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Role of the microbiome in systemic therapy for pancreatic ductal adenocarcinoma (Review)

  • Authors:
    • Xing Huang
    • Mao Li
    • Shengzhong Hou
    • Bole Tian
  • View Affiliations / Copyright

    Affiliations: Department of Pancreatic Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 101
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    Published online on: November 2, 2021
       https://doi.org/10.3892/ijo.2021.5281
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Abstract

A large body of evidence has revealed that the microbiome serves a role in all aspects of cancer, particularly cancer treatment. To date, studies investigating the relationship between the microbiome and systemic therapy for pancreatic ductal adenocarcinoma (PDAC) are lacking. PDAC is a high‑mortality malignancy (5‑year survival rate; <9% for all stages). Systemic therapy is one of the most important treatment choices for all patients; however, resistance or toxicity can affect its efficacy. Studies have supported the hypothesis that the microbiome is closely associated with the response to systemic therapy in PDAC, including the induction of drug resistance, or toxicity and therapy‑related changes in microbiota composition. The present review comprehensively summarized the role of the microbiome in systemic therapy for PDAC and the associated molecular mechanisms in an attempt to provide a novel direction for the improvement of treatment response and proposed potential directions for in‑depth research.
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Copy and paste a formatted citation
Spandidos Publications style
Huang X, Li M, Hou S and Tian B: Role of the microbiome in systemic therapy for pancreatic ductal adenocarcinoma (Review). Int J Oncol 59: 101, 2021.
APA
Huang, X., Li, M., Hou, S., & Tian, B. (2021). Role of the microbiome in systemic therapy for pancreatic ductal adenocarcinoma (Review). International Journal of Oncology, 59, 101. https://doi.org/10.3892/ijo.2021.5281
MLA
Huang, X., Li, M., Hou, S., Tian, B."Role of the microbiome in systemic therapy for pancreatic ductal adenocarcinoma (Review)". International Journal of Oncology 59.6 (2021): 101.
Chicago
Huang, X., Li, M., Hou, S., Tian, B."Role of the microbiome in systemic therapy for pancreatic ductal adenocarcinoma (Review)". International Journal of Oncology 59, no. 6 (2021): 101. https://doi.org/10.3892/ijo.2021.5281
Copy and paste a formatted citation
x
Spandidos Publications style
Huang X, Li M, Hou S and Tian B: Role of the microbiome in systemic therapy for pancreatic ductal adenocarcinoma (Review). Int J Oncol 59: 101, 2021.
APA
Huang, X., Li, M., Hou, S., & Tian, B. (2021). Role of the microbiome in systemic therapy for pancreatic ductal adenocarcinoma (Review). International Journal of Oncology, 59, 101. https://doi.org/10.3892/ijo.2021.5281
MLA
Huang, X., Li, M., Hou, S., Tian, B."Role of the microbiome in systemic therapy for pancreatic ductal adenocarcinoma (Review)". International Journal of Oncology 59.6 (2021): 101.
Chicago
Huang, X., Li, M., Hou, S., Tian, B."Role of the microbiome in systemic therapy for pancreatic ductal adenocarcinoma (Review)". International Journal of Oncology 59, no. 6 (2021): 101. https://doi.org/10.3892/ijo.2021.5281
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