Sequestosome 1/p62: A multitasker in the regulation of malignant tumor aggression (Review)
- Authors:
- Jinlong Tang
- Yuan Li
- Shuli Xia
- Jinfan Li
- Qi Yang
- Kefeng Ding
- Honghe Zhang
-
Affiliations: Department of Pathology and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China, Department of Pediatrics, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang 310000, P.R. China, Department of Pathology, Zhejiang University School of Medicine, Research Unit of Intelligence Classification of Tumor Pathology and Precision Therapy, Chinese Academy of Medical Sciences, Hangzhou, Zhejiang 310058, P.R. China, Department of Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China - Published online on: August 18, 2021 https://doi.org/10.3892/ijo.2021.5257
- Article Number: 77
-
Copyright: © Tang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
Park I, Chung J, Walsh CT, Yun Y, Strominger JL and Shin J: Phosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal region. Proc Natl Acad Sci USA. 92:12338–12342. 1995. View Article : Google Scholar | |
Moscat J and Diaz-Meco MT: p62 at the crossroads of autophagy, apoptosis, and cancer. Cell. 137:1001–1004. 2009. View Article : Google Scholar | |
Ishaq M, Khan MA, Sharma K, Sharma G, Dutta RK and Majumdar S: Gambogic acid induced oxidative stress dependent caspase activation regulates both apoptosis and autophagy by targeting various key molecules (NF-κB, Beclin-1, p62 and NBR1) in human bladder cancer cells. Biochim Biophys Acta. 1840:3374–3384. 2014. View Article : Google Scholar | |
Li S, Yang G, Zhu X, Cheng L, Sun Y and Zhao Z: Combination of rapamycin and garlic-derived S-allylmercaptocysteine induces colon cancer cell apoptosis and suppresses tumor growth in xenograft nude mice through autophagy/p62/Nrf2 pathway. Oncol Rep. 38:1637–1644. 2017. View Article : Google Scholar | |
Wang Y, Zhang N, Zhang L, Li R, Fu W, Ma K, Li X, Wang L, Wang J, Zhang H, et al: Autophagy regulates chromatin ubiquitination in DNA damage response through elimination of SQSTM1/p62. Mol Cell. 63:34–48. 2016. View Article : Google Scholar | |
Lee Y and Weihl CC: Regulation of SQSTM1/p62 via UBA domain ubiquitination and its role in disease. Autophagy. 13:1615–1616. 2017. View Article : Google Scholar | |
Seibenhener ML, Babu JR, Geetha T, Wong HC, Krishna NR and Wooten MW: Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation. Mol Cell Biol. 24:8055–8068. 2004. View Article : Google Scholar | |
Cohen-Kaplan V, Livneh I, Avni N, Fabre B, Ziv T, Kwon YT and Ciechanover A: p62- and ubiquitin-dependent stress-induced autophagy of the mammalian 26S proteasome. Proc Natl Acad Sci USA. 113:E7490–E7499. 2016. View Article : Google Scholar | |
Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, et al: Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1. Autophagy. 17:1–382. 2021. View Article : Google Scholar | |
Matsumoto G, Wada K, Okuno M, Kurosawa M and Nukina N: Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins. Mol Cell. 44:279–289. 2011. View Article : Google Scholar | |
Zhu L, Zhu Y, Han S, Chen M, Song P, Dai D, Xu W, Jiang T, Feng L, Shin VY, et al: Impaired autophagic degradation of lncRNA ARHGAP5-AS1 promotes chemoresistance in gastric cancer. Cell Death Dis. 10:3832019. View Article : Google Scholar | |
Clausen TH, Lamark T, Isakson P, Finley K, Larsen KB, Brech A, Øvervatn A, Stenmark H, Bjørkøy G, Simonsen A and Johansen T: p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy. Autophagy. 6:330–344. 2010. View Article : Google Scholar | |
Ichimura Y, Waguri S, Sou YS, Kageyama S, Hasegawa J, Ishimura R, Saito T, Yang Y, Kouno T, Fukutomi T, et al: Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. Mol Cell. 51:618–631. 2013. View Article : Google Scholar | |
Park JY, Sohn HY, Koh YH and Jo C: Curcumin activates Nrf2 through PKCδ-mediated p62 phosphorylation at Ser351. Sci Rep. 11:84302021. View Article : Google Scholar | |
Ling J, Kang Y, Zhao R, Xia Q, Lee DF, Chang Z, Li J, Peng B, Fleming JB, Wang H, et al: KrasG12D-induced IKK2/β/NF-κB activation by IL-1α and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma. Cancer Cell. 21:105–120. 2012. View Article : Google Scholar | |
Duran A, Linares JF, Galvez AS, Wikenheiser K, Flores JM, Diaz-Meco MT and Moscat J: The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesis. Cancer Cell. 13:343–354. 2008. View Article : Google Scholar | |
Nakamura K, Kimple AJ, Siderovski DP and Johnson GL: PB1 domain interaction of p62/sequestosome 1 and MEKK3 regulates NF-kappaB activation. J Biol Chem. 285:2077–2089. 2010. View Article : Google Scholar | |
Usategui-Martin R, Gestoso-Uzal N, Calero-Paniagua I, De Pereda JM, Del Pino-Montes J and González-Sarmiento R: A mutation in p62 protein (R321C), associated to Paget's disease of bone, causes a blockade of autophagy and an activation of NF-kB pathway. Bone. 133:1152652020. View Article : Google Scholar | |
Wang Y, Xiong H, Liu D, Hill C, Ertay A, Li J, Zou Y, Miller P, White E, Downward J, et al: Autophagy inhibition specifically promotes epithelial-mesenchymal transition and invasion in RAS-mutated cancer cells. Autophagy. 15:886–899. 2019. View Article : Google Scholar | |
Hua F and Hu ZW: TRIB3-P62 interaction, diabetes and autophagy. Oncotarget. 6:34061–34062. 2015. View Article : Google Scholar | |
Hewitt G, Carroll B, Sarallah R, Correia-Melo C, Ogrodnik M, Nelson G, Otten EG, Manni D, Antrobus R, Morgan BA, et al: SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair. Autophagy. 12:1917–1930. 2016. View Article : Google Scholar | |
Wang Y, Zhu WG and Zhao Y: Autophagy substrate SQSTM1/p62 regulates chromatin ubiquitination during the DNA damage response. Autophagy. 13:212–213. 2017. View Article : Google Scholar | |
Wang L, Howell MEA, Sparks-Wallace A, Hawkins C, Nicksic CA, Kohne C, Hall KH, Moorman JP, Yao ZQ and Ning S: p62-mediated selective autophagy endows virus-transformed cells with insusceptibility to DNA damage under oxidative stress. PLoS Pathog. 15:e10075412019. View Article : Google Scholar | |
Mohamed A, Ayman A, Deniece J, Wang T, Kovach C, Siddiqui MT and Cohen C: P62/Ubiquitin IHC expression correlated with clinicopathologic parameters and outcome in gastrointestinal carcinomas. Front Oncol. 5:702015. View Article : Google Scholar | |
Adams O, Dislich B, Berezowska S, Schläfli AM, Seiler CA, Kröll D, Tschan MP and Langer R: Prognostic relevance of autophagy markers LC3B and p62 in esophageal adenocarcinomas. Oncotarget. 7:39241–39255. 2016. View Article : Google Scholar | |
Masuda GO, Yashiro M, Kitayama K, Miki Y, Kasashima H, Kinoshita H, Morisaki T, Fukuoka T, Hasegawa T, Sakurai K, et al: Clinicopathological correlations of autophagy-related proteins LC3, beclin 1 and p62 in gastric cancer. Anticancer Res. 36:129–136. 2016. | |
Park JM, Huang S, Wu TT, Foster NR and Sinicrope FA: Prognostic impact of beclin 1p62/sequestosome 1 and LC3 protein expression in colon carcinomas from patients receiving 5-fluorouracil as adjuvant chemotherapy. Cancer Biol Ther. 14:100–107. 2013. View Article : Google Scholar | |
Kosumi K, Masugi Y, Yang J, Qian ZR, Kim SA, Li W, Shi Y, da Silva A, Hamada T, Liu L, et al: Tumor SQSTM1 (p62) expression and T cells in colorectal cancer. Oncoimmunology. 6:e12847202017. View Article : Google Scholar | |
Schmitz KJ, Ademi C, Bertram S, Schmid KW and Baba HA: Prognostic relevance of autophagy-related markers LC3, p62/sequestosome 1, beclin-1 and ULK1 in colorectal cancer patients with respect to KRAS mutational status. World J Surg Oncol. 14:1892016. View Article : Google Scholar | |
Goulielmaki M, Koustas E, Moysidou E, Vlassi M, Sasazuki T, Shirasawa S, Zografos G, Oikonomou E and Pintzas A: BRAF associated autophagy exploitation: BRAF and autophagy inhibitors synergise to efficiently overcome resistance of BRAF mutant colorectal cancer cells. Oncotarget. 7:9188–9221. 2016. View Article : Google Scholar | |
Ren F, Shu G, Liu G, Liu D and Zhou J, Yuan L and Zhou J: Knockdown of p62/sequestosome 1 attenuates autophagy and inhibits colorectal cancer cell growth. Mol Cell Biochem. 385:95–102. 2014. View Article : Google Scholar | |
Petherick KJ, Williams AC, Lane JD, Ordóñez-Morán P, Huelsken J, Collard TJ, Smartt HJ, Batson J, Malik K, Paraskeva C and Greenhough A: Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk. EMBO J. 32:1903–1916. 2013. View Article : Google Scholar | |
Samarasinghe B, Wales CT, Taylor FR and Jacobs AT: Heat shock factor 1 confers resistance to Hsp90 inhibitors through p62/SQSTM1 expression and promotion of autophagic flux. Biochem Pharmacol. 87:445–455. 2014. View Article : Google Scholar | |
Wang Z, Chen Q, Li B, Xie JM, Yang XD, Zhao K, Wu Y, Ye ZY, Chen ZR, Qin ZH, et al: Escin-induced DNA damage promotes escin-induced apoptosis in human colorectal cancer cells via p62 regulation of the ATM/γH2AX pathway. Acta Pharmacol Sin. 39:1645–1660. 2018. View Article : Google Scholar | |
Kim JH and Kim IW: p62 manipulation affects chlorin e6-mediated photodynamic therapy efficacy in colorectal cancer cell lines. Oncol Lett. 19:3907–3916. 2020. | |
Duran A, Hernandez ED, Reina-Campos M, Castilla EA, Subramaniam S, Raghunandan S, Roberts LR, Kisseleva T, Karin M, Diaz-Meco MT and Moscat J: p62/SQSTM1 by binding to vitamin D receptor inhibits hepatic stellate cell activity, fibrosis, and liver cancer. Cancer Cell. 30:595–609. 2016. View Article : Google Scholar | |
Shimizu T, Inoue K, Hachiya H, Shibuya N, Aoki T and Kubota K: Accumulation of phosphorylated p62 is associated with NF-E2-related factor 2 activation in hepatocellular carcinoma. J Hepatobiliary Pancreat Sci. 23:467–471. 2016. View Article : Google Scholar | |
Saito T, Ichimura Y, Taguchi K, Suzuki T, Mizushima T, Takagi K, Hirose Y, Nagahashi M, Iso T, Fukutomi T, et al: p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming. Nat Commun. 7:120302016. View Article : Google Scholar | |
Jain A, Lamark T, Sjottem E, Larsen KB, Awuh JA, Øvervatn A, McMahon M, Hayes JD and Johansen T: p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription. J Biol Chem. 285:22576–22591. 2010. View Article : Google Scholar | |
Umemura A, He F, Taniguchi K, Nakagawa H, Yamachika S, Font-Burgada J, Zhong Z, Subramaniam S, Raghunandan S, Duran A, et al: p62, upregulated during preneoplasia, induces hepatocellular carcinogenesis by maintaining survival of stressed HCC-initiating cells. Cancer Cell. 29:935–948. 2016. View Article : Google Scholar | |
Hoadley KA, Yau C, Wolf DM, Cherniack AD, Tamborero D, Ng S, Leiserson MDM, Niu B, McLellan MD, Uzunangelov V, et al: Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin. Cell. 158:929–944. 2014. View Article : Google Scholar | |
Taguchi K, Fujikawa N, Komatsu M, Ishii T, Unno M, Akaike T, Motohashi H and Yamamoto M: Keap1 degradation by autophagy for the maintenance of redox homeostasis. Proc Natl Acad Sci USA. 109:13561–13566. 2012. View Article : Google Scholar | |
Vegliante R, Desideri E, Di Leo L and Ciriolo MR: Dehydroepiandrosterone triggers autophagic cell death in human hepatoma cell line HepG2 via JNK-mediated p62/SQSTM1 expression. Carcinogenesis. 37:233–244. 2016. View Article : Google Scholar | |
Yan J, Seibenhener ML, Calderilla-Barbosa L, Diaz-Meco MT, Moscat J, Jiang J, Wooten MW and Wooten MC: SQSTM1/p62 interacts with HDAC6 and regulates deacetylase activity. PLoS One. 8:e760162013. View Article : Google Scholar | |
Chen Q, Yue F, Li W, Zou J, Xu T, Huang C, Zhang Y, Song K, Huang G, Xu G, et al: Potassium bisperoxo(1,10-phenanthroline) oxovanadate (bpV(phen)) induces apoptosis and pyroptosis and disrupts the P62-HDAC6 protein interaction to suppress the acetylated microtubule-dependent degradation of autophagosomes. J Biol Chem. 290:26051–26058. 2015. View Article : Google Scholar | |
Ryoo IG, Choi BH, Ku SK and Kwak MK: High CD44 expression mediates p62-associated NFE2L2/NRF2 activation in breast cancer stem cell-like cells: Implications for cancer stem cell resistance. Redox Biol. 17:246–258. 2018. View Article : Google Scholar | |
Ryoo IG, Choi BH and Kwak MK: Activation of NRF2 by p62 and proteasome reduction in sphere-forming breast carcinoma cells. Oncotarget. 6:8167–8184. 2015. View Article : Google Scholar | |
Jain A, Rusten TE, Katheder N, Elvenes J, Bruun JA, Sjøttem E, Lamark T and Johansen T: p62/sequestosome-1, autophagy-related gene 8, and autophagy in drosophila are regulated by nuclear factor erythroid 2-related factor 2 (NRF2), independent of transcription factor TFEB. J Biol Chem. 290:14945–14962. 2015. View Article : Google Scholar | |
Xu LZ, Li SS, Zhou W, Kang ZJ, Zhang QX, Kamran M, Xu J, Liang DP, Wang CL, Hou ZJ, et al: p62/SQSTM1 enhances breast cancer stem-like properties by stabilizing MYC mRNA. Oncogene. 36:304–317. 2017. View Article : Google Scholar | |
Gao C, Cao W, Bao L, Zuo W, Xie G, Cai T, Fu W, Zhang J, Wu W, Zhang X and Chen YG: Autophagy negatively regulates Wnt signalling by promoting dishevelled degradation. Nat Cell Biol. 12:781–790. 2010. View Article : Google Scholar | |
Ahn JS, Ann EJ, Kim MY, Yoon JH, Lee HJ, Jo EH, Lee K, Lee JS and Park HS: Autophagy negatively regulates tumor cell proliferation through phosphorylation dependent degradation of the Notch1 intracellular domain. Oncotarget. 7:79047–79063. 2016. View Article : Google Scholar | |
Cai-McRae X and Karantza V: p62: A hub of multiple signaling pathways in HER2-induced mammary tumorigenesis. Mol Cell Oncol. 2:e9750352015. View Article : Google Scholar | |
Cai-McRae X, Zhong H and Karantza V: Sequestosome 1/p62 facilitates HER2-induced mammary tumorigenesis through multiple signaling pathways. Oncogene. 34:2968–2977. 2015. View Article : Google Scholar | |
Wei H, Wang C, Croce CM and Guan JL: p62/SQSTM1 synergizes with autophagy for tumor growth in vivo. Genes Dev. 28:1204–1216. 2014. View Article : Google Scholar | |
Puvirajesinghe TM, Bertucci F, Jain A, Scerbo P, Belotti E, Audebert S, Sebbagh M, Lopez M, Brech A, Finetti P, et al: Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2-JNK signalling in breast cancer. Nat Commun. 7:103182016. View Article : Google Scholar | |
Chen S, Zhou L, Zhang Y, Leng Y, Pei XY, Lin H, Jones R, Orlowski RZ, Dai Y and Grant S: Targeting SQSTM1/p62 induces cargo loading failure and converts autophagy to apoptosis via NBK/Bik. Mol Cell Biol. 34:3435–3449. 2014. View Article : Google Scholar | |
Choi YK, Cho SG, Woo SM, Yun YJ, Park S, Shin YC and Ko SG: Herbal extract SH003 suppresses tumor growth and metastasis of MDA-MB-231 breast cancer cells by inhibiting STAT3-IL-6 signaling. Mediators Inflamm. 2014:4921732014. View Article : Google Scholar | |
Luo RZ, Yuan ZY, Li M, Xi SY, Fu J and He J: Accumulation of p62 is associated with poor prognosis in patients with triple-negative breast cancer. Onco Targets Ther. 6:883–888. 2013. | |
Wei Y, Liu D, Jin X, Gao P, Wang Q, Zhang J and Zhang N: PA-MSHA inhibits the growth of doxorubicin-resistant MCF-7/ADR human breast cancer cells by downregulating Nrf2/p62. Cancer Med. 5:3520–3531. 2016. View Article : Google Scholar | |
Fuchinoue F, Hirotani Y, Nakanishi Y, Yamaguchi H, Nishimaki H, Noda H, Tang XY, Iizuka M, Amano S, Sugitani M, et al: Overexpression of PGC1α and accumulation of p62 in apocrine carcinoma of the breast. Pathol Int. 65:19–26. 2015. View Article : Google Scholar | |
Nozaki F, Hirotani Y, Nakanishi Y, Yamaguchi H, Nishimaki H, Noda H, Tang X, Yamamoto H, Suzuki A, Seki T and Masuda S: p62 regulates the proliferation of molecular apocrine breast cancer cells. Acta Histochem Cytochem. 49:125–130. 2016. View Article : Google Scholar | |
Shen P, Chen M, He M, Chen L, Song Y, Xiao P, Wan X, Dai F, Pan T and Wang Q: Inhibition of ERα/ERK/P62 cascades induces 'autophagic switch' in the estrogen receptor-positive breast cancer cells exposed to gemcitabine. Oncotarget. 7:48501–48516. 2016. View Article : Google Scholar | |
Fang J and Starczynowski DT: Genomic instability establishes dependencies on acquired gene regulatory networks: A novel role of p62 in myeloid malignancies with del(5q). Mol Cell Oncol. 2:e10142192015. View Article : Google Scholar | |
Fang J, Barker B, Bolanos L, Liu X, Jerez A, Makishima H, Christie S, Chen X, Rao DS, Grimes HL, et al: Myeloid malignancies with chromosome 5q deletions acquire a dependency on an intrachromosomal NF-κB gene network. Cell Rep. 8:1328–1338. 2014. View Article : Google Scholar | |
Sanz L, Diaz-Meco MT, Nakano H and Moscat J: The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1TRAF6 pathway. EMBO J. 19:1576–1586. 2000. View Article : Google Scholar | |
Teramachi J, Silbermann R, Yang P, Zhao W, Mohammad KS, Guo J, Anderson JL, Zhou D, Feng R, Myint KZ, et al: Blocking the ZZ domain of sequestosome1/p62 suppresses myeloma growth and osteoclast formation in vitro and induces dramatic bone formation in myeloma-bearing bones in vivo. Leukemia. 30:390–398. 2016. View Article : Google Scholar | |
Sanz L, Sanchez P, Lallena MJ, Diaz-Meco MT and Moscat J: The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation. EMBO J. 18:3044–3053. 1999. View Article : Google Scholar | |
Rubio N, Verrax J, Dewaele M, Verfaillie T, Johansen T, Piette J and Agostinis P: p38(MAPK)-regulated induction of p62 and NBR1 after photodynamic therapy promotes autophagic clearance of ubiquitin aggregates and reduces reactive oxygen species levels by supporting Nrf2-antioxidant signaling. Free Radic Biol Med. 67:292–303. 2014. View Article : Google Scholar | |
Chang KH, Sengupta A, Nayak RC, Duran A, Lee SJ, Pratt RG, Wellendorf AM, Hill SE, Watkins M, Gonzalez-Nieto D, et al: p62 is required for stem cell/progenitor retention through inhibition of IKK/NF-κB/Ccl4 signaling at the bone marrow macrophage-osteoblast niche. Cell Rep. 9:2084–2097. 2014. View Article : Google Scholar | |
Milan E, Perini T, Resnati M, Orfanelli U, Oliva L, Raimondi A, Cascio P, Bachi A, Marcatti M, Ciceri F and Cenci S: A plastic SQSTM1/p62-dependent autophagic reserve maintains proteostasis and determines proteasome inhibitor susceptibility in multiple myeloma cells. Autophagy. 11:1161–1178. 2015. View Article : Google Scholar | |
Riz I, Hawley TS and Hawley RG: KLF4-SQSTM1/p62-associated prosurvival autophagy contributes to carfilzomib resistance in multiple myeloma models. Oncotarget. 6:14814–14831. 2015. View Article : Google Scholar | |
Trocoli A, Bensadoun P, Richard E, Labrunie G, Merhi F, Schläfli AM, Brigger D, Souquere S, Pierron G, Pasquet JM, et al: p62/SQSTM1 upregulation constitutes a survival mechanism that occurs during granulocytic differentiation of acute myeloid leukemia cells. Cell Death Differ. 21:1852–1861. 2014. View Article : Google Scholar | |
Ségal-Bendirdjian E, Tschan MP, Reiffers J and Djavaheri-Mergny M: Pro-survival role of p62 during granulocytic differentiation of acute myeloid leukemia cells. Mol Cell Oncol. 1:e9700662014. View Article : Google Scholar | |
Goussetis DJ, Gounaris E, Wu EJ, Vakana E, Sharma B, Bogyo M, Altman JK and Platanias LC: Autophagic degradation of the BCR-ABL oncoprotein and generation of antileukemic responses by arsenic trioxide. Blood. 120:3555–3562. 2012. View Article : Google Scholar | |
Zhong Z, Sanchez-Lopez E and Karin M: Autophagy, inflammation, and immunity: A Troika governing cancer and its treatment. Cell. 166:288–298. 2016. View Article : Google Scholar | |
Moscat J, Karin M and Diaz-Meco MT: p62 in cancer: Signaling adaptor beyond autophagy. Cell. 167:606–609. 2016. View Article : Google Scholar | |
Wang X, Du Z, Li L, Shi M and Yu Y: Beclin 1 and p62 expression in non-small cell lung cancer: Relation with malignant behaviors and clinical outcome. Int J Clin Exp Pathol. 8:10644–10652. 2015. | |
Schläfli AM, Adams O, Galván JA, Gugger M, Savic S, Bubendorf L, Schmid RA, Becker KF, Tschan MP, Langer R and Berezowska S: Prognostic value of the autophagy markers LC3 and p62/SQSTM1 in early-stage non-small cell lung cancer. Oncotarget. 7:39544–39555. 2016. View Article : Google Scholar | |
Huang H, Zhu J, Li Y, Zhang L, Gu J, Xie Q, Jin H, Che X, Li J, Huang C, et al: Upregulation of SQSTM1/p62 contributes to nickel-induced malignant transformation of human bronchial epithelial cells. Autophagy. 12:1687–1703. 2016. View Article : Google Scholar | |
Linares JF, Duran A, Yajima T, Pasparakis M, Moscat J and Diaz-Meco MT: K63 polyubiquitination and activation of mTOR by the p62-TRAF6 complex in nutrient-activated cells. Mol Cell. 51:283–296. 2013. View Article : Google Scholar | |
Lou JS, Yan L, Bi CW, Chan GK, Wu QY, Liu YL, Huang Y, Yao P, Du CY, Dong TT and Tsim KW: Yu Ping Feng San reverses cisplatin-induced multi-drug resistance in lung cancer cells via regulating drug transporters and p62/TRAF6 signalling. Sci Rep. 6:319262016. View Article : Google Scholar | |
Lau A, Zheng Y, Tao S, Wang H, Whitman SA, White E and Zhang DD: Arsenic inhibits autophagic flux, activating the Nrf2-Keap1 pathway in a p62-dependent manner. Mol Cell Biol. 33:2436–2446. 2013. View Article : Google Scholar | |
Son YO, Pratheeshkumar P, Roy RV, Hitron JA, Wang L, Zhang Z and Shi X: Nrf2/p62 signaling in apoptosis resistance and its role in cadmium-induced carcinogenesis. J Biol Chem. 289:28660–28675. 2014. View Article : Google Scholar | |
Wang Y, Zhang J, Huang ZH, Huang XH, Zheng WB, Yin XF, Li YL, Li B and He QY: Isodeoxyelephantopin induces protective autophagy in lung cancer cells via Nrf2-p62-keap1 feedback loop. Cell Death Dis. 8:e28762017. View Article : Google Scholar | |
Xia M, Gonzalez P, Li C, Meng G, Jiang A, Wang H, Gao Q, Debatin KM, Beltinger C and Wei J: Mitophagy enhances oncolytic measles virus replication by mitigating DDX58/RIG-I-like receptor signaling. J Virol. 88:5152–5164. 2014. View Article : Google Scholar | |
Nihira K, Miki Y, Ono K, Suzuki T and Sasano H: An inhibition of p62/SQSTM1 caused autophagic cell death of several human carcinoma cells. Cancer Sci. 105:568–575. 2014. View Article : Google Scholar | |
Zhang J, Ma K, Qi T, Wei X, Zhang Q, Li G and Chiu JF: P62 regulates resveratrol-mediated Fas/Cav-1 complex formation and transition from autophagy to apoptosis. Oncotarget. 6:789–801. 2015. View Article : Google Scholar | |
Xu L, Xu F, Kong Q, Yang T, Tan D, Zhang X, Li N, Zhao S, Zhao J and Li M: Inhibition of p62/SQSTM1 sensitizes small-cell lung cancer cells to cisplatin-induced cytotoxicity by targeting NEDD9 expression. Mol Carcinog. 59:967–979. 2020. View Article : Google Scholar | |
Kim MJ, Min Y, Im JS, Son J, Lee JS and Lee KY: p62 is negatively implicated in the TRAF6-BECN1 signaling axis for autophagy activation and cancer progression by toll-like receptor 4 (TLR4). Cells. 9:11422020. View Article : Google Scholar | |
Kim MJ, Min Y, Kwon J, Son J, Im JS, Shin J and Lee KY: p62 negatively regulates TLR4 signaling via functional regulation of the TRAF6-ECSIT complex. Immune Netw. 19:e162019. View Article : Google Scholar | |
Li S and Wei Y: Association of HMGB1, BRCA1 and P62 expression in ovarian cancer and chemotherapy sensitivity. Oncol Lett. 15:9572–9576. 2018. | |
Iwadate R, Inoue J, Tsuda H, Takano M, Furuya K, Hirasawa A, Aoki D and Inazawa J: High expression of SQSTM1/p62 protein is associated with poor prognosis in epithelial ovarian cancer. Acta Histochem Cytochem. 47:295–301. 2014. View Article : Google Scholar | |
Ju LL, Zhao CY, Ye KF, Yang H and Zhang J: Expression and clinical implication of beclin1, HMGB1, p62, survivin, BRCA1 and ERCC1 in epithelial ovarian tumor tissues. Eur Rev Med Pharmacol Sci. 20:1993–2003. 2016. | |
Wang J, Garbutt C, Ma H, Gao P, Hornicek FJ, Kan Q, Shi H and Duan Z: Expression and role of autophagy-associated p62 (SQSTM1) in multidrug resistant ovarian cancer. Gynecol Oncol. 150:143–150. 2018. View Article : Google Scholar | |
Bartsch G, Jennewein L, Harter PN, Antonietti P, Blaheta RA, Kvasnicka HM, Kögel D, Haferkamp A, Mittelbronn M and Mani J: Autophagy-associated proteins BAG3 and p62 in testicular cancer. Oncol Rep. 35:1629–1635. 2016. View Article : Google Scholar | |
Iwadate R, Inoue J, Tsuda H, Takano M, Furuya K, Hirasawa A, Aoki D and Inazawa J: High expression of p62 protein is associated with poor prognosis and aggressive phenotypes in endometrial cancer. Am J Pathol. 185:2523–2533. 2015. View Article : Google Scholar | |
Darvekar SR, Elvenes J, Brenne HB, Johansen T and Sjøttem E: SPBP is a sulforaphane induced transcriptional coactivator of NRF2 regulating expression of the autophagy receptor p62/SQSTM1. PLoS One. 9:e852622014. View Article : Google Scholar | |
Jung D, Khurana A, Roy D, Kalogera E, Bakkum-Gamez J, Chien J and Shridhar V: Quinacrine upregulates p21/p27 independent of p53 through autophagy-mediated downregulation of p62-Skp2 axis in ovarian cancer. Sci Rep. 8:24872018. View Article : Google Scholar | |
Xia MH, Yan XY, Zhou L, Xu L, Zhang LC, Yi HW and Su J: p62 suppressed VK3-induced oxidative damage through Keap1/Nrf2 pathway in human ovarian cancer cells. J Cancer. 11:1299–1307. 2020. View Article : Google Scholar | |
Yan XY, Zhong XR, Yu SH, Zhang LC, Liu YN, Zhang Y, Sun LK and Su J: p62 aggregates mediated caspase 8 activation is responsible for progression of ovarian cancer. J Cell Mol Med. 23:4030–4042. 2019. View Article : Google Scholar | |
Chang MA, Morgado M, Warren CR, Hinton CV, Farach-Carson MC and Delk NA: p62/SQSTM1 is required for cell survival of apoptosis-resistant bone metastatic prostate cancer cell lines. Prostate. 74:149–163. 2014. View Article : Google Scholar | |
Falasca L, Torino F, Marconi M, Costantini M, Pompeo V, Sentinelli S, De Salvo L, Patrizio M, Padula C, Gallucci M, et al: AMBRA1 and SQSTM1 expression pattern in prostate cancer. Apoptosis. 20:1577–1586. 2015. View Article : Google Scholar | |
Wang L, Kim D, Wise JT, Shi X, Zhang Z and DiPaola RS: p62 as a therapeutic target for inhibition of autophagy in prostate cancer. Prostate. 78:390–400. 2018. View Article : Google Scholar | |
Burdelski C, Reiswich V, Hube-Magg C, Kluth M, Minner S, Koop C, Graefen M, Heinzer H, Tsourlakis MC, Wittmer C, et al: Cytoplasmic accumulation of sequestosome 1 (p62) is a predictor of biochemical recurrence, rapid tumor cell proliferation, and genomic instability in prostate cancer. Clin Cancer Res. 21:3471–3479. 2015. View Article : Google Scholar | |
Kim JH, Hong SK, Wu PK, Richards AL, Jackson WT and Park JI: Raf/MEK/ERK can regulate cellular levels of LC3B and SQSTM1/p62 at expression levels. Exp Cell Res. 327:340–352. 2014. View Article : Google Scholar | |
Linares JF, Duran A, Reina-Campos M, Aza-Blanc P, Campos A, Moscat J and Diaz-Meco MT: Amino acid activation of mTORC1 by a PB1-domain-driven kinase complex cascade. Cell Rep. 12:1339–1352. 2015. View Article : Google Scholar | |
Jones S, Cunningham DL, Rappoport JZ and Heath JK: The non-receptor tyrosine kinase Ack1 regulates the fate of activated EGFR by inducing trafficking to the p62/NBR1 pre-autophagosome. J Cell Sci. 127:994–1006. 2014. | |
Jiang G, Liang X, Huang Y, Lan Z, Zhang Z, Su Z, Fang Z, Lai Y, Yao W, Liu T, et al: p62 promotes proliferation, apoptosis-resistance and invasion of prostate cancer cells through the Keap1/Nrf2/ARE axis. Oncol Rep. 43:1547–1557. 2020. | |
Huang J, Duran A, Reina-Campos M, Valencia T, Castilla EA, Müller TD, Tschöp MH, Moscat J and Diaz-Meco MT: Adipocyte p62/SQSTM1 suppresses tumorigenesis through opposite regulations of metabolism in adipose tissue and tumor. Cancer Cell. 33:770–784.e6. 2018. View Article : Google Scholar | |
Valencia T, Kim JY, Abu-Baker S, Moscat-Pardos J, Ahn CS, Reina-Campos M, Duran A, Castilla EA, Metallo CM, Diaz-Meco MT and Moscat J: Metabolic reprogramming of stromal fibroblasts through p62-mTORC1 signaling promotes inflammation and tumorigenesis. Cancer Cell. 26:121–135. 2014. View Article : Google Scholar | |
Chang MA, Patel V, Gwede M, Morgado M, Tomasevich K, Fong EL, Farach-Carson MC and Delk NA: IL-1β induces p62/SQSTM1 and represses androgen receptor expression in prostate cancer cells. J Cell Biochem. 115:2188–2197. 2014. View Article : Google Scholar | |
Chen K, Zeng J, Xiao H, Huang C, Hu J, Yao W, Yu G, Xiao W, Xu H and Ye Z: Regulation of glucose metabolism by p62/SQSTM1 through HIF1α. J Cell Sci. 129:817–830. 2016. | |
Liu XD, Yao J, Tripathi DN, Ding Z, Xu Y, Sun M, Zhang J, Bai S, German P, Hoang A, et al: Autophagy mediates HIF2α degradation and suppresses renal tumorigenesis. Oncogene. 34:2450–2460. 2015. View Article : Google Scholar | |
Li T, Jiang D and Wu K: p62 promotes bladder cancer cell growth by activating KEAP1/NRF2-dependent antioxidative response. Cancer Sci. 111:1156–1164. 2020. View Article : Google Scholar | |
Liu JL, Chen FF, Lung J, Lo CH, Lee FH, Lu YC and Hung CH: Prognostic significance of p62/SQSTM1 subcellular localization and LC3B in oral squamous cell carcinoma. Br J Cancer. 111:944–954. 2014. View Article : Google Scholar | |
Kuo WL, Sharifi MN, Lingen MW, Ahmed O, Liu J, Nagilla M, Macleod KF and Cohen EE: p62/SQSTM1 accumulation in squamous cell carcinoma of head and neck predicts sensitivity to phosphatidylinositol 3-kinase pathway inhibitors. PLoS One. 9:e901712014. View Article : Google Scholar | |
Liang L, Luo H, He Q, You Y, Fan Y and Liang J: Investigation of cancer-associated fibroblasts and p62 expression in oral cancer before and after chemotherapy. J Craniomaxillofac Surg. 46:605–610. 2018. View Article : Google Scholar | |
Yoshihara N, Takagi A, Ueno T and Ikeda S: Inverse correlation between microtubule-associated protein 1A/1B-light chain 3 and p62/sequestosome-1 expression in the progression of cutaneous squamous cell carcinoma. J Dermatol. 41:311–315. 2014. View Article : Google Scholar | |
Shah P, Trinh E, Qiang L, Xie L, Hu WY, Prins GS, Pi J and He YY: Arsenic induces p62 expression to form a positive feedback loop with Nrf2 in human epidermal keratinocytes: Implications for preventing arsenic-induced skin cancer. Molecules. 22:1942017. View Article : Google Scholar | |
Colunga A, Bollino D, Schech A and Aurelian L: Calpain-dependent clearance of the autophagy protein p62/SQSTM1 is a contributor to ΔPK oncolytic activity in melanoma. Gene Ther. 21:371–378. 2014. View Article : Google Scholar | |
Yeh LY, Liu CJ, Wong YK, Chang C, Lin SC and Chang KW: miR-372 inhibits p62 in head and neck squamous cell carcinoma in vitro and in vivo. Oncotarget. 6:6062–6075. 2015. View Article : Google Scholar | |
Yamanaka T, Tosaki A, Kurosawa M, Matsumoto G, Koike M, Uchiyama Y, Maity SN, Shimogori T, Hattori N and Nukina N: NF-Y inactivation causes atypical neurodegeneration characterized by ubiquitin and p62 accumulation and endoplasmic reticulum disorganization. Nat Commun. 5:33542014. View Article : Google Scholar | |
Wang C, Chen S, Yeo S, Karsli-Uzunbas G, White E, Mizushima N, Virgin HW and Guan JL: Correction: Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide. J Cell Biol. 212:8792016. View Article : Google Scholar | |
Wang C, Chen S, Yeo S, Karsli-Uzunbas G, White E, Mizushima N, Virgin HW and Guan JL: Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide. J Cell Biol. 212:545–560. 2016. View Article : Google Scholar | |
Ivankovic D, Chau KY, Schapira AH and Gegg ME: Mitochondrial and lysosomal biogenesis are activated following PINK1/parkin-mediated mitophagy. J Neurochem. 136:388–402. 2016. View Article : Google Scholar | |
Su J, Liu F, Xia M, Xu Y, Li X, Kang J, Li Y and Sun L: p62 participates in the inhibition of NF-κB signaling and apoptosis induced by sulfasalazine in human glioma U251 cells. Oncol Rep. 34:235–243. 2015. View Article : Google Scholar | |
Zeng RX, Zhang YB, Fan Y and Wu GL: p62/SQSTM1 is involved in caspase-8 associated cell death induced by proteasome inhibitor MG132 in U87MG cells. Cell Biol Int. 38:1221–1226. 2014. View Article : Google Scholar | |
De Craene B and Berx G: Regulatory networks defining EMT during cancer initiation and progression. Nat Rev Cancer. 13:97–110. 2013. View Article : Google Scholar | |
Qiang L, Zhao B, Ming M, Wang N, He TC, Hwang S, Thorburn A and He YY: Regulation of cell proliferation and migration by p62 through stabilization of Twist1. Proc Natl Acad Sci USA. 111:9241–9246. 2014. View Article : Google Scholar | |
Qiang L and He YY: Autophagy deficiency stabilizes TWIST1 to promote epithelial-mesenchymal transition. Autophagy. 10:1864–1865. 2014. View Article : Google Scholar | |
Bertrand M, Petit V, Jain A, Amsellem R, Johansen T, Larue L, Codogno P and Beau I: SQSTM1/p62 regulates the expression of junctional proteins through epithelial-mesenchymal transition factors. Cell Cycle. 14:364–374. 2015. View Article : Google Scholar | |
Jiang X, Huang Y, Liang X, Jiang F, He Y, Li T, Xu G, Zhao H, Yang W, Jiang G, et al: Metastatic prostate cancer-associated P62 inhibits autophagy flux and promotes epithelial to mesenchymal transition by sustaining the level of HDAC6. Prostate. 78:426–434. 2018. View Article : Google Scholar | |
Grassi G, Di Caprio G, Santangelo L, Fimia GM, Cozzolino AM, Komatsu M, Ippolito G, Tripodi M and Alonzi T: Autophagy regulates hepatocyte identity and epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions promoting snail degradation. Cell Death Dis. 6:e18802015. View Article : Google Scholar | |
Geng Y, Ju Y, Ren F, Qiu Y, Tomita Y, Tomoeda M, Kishida M, Wang Y, Jin L, Su F, et al: Insulin receptor substrate 1/2 (IRS1/2) regulates Wnt/β-catenin signaling through blocking autophagic degradation of dishevelled2. J Biol Chem. 289:11230–11241. 2014. View Article : Google Scholar | |
Ma JB, Hu SL, Zang RK, Su Y, Liang YC and Wang Y: MicroRNA-487a promotes proliferation of esophageal cancer cells by inhibiting p62 expression. Eur Rev Med Pharmacol Sci. 23:1502–1512. 2019. | |
Zhong JH, Xiang X, Wang YY, Liu X, Qi LN, Luo CP, Wei WE, You XM, Ma L, Xiang BD and Li LQ: The lncRNA SNHG16 affects prognosis in hepatocellular carcinoma by regulating p62 expression. J Cell Physiol. 235:1090–1102. 2020. View Article : Google Scholar | |
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, et al: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12:1–222. 2016. View Article : Google Scholar | |
Adamik J, Silbermann R, Marino S, Sun Q, Anderson J L, Zhou D, Xie XQ, Roodman GD and Galson DL: XRK3F2 inhibition of p62-ZZ domain signaling rescues myeloma-induced GFI1-driven epigenetic repression of the Runx2 gene in pre-osteoblasts to overcome differentiation suppression. Front Endocrinol (Lausanne). 9. pp. 3442018, View Article : Google Scholar | |
Li Y, Li Y, Yin J, Wang C, Yang M, Gu J, He M, Xu H, Fu W, Zhang W, et al: A mitophagy inhibitor targeting p62 attenuates the leukemia-initiation potential of acute myeloid leukemia cells. Cancer Lett. 510:24–36. 2021. View Article : Google Scholar | |
Andersen AN, Landsverk OJ, Simonsen A, Bogen B, Corthay A and Øynebråten I: Coupling of HIV-1 antigen to the selective autophagy receptor SQSTM1/p62 promotes T-cell-mediated immunity. Front Iunol. 7:1672016. | |
Venanzi F, Shifrin V, Sherman M, Gabai V, Kiselev O, Komissarov A, Grudinin M, Shartukova M, Romanovskaya-Romanko EA, Kudryavets Y, et al: Broad-spectrum anti-tumor and anti-metastatic DNA vaccine based on p62-encoding vector. Oncotarget. 4:1829–1835. 2013. View Article : Google Scholar | |
Gabai V, Venanzi FM, Bagashova E, Rud O, Mariotti F, Vullo C, Catone G, Sherman MY, Concetti A, Chursov A, et al: Pilot study of p62 DNA vaccine in dogs with mammary tumors. Oncotarget. 5:12803–12810. 2014. View Article : Google Scholar | |
Ponomarenko DM, Klimova ID, Chapygina YA, Dvornichenko VV, Zhukova NV, Orlova RV, Manikhas GM, Zyryanov AV, Burkhanova LA, Badrtdinova II, et al: Safety and efficacy of p62 DNA vaccine ELENAGEN in a first-in-human trial in patients with advanced solid tumors. Oncotarget. 8:53730–53739. 2017. View Article : Google Scholar |