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Obesity, colorectal cancer and MACC1 expression: A possible novel molecular association

  • Authors:
    • Ina Bähr
    • Lina Jaeschke
    • Katharina Nimptsch
    • Jürgen Janke
    • Pia Herrmann
    • Dennis Kobelt
    • Heike Kielstein
    • Tobias Pischon
    • Ulrike Stein
  • View Affiliations / Copyright

    Affiliations: Institute of Anatomy and Cell Biology, Medical Faculty of Martin Luther University Halle‑Wittenberg, D‑06108 Halle (Saale), Germany, Max‑Delbrück‑Center for Molecular Medicine in The Helmholtz Association, Molecular Epidemiology Research Group, D‑13125 Berlin, Germany, Translational Oncology of Solid Tumors, Experimental and Clinical Research Center, Charité‑Universitätsmedizin Berlin and Max‑Delbrück‑Center for Molecular Medicine in The Helmholtz Association, D‑13125 Berlin, Germany
    Copyright: © Bähr et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 17
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    Published online on: January 10, 2022
       https://doi.org/10.3892/ijo.2022.5307
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Abstract

Obesity is a major and increasing public health concern, associated with an increased risk of and mortality from several types of cancer including colorectal cancer (CRC), being associated with cancer progression, metastasis and resistance to therapy. It was hypothesized that the expression of cancer/metastasis‑inducing gene metastasis‑associated in colon cancer 1 (MACC1) is increased in obesity, which may constitute a link to obesity‑induced cancer. The present study thus analyzed circulating cell‑free plasma MACC1 expression levels in human obese (vs. normal weight) adult individuals from independent studies, namely the Martin Luther University (MLU) study (n=32) and the Metabolic syndrome study (MetScan, Berlin) (n=191). Higher plasma MACC1 levels were found in obese individuals, increasing with a greater body fat mass and body mass index; these levels were predominantly observed in male and to a lesser extent in female individuals, although the results were not significant. A reduction in body fat mass following dietary intervention and physical exercise decreased the MACC1 expression levels in the MLU study. Furthermore, Wistar rats with diet‑induced obesity exhibited slightly increased plasma MACC1 levels compared with rats of normal weight. The obese Wistar rats exposed to azoxymethane to induce colon cancer exhibited a more severe colon tumor outcome, which was associated with significantly increased MACC1 levels compared with their non‑obese littermates. On the whole, the findings of the present study suggest an association between MACC1 and obesity, as well as with obesity‑induced CRC.
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Copy and paste a formatted citation
Spandidos Publications style
Bähr I, Jaeschke L, Nimptsch K, Janke J, Herrmann P, Kobelt D, Kielstein H, Pischon T and Stein U: Obesity, colorectal cancer and MACC1 expression: A possible novel molecular association. Int J Oncol 60: 17, 2022.
APA
Bähr, I., Jaeschke, L., Nimptsch, K., Janke, J., Herrmann, P., Kobelt, D. ... Stein, U. (2022). Obesity, colorectal cancer and MACC1 expression: A possible novel molecular association. International Journal of Oncology, 60, 17. https://doi.org/10.3892/ijo.2022.5307
MLA
Bähr, I., Jaeschke, L., Nimptsch, K., Janke, J., Herrmann, P., Kobelt, D., Kielstein, H., Pischon, T., Stein, U."Obesity, colorectal cancer and MACC1 expression: A possible novel molecular association". International Journal of Oncology 60.2 (2022): 17.
Chicago
Bähr, I., Jaeschke, L., Nimptsch, K., Janke, J., Herrmann, P., Kobelt, D., Kielstein, H., Pischon, T., Stein, U."Obesity, colorectal cancer and MACC1 expression: A possible novel molecular association". International Journal of Oncology 60, no. 2 (2022): 17. https://doi.org/10.3892/ijo.2022.5307
Copy and paste a formatted citation
x
Spandidos Publications style
Bähr I, Jaeschke L, Nimptsch K, Janke J, Herrmann P, Kobelt D, Kielstein H, Pischon T and Stein U: Obesity, colorectal cancer and MACC1 expression: A possible novel molecular association. Int J Oncol 60: 17, 2022.
APA
Bähr, I., Jaeschke, L., Nimptsch, K., Janke, J., Herrmann, P., Kobelt, D. ... Stein, U. (2022). Obesity, colorectal cancer and MACC1 expression: A possible novel molecular association. International Journal of Oncology, 60, 17. https://doi.org/10.3892/ijo.2022.5307
MLA
Bähr, I., Jaeschke, L., Nimptsch, K., Janke, J., Herrmann, P., Kobelt, D., Kielstein, H., Pischon, T., Stein, U."Obesity, colorectal cancer and MACC1 expression: A possible novel molecular association". International Journal of Oncology 60.2 (2022): 17.
Chicago
Bähr, I., Jaeschke, L., Nimptsch, K., Janke, J., Herrmann, P., Kobelt, D., Kielstein, H., Pischon, T., Stein, U."Obesity, colorectal cancer and MACC1 expression: A possible novel molecular association". International Journal of Oncology 60, no. 2 (2022): 17. https://doi.org/10.3892/ijo.2022.5307
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