|
1
|
Bayat Mokhtari R, Homayouni TS, Baluch N,
Morgatskaya E, Kumar S, Das B and Yeger H: Combination therapy in
combating cancer. Oncotarget. 23:38022–38043. 2017. View Article : Google Scholar
|
|
2
|
Tolcher AW and Mayer LD: Improving
combination cancer therapy: The CombiPlex® development
platform. Future Oncol. 14:1317–1332. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Bozic I, Reiter JG, Allen B, Antal T,
Chatterjee K, Shah P, Moon YS, Yaqubie A, Kelly N, Le DT, et al:
Evolutionary dynamics of cancer in response to targeted combination
therapy. Elife. 2:e007472013. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Sun X, Xu H, Huang T, Zhang C, Wu J and
Luo S: Simultaneous delivery of anti-miRNA and docetaxel with
supramolecular self-assembled 'chitosome' for improving
chemosensitivity of triple negative breast cancer cells. Drug Deliv
Transl Res. 11:192–204. 2021. View Article : Google Scholar
|
|
5
|
Gasparello J, Gambari L, Papi C, Rozzi A,
Manicardi A, Corradini R, Gambari R and Finotti A: High Levels of
apoptosis are induced in the human colon cancer HT-29 cell line by
co-administration of sulforaphane and a peptide nucleic acid
targeting miR-15b-5p. Nucleic Acid Ther. 30:164–174. 2020.
View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Palmer AC and Sorger PK: Combination
cancer therapy can confer benefit via patient-to-patient
variability without drug additivity or synergy. Cell.
171:1678–1691.e13. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
von Neubeck C, Seidlitz A, Kitzler HH,
Beuthien-Baumann B and Krause M: Glioblastoma multiforme: Emerging
treatments and stratification markers beyond new drugs. Br J
Radiol. 88:201503542015. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Buczkowicz P and Hawkins C: Pathology,
molecular genetics, and epigenetics of diffuse intrinsic pontine
glioma. Front Oncol. 5:1472015. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Pace A, Dirven L, Koekkoek JAF, Golla H,
Fleming J, Rudà R, Marosi C, Le Rhun E, Grant R, Oliver K, et al:
European association for neuro-oncology (EANO) guidelines for
palliative care in adults with glioma. Lancet Oncol. 18:e330–e340.
2017. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Anjum K, Shagufta BI, Abbas SQ, Patel S,
Khan I, Shah SAA, Akhter N and Hassan SSU: Current status and
future therapeutic perspectives of glioblastoma multiforme (GBM)
therapy: A review. Biomed Pharmacother. 92:681–689. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Santangelo A, Rossato M, Lombardi G,
Benfatto S, Lavezzari D, De Salvo GL, Indraccolo S, Dechecchi MC,
Prandini P, Gambari R, et al: A molecular signature associated with
prolonged survival in glioblastoma patients treated with
regorafenib. Neuro Oncol. 23:264–276. 2021. View Article : Google Scholar :
|
|
12
|
Touat M, Idbaih A, Sanson M and Ligon KL:
Glioblastoma targeted therapy: Updated approaches from recent
biological insights. Ann Oncol. 28:1457–1472. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Sontheimer EJ and Carthew RW: Silence from
within: Endogenous siRNAs and miRNAs. Cell. 122:9–12. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Alvarez-Garcia I and Miska EA: MicroRNA
functions in animal development and human disease. Development.
132:4653–4662. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
He L and Hannon GJ: MicroRNAs: Small RNAs
with a big role in gene regulation. Nat Rev Genet. 5:522–531. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Fabbri M, Ivan M, Cimmino A, Negrini M and
Calin GA: Regulatory mechanisms of microRNAs involvement in cancer.
Expert Opin Biol Ther. 7:1009–1019. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Taylor MA and Schiemann WP: Therapeutic
opportunities for targeting microRNAs in cancer. Mol Cell Ther.
2:1–13. 2014. View Article : Google Scholar
|
|
18
|
Gambari R, Brognara E, Spandidos DA and
Fabbri E: Targeting oncomiRNAs and mimicking tumor suppressor
miRNAs: New trends in the development of miRNA therapeutic
strategies in oncology (review). Int J Oncol. 49:5–32. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Miroshnichenko S and Patutina O: Enhanced
inhibition of tumorigenesis using combinations of miRNA-targeted
therapeutics. Front Pharmacol. 10:4882019. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Gajda E, Godlewska M, Mariak Z, Nazaruk E
and Gawel D: Combinatory treatment with miR-7-5p and drug-loaded
cubosomes effectively impairs cancer cells. Int J Mol Sci.
21:50392020. View Article : Google Scholar :
|
|
21
|
Ghasabi M, Majidi J, Mansoori B, Mohammadi
A, Shomali N, Shirafkan N, Baghbani E, Kazemi T and Baradaran B:
The effect of combined miR-200c replacement and cisplatin on
apoptosis induction and inhibition of gastric cancer cell line
migration. J Cell Physiol. 234:22581–22592. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
He JQ, Zheng MX, Ying HZ, Zhong YS, Zhang
HH, Xu M and Yu CH: PRP1, a heteropolysaccharide from platycodonis
radix, induced apoptosis of HepG2 cells via regulating
miR-21-mediated PI3K/AKT pathway. Int J Biol Macromol. 158:542–551.
2020. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Tao Y, Zhan S, Wang Y, Zhou G, Liang H,
Chen X and Shen H: Baicalin, the major component of traditional
Chinese medicine Scutellaria baicalensis induces colon cancer cell
apoptosis through inhibition of oncomiRNAs. Sci Rep. 8:144772018.
View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Zhang H, Duan J, Qu Y, Deng T, Liu R,
Zhang L, Bai M, Li J, Ning T, Ge S, et al: Onco-miR-24 regulates
cell growth and apoptosis by targeting BCL2L11 in gastric cancer.
Protein Cell. 7:141–151. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Wu Z, Liu K, Wang Y, Xu Z, Meng J and Gu
S: Upregulation of microRNA-96 and its oncogenic functions by
targeting CDKN1A in bladder cancer. Cancer Cell Int. 15:1072015.
View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Nielsen PE, Egholm M, Berg RH and Buchardt
O: Sequence-selective recognition of DNA by strand displacement
with a thymine-substituted polyamide. Science. 254:1497–1500. 1991.
View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Egholm M, Buchardt O, Christensen L,
Behrens C, Freier SM, Driver DA, Berg RH, Kim SK, Norden B and
Nielsen PE: PNA hybridizes to complementary oligonucleotides
obeying the watson-crick hydrogen-bonding rules. Nature.
365:566–568. 1993. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Fabani MM and Gait MJ: miR-122 targeting
with LNA/2′-O-methyl oligonucleotide mixmers, peptide nucleic acids
(PNA), and PNA-peptide conjugates. RNA. 14:336–346. 2008.
View Article : Google Scholar :
|
|
29
|
Brown PN and Yin H: PNA-based microRNA
inhibitors elicit anti-inflammatory effects in microglia cells.
Chem Commun (Camb). 49:4415–4417. 2013. View Article : Google Scholar
|
|
30
|
Fabani MM, Abreu-Goodger C, Williams D,
Lyons PA, Torres AG, Smith KG, Enright AJ, Gait MJ and Vigorito E:
Efficient inhibition of miR-155 function in vivo by peptide nucleic
acids. Nucleic Acids Res. 38:4466–4475. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Fabbri E, Manicardi A, Tedeschi T, Sforza
S, Bianchi N, Brognara E, Finotti A, Breveglieri G, Borgatti M,
Corradini R, et al: Modulation of the biological activity of
microRNA-210 with peptide nucleic acids (PNAs). ChemMedChem.
6:2192–2202. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Brognara E, Fabbri E, Bazzoli E, Montagner
G, Ghimenton C, Eccher A, Cantù C, Manicardi A, Bianchi N, Finotti
A, et al: Uptake by human glioma cell lines and biological effects
of a peptide-nucleic acids targeting miR-221. J Neurooncol.
118:19–28. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Gambari R, Fabbri E, Borgatti M, Lampronti
I, Finotti A, Brognara E, Bianchi N, Manicardi A, Marchelli R and
Corradini R: Targeting microRNAs involved in human diseases: A
novel approach for modification of gene expression and drug
development. Biochem Pharmacol. 82:1416–1429. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Fabbri E, Tamanini A, Jakova T, Gasparello
J, Manicardi A, Corradini R, Sabbioni G, Finotti A, Borgatti M,
Lampronti I, et al: A peptide nucleic acid against MicroRNA
miR-145-5p enhances the expression of the cystic fibrosis
transmembrane conductance regulator (CFTR) in Calu-3 cells.
Molecules. 23:712017. View Article : Google Scholar
|
|
35
|
Swellam M, Ezz El Arab L, Al-Posttany AS
and B Said S: Clinical impact of circulating oncogenic MiRNA-221
and MiRNA-222 in glioblastoma multiform. J Neurooncol. 144:545–551.
2019. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Chen YY, Ho HL, Lin SC, Ho TD and Hsu CY:
Upregulation of miR-125b, miR-181d, and miR-221 predicts poor
prognosis in MGMT promoter-unmethylated glioblastoma patients. Am J
Clin Pathol. 149:412–417. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Yang JK, Yang JP, Tong J, Jing SY, Fan B,
Wang F, Sun GZ and Jiao BH: Exosomal miR-221 targets DNM3 to induce
tumor progression and temozolomide resistance in glioma. J
Neurooncol. 131:255–265. 2017. View Article : Google Scholar
|
|
38
|
Xie Q, Yan Y, Huang Z, Zhong X and Huang
L: MicroRNA-221 targeting PI3-K/Akt signaling axis induces cell
proliferation and BCNU resistance in human glioblastoma.
Neuropathology. 34:455–464. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Xu CH, Liu Y, Xiao LM, Chen LK, Zheng SY,
Zeng EM, Li DH and Li YP: Silencing microRNA-221/222 cluster
suppresses glioblastoma angiogenesis by suppressor of cytokine
signaling-3-dependent JAK/STAT pathway. J Cell Physiol.
234:22272–22284. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Tao K, Yang J, Guo Z, Hu Y, Sheng H, Gao H
and Yu H: Prognostic value of miR-221-3p miR-342-3p and miR-491-5p
expression in colon cancer. Am J Transl Res. 6:391–401. 2014.
|
|
41
|
Dong Y, Zhang N, Zhao S, Chen X, Li F and
Tao X: miR-221-3p and miR-15b-5p promote cell proliferation and
invasion by targeting Axin2 in liver cancer. Oncol Lett.
18:6491–6500. 2019.PubMed/NCBI
|
|
42
|
Yin G, Zhang B and Li J: miR-221-3p
promotes the cell growth of non-small cell lung cancer by targeting
p27. Mol Med Rep. 20:604–612. 2019.PubMed/NCBI
|
|
43
|
Li F, Xu JW, Wang L, Liu H, Yan Y and Hu
SY: MicroRNA-221-3p is up-regulated and serves as a potential
biomarker in pancreatic cancer. Artif Cells Nanomed Biotechnol.
46:482–487. 2018. View Article : Google Scholar
|
|
44
|
Romagnoli R, Prencipe F, Oliva P, Cacciari
B, Balzarini J, Liekens S, Hamel E, Brancale A, Ferla S, Manfredini
S, et al: Synthesis and biological evaluation of new antitubulin
agents containing
2-(3′,4′,5′-trimethoxyanilino)-3,6-disubstituted-4,5,6,7-tetrahydrothieno[2,3-c]pyridine
scaffold. Molecules. 25:16902020. View Article : Google Scholar
|
|
45
|
Khodyuk RGD, Bai R, Hamel E, Lourenço EMG,
Barbosa EG, Beatriz A, Dos Santos EDA and de Lima DP: Diaryl
disulfides and thiosulfonates as combretastatin A-4 analogues:
Synthesis, cytotoxicity and antitubulin activity. Bioorg Chem.
101:1040172020. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Liu H, Fu Q, Lu Y, Zhang W, Yu P, Liu Z
and Sun X: Anti-tubulin agent vinorelbine inhibits metastasis of
cancer cells by regulating epithelial-mesenchymal transition. Eur J
Med Chem. 200:1123322020. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Wang G, Liu W, Gong Z, Huang Y, Li Y and
Peng Z: Design, synthesis, biological evaluation and molecular
docking studies of new chalcone derivatives containing diaryl ether
moiety as potential anticancer agents and tubulin polymerization
inhibitors. Bioorg Chem. 95:1035652020. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Yang F, Yu LZ, Diao PC, Jian XE, Zhou MF,
Jiang CS, You WW, Ma WF and Zhao PL: Novel
[1,2,4]triazolo[1,5-a]pyrimidine derivatives as potent antitubulin
agents: Design, multicomponent synthesis and antiproliferative
activities. Bioorg Chem. 92:1032602019. View Article : Google Scholar
|
|
49
|
Pen A, Durocher Y, Slinn J, Rukhlova M,
Charlebois C, Stanimirovic DB and Moreno MJ: Insulin-like growth
factor binding protein 7 exhibits tumor suppressive and vessel
stabilization properties in U87MG and T98G glioblastoma cell lines.
Cancer Biol Ther. 12:634–646. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Twentyman PR and Luscombe M: A study of
some variables in a tetrazolium dye (MTT) based assay for cell
growth and chemosensitivity. Br J Cancer. 56:279–285. 1987.
View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Cao X, Gu Y, Jiang L, Wang Y, Liu F, Xu Y,
Deng J, Nan Y, Zhang L, Ye J and Li Q: A new approach to screening
cancer stem cells from the U251 human glioma cell line based on
cell growth state. Oncol Rep. 29:1013–1018. 2013. View Article : Google Scholar
|
|
52
|
Munshi A, Hobbs M and Meyn RE: Clonogenic
cell survival assay. Methods Mol Med. 110:21–28. 2005.PubMed/NCBI
|
|
53
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar
|
|
54
|
Milani R, Brognara E, Fabbri E, Manicardi
A, Corradini R, Finotti A, Gasparello J, Borgatti M, Cosenza LC,
Lampronti I, et al: Targeting miR-155-5p and miR-221-3p by peptide
nucleic acids induces caspase-3 activation and apoptosis in
temozolomide-resistant T98G glioma cells. Int J Oncol. 55:59–68.
2019.PubMed/NCBI
|
|
55
|
Shen H, Lin Z, Shi H, Wu L, Ma B, Li H,
Yin B, Tang J, Yu H and Yin X: MiR-221/222 promote migration and
invasion, and inhibit autophagy and apoptosis by modulating ATG10
in aggressive papillary thyroid carcinoma. 3 Biotech. 10:3392020.
View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Hu XH, Zhao ZX, Dai J, Geng DC and Xu YZ:
MicroRNA-221 regulates osteosarcoma cell proliferation, apoptosis,
migration, and invasion by targeting CDKN1B/p27. J Cell Biochem.
120:4665–4674. 2019. View Article : Google Scholar
|
|
57
|
Xie X, Huang Y, Chen L and Wang J: miR-221
regulates proliferation and apoptosis of ovarian cancer cells by
targeting BMF. Oncol Lett. 16:6697–6704. 2018.PubMed/NCBI
|
|
58
|
Li J, Li Q, Huang H, Li Y, Li L, Hou W and
You Z: Overexpression of miRNA-221 promotes cell proliferation by
targeting the apoptotic protease activating factor-1 and indicates
a poor prognosis in ovarian cancer. Int J Oncol. 50:1087–1096.
2017. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Zhou L, Jiang F, Chen X, Liu Z, Ouyang Y,
Zhao W and Yu D: Downregulation of miR-221/222 by a microRNA sponge
promotes apoptosis in oral squamous cell carcinoma cells through
upregulation of PTEN. Oncol Lett. 12:4419–4426. 2016. View Article : Google Scholar
|
|
60
|
Sarkar S, Dubaybo H, Ali S, Goncalves P,
Kollepara SL, Sethi S, Philip PA and Li Y: Down-regulation of
miR-221 inhibits proliferation of pancreatic cancer cells through
up-regulation of PTEN, p27(kip1), p57(kip2), and PUMA. Am J Cancer
Res. 3:465–477. 2013.PubMed/NCBI
|
|
61
|
Zhang CZ, Zhang JX, Zhang AL, Shi ZD, Han
L, Jia ZF, Yang WD, Wang GX, Jiang T, You YP, et al: MiR-221 and
miR-222 target PUMA to induce cell survival in glioblastoma. Mol
Cancer. 9:2292010. View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Zhang C, Zhang J, Zhang A, Wang Y, Han L,
You Y, Pu P and Kang C: PUMA is a novel target of miR-221/222 in
human epithelial cancers. Int J Oncol. 37:1621–1626.
2010.PubMed/NCBI
|
|
63
|
Döbber A, Phoa AF, Abbassi RH, Stringer
BW, Day BW, Johns TG, Abadleh M, Peifer C and Munoz L: Development
and biological evaluation of a photoactivatable small molecule
microtubule-targeting agent. ACS Med Chem Lett. 8:395–400. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Cherry AE, Haas BR, Naydenov AV, Fung S,
Xu C, Swinney K, Wagenbach M, Freeling J, Canton DA, Coy J, et al:
ST-11: A new brain-penetrant microtubule-destabilizing agent with
therapeutic potential for glioblastoma multiforme. Mol Cancer Ther.
15:2018–2029. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Nam GH, Jo KJ, Park YS, Kawk HW, Kim SY
and Kim YM: In vitro and in vivo induction of p53-dependent
apoptosis by extract of euryale ferox salisb in A549 human
caucasian lung carcinoma cancer cells is mediated through Akt
signaling pathway. Front Oncol. 9:4062019. View Article : Google Scholar :
|
|
66
|
Kim EJ, Kim GT, Kim BM, Lim EG, Kim SY and
Kim YM: Apoptosis-induced effects of extract from artemisia annua
linné by modulating PTEN/p53/PDK1/Akt/signal pathways through
PTEN/p53-independent manner in HCT116 colon cancer cells. BMC
Complement Altern Med. 17:2362017. View Article : Google Scholar
|
