Open Access

Sequestosome 1/p62: A multitasker in the regulation of malignant tumor aggression (Review)

  • Authors:
    • Jinlong Tang
    • Yuan Li
    • Shuli Xia
    • Jinfan Li
    • Qi Yang
    • Kefeng Ding
    • Honghe Zhang
  • View Affiliations

  • Published online on: August 18, 2021     https://doi.org/10.3892/ijo.2021.5257
  • Article Number: 77
  • Copyright: © Tang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Sequestosome 1 (SQSTM1)/p62 is an adapter protein mainly involved in the transportation, degradation and destruction of various proteins that cooperates with components of autophagy and the ubiquitin‑proteasome degradation pathway. Numerous studies have shown that SQSTM1/p62 functions at multiple levels, including involvement in genetic stability or modification, post‑transcriptional regulation and protein function. As a result, SQSTM1/p62 is a versatile protein that is a critical core regulator of tumor cell genetic stability, autophagy, apoptosis and other forms of cell death, malignant growth, proliferation, migration, invasion, metastasis and chemoradiotherapeutic response, and an indicator of patient prognosis. SQSTM1/p62 regulates these processes via its distinct molecular structure, through which it participates in a variety of activating or inactivating tumor‑related and tumor microenvironment‑related signaling pathways, particularly positive feedback loops and epithelial‑mesenchymal transition‑related pathways. Therefore, functioning as a proto‑oncogene or tumor suppressor gene in various types of cancer and tumor‑associated microenvironments, SQSTM1/p62 is capable of promoting or retarding malignant tumor aggression, giving rise to immeasurable effects on tumor occurrence and development, and on patient treatment and prognosis.
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October-2021
Volume 59 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Tang J, Li Y, Xia S, Li J, Yang Q, Ding K and Zhang H: Sequestosome 1/p62: A multitasker in the regulation of malignant tumor aggression (Review). Int J Oncol 59: 77, 2021
APA
Tang, J., Li, Y., Xia, S., Li, J., Yang, Q., Ding, K., & Zhang, H. (2021). Sequestosome 1/p62: A multitasker in the regulation of malignant tumor aggression (Review). International Journal of Oncology, 59, 77. https://doi.org/10.3892/ijo.2021.5257
MLA
Tang, J., Li, Y., Xia, S., Li, J., Yang, Q., Ding, K., Zhang, H."Sequestosome 1/p62: A multitasker in the regulation of malignant tumor aggression (Review)". International Journal of Oncology 59.4 (2021): 77.
Chicago
Tang, J., Li, Y., Xia, S., Li, J., Yang, Q., Ding, K., Zhang, H."Sequestosome 1/p62: A multitasker in the regulation of malignant tumor aggression (Review)". International Journal of Oncology 59, no. 4 (2021): 77. https://doi.org/10.3892/ijo.2021.5257