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Review

Lactoferrin may inhibit the development of cancer via its immunostimulatory and immunomodulatory activities (Review)

  • Authors:
    • Sian Pan
    • Huiting Weng
    • Guohong Hu
    • Shiwen Wang
    • Tian Zhao
    • Xueping Yao
    • Libin Liao
    • Xiaopeng Zhu
    • Yanshan Ge
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Zhuzhou Central Hospital, Zhuzhou, Hunan 412000, P.R. China, Department of Clinical Nursing, The Second Xiangya Hospital of Central South University, Changsha, Hunan 430011, P.R. China, Department of Histology and Embryology, School of Basic Medicine Sciences, Xinjiang Medical University, Urumqi, Xinjiang 830017, P.R. China, The Key Laboratory of Carcinogenesis and Cancer Invasion of The Chinese Ministry of Education, The Third Affiliated Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China
  • Article Number: 85
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    Published online on: September 17, 2021
       https://doi.org/10.3892/ijo.2021.5265
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Abstract

Lactoferrin (Lf) is secreted by ectodermal tissue and has a structure similar to that of transferrin. Although Lf seems to be multifunctional, its main function is related to the natural defense system of mammals. The present review aims to highlight the major actions of Lf, including the regulation of cell growth, the inhibition of toxic compound formation, the removal of harmful free radicals and its important role in immune response regulation. Moreover, Lf has antibacterial, antiviral, antioxidant, anticancer and anti‑inflammatory activities. In addition, the use of Lf for functionalization of drug nanocarriers, with emphasis on tumor‑targeted drug delivery, is illustrated. Such effects serve as an important theoretical basis for its future development and application. In neurodegenerative diseases and the brains of elderly people, Lf expression is markedly upregulated. Lf may exert an anti‑inflammatory effect by inhibiting the formation of hydroxyl free radicals. Through its antioxidant properties, Lf can prevent DNA damage, thereby preventing tumor formation in the central nervous system. In addition, Lf specifically activates the p53 tumor suppressor gene.
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1 

Rascon-Cruz Q, Espinoza-Sanchez EA, Siqueiros-Cendon TS, Nakamura-Bencomo SI, Arévalo-Gallegos S and Iglesias-Figueroa BF: Lactoferrin: A glycoprotein involved in immunomodulation, anticancer, and antimicrobial processes. Molecules. 26:2052021. View Article : Google Scholar

2 

Baker EN, Baker HM and Kidd RD: Lactoferrin and transferrin: Functional variations on a common structural framework. Biochem Cell Biol. 80:27–34. 2002. View Article : Google Scholar

3 

Lambert LA, Perri H and Meehan TJ: Evolution of duplications in the transferrin family of proteins. Comp Biochem Physiol B Biochem Mol Biol. 140:11–25. 2005. View Article : Google Scholar

4 

Pierce A, Legrand D and Mazurier J: Lactoferrin: A multifunctional protein. Med Sci (Paris). 25:361–369. 2009.In French. View Article : Google Scholar

5 

Hao L, Shan Q, Wei J, Ma F and Sun P: Lactoferrin: Major physiological functions and applications. Curr Protein Pept Sci. 20:139–144. 2019. View Article : Google Scholar

6 

Garcia-Montoya IA, Cendon TS, Arevalo-Gallegos S and Rascon-Cruz Q: Lactoferrin a multiple bioactive protein: An overview. Biochim Biophys Acta. 1820:226–236. 2012. View Article : Google Scholar

7 

Legrand D, Pierce A, Elass E, Carpentier M, Mariller C and Mazurier J: Lactoferrin structure and functions. Adv Exp Med Biol. 606:163–194. 2008. View Article : Google Scholar

8 

Yanaihara A, Toma Y, Saito H and Yanaihara T: Cell proliferation effect of lactoferrin in human endometrial stroma cells. Mol Hum Reprod. 6:469–473. 2000. View Article : Google Scholar

9 

Huang N, Bethell D, Card C, Cornish J, Marchbank T, Wyatt D, Mabery K and Playford R: Bioactive recombinant human lactoferrin, derived from rice, stimulates mammalian cell growth. In Vitro Cell Dev Biol Anim. 44:464–471. 2008. View Article : Google Scholar

10 

Siebert PD and Huang BC: Identification of an alternative form of human lactoferrin mRNA that is expressed differentially in normal tissues and tumor-derived cell lines. Proc Natl Acad Sci USA. 94:2198–2203. 1997. View Article : Google Scholar

11 

Klein G, Imreh S and Zabarovsky ER: Why do we not all die of cancer at an early age? Adv Cancer Res. 98:1–16. 2007. View Article : Google Scholar

12 

Mariller C, Hardiville S, Hoedt E, Huvent I, Pina-Canseco S and Pierce A: Delta-lactoferrin, an intracellular lactoferrin isoform that acts as a transcription factor. Biochem Cell Biol. 90:307–319. 2012. View Article : Google Scholar

13 

Tsuda H, Ohshima Y, Nomoto H, Fujita K, Matsuda E, Iigo M, Takasuka N and Moore MA: Cancer prevention by natural compounds. Drug Metab Pharmacokinet. 19:245–263. 2004. View Article : Google Scholar

14 

Guedes JP, Pereira CS, Rodrigues LR and Corte-Real M: Bovine milk lactoferrin selectively kills highly metastatic prostate cancer PC-3 and osteosarcoma MG-63 cells in vitro. Front Oncol. 8:2002018. View Article : Google Scholar

15 

Gonzalez-Chavez SA, Arevalo-Gallegos S and Rascon-Cruz Q: Lactoferrin: Structure, function and applications. Int J Antimicrob Agents. 33:301.e1–e8. 2009. View Article : Google Scholar

16 

Actor JK, Hwang SA and Kruzel ML: Lactoferrin as a natural immune modulator. Curr Pharm Des. 15:1956–1973. 2009. View Article : Google Scholar

17 

Appelmelk BJ, An YQ, Geerts M, Thijs BG, de Boer HA, MacLaren DM, de Graaff J and Nuijens JH: Lactoferrin is a lipid A-binding protein. Infect Immun. 62:2628–2632. 1994. View Article : Google Scholar

18 

Elass-Rochard E, Roseanu A, Legrand D, Trif M, Salmon V, Motas C, Montreuil J and Spik G: Lactoferrin-lipopolysaccharide interaction: Involvement of the 28-34 loop region of human lactoferrin in the high-affinity binding to Escherichia coli 055B5 lipopolysaccharide. Biochem J. 312:839–845. 1995. View Article : Google Scholar

19 

Hu P, Zhao F, Wang J and Zhu W: Lactoferrin attenuates lipopolysaccharide-stimulated inflammatory responses and barrier impairment through the modulation of NF-kappaB/MAPK/Nrf2 pathways in IPEC-J2 cells. Food Funct. 11:8516–8526. 2020. View Article : Google Scholar

20 

Baker HM and Baker EN: A structural perspective on lactoferrin function. Biochem Cell Biol. 90:320–328. 2012. View Article : Google Scholar

21 

Cools-Lartigue J, Spicer J, McDonald B, Gowing S, Chow S, Giannias B, Bourdeau F, Kubes P and Ferri L: Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis. J Clin Invest. 123:3446–3458. 2013. View Article : Google Scholar

22 

van der Does AM, Hensbergen PJ, Bogaards SJ, Cansoy M, Deelder AM, van Leeuwen HC, Drijfhout JW, van Dissel JT and Nibbering PH: The human lactoferrin-derived peptide hLF1-11 exerts immunomodulatory effects by specific inhibition of myeloperoxidase activity. J Immunol. 188:5012–5019. 2012. View Article : Google Scholar

23 

Park HW, Park SH, Jo HJ, Kim TG, Lee JH, Kang SG, Jang YS and Kim PH: Lactoferrin induces tolerogenic bone marrow-derived dendritic cells. Immune Netw. 20:e382020. View Article : Google Scholar

24 

Eipper S, Steiner R, Lesner A, Sienczyk M, Palesch D, Halatsch ME, Zaczynska E, Heim C, Hartmann MD, Zimecki M, et al: Lactoferrin is an allosteric enhancer of the proteolytic activity of cathepsin G. PLoS One. 11:e1515092016. View Article : Google Scholar

25 

Penco S, Scarfi S, Giovine M, Damonte G, Millo E, Villaggio B, Passalacqua M, Pozzolini M, Garrè C and Benatti U: Identification of an import signal for, and the nuclear localization of, human lactoferrin. Biotechnol Appl Biochem. 34:151–159. 2001. View Article : Google Scholar

26 

Vogel HJ: Lactoferrin, a bird's eye view. Biochem Cell Biol. 90:233–244. 2012. View Article : Google Scholar

27 

Takayama Y and Aoki R: Roles of lactoferrin on skin wound healing. Biochem Cell Biol. 90:497–503. 2012. View Article : Google Scholar

28 

Kabanov AV and Batrakova EV: New technologies for drug delivery across the blood brain barrier. Curr Pharm Des. 10:1355–1363. 2004. View Article : Google Scholar

29 

Elzoghby AO, Abdelmoneem MA, Hassanin IA, Abd Elwakil MM, Elnaggar MA, Mokhtar S, Fang JY and Elkhodairy KA: Lactoferrin, a multi-functional glycoprotein: Active therapeutic, drug nanocarrier & targeting ligand. Biomaterials. 263:1203552020. View Article : Google Scholar

30 

Thangavel P, Ramachandran B, Chakraborty S, Kannan R, Lonchin S and Muthuvijayan V: Accelerated healing of diabetic wounds treated with L-Glutamic acid loaded hydrogels through enhanced collagen deposition and angiogenesis: An in vivo study. Sci Rep. 7:107012017. View Article : Google Scholar

31 

Iigo M, Alexander DB, Long N, Xu J, Fukamachi K, Futakuchi M, Takase M and Tsuda H: Anticarcinogenesis pathways activated by bovine lactoferrin in the murine small intestine. Biochimie. 91:86–101. 2009. View Article : Google Scholar

32 

Xu XX, Jiang HR, Li HB, Zhang TN, Zhou Q and Liu N: Apoptosis of stomach cancer cell SGC-7901 and regulation of Akt signaling way induced by bovine lactoferrin. J Dairy Sci. 93:2344–2350. 2010. View Article : Google Scholar

33 

Wong SH, Francis N, Chahal H, Raza K, Salmon M, Scheel-Toellner D and Lord JM: Lactoferrin is a survival factor for neutrophils in rheumatoid synovial fluid. Rheumatology (Oxford). 48:39–44. 2009. View Article : Google Scholar

34 

Kruzel ML, Zimecki M and Actor JK: Lactoferrin in a context of inflammation-induced pathology. Front Immunol. 8:14382017. View Article : Google Scholar

35 

Bournazou I, Pound JD, Duffin R, Bournazos S, Melville LA, Brown SB, Rossi AG and Gregory CD: Apoptotic human cells inhibit migration of granulocytes via release of lactoferrin. J Clin Invest. 119:20–32. 2009.

36 

Bezault J, Bhimani R, Wiprovnick J and Furmanski P: Human lactoferrin inhibits growth of solid tumors and development of experimental metastases in mice. Cancer Res. 54:2310–2312. 1994.PubMed/NCBI

37 

Damiens E, Mazurier J, el Yazidi I, Masson M, Duthille I, Spik G and Boilly-Marer Y: Effects of human lactoferrin on NK cell cytotoxicity against haematopoietic and epithelial tumour cells. Biochim Biophys Acta. 1402:277–287. 1998. View Article : Google Scholar

38 

Shi H and Li W: Inhibitory effects of human lactoferrin on U14 cervical carcinoma through upregulation of the immune response. Oncol Lett. 7:820–826. 2014. View Article : Google Scholar

39 

Iyer S, Yip TT, Hutchens TW and Lonnerdal B: Lactoferrin-receptor interaction. Effect of surface exposed histidine residues. Adv Exp Med Biol. 357:245–252. 1994. View Article : Google Scholar

40 

Rastogi N, Singh A, Pandey SN, Sinha M, Bhushan A, Kaur P, Sharma S and Singh TP: Structure of the iron-free true C-terminal half of bovine lactoferrin produced by tryptic digestion and its functional significance in the gut. FEBS J. 281:2871–2882. 2014. View Article : Google Scholar

41 

Teng CT: Factors regulating lactoferrin gene expression. Biochem Cell Biol. 84:263–267. 2006. View Article : Google Scholar

42 

Ieni A, Barresi V, Licata L, Cardia R, Fazzari C, Nuciforo G, Caruso F, Caruso M, Adamo V and Tuccari G: Immunoexpression of lactoferrin in triple-negative breast cancer patients: A proposal to select a less aggressive subgroup. Oncol Lett. 13:3205–3209. 2017. View Article : Google Scholar

43 

Tsuda H, Kozu T, Iinuma G, Ohashi Y, Saito Y, Saito D, Akasu T, Alexander DB, Futakuchi M, Fukamachi K, et al: Cancer prevention by bovine lactoferrin: From animal studies to human trial. Biometals. 23:399–409. 2010. View Article : Google Scholar

44 

Gibbons JA, Kanwar RK and Kanwar JR: Lactoferrin and cancer in different cancer models. Front Biosci (Schol Ed). 3:1080–1088. 2011. View Article : Google Scholar

45 

Digumarti R, Wang Y, Raman G, Doval DC, Advani SH, Julka PK, Parikh PM, Patil S, Nag S, Madhavan J, et al: A randomized, double-blind, placebo-controlled, phase II study of oral talactoferrin in combination with carboplatin and paclitaxel in previously untreated locally advanced or metastatic non-small cell lung cancer. J Thorac Oncol. 6:1098–1103. 2011. View Article : Google Scholar

46 

Hoedt E, Hardiville S, Mariller C, Elass E, Perraudin JP and Pierce A: Discrimination and evaluation of lactoferrin and delta-lactoferrin gene expression levels in cancer cells and under inflammatory stimuli using TaqMan real-time PCR. Biometals. 23:441–452. 2010. View Article : Google Scholar

47 

Zadvornyi TV, Lukianova NY, Borikun TV and Chekhun VF: Effects of exogenous lactoferrin on phenotypic profile and invasiveness of human prostate cancer cells (DU145 and LNCaP) in vitro. Exp Oncol. 40:184–189. 2018. View Article : Google Scholar

48 

Cutone A, Ianiro G, Lepanto MS, Rosa L, Valenti P, Bonaccorsi di Patti MC and Musci G: Lactoferrin in the prevention and treatment of intestinal inflammatory pathologies associated with colorectal cancer development. Cancers (Basel). 12:38062020. View Article : Google Scholar

49 

Duchardt F, Ruttekolk IR, Verdurmen WP, Lortat-Jacob H, Bürck J, Hufnagel H, Fischer R, van den Heuvel M, Löwik DW, Vuister GW, et al: A cell-penetrating peptide derived from human lactoferrin with conformation-dependent uptake efficiency. J biol Chem. 284:36099–36108. 2009. View Article : Google Scholar

50 

Riedl S, Leber R, Rinner B, Schaider H, Lohner K and Zweytick D: Human lactoferricin derived di-peptides deploying loop structures induce apoptosis specifically in cancer cells through targeting membranous phosphatidylserine. Biochim Biophys Acta. 1848:2918–2931. 2015. View Article : Google Scholar

51 

Kühnle A, Veelken R, Galuska CE, Saftenberger M, Verleih M, Schuppe HC, Rudloff S, Kunz C and Galuska SP: Polysialic acid interacts with lactoferrin and supports its activity to inhibit the release of neutrophil extracellular traps. Carbohydr Polym. 208:32–41. 2019. View Article : Google Scholar

52 

El YI, Legrand D, Nuijens J, Slomianny MC, van Berkel P and Spik G: The binding of lactoferrin to glycosaminoglycans on enterocyte-like HT29-18-C1 cells is mediated through basic residues located in the N-terminus. Biochim Biophys Acta. 1568:197–204. 2001. View Article : Google Scholar

53 

Jiang R and Lönnerdal B: Bovine lactoferrin and lactoferricin exert antitumor activities on human colorectal cancer cells (HT-29) by activating various signaling pathways. Biochem Cell Biol. 95:99–109. 2017. View Article : Google Scholar

54 

Sharma A, Shandilya UK, Sodhi M, Mohanty AK, Jain P and Mukesh M: Evaluation of milk colostrum derived lactoferrin of sahiwal (Bos indicus) and karan fries (Cross-Bred) cows for its anti-cancerous potential. Int J Mol Sci. 20:63182019. View Article : Google Scholar

55 

Arias M, Hilchie AL, Haney EF, Bolscher JG, Hyndman ME, Hancock RE and Vogel HJ: Anticancer activities of bovine and human lactoferricin-derived peptides. Biochem Cell Biol. 95:91–98. 2017. View Article : Google Scholar

56 

Zhou Y, Zeng Z, Zhang W, Xiong W, Wu M, Tan Y, Yi W, Xiao L, Li X, Huang C, et al: Lactotransferrin: A candidate tumor suppressor-Deficient expression in human nasopharyngeal carcinoma and inhibition of NPC cell proliferation by modulating the mitogen-activated protein kinase pathway. INT J Cancer. 123:2065–2072. 2008. View Article : Google Scholar

57 

Onishi J, Roy MK, Juneja LR, Watanabe Y and Tamai Y: A lactoferrin-derived peptide with cationic residues concentrated in a region of its helical structure induces necrotic cell death in a leukemic cell line (HL-60). J Pept Sci. 14:1032–1038. 2008. View Article : Google Scholar

58 

Lee SH, Park SW, Pyo CW, Yoo NK, Kim J and Choi SY: Requirement of the JNK-associated Bcl-2 pathway for human lactoferrin-induced apoptosis in the Jurkat leukemia T cell line. Biochimie. 91:102–108. 2009. View Article : Google Scholar

59 

Fujita K, Matsuda E, Sekine K, Iigo M and Tsuda H: Lactoferrin enhances Fas expression and apoptosis in the colon mucosa of Azoxymethane-treated rats. Carcinogenesis. 25:1961–1966. 2004. View Article : Google Scholar

60 

Gopal SH and Das SK: Role of lactoferrin in the carcinogenesis of triple-negative breast cancer. J Cancer Clin Trials. 1:e1052016.

61 

Velliyagounder K, Bahdila D, Pawar S and Fine DH: Role of lactoferrin and lactoferrin-derived peptides in oral and maxillofacial diseases. Oral Dis. 25:652–669. 2019. View Article : Google Scholar

62 

Damiens E, El YI, Mazurier J, Duthille I, Spik G and Boilly-Marer Y: Lactoferrin inhibits G1 cyclin-dependent kinases during growth arrest of human breast carcinoma cells. J Cell Biochem. 74:486–498. 1999. View Article : Google Scholar

63 

Ibrahim HM, Mohamed AH, Salem ML, Osman GY and Morsi DS: Anti-neoplastic and immunomodulatory potency of co-treatment based on bovine lactoferrin and/or muramyl dipeptide in tumor-bearing mice. Toxicol Res (Camb). 9:137–147. 2020. View Article : Google Scholar

64 

Sangermano R, Pernarella S, Straker M, Lepanto MS, Rosa L, Cutone A, Valenti P and Ottolenghi L: The treatment of black stain associated with of iron metabolism disorders with lactoferrin: A litterature search and two case studies. Clin Ter. 170:e373–e381. 2019.PubMed/NCBI

65 

Li HY, Li M, Luo CC, Wang JQ and Zheng N: Lactoferrin exerts antitumor effects by inhibiting angiogenesis in a HT29 human colon tumor model. J Agric Food Chem. 65:10464–10472. 2017. View Article : Google Scholar

66 

Tammam SN, Azzazy H and Lamprecht A: Nuclear and cytoplasmic delivery of lactoferrin in glioma using chitosan nanoparticles: Cellular location dependent-action of lactoferrin. Eur J Pharm Biopharm. 129:74–79. 2018. View Article : Google Scholar

67 

Golla K, Bhaskar C, Ahmed F and Kondapi AK: A target-specific oral formulation of Doxorubicin-protein nanoparticles: Efficacy and safety in hepatocellular cancer. J Cancer. 4:644–652. 2013. View Article : Google Scholar

68 

Sabra S and Agwa MM: Lactoferrin, a unique molecule with diverse therapeutical and nanotechnological applications. Int J Biol Macromol. 164:1046–1060. 2020. View Article : Google Scholar

69 

Song MM, Xu HL, Liang JX, Xiang HH, Liu R and Shen YX: Lactoferrin modified graphene oxide iron oxide nanocomposite for glioma-targeted drug delivery. Mater Sci Eng C Mater Biol Appl. 77:904–911. 2017. View Article : Google Scholar

70 

Tomitaka A, Arami H, Gandhi S and Krishnan KM: Lactoferrin conjugated iron oxide nanoparticles for targeting brain glioma cells in magnetic particle imaging. Nanoscale. 7:16890–16898. 2015. View Article : Google Scholar

71 

Zhang M, Asghar S, Tian C, Hu Z, Ping Q, Chen Z, Shao F and Xiao Y: Lactoferrin/phenylboronic acid-functionalized hyaluronic acid nanogels loading doxorubicin hydrochloride for targeting glioma. Carbohydr Polym. 253:1171942021. View Article : Google Scholar

72 

Yin Y, Fu C, Li M, Li X, Wang M, He L, Zhang LM and Peng Y: A pH-sensitive hyaluronic acid prodrug modified with lactoferrin for glioma dual-targeted treatment. Mater Sci Eng C Mater Biol Appl. 67:159–169. 2016. View Article : Google Scholar

73 

Guan Q: A comprehensive review and update on the pathogenesis of inflammatory bowel disease. J Immunol Res. 2019:72472382019. View Article : Google Scholar

74 

Frioni A, Conte MP, Cutone A, Longhi C, Musci G, di Patti MC, Natalizi T, Marazzato M, Lepanto MS, Puddu P, et al: Lactoferrin differently modulates the inflammatory response in epithelial models mimicking human inflammatory and infectious diseases. Biometals. 27:843–856. 2014. View Article : Google Scholar

75 

Sessa R, Di Pietro M, Filardo S, Bressan A, Rosa L, Cutone A, Frioni A, Berlutti F, Paesano R and Valenti P: Effect of bovine lactoferrin on chlamydia trachomatis infection and inflammation. Biochem Cell Biol. 95:34–40. 2017. View Article : Google Scholar

76 

Valenti P, Frioni A, Rossi A, Ranucci S, De Fino I, Cutone A, Rosa L, Bragonzi A and Berlutti F: Aerosolized bovine lactoferrin reduces neutrophils and pro-inflammatory cytokines in mouse models of Pseudomonas aeruginosa lung infections. Biochem Cell Biol. 95:41–47. 2017. View Article : Google Scholar

77 

Svendsen J, Grant TM, Rennison D, Brimble MA and Svenson J: Very short and stable lactoferricin-derived antimicrobial peptides: Design principles and potential uses. Acc Chem Res. 52:749–759. 2019. View Article : Google Scholar

78 

Dial EJ, Romero JJ, Headon DR and Lichtenberger LM: Recombinant human lactoferrin is effective in the treatment of Helicobacter Felis-infected mice. J Pharm Pharmacol. 52:1541–1546. 2000. View Article : Google Scholar

79 

Rodríguez-Franco DA, Vázquez-Moreno L and Ramos-Clamont MG: Antimicrobial mechanisms and potential clinical application of lactoferrin. Rev Latinoam Microbiol. 47:102–111. 2005.In Spanish.

80 

Ellison RR and Giehl TJ: Killing of gram-negative bacteria by lactoferrin and lysozyme. J Clin Invest. 88:1080–1091. 1991. View Article : Google Scholar

81 

Dhaenens L, Szczebara F and Husson MO: Identification, characterization, and immunogenicity of the lactoferrin-binding protein from Helicobacter pylori. Infect Immun. 65:514–518. 1997. View Article : Google Scholar

82 

Kuipers ME, de Vries HG, Eikelboom MC, Meijer DK and Swart PJ: Synergistic fungistatic effects of lactoferrin in combination with antifungal drugs against clinical Candida isolates. Antimicrob Agents Chemother. 43:2635–2641. 1999. View Article : Google Scholar

83 

Hakansson A, Roche H, Mirza S, McDaniel LS, Brooks-Walter A and Briles DE: Characterization of binding of human lactoferrin to pneumococcal surface protein A. Infect Immun. 69:3372–3381. 2001. View Article : Google Scholar

84 

van der Strate BW, Beljaars L, Molema G, Harmsen MC and Meijer DK: Antiviral activities of lactoferrin. Antiviral Res. 52:225–239. 2001. View Article : Google Scholar

85 

Campione E, Cosio T, Rosa L, Lanna C, Di Girolamo S, Gaziano R, Valenti P and Bianchi L: Lactoferrin as protective natural barrier of respiratory and intestinal mucosa against coronavirus infection and inflammation. Int J Mol Sci. 21:49032020. View Article : Google Scholar

86 

Kell DB, Heyden EL and Pretorius E: The biology of lactoferrin, an iron-binding protein that can help defend against viruses and bacteria. Front Immunol. 11:12212020. View Article : Google Scholar

87 

Fu Q, Sun J, Zhang W, Sui X, Yan Z and He Z: Nanoparticle albumin-bound (NAB) technology is a promising method for anti-cancer drug delivery. Recent Pat Anticancer Drug Discov. 4:262–272. 2009. View Article : Google Scholar

88 

Yi M, Kaneko S, Yu DY and Murakami S: Hepatitis C virus envelope proteins bind lactoferrin. J Virol. 71:5997–6002. 1997. View Article : Google Scholar

89 

Bennett RM, Merritt MM and Gabor G: Lactoferrin binds to neutrophilic membrane DNA. Br J Haematol. 63:105–117. 1986. View Article : Google Scholar

90 

He J and Furmanski P: Sequence specificity and transcriptional activation in the binding of lactoferrin to DNA. Nature. 373:721–724. 1995. View Article : Google Scholar

91 

Brandl N, Zemann A, Kaupe I, Marlovits S, Huettinger P, Goldenberg H and Huettinger M: Signal transduction and metabolism in chondrocytes is modulated by lactoferrin. Osteoarthritis Cartilage. 18:117–125. 2010. View Article : Google Scholar

92 

Kanyshkova TG, Babina SE, Semenov DV, Isaeva N, Vlassov AV, Neustroev KN, Kul'minskaya AA, Buneva VN and Nevinsky GA: Multiple enzymic activities of human milk lactoferrin. Eur J Biochem. 270:3353–3361. 2003. View Article : Google Scholar

93 

Fang JH, Lai YH, Chiu TL, Chen YY, Hu SH and Chen SY: Magnetic core-shell nanocapsules with dual-targeting capabilities and co-delivery of multiple drugs to treat brain gliomas. Adv Healthc Mater. 3:1250–1260. 2014. View Article : Google Scholar

94 

Wei M, Guo X, Tu L, Zou Q, Li Q, Tang C, Chen B, Xu Y and Wu C: Lactoferrin-modified PEGylated liposomes loaded with doxorubicin for targeting delivery to hepatocellular carcinoma. Int J Nanomedicine. 10:5123–5137. 2015.PubMed/NCBI

95 

Golla K, Cherukuvada B, Ahmed F and Kondapi AK: Efficacy, safety and anticancer activity of protein nanoparticle-based delivery of doxorubicin through intravenous administration in rats. PLoS One. 7:e519602012. View Article : Google Scholar

96 

Kumar P, Lakshmi YS, C B, Golla K and Kondapi AK: Improved safety, bioavailability and pharmacokinetics of zidovudine through lactoferrin nanoparticles during oral administration in rats. PLoS One. 10:e1403992015. View Article : Google Scholar

97 

Kumari S and Kondapi AK: Receptor-mediated targeted delivery of DNA using Lactoferrin nanoparticles. Int J Biol Macromol. 108:401–407. 2018. View Article : Google Scholar

98 

Elfinger M, Maucksch C and Rudolph C: Characterization of lactoferrin as a targeting ligand for nonviral gene delivery to airway epithelial cells. Biomaterials. 28:3448–3455. 2007. View Article : Google Scholar

99 

Yan JK, Qiu WY, Wang YY and Wu JY: Biocompatible polyelectrolyte complex nanoparticles from lactoferrin and pectin as potential vehicles for antioxidative curcumin. J Agric Food Chem. 65:5720–5730. 2017. View Article : Google Scholar

100 

Wang J, Li Q, Li K, Ou Y, Han Z, Gao D and Li J: Effects of adenovirus vectors mediated human lactoferrin cDNA on mice bearing EMT6 breast carcinoma. Pharmazie. 66:704–709. 2011.

101 

Pereira CS, Guedes JP, Goncalves M, Loureiro L, Castro L, Gerós H, Rodrigues LR and Côrte-Real M: Lactoferrin selectively triggers apoptosis in highly metastatic breast cancer cells through inhibition of plasmalemmal V-H+-ATPase. Oncotarget. 7:62144–62158. 2016. View Article : Google Scholar

102 

Lonnerdal B, Jiang R and Du X: Bovine lactoferrin can be taken up by the human intestinal lactoferrin receptor and exert bioactivities. J Pediatr Gastroenterol Nutr. 53:606–614. 2011. View Article : Google Scholar

103 

Machado S, Alves R, Lima M, Leal I and Massa A: Cutaneous necrobiotic xanthogranuloma (NXG)-successfully treated with low dose chlorambucil. Eur J Dermatol. 11:458–462. 2001.PubMed/NCBI

104 

Arcella A, Oliva MA, Staffieri S, Aalberti S, Grillea G, Madonna M, Bartolo M, Pavone L, Giangaspero F, Cantore G and Frati A: In vitro and in vivo effect of human lactoferrin on glioblastoma growth. J Neurosurg. 123:1026–1035. 2015. View Article : Google Scholar

105 

Son HJ, Lee SH and Choi SY: Human lactoferrin controls the level of retinoblastoma protein and its activity. Biochem Cell Biol. 84:345–350. 2006. View Article : Google Scholar

106 

Tung YT, Chen HL, Yen CC, Lee PY, Tsai HC, Lin MF and Chen CM: Bovine lactoferrin inhibits lung cancer growth through suppression of both inflammation and expression of vascular endothelial growth factor. J Dairy Sci. 96:2095–2106. 2013. View Article : Google Scholar

107 

Deng M, Zhang W, Tang H, Ye Q, Liao Q, Zhou Y, Wu M, Xiong W, Zheng Y, Guo X, et al: Lactotransferrin acts as a tumor suppressor in nasopharyngeal carcinoma by repressing AKT through multiple mechanisms. Oncogene. 32:4273–4283. 2013. View Article : Google Scholar

108 

Chea C, Miyauchi M, Inubushi T, Febriyanti Ayuningtyas N, Subarnbhesaj A, Nguyen PT, Shrestha M, Haing S, Ohta K and Takata T: Molecular mechanism of inhibitory effects of bovine lactoferrin on the growth of oral squamous cell carcinoma. PLoS One. 13:e1916832018. View Article : Google Scholar

109 

Sabra SA, Elzoghby AO, Sheweita SA, Haroun M, Helmy MW, Eldemellawy MA, Xia Y, Goodale D, Allan AL and Rohani S: Self-assembled amphiphilic zein-lactoferrin micelles for tumor targeted co-delivery of rapamycin and wogonin to breast cancer. Eur J Pharm Biopharm. 128:156–169. 2018. View Article : Google Scholar

110 

Sabra SA, Sheweita SA, Haroun M, Ragab D, Eldemellawy MA, Xia Y, Goodale D, Allan AL, Elzoghby AO and Rohani S: Magnetically guided self-assembled protein micelles for enhanced delivery of dasatinib to human triple-negative breast cancer cells. J Pharm Sci. 108:1713–1725. 2019. View Article : Google Scholar

111 

Abd Elwakil MM, Mabrouk MT, Helmy MW, Abdelfattah EA, Khiste SK, Elkhodairy KA and Elzoghby AO: Inhalable lactoferrin-chondroitin nanocomposites for combined delivery of doxorubicin and ellagic acid to lung carcinoma. Nanomedicine (Lond). 13:2015–2035. 2018. View Article : Google Scholar

112 

Kumari S, Ahsan SM, Kumar JM, Kondapi AK and Rao NM: Overcoming blood brain barrier with a dual purpose Temozolomide loaded lactoferrin nanoparticles for combating glioma (SERP-17-12433). Sci Rep. 7:66022017. View Article : Google Scholar

113 

Kumari S and Kondapi AK: Lactoferrin nanoparticle mediated targeted delivery of 5-fluorouracil for enhanced therapeutic efficacy. Int J Biol Macromol. 95:232–237. 2017. View Article : Google Scholar

114 

Wang H, Tang Y, Fang Y, Zhang M, Wang H, He Z, Wang B, Xu Q and Huang Y: Reprogramming Tumor Immune Microenvironment (TIME) and metabolism via biomimetic targeting Codelivery of Shikonin/JQ1. Nano Lett. 19:2935–2944. 2019. View Article : Google Scholar

115 

Kumar P, Lakshmi YS and Kondapi AK: An oral formulation of efavirenz-loaded lactoferrin nanoparticles with improved biodistribution and pharmacokinetic profile. HIV Med. 18:452–462. 2017. View Article : Google Scholar

116 

Zhang ZH, Wang XP, Ayman WY, Munyendo WL, Lv HX and Zhou JP: Studies on lactoferrin nanoparticles of gambogic acid for oral delivery. Drug Deliv. 20:86–93. 2013. View Article : Google Scholar

117 

Shankaranarayanan JS, Kanwar JR, Al-Juhaishi AJ and Kanwar RK: Doxorubicin conjugated to immunomodulatory anticancer lactoferrin displays improved cytotoxicity overcoming prostate cancer chemo resistance and inhibits tumour development in TRAMP mice. Sci Rep. 6:320622016. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Pan S, Weng H, Hu G, Wang S, Zhao T, Yao X, Liao L, Zhu X and Ge Y: Lactoferrin may inhibit the development of cancer via its immunostimulatory and immunomodulatory activities (Review). Int J Oncol 59: 85, 2021.
APA
Pan, S., Weng, H., Hu, G., Wang, S., Zhao, T., Yao, X. ... Ge, Y. (2021). Lactoferrin may inhibit the development of cancer via its immunostimulatory and immunomodulatory activities (Review). International Journal of Oncology, 59, 85. https://doi.org/10.3892/ijo.2021.5265
MLA
Pan, S., Weng, H., Hu, G., Wang, S., Zhao, T., Yao, X., Liao, L., Zhu, X., Ge, Y."Lactoferrin may inhibit the development of cancer via its immunostimulatory and immunomodulatory activities (Review)". International Journal of Oncology 59.5 (2021): 85.
Chicago
Pan, S., Weng, H., Hu, G., Wang, S., Zhao, T., Yao, X., Liao, L., Zhu, X., Ge, Y."Lactoferrin may inhibit the development of cancer via its immunostimulatory and immunomodulatory activities (Review)". International Journal of Oncology 59, no. 5 (2021): 85. https://doi.org/10.3892/ijo.2021.5265
Copy and paste a formatted citation
x
Spandidos Publications style
Pan S, Weng H, Hu G, Wang S, Zhao T, Yao X, Liao L, Zhu X and Ge Y: Lactoferrin may inhibit the development of cancer via its immunostimulatory and immunomodulatory activities (Review). Int J Oncol 59: 85, 2021.
APA
Pan, S., Weng, H., Hu, G., Wang, S., Zhao, T., Yao, X. ... Ge, Y. (2021). Lactoferrin may inhibit the development of cancer via its immunostimulatory and immunomodulatory activities (Review). International Journal of Oncology, 59, 85. https://doi.org/10.3892/ijo.2021.5265
MLA
Pan, S., Weng, H., Hu, G., Wang, S., Zhao, T., Yao, X., Liao, L., Zhu, X., Ge, Y."Lactoferrin may inhibit the development of cancer via its immunostimulatory and immunomodulatory activities (Review)". International Journal of Oncology 59.5 (2021): 85.
Chicago
Pan, S., Weng, H., Hu, G., Wang, S., Zhao, T., Yao, X., Liao, L., Zhu, X., Ge, Y."Lactoferrin may inhibit the development of cancer via its immunostimulatory and immunomodulatory activities (Review)". International Journal of Oncology 59, no. 5 (2021): 85. https://doi.org/10.3892/ijo.2021.5265
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