia S, Rocchi P, Arnaud C, Dagorn JC, Iovanna JL and Vasseur S: Inactivation of stress protein p8 increases murine carbon tetrachloride hepatotoxicity via preserved CYP2E1 activity. Hepatology. 42:176–182. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Vasseur S, Hoffmeister A, Garcia-Montero A, Mallo GV, Feil R, Kühbandner S, Dagorn JC and Iovanna JL: p8-deficient fibroblasts grow more rapidly and are more resistant to adriamycin-induced apoptosis. Oncogene. 21:1685–1694. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Kallwellis K, Grempler R, Günther S, Päth G and Walther R: Tumor necrosis factor alpha induces the expression of the nuclear protein p8 via a novel NF kappaB binding site within the promoter. Horm Metab Res. 38:570–574. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Yammani RR and Loeser RF: Brief report: Stress-inducible nuclear protein 1 regulates matrix metalloproteinase 13 expression in human articular chondrocytes. Arthritis Rheumatol. 66:1266–1271. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Jiang YF, Vaccaro MI, Fiedler F, Calvo EL and Iovanna JL: Lipopolysaccharides induce p8 mRNA expression in vivo and in vitro. Biochem Biophys Res Commun. 260:686–690. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Motoo Y, Iovanna JL, Mallo GV, Su SB, Xie MJ and Sawabu N: P8 expression is induced in acinar cells during chronic pancreatitis. Dig Dis Sci. 46:1640–1646. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Hollenbach M, Klöting N, Sommerer I, Lorenz J, Heindl M, Kern M, Mössner J, Blüher M and Hoffmeister A: p8 deficiency leads to elevated pancreatic beta cell mass but does not contribute to insulin resistance in mice fed with high-fat diet. PLoS One. 13:e02011592018. View Article : Google Scholar : PubMed/NCBI | |
|
Bratland A, Risberg K, Maelandsmo GM, Gützkow KB, Olsen OE, Moghaddam A, Wang MY, Hansen CM, Blomhoff HK, Berg JP, et al: Expression of a novel factor, com1, is regulated by 1,25-dihydroxyvitamin D3 in breast cancer cells. Cancer Res. 60:5578–5583. 2000.PubMed/NCBI | |
|
Santofimia-Castaño P, Xia Y, Lan W, Zhou Z, Huang C, Peng L, Soubeyran P, Velázquez-Campoy A, Abián O, Rizzuti B, et al: Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis. J Clin Invest. 129:2500–2513. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Neira JL, Bintz J, Arruebo M, Rizzuti B, Bonacci T, Vega S, Lanas A, Velázquez-Campoy A, Iovanna JL and Abián O: Identification of a drug targeting an intrinsically disordered protein involved in pancreatic adenocarcinoma. Sci Rep. 7:397322017. View Article : Google Scholar : PubMed/NCBI | |
|
Deng ZH, Meng J, Tang J, Hu GY and Tao LJ: Fluorofenidone Inhibits the Proliferation of Lung Adenocarcinoma Cells. J Cancer. 8:1917–1926. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Santofimia-Castaño P, Rizzuti B, Abián O, Velázquez-Campoy A, Iovanna JL and Neira JL: Amphipathic helical peptides hamper protein-protein interactions of the intrinsically disordered chromatin nuclear protein 1 (NUPR1). Biochim Biophys Acta Gen Subj. 1862:1283–1295. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Botto C, Augello G, Amore E, Emma MR, Azzolina A, Cavallaro G, Cervello M and Bondì ML: Cationic solid lipid nanoparticles as non viral vectors for the inhibition of hepatocellular carcinoma growth by RNA interference. J Biomed Nanotechnol. 14:1009–1016. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Khan HY, Ge J, Nagasaka M, Aboukameel A, Mpilla G, Muqbil I, Szlaczky M, Chaker M, Baloglu E, Landesman Y, et al: Targeting XPO1 and PAK4 in 8505C anaplastic thyroid cancer cells: Putative implications for overcoming lenvatinib therapy resistance. Int J Mol Sci. 21:2372019. View Article : Google Scholar | |
|
Vincent AJ, Ren S, Harris LG, Devine DJ, Samant RS, Fodstad O and Shevde LA: Cytoplasmic translocation of p21 mediates NUPR1-induced chemoresistance: NUPR1 and p21 in chemoresistance. FEBS Lett. 586:3429–3434. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Palam LR, Gore J, Craven KE, Wilson JL and Korc M: Integrated stress response is critical for gemcitabine resistance in pancreatic ductal adenocarcinoma. Cell Death Dis. 6:e19132015. View Article : Google Scholar : PubMed/NCBI | |
|
Augello G, Emma MR, Cusimano A, Azzolina A, Mongiovì S, Puleio R, Cassata G, Gulino A, Belmonte B, Gramignoli R, et al: Targeting HSP90 with the small molecule inhibitor AUY922 (luminespib) as a treatment strategy against hepatocellular carcinoma. Int J Cancer. 144:2613–2624. 2019. View Article : Google Scholar | |
|
Yu SL, Lee DC, Baek SW, Cho DY, Choi JG and Kang J: Identification of mTOR inhibitor-resistant genes in cutaneous squamous cell carcinoma. Cancer Manag Res. 10:6379–6389. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Real NE, Castro GN, Darío Cuello-Carrión F, Perinetti C, Röhrich H, Cayado-Gutiérrez N, Guerrero-Gimenez ME and Ciocca DR: Molecular markers of DNA damage and repair in cervical cancer patients treated with cisplatin neoadjuvant chemotherapy: An exploratory study. Cell Stress Chaperones. 22:811–822. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Schroll MM, LaBonia GJ, Ludwig KR and Hummon AB: Glucose restriction combined with autophagy inhibition and chemotherapy in HCT 116 spheroids decreases cell clonogenicity and viability regulated by tumor suppressor genes. J Proteome Res. 16:3009–3018. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Schnepp PM, Shelley G, Dai J, Wakim N, Jiang H, Mizokami A and Keller ET: Single-cell transcriptomics analysis identifies nuclear protein 1 as a regulator of docetaxel resistance in prostate cancer cells. Mol Cancer Res. 18:1290–1301. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Urrutia R, Velez G, Lin M, Lomberk G, Neira JL and Iovanna J: Evidence supporting the existence of a NUPR1-like family of helix-loop-helix chromatin proteins related to, yet distinct from, AT hook-containing HMG proteins. J Mol Model. 20:23572014. View Article : Google Scholar : PubMed/NCBI | |
|
Ree AH, Pacheco MM, Tvermyr M, Fodstad O and Brentani MM: Expression of a novel factor, com1, in early tumor progression of breast cancer. Clin Cancer Res. 6:1778–1783. 2000.PubMed/NCBI | |
|
Cano CE, Sandí MJ, Hamidi T, Calvo EL, Turrini O, Bartholin L, Loncle C, Secq V, Garcia S, Lomberk G, et al: Homotypic cell cannibalism, a cell-death process regulated by the nuclear protein 1, opposes to metastasis in pancreatic cancer. EMBO Mol Med. 4:964–979. 2012. View Article : Google Scholar : PubMed/NCBI |
