Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
July-2022 Volume 61 Issue 1

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2022 Volume 61 Issue 1

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

MDIG, a 2‑oxoglutarate‑dependent oxygenase, acts as an oncogene and predicts the prognosis of multiple types of cancer

  • Authors:
    • Feng Geng
    • Wei Yang
    • Dandan Song
    • Haijia Hou
    • Bing Han
    • Yecheng Chen
    • Hongwen Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Pulmonary and Critical Care Medicine, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of Pulmonary and Critical Care Medicine, General Hospital of Northern Theatre Command, Shenyang, Liaoning 110001, P.R. China
    Copyright: © Geng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 82
    |
    Published online on: May 17, 2022
       https://doi.org/10.3892/ijo.2022.5372
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Recent studies have indicated that mineral dust‑induced gene (MDIG) is an oncogene induced by environmental factors, which has a key role in the development and progression of various tumor types, through epigenetic modifications; however, there are no previous pan‑cancer analyses of MDIG. In the present study, a comprehensive pan‑cancer analysis of MDIG was performed using public databases. The results demonstrated that MDIG was upregulated in tumor tissue samples compared with normal tissue, that it was present in all cancer cell lines and it was closely associated with the prognosis of patients with different tumor types. Furthermore, MDIG expression was closely associated with the immunological characteristics of the tumor microenvironment (TME), such as the frequency of tumor‑infiltrating immune cells, TME‑relevant signatures, immunostimulatory genes, immune checkpoint genes, chemokine receptor genes, tumor mutational burden and microsatellite instability. In parallel, high expression of MDIG was associated with improved overall survival of patients and this was verified in a cohort of patients who had received anti‑programmed cell death 1 ligand 1 treatment. Furthermore, high expression of MDIG led to multiple drug resistance in The Cancer Genome Atlas‑lung adenocarcinoma cohort. In addition, gene set variant analysis and gene set enrichment analysis indicated that MDIG was involved in cell cycle regulation. In vitro experiments suggested that MDIG promoted cell proliferation through the mTOR complex 2/Akt and pyruvate dehydrogenase kinase 1/Akt signaling pathways. In summary, the present study suggests that MDIG may be a prognostic biomarker and therapeutic target for various cancer types.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

Figure 10

Figure 11

Figure 12

Figure 13

View References

1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar

2 

Wu K, Li L, Thakur C, Lu Y, Zhang X, Yi Z and Chen F: Proteomic characterization of the world trade center dust-activated mdig and c-myc signaling circuit linked to multiple myeloma. Sci Rep. 6:363052016. View Article : Google Scholar

3 

Zhang Y, Lu Y, Yuan BZ, Castranova V, Shi X, Stauffer JL, Demers LM and Chen F: The Human mineral dust-induced gene, mdig, is a cell growth regulating gene associated with lung cancer. Oncogene. 24:4873–4882. 2005. View Article : Google Scholar

4 

Sun J, Yu M, Lu Y, Thakur C, Chen B, Qiu P, Zhao H and Chen F: Carcinogenic metalloid arsenic induces expression of mdig oncogene through JNK and STAT3 activation. Cancer Lett. 346:257–263. 2014. View Article : Google Scholar

5 

Thakur C, Wolfarth M, Sun J, Zhang Y, Lu Y, Battelli L, Porter DW and Chen F: Oncoprotein mdig contributes to silica-induced pulmonary fibrosis by altering balance between Th17 and Treg T cells. Oncotarget. 6:3722–3736. 2015. View Article : Google Scholar

6 

Tsuneoka M, Koda Y, Soejima M, Teye K and Kimura H: A novel myc target gene, mina53, that is involved in cell proliferation. J Biol Chem. 277:35450–35459. 2002. View Article : Google Scholar

7 

Eilbracht J, Kneissel S, Hofmann A and Schmidt-Zachmann MS: Protein NO52-a constitutive nucleolar component sharing high sequence homologies to protein NO66. Eur J Cell Biol. 84:279–294. 2005. View Article : Google Scholar

8 

Chowdhury R, Sekirnik R, Brissett NC, Krojer T, Ho CH, Ng SG, Clifton LJ, Ge W, Kershaw NJ, Fox GC, et al: Ribosomal oxygenases are structurally conserved from prokaryotes to humans. Nature. 510:422–426. 2014. View Article : Google Scholar

9 

Aziz N, Hong YH, Jo M, Kim JK, Kim KH, Ashktorab H, Smoot DT, Hur H, Yoo BC and Cho AJY: Molecular signatures of JMJD10/MINA53 in gastric cancer. Cancers. 12:11412020. View Article : Google Scholar

10 

Ge W, Wolf A, Feng T, Ho CH, Sekirnik R, Zayer A, Granatino N, Cockman ME, Loenarz C and Loik ND: Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans. Nat Chem Biol. 8:960–962. 2012. View Article : Google Scholar

11 

Zhang Q, Thakur C, Shi J, Sun J, Fu Y, Stemmer P and Chen F: New discoveries of mdig in the epigenetic regulation of cancers. Semin Cancer Biol. 57:27–35. 2019. View Article : Google Scholar

12 

Komiya K, Sueoka-Aragane N, Sato A, Hisatomi T, Sakuragi T, Mitsuoka M, Sato T, Hayashi S, Izumi H, Tsuneoka M and Sueoka E: Mina53, a novel c-Myc target gene, is frequently expressed in lung cancers and exerts oncogenic property in NIH/3T3 cells. J Cancer Res Clin Oncol. 136:465–473. 2010. View Article : Google Scholar

13 

Thakur C, Lu Y, Sun J, Yu M, Chen B and Chen F: Increased expression of mdig predicts poorer survival of the breast cancer patients. Gene. 535:218–224. 2014. View Article : Google Scholar

14 

Zhang L, Huo Q, Ge C, Zhao F, Zhou Q, Chen X, Tian H, Chen T, Xie H, Cui Y, et al: ZNF143-mediated H3K9 trimethylation upregulates CDC6 by activating MDIG in hepatocellular carcinoma. Cancer Res. 80:2599–2611. 2020. View Article : Google Scholar

15 

Teye K, Tsuneoka M, Arima N, Koda Y, Nakamura Y, Ueta Y, Shirouzu K and Kimura H: Increased expression of a Myc target gene Mina53 in human colon cancer. Am J Pathol. 164:205–216. 2004. View Article : Google Scholar

16 

Xing J, Wang K, Liu PW, Miao Q and Chen XY: Mina53, a novel molecular marker for the diagnosis and prognosis of gastric adenocarcinoma. Oncol Rep. 31:634–640. 2014. View Article : Google Scholar

17 

Bellut J, Bertz S, Nolte E, Stöhr C, Polifka I, Lieb V, Herrmann E, Jung R, Hartmann A, Wullich B, et al: Differential prognostic value of MYC immunohistochemistry in subtypes of papillary renal cell carcinoma. Sci Rep. 7:164242017. View Article : Google Scholar

18 

Kuratomi K, Yano H, Tsuneoka M, Sakamoto K, Kusukawa J and Kojiro M: Immunohistochemical expression of Mina53 and Ki67 proteins in human primary gingival squamous cell carcinoma. Kurume Med J. 53:71–78. 2006. View Article : Google Scholar

19 

Teye K, Arima N, Nakamura Y, Sakamoto K, Sueoka E, Kimura H and Tsuneoka M: Expression of myc target gene mina53 in subtypes of human lymphoma. Oncol Rep. 18:841–848. 2007.

20 

Thakur C and Chen F: Current understanding of mdig/MINA in human cancers. Genes Cancer. 6:288–302. 2015. View Article : Google Scholar

21 

Komiya K, Sueoka-Aragane N, Sato A, Hisatomi T, Sakuragi T, Mitsuoka M, Sato T, Hayashi S, Izumi H, Tsuneoka M and Sueoka E: Expression of Mina53, a novel c-Myc target gene, is a favorable prognostic marker in early stage lung cancer. Lung Cancer. 69:232–238. 2010. View Article : Google Scholar

22 

Yu M, Sun J, Thakur C, Chen B, Lu Y, Zhao H and Chen F: Paradoxical roles of mineral dust induced gene on cell proliferation and migration/invasion. PLoS One. 9:e879982014. View Article : Google Scholar

23 

Thakur C, Chen B, Li L, Zhang Q, Yang ZQ and Chen F: Loss of mdig expression enhances DNA and histone methylation and metastasis of aggressive breast cancer. Signal Transduct Target Ther. 3:252018. View Article : Google Scholar

24 

Wang Q, Geng F, Zhou H, Chen Y, Du Y, Zhang X, Song D and Zhao H: MDIG promotes cisplatin resistance of lung adenocarcinoma by regulating ABC transporter expression via activation of the WNT/β-catenin signaling pathway. Oncol Lett. 18:4294–4307. 2019.

25 

Xuan F, Huang M, Zhao E and Cui H: MINA53 deficiency leads to glioblastoma cell apoptosis via inducing DNA replication stress and diminishing DNA damage response. Cell Death Dis. 9:10622018. View Article : Google Scholar

26 

Zhou H, Geng F, Chen Y, Du J, Zhang X, Liu B, Song D, Hou H and Zhao H: The mineral dust-induced gene, mdig, regulates angiogenesis and lymphangiogenesis in lung adenocarcinoma by modulating the expression of VEGF-A/C/D via EGFR and HIF-1α signaling. Oncol Rep. 45:602021. View Article : Google Scholar

27 

GTEx Consortium: The genotype-tissue expression (GTEx) project. Nat Gen. 45:580–585. 2013. View Article : Google Scholar

28 

The TCGA Legacy: Cell. 173:281–282. 2018. View Article : Google Scholar

29 

Wang S, Xiong Y, Zhao L, Gu K, Li Y, Zhao F, Li J, Wang M, Wang H, Tao Z, et al: UCSCXenaShiny: An R/CRAN Package for interactive analysis of UCSC xena data. Bioinformatics. 38:527–529. 2021. View Article : Google Scholar

30 

Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, et al: Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal. 6:112013. View Article : Google Scholar

31 

Chandrashekar DS, Bashel B, Balasubramanya SAH, Creighton CJ, Ponce-Rodriguez I, Chakravarthi BVSK and Varambally S: UALCAN: A portal for facilitating tumor subgroup gene expression and survival analyses. Neoplasia. 19:649–658. 2017. View Article : Google Scholar

32 

Massó-Vallés D, Beaulieu ME and Soucek L: MYC, MYCL, and MYCN as therapeutic targets in lung cancer. Expert Opin Ther Targets. 24:101–114. 2020. View Article : Google Scholar

33 

Huang CL, Yokomise H and Miyatake A: Clinical significance of the p53 pathway and associated gene therapy in non-small cell lung cancers. Future Oncol. 3:83–93. 2007. View Article : Google Scholar

34 

Chen B, Khodadoust MS, Liu CL, Newman AM and Alizadeh AA: Profiling tumor infiltrating immune cells with CIBERSORT. Methods Mol Biol. 1711:243–259. 2018. View Article : Google Scholar

35 

Ju M, Jiang L, Wei Q, Yu L, Chen L, Wang Y, Hu B, Qian P, Zhang M, Zhou C, et al: A immune-related signature associated with TME can serve as a potential biomarker for survival and sorafenib resistance in liver cancer. Onco Targets Ther. 14:5065–5083. 2021. View Article : Google Scholar

36 

Zeng D, Li M, Zhou R, Zhang J, Sun H, Shi M, Bin J, Liao Y, Rao J and Liao W: Tumor microenvironment characterization in gastric cancer identifies prognostic and immunotherapeutically relevant gene signatures. Cancer Immunol Res. 7:737–750. 2019. View Article : Google Scholar

37 

Meyers DE and Banerji S: Biomarkers of immune checkpoint inhibitor efficacy in cancer. Curr Oncol. 27(Suppl 2): S106–S114. 2020.

38 

Ru B, Wong CN, Tong Y, Zhong JY, Zhong SSW, Wu WC, Chu KC, Wong CY, Lau CY, Chen I, et al: TISIDB: An integrated repository portal for tumor-immune system interactions. Bioinformatics. 35:4200–4202. 2019. View Article : Google Scholar

39 

Mariathasan S, Turley SJ, Nickles D, Castiglioni A, Yuen K, Wang Y, Kadel EE III, Koeppen H, Astarita JL, Cubas R, et al: TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells. Nat. 554:544–548. 2018. View Article : Google Scholar

40 

Yang W, Soares J, Greninger P, Edelman EJ, Lightfoot H, Forbes S, Bindal N, Beare D, Smith JA, Thompson IR, et al: Genomics of drug sensitivity in cancer (GDSC): A resource for therapeutic biomarker discovery in cancer cells. Nucleic Acids Res. 41:D955–D961. 2013. View Article : Google Scholar

41 

Geeleher P, Cox N and Huang RS: pRRophetic: An R package for prediction of clinical chemotherapeutic response from tumor gene expression levels. PLoS One. 9:e1074682014. View Article : Google Scholar

42 

Geeleher P, Cox NJ and Huang RS: Clinical drug response can be predicted using baseline gene expression levels and in vitro drug sensitivity in cell lines. Genome Biol. 15:R472014. View Article : Google Scholar

43 

Hänzelmann S, Castelo R and Guinney J: GSVA: Gene set variation analysis for microarray and RNA-seq data. BMC Bioinformatics. 14:72013. View Article : Google Scholar

44 

Powers RK, Goodspeed A, Pielke-Lombardo H, Tan AC and Costello JC: GSEA-InContext: Identifying novel and common patterns in expression experiments. Bioinformatics. 34:i555–i564. 2018. View Article : Google Scholar

45 

Choucair K, Morand S, Stanbery L, Edelman G, Dworkin L and Nemunaitis J: TMB: A promising immune-response biomarker, and potential spearhead in advancing targeted therapy trials. Cancer Gene Ther. 27:841–853. 2020. View Article : Google Scholar

46 

Bouchez C, Kempf E and Tournigand C: MSI Metastatic solid tumors treatment and immunotherapies. Bull Cancer. 106:143–150. 2019. View Article : Google Scholar

47 

Kaur J, Elms J, Munn AL, Good D and Wei MQ: Immunotherapy for non-small cell lung cancer (NSCLC), as a stand-alone and in combination therapy. Crit Rev Oncol Hematol. 164:1034172021. View Article : Google Scholar

48 

Yu JS and Cui W: Proliferation, survival and metabolism: The role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination. Development. 143:3050–3060. 2016. View Article : Google Scholar

49 

Ferreira MJ, Pires-Luís AS, Vieira-Coimbra M, Costa-Pinheiro P, Antunes L, Dias PC, Lobo F, Oliveira J, Gonçalves CS, Costa BM, et al: SETDB2 and RIOX2 are differentially expressed among renal cell tumor subtypes, associating with prognosis and metastization. Epigenetics. 12:1057–1064. 2017. View Article : Google Scholar

50 

Shi J, Thakur C, Zhao Y, Li Y, Nie L, Zhang Q, Bi Z, Fu Y, Wadgaonkar P, Almutairy B, et al: Pathological and prognostic indications of the mdig gene in human lung cancer. Cell Physiol Biochem. 55:13–28. 2021. View Article : Google Scholar

51 

Tan XP, Dong WG, Zhang Q, Yang ZR, Lei XF and Ai MH: Potential effects of Mina53 on tumor growth in human pancreatic cancer. Cell Biochem Biophys. 69:619–625. 2014. View Article : Google Scholar

52 

Kulis M and Esteller M: DNA methylation and cancer. Adv Genet. 70:27–56. 2010. View Article : Google Scholar

53 

Arneth B: Tumor microenvironment. Medicina (Kaunas). 56:152019. View Article : Google Scholar

54 

Mori T, Okamoto K, Tanaka Y, Teye K, Umata T, Ohneda K, Tokuyama K, Okabe M and Tsuneoka M: Ablation of Mina53 in mice reduces allergic response in the airways. Cell Struct Funct. 38:155–167. 2013. View Article : Google Scholar

55 

Pillai MR, Mihi B, Ishiwata K, Nakamura K, Sakuragi N, Finkelstein DB, McGargill MA, Nakayama T, Ayabe T, Coleman ML and Bix M: Myc-induced nuclear antigen constrains a latent intestinal epithelial cell-intrinsic anthelmintic pathway. PLoS One. 14:e02112442019. View Article : Google Scholar

56 

Chen T, Yang C, Dou R and Xiong B: Identification of a novel 10 immune-related genes signature as a prognostic biomarker panel for gastric cancer. Cancer Med. 10:6546–6560. 2021. View Article : Google Scholar

57 

Yamada N, Oizumi S, Kikuchi E, Shinagawa N, Konishi-Sakakibara J, Ishimine A, Aoe K, Gemba K, Kishimoto T, Torigoe T and Nishimura M: CD8+ tumor-infiltrating lymphocytes predict favorable prognosis in malignant pleural mesothelioma after resection. Cancer Immunol Immunother. 59:1543–1549. 2010. View Article : Google Scholar

58 

Pilard C, Ancion M, Delvenne P, Jerusalem G, Hubert P and Herfs M: Cancer immunotherapy: It's time to better predict patients' response. Br J Cancer. 125:927–938. 2021. View Article : Google Scholar

59 

Postow MA, Sidlow R and Hellmann MD: Immune-related adverse events associated with immune checkpoint blockade. N Engl J Med. 378:158–168. 2018. View Article : Google Scholar

60 

Gibney GT, Weiner LM and Atkins MB: Predictive biomarkers for checkpoint inhibitor-based immunotherapy. Lancet Oncol. 17:e542–e551. 2016. View Article : Google Scholar

61 

Nowak RP, Tumber A, Hendrix E, Ansari MSZ, Sabatino M, Antonini L, Andrijes R, Salah E, Mautone N, Pellegrini FR, et al: First-in-class inhibitors of the ribosomal oxygenase MINA53. J Med Chem. 64:17031–17050. 2021. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Geng F, Yang W, Song D, Hou H, Han B, Chen Y and Zhao H: MDIG, a 2‑oxoglutarate‑dependent oxygenase, acts as an oncogene and predicts the prognosis of multiple types of cancer. Int J Oncol 61: 82, 2022.
APA
Geng, F., Yang, W., Song, D., Hou, H., Han, B., Chen, Y., & Zhao, H. (2022). MDIG, a 2‑oxoglutarate‑dependent oxygenase, acts as an oncogene and predicts the prognosis of multiple types of cancer. International Journal of Oncology, 61, 82. https://doi.org/10.3892/ijo.2022.5372
MLA
Geng, F., Yang, W., Song, D., Hou, H., Han, B., Chen, Y., Zhao, H."MDIG, a 2‑oxoglutarate‑dependent oxygenase, acts as an oncogene and predicts the prognosis of multiple types of cancer". International Journal of Oncology 61.1 (2022): 82.
Chicago
Geng, F., Yang, W., Song, D., Hou, H., Han, B., Chen, Y., Zhao, H."MDIG, a 2‑oxoglutarate‑dependent oxygenase, acts as an oncogene and predicts the prognosis of multiple types of cancer". International Journal of Oncology 61, no. 1 (2022): 82. https://doi.org/10.3892/ijo.2022.5372
Copy and paste a formatted citation
x
Spandidos Publications style
Geng F, Yang W, Song D, Hou H, Han B, Chen Y and Zhao H: MDIG, a 2‑oxoglutarate‑dependent oxygenase, acts as an oncogene and predicts the prognosis of multiple types of cancer. Int J Oncol 61: 82, 2022.
APA
Geng, F., Yang, W., Song, D., Hou, H., Han, B., Chen, Y., & Zhao, H. (2022). MDIG, a 2‑oxoglutarate‑dependent oxygenase, acts as an oncogene and predicts the prognosis of multiple types of cancer. International Journal of Oncology, 61, 82. https://doi.org/10.3892/ijo.2022.5372
MLA
Geng, F., Yang, W., Song, D., Hou, H., Han, B., Chen, Y., Zhao, H."MDIG, a 2‑oxoglutarate‑dependent oxygenase, acts as an oncogene and predicts the prognosis of multiple types of cancer". International Journal of Oncology 61.1 (2022): 82.
Chicago
Geng, F., Yang, W., Song, D., Hou, H., Han, B., Chen, Y., Zhao, H."MDIG, a 2‑oxoglutarate‑dependent oxygenase, acts as an oncogene and predicts the prognosis of multiple types of cancer". International Journal of Oncology 61, no. 1 (2022): 82. https://doi.org/10.3892/ijo.2022.5372
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team