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The impact of radiation therapy on the TCR Vβ chain repertoire in patients with prostate cancer

  • Authors:
    • Maria Goulielmaki
    • Nikolaos Davanos
    • Paraskevi Kogionou
    • Panagiota Batsaki
    • Savvas Stokidis
    • Maria Adamaki
    • Eftychia Mosa
    • Evanthia Vasilakou
    • Charalambos Zambatis
    • Angelos D. Gritzapis
    • Vassilios Zoumpourlis
    • Constantin N. Baxevanis
    • Sotirios P. Fortis
  • View Affiliations / Copyright

    Affiliations: Cancer Immunology and Immunotherapy Center, Saint Savas Cancer Hospital, 11522 Athens, Greece, ANTISEL S.A., 11527 Athens, Greece, Biomedical Applications Unit, Institute of Chemical Biology, National Hellenic Research Foundation, 11635 Athens, Greece, Department of Radiation Oncology, Saint Savas Cancer Hospital, 11522 Athens, Greece
    Copyright: © Goulielmaki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 71
    |
    Published online on: April 21, 2022
       https://doi.org/10.3892/ijo.2022.5361
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Abstract

Radiation therapy (RT) is an essential component in the therapeutic treatment of patients with localized prostate cancer (LPCa). Besides its local effects, ionizing radiation has been linked to mechanisms leading to systemic immune activation. The present study explored the effect of RT on the T‑cell receptor variable β (TCR Vβ) chain repertoire of peripheral blood T cells in patients with LPCa. High‑throughput TCR Vβ sequencing was performed on 20 blood samples collected from patients with LPCa at baseline and 3 months post‑RT. The diversity index was altered, as were TCR Vβ clonal evenness and convergence before and post‑RT; however, these findings were not significant. Notably, marked changes in the frequencies among the top 10 TCR Vβ clonotypes were detected and some patients developed new clonotypes of high abundance. These data provided initial evidence that RT in patients with LPCa may induce systemic immune changes, which could be exploited by future therapies for improved clinical results.
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Copy and paste a formatted citation
Spandidos Publications style
Goulielmaki M, Davanos N, Kogionou P, Batsaki P, Stokidis S, Adamaki M, Mosa E, Vasilakou E, Zambatis C, Gritzapis AD, Gritzapis AD, et al: The impact of radiation therapy on the TCR Vβ chain repertoire in patients with prostate cancer. Int J Oncol 60: 71, 2022.
APA
Goulielmaki, M., Davanos, N., Kogionou, P., Batsaki, P., Stokidis, S., Adamaki, M. ... Fortis, S.P. (2022). The impact of radiation therapy on the TCR Vβ chain repertoire in patients with prostate cancer. International Journal of Oncology, 60, 71. https://doi.org/10.3892/ijo.2022.5361
MLA
Goulielmaki, M., Davanos, N., Kogionou, P., Batsaki, P., Stokidis, S., Adamaki, M., Mosa, E., Vasilakou, E., Zambatis, C., Gritzapis, A. D., Zoumpourlis, V., Baxevanis, C. N., Fortis, S. P."The impact of radiation therapy on the TCR Vβ chain repertoire in patients with prostate cancer". International Journal of Oncology 60.6 (2022): 71.
Chicago
Goulielmaki, M., Davanos, N., Kogionou, P., Batsaki, P., Stokidis, S., Adamaki, M., Mosa, E., Vasilakou, E., Zambatis, C., Gritzapis, A. D., Zoumpourlis, V., Baxevanis, C. N., Fortis, S. P."The impact of radiation therapy on the TCR Vβ chain repertoire in patients with prostate cancer". International Journal of Oncology 60, no. 6 (2022): 71. https://doi.org/10.3892/ijo.2022.5361
Copy and paste a formatted citation
x
Spandidos Publications style
Goulielmaki M, Davanos N, Kogionou P, Batsaki P, Stokidis S, Adamaki M, Mosa E, Vasilakou E, Zambatis C, Gritzapis AD, Gritzapis AD, et al: The impact of radiation therapy on the TCR Vβ chain repertoire in patients with prostate cancer. Int J Oncol 60: 71, 2022.
APA
Goulielmaki, M., Davanos, N., Kogionou, P., Batsaki, P., Stokidis, S., Adamaki, M. ... Fortis, S.P. (2022). The impact of radiation therapy on the TCR Vβ chain repertoire in patients with prostate cancer. International Journal of Oncology, 60, 71. https://doi.org/10.3892/ijo.2022.5361
MLA
Goulielmaki, M., Davanos, N., Kogionou, P., Batsaki, P., Stokidis, S., Adamaki, M., Mosa, E., Vasilakou, E., Zambatis, C., Gritzapis, A. D., Zoumpourlis, V., Baxevanis, C. N., Fortis, S. P."The impact of radiation therapy on the TCR Vβ chain repertoire in patients with prostate cancer". International Journal of Oncology 60.6 (2022): 71.
Chicago
Goulielmaki, M., Davanos, N., Kogionou, P., Batsaki, P., Stokidis, S., Adamaki, M., Mosa, E., Vasilakou, E., Zambatis, C., Gritzapis, A. D., Zoumpourlis, V., Baxevanis, C. N., Fortis, S. P."The impact of radiation therapy on the TCR Vβ chain repertoire in patients with prostate cancer". International Journal of Oncology 60, no. 6 (2022): 71. https://doi.org/10.3892/ijo.2022.5361
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