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Article Open Access

Differences in actionable genomic alterations between brain metastases and non‑brain metastases in patients with non‑small cell lung cancer

  • Authors:
    • Rui Nian
    • Huihui Jiang
    • Jiangman Zhao
    • Wanle Hou
    • Hua Zhang
    • Jiangtao Ma
    • Pengbiao Lv
    • Lisha Jiang
    • Yongpan Wang
    • Yue Xu
    • Shouxin Wu
    • Jingwei Lou
    • Wanjun Li
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Affiliated 3201 Hospital of Xi'an Jiaotong University, Shaanxi, Hanzhong 723000, P.R. China, Zhangjiang Center for Translational Medicine, Shanghai Biotecan Pharmaceuticals Co., Ltd., Shanghai 200135, P.R. China, Department of Laboratory Medicine, First Hospital of Laohekou City, Hubei, Xiangyang 441800, P.R. China, Department of Pathology, Hanzhong People's Hospital, Shaanxi, Hanzhong 723000, P.R. China, Medical Laboratory Science, Hanzhong Railway Central Hospital, Shaanxi, Hanzhong 723000, P.R. China, Department of Surgical Oncology, Hanzhong People's Hospital, Shaanxi, Hanzhong 723000, P.R. China
    Copyright: © Nian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 100
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    Published online on: July 5, 2022
       https://doi.org/10.3892/ijo.2022.5390
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Abstract

Brain metastases (BM) have been closely associated with increased morbidity and poor survival outcomes in patients with non‑small cell lung cancer (NSCLC). Excluding risk factors in histological subtypes, genomic alterations, including epidermal growth factor receptor mutations and anaplastic lymphoma kinase (ALK) rearrangements have been also regarded as greater risk factors for BM in the aspect of molecular subtypes. In the present study, 69 tumor tissues and 51 peripheral blood samples from patients with NSCLC were analyzed using a hybridization capture‑based next‑generation sequencing (NGS) panel, including 95 known cancer genes. Among the 90 patients with stage IV NSCLC, 26 cases suffered from BM and 64 cases did not. In total, 174 somatic mutations in 35 mutated genes were identified, and 12 of these genes were concurrently present in the BM group and the non‑BM group. Importantly, five mutated genes including ALK, cytidine deaminase (CDA), SMAD family member 4 (SMAD4), superoxide dismutase 2 (SOD2) and Von Hippel‑Lindau tumor suppressor (VHL) genes were uniquely detected in the BM group, and they were enriched in the Hippo signaling pathway, pyrimidine metabolism and pantothenate and co‑enzyme A (CoA) biosynthesis, as demonstrated using Kyoto Encyclopedia of Genes and Genomes enrichment analysis. RNA polymerase II transcription regulator complex and promyelocytic leukemia nuclear body were the top functional categories according to the Gene Ontology enrichment analysis in the BM group and non‑BM group, respectively. Furthermore, 43.33% (13/30) of mutated genes were detected by both tumor tissue deoxyribonucleic acid (DNA) and plasma‑derived circulating tumor DNA (ctDNA) in the non‑BM group, while this percentage was only limited to 29.41% (5/17) in the BM group. To summarize, significant differences in somatic mutations, somatic interactions, key signaling pathways, functional biological information, and clinical actionability for the therapy of targeted agents were founded between the BM group and the non‑BM group, and ctDNA analysis may by applied as a more credible alternative for genomic profiling in patients with advanced NSCLC without BM, due to its higher consistency for genomic profiling between ctDNA analysis and tissue DNA analysis.
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1 

Schuette W: Treatment of brain metastases from lung cancer: Chemotherapy. Lung Cancer. 45(Suppl 2): S253–S257. 2004. View Article : Google Scholar : PubMed/NCBI

2 

Khalifa J, Amini A, Popat S, Gaspar LE and Faivre-Finn C: International Association for the Study of Lung Cancer Advanced Radiation Technology C: Brain metastases from NSCLC: Radiation therapy in the Era of targeted therapies. J Thorac Oncol. 11:1627–1643. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Langer CJ and Mehta MP: Current management of brain metastases, with a focus on systemic options. J Clin Oncol. 23:6207–6219. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Owen S and Souhami L: The management of brain metastases in non-small cell lung cancer. Front Oncol. 4:2482014. View Article : Google Scholar : PubMed/NCBI

5 

D'Antonio C, Passaro A, Gori B, Del Signore E, Migliorino MR, Ricciardi S, Fulvi A and de Marinis F: Bone and brain metastasis in lung cancer: Recent advances in therapeutic strategies. Ther Adv Med Oncol. 6:101–114. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Lagerwaard FJ, Levendag PC, Nowak PJ, Eijkenboom WM, Hanssens PE and Schmitz PI: Identification of prognostic factors in patients with brain metastases: A review of 1292 patients. Int J Radiat Oncol Biol Phys. 43:795–803. 1999. View Article : Google Scholar : PubMed/NCBI

7 

Shi AA, Digumarthy SR, Temel JS, Halpern EF, Kuester LB and Aquino SL: Does initial staging or tumor histology better identify asymptomatic brain metastases in patients with non-small cell lung cancer? J Thorac Oncol. 1:205–210. 2006. View Article : Google Scholar

8 

Mujoomdar A, Austin JH, Malhotra R, Powell CA, Pearson GD, Shiau MC and Raftopoulos H: Clinical predictors of metastatic disease to the brain from non-small cell lung carcinoma: Primary tumor size, cell type, and lymph node metastases. Radiology. 242:882–888. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Shin DY, Na II, Kim CH, Park S, Baek H and Yang SH: EGFR mutation and brain metastasis in pulmonary adenocarcinomas. J Thorac Oncol. 9:195–199. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Fallet V, Cadranel J, Doubre H, Toper C, Monnet I, Chinet T, Oliviero G, Foulon G, De Cremoux H, Vieira T, et al: Prospective screening for ALK: Clinical features and outcome according to ALK status. Eur J Cancer. 50:1239–1246. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Heigener DF, Kerr KM, Laing GM, Mok TSK, Moiseyenko FV and Reck M: Redefining treatment paradigms in first-line advanced non-small-cell lung cancer. Clin Cancer Res. 25:4881–4887. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, Harris PL, Haserlat SM, Supko JG, Haluska FG, et al: Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 350:2129–2139. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Brastianos PK, Carter SL, Santagata S, Cahill DP, Taylor-Weiner A, Jones RT, Van Allen EM, Lawrence MS, Horowitz PM, Cibulskis K, et al: Genomic characterization of brain metastases reveals branched evolution and potential therapeutic targets. Cancer Discov. 5:1164–1177. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Shih DJH, Nayyar N, Bihun I, Dagogo-Jack I, Gill CM, Aquilanti E, Bertalan M, Kaplan A, D'Andrea MR, Chukwueke U, et al: Genomic characterization of human brain metastases identifies drivers of metastatic lung adenocarcinoma. Nat Genet. 52:371–377. 2020. View Article : Google Scholar : PubMed/NCBI

15 

Fernandes Marques J, Pereira Reis J, Fernandes G, Hespanhol V, Machado JC and Costa JL: Circulating tumor DNA: A step into the future of cancer management. Acta Cytol. 63:456–465. 2019. View Article : Google Scholar : PubMed/NCBI

16 

Jahr S, Hentze H, Englisch S, Hardt D, Fackelmayer FO, Hesch RD and Knippers R: DNA fragments in the blood plasma of cancer patients: Quantitations and evidence for their origin from apoptotic and necrotic cells. Cancer Res. 61:1659–1665. 2001.PubMed/NCBI

17 

Wan JCM, Massie C, Garcia-Corbacho J, Mouliere F, Brenton JD, Caldas C, Pacey S, Baird R and Rosenfeld N: Liquid biopsies come of age: Towards implementation of circulating tumour DNA. Nat Rev Cancer. 17:223–238. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Keller L and Pantel K: Unravelling tumour heterogeneity by single-cell profiling of circulating tumour cells. Nat Rev Cancer. 19:553–567. 2019. View Article : Google Scholar : PubMed/NCBI

19 

Gerlinger M, Rowan AJ, Horswell S, Math M, Larkin J, Endesfelder D, Gronroos E, Martinez P, Matthews N, Stewart A, et al: Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med. 366:883–892. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Murtaza M, Dawson SJ, Pogrebniak K, Rueda OM, Provenzano E, Grant J, Chin SF, Tsui DWY, Marass F, Gale D, et al: Multifocal clonal evolution characterized using circulating tumour DNA in a case of metastatic breast cancer. Nat Commun. 6:87602015. View Article : Google Scholar : PubMed/NCBI

21 

Marusyk A, Janiszewska M and Polyak K: Intratumor heterogeneity: The Rosetta stone of therapy resistance. Cancer Cell. 37:471–484. 2020. View Article : Google Scholar : PubMed/NCBI

22 

Rolfo C, Mack PC, Scagliotti GV, Baas P, Barlesi F, Bivona TG, Herbst RS, Mok TS, Peled N, Pirker R, et al: Liquid biopsy for advanced non-small cell lung cancer (NSCLC): A statement paper from the IASLC. J Thorac Oncol. 13:1248–1268. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Chen G, Cai Z, Li Z, Dong X, Xu H, Lin J, Chen L, Zhang H, Liu X and Liu J: Clonal evolution in long-term follow-up patients with hepatocellular carcinoma. Int J Cancer. 143:2862–2870. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Travis WD, Brambilla E, Nicholson AG, Yatabe Y, Austin JHM, Beasley MB, Chirieac LR, Dacic S, Duhig E, Flieder DB, et al: The 2015 World health organization classification of lung tumors: Impact of genetic, clinical and radiologic advances since the 2004 classification. J Thorac Oncol. 10:1243–1260. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Gandevia B and Tovell A: Declaration of Helsinki. Med J Aust. 2:320–321. 1964. View Article : Google Scholar : PubMed/NCBI

26 

Li H and Durbin R: Fast and accurate long-read alignment with Burrows-Wheeler transform. Bioinformatics. 26:589–595. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Lai Z, Markovets A, Ahdesmaki M, Chapman B, Hofmann O, McEwen R, Johnson J, Dougherty B, Barrett JC and Dry JR: VarDict: A novel and versatile variant caller for next-generation sequencing in cancer research. Nucleic Acids Res. 44:e1082016. View Article : Google Scholar : PubMed/NCBI

28 

Wang K, Li M and Hakonarson H: ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res. 38:e1642010. View Article : Google Scholar : PubMed/NCBI

29 

Adzhubei IA, Schmidt S, Peshkin L, Ramensky VE, Gerasimova A, Bork P, Kondrashov AS and Sunyaev SR: A method and server for predicting damaging missense mutations. Nat Methods. 7:248–249. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Schwarz JM, Rodelsperger C, Schuelke M and Seelow D: MutationTaster evaluates disease-causing potential of sequence alterations. Nat Methods. 7:575–576. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Yu G, Wang LG, Han Y and He QY: clusterProfiler: An R package for comparing biological themes among gene clusters. OMICS. 16:284–287. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Pao W, Wang TY, Riely GJ, Miller VA, Pan Q, Ladanyi M, Zakowski MF, Heelan RT, Kris MG and Varmus HE: KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib. PLoS Med. 2:e172005. View Article : Google Scholar : PubMed/NCBI

33 

Lin JJ, Riely GJ and Shaw AT: Targeting ALK: Precision medicine takes on drug resistance. Cancer Discov. 7:137–155. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Holla VR, Elamin YY, Bailey AM, Johnson AM, Litzenburger BC, Khotskaya YB, Sanchez NS, Zeng J, Shufean MA, Shaw KR, et al: ALK: A tyrosine kinase target for cancer therapy. Cold Spring Harb Mol Case Stud. 3:a0011152017. View Article : Google Scholar : PubMed/NCBI

35 

Camidge DR, Kim DW, Tiseo M, Langer CJ, Ahn MJ, Shaw AT, Huber RM, Hochmair MJ, Lee DH, Bazhenova LA, et al: Exploratory analysis of brigatinib activity in patients with anaplastic lymphoma kinase-positive non-small-cell lung cancer and brain metastases in two clinical trials. J Clin Oncol. 36:2693–2701. 2018. View Article : Google Scholar : PubMed/NCBI

36 

Gadgeel SM, Gandhi L, Riely GJ, Chiappori AA, West HL, Azada MC, Morcos PN, Lee RM, Garcia L, Yu L, et al: Safety and activity of alectinib against systemic disease and brain metastases in patients with crizotinib-resistant ALK-rearranged non-small-cell lung cancer (AF-002JG): Results from the dose-finding portion of a phase 1/2 study. Lancet Oncol. 15:1119–1128. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Tomasini P, Egea J, Souquet-Bressand M, Greillier L and Barlesi F: Alectinib in the treatment of ALK-positive metastatic non-small cell lung cancer: Clinical trial evidence and experience with a focus on brain metastases. Ther Adv Respir Dis. Feb 21–2019.Epub ahead of print. View Article : Google Scholar : PubMed/NCBI

38 

Solomon BJ, Besse B, Bauer TM, Felip E, Soo RA, Camidge DR, Chiari R, Bearz A, Lin CC, Gadgeel SM, et al: Lorlatinib in patients with ALK-positive non-small-cell lung cancer: Results from a global phase 2 study. Lancet Oncol. 19:1654–1667. 2018. View Article : Google Scholar : PubMed/NCBI

39 

Naito T, Shiraishi H and Fujiwara Y: Brigatinib and lorlatinib: Their effect on ALK inhibitors in NSCLC focusing on resistant mutations and central nervous system metastases. Jpn J Clin Oncol. 51:37–44. 2021. View Article : Google Scholar

40 

Chao D, Pang L, Shi Y, Wang W and Liu K: AZD3759 induces apoptosis in hepatoma cells by activating a p53-SMAD4 positive feedback loop. Biochem Biophys Res Commun. 509:535–540. 2019. View Article : Google Scholar : PubMed/NCBI

41 

Hochmair M: Medical treatment options for patients with epidermal growth factor receptor mutation-positive non-small cell lung cancer suffering from brain metastases and/or leptomeningeal disease. Target Oncol. 13:269–285. 2018. View Article : Google Scholar : PubMed/NCBI

42 

Lorenzetto E, Brenca M, Boeri M, Verri C, Piccinin E, Gasparini P, Facchinetti F, Rossi S, Salvatore G, Massimino M, et al: YAP1 acts as oncogenic target of 11q22 amplification in multiple cancer subtypes. Oncotarget. 5:2608–2621. 2014. View Article : Google Scholar : PubMed/NCBI

43 

You B, Yang YL, Xu Z, Dai Y, Liu S, Mao JH, Tetsu O, Li H, Jablons DM and You L: Inhibition of ERK1/2 down-regulates the Hippo/YAP signaling pathway in human NSCLC cells. Oncotarget. 6:4357–4368. 2015. View Article : Google Scholar : PubMed/NCBI

44 

Cheng H, Zhang Z, Rodriguez-Barrueco R, Borczuk A, Liu H, Yu J, Silva JM, Cheng SK, Perez-Soler R and Halmos B: Functional genomics screen identifies YAP1 as a key determinant to enhance treatment sensitivity in lung cancer cells. Oncotarget. 7:28976–28988. 2016. View Article : Google Scholar :

45 

Hsu PC, You B, Yang YL, Zhang WQ, Wang YC, Xu Z, Dai Y, Liu S, Yang CT, Li H, et al: YAP promotes erlotinib resistance in human non-small cell lung cancer cells. Oncotarget. 7:51922–51933. 2016. View Article : Google Scholar : PubMed/NCBI

46 

Hsu PC, Miao J, Huang Z, Yang YL, Xu Z, You J, Dai Y, Yeh CC, Chan G, Liu S, et al: Inhibition of yes-associated protein suppresses brain metastasis of human lung adenocarcinoma in a murine model. J Cell Mol Med. 22:3073–3085. 2018. View Article : Google Scholar : PubMed/NCBI

47 

Villa E, Ali ES, Sahu U and Ben-Sahra I: Cancer cells tune the signaling pathways to empower de novo synthesis of nucleotides. Cancers(Basel). 11:6882019.

48 

Buj R and Aird KM: Deoxyribonucleotide triphosphate metabolism in cancer and metabolic disease. Front Endocrinol (Lausanne). 9:1772018. View Article : Google Scholar

49 

Shiotani T, Hashimoto Y, Fujita J, Yamauchi N, Yamaji Y, Futami H, Bungo M, Nakamura H, Tanaka T and Irino S: Reversal of enzymic phenotype of thymidine metabolism in induced differentiation of U-937 cells. Cancer Res. 49:6758–6763. 1989.PubMed/NCBI

50 

Hanssen A, Riebensahm C, Mohme M, Joosse SA, Velthaus JL, Berger LA, Bernreuther C, Glatzel M, Loges S, Lamszus K, et al: Frequency of circulating tumor cells (CTC) in patients with brain metastases: Implications as a risk assessment marker in oligo-metastatic disease. Cancers (Basel). 10:5272018. View Article : Google Scholar

51 

Riebensahm C, Joosse SA, Mohme M, Hanssen A, Matschke J, Goy Y, Witzel I, Lamszus K, Kropidlowski J, Petersen C, et al: Clonality of circulating tumor cells in breast cancer brain metastasis patients. Breast Cancer Res. 21:1012019. View Article : Google Scholar : PubMed/NCBI

52 

Ye Y, Luo Z and Shi D: Use of cell free DNA as a prognostic biomarker in non-small cell lung cancer patients with bone metastasis. Int J Biol Markers. 34:381–388. 2019. View Article : Google Scholar : PubMed/NCBI

53 

Aldea M, Hendriks L, Mezquita L, Jovelet C, Planchard D, Auclin E, Remon J, Howarth K, Benitez JC, Gazzah A, et al: Circulating tumor DNA analysis for patients with oncogene-addicted NSCLC with isolated central nervous system progression. J Thorac Oncol. 15:383–391. 2020. View Article : Google Scholar

54 

Gedvilaite V, Schveigert D and Cicenas S: Cell-free DNA in non-small cell lung cancer. Acta Med Litu. 24:138–144. 2017.PubMed/NCBI

55 

Nygaard AD, Garm Spindler KL, Pallisgaard N, Andersen RF and Jakobsen A: The prognostic value of KRAS mutated plasma DNA in advanced non-small cell lung cancer. Lung Cancer. 79:312–317. 2013. View Article : Google Scholar

56 

Aggarwal C, Thompson JC, Black TA, Katz SI, Fan R, Yee SS, Chien AL, Evans TL, Bauml JM, Alley EW, et al: Clinical implications of plasma-based genotyping with the delivery of personalized therapy in metastatic non-small cell lung cancer. JAMA Oncol. 5:173–180. 2019. View Article : Google Scholar

57 

Mack PC, Banks KC, Espenschied CR, Burich RA, Zill OA, Lee CE, Riess JW, Mortimer SA, Talasaz A, Lanman RB and Gandara DR: Spectrum of driver mutations and clinical impact of circulating tumor DNA analysis in non-small cell lung cancer: Analysis of over 8000 cases. Cancer. 126:3219–3228. 2020. View Article : Google Scholar : PubMed/NCBI

58 

Adzhubei I, Jordan DM and Sunyaev SR: Predicting functional effect of human missense mutations using PolyPhen-2. Curr Protoc Hum Genet. Chapter 7: Unit7 20. 2013. View Article : Google Scholar : PubMed/NCBI

59 

1000 Genomes Project Consortium; Auton A, Brooks LD, Durbin RM, Garrison EP, Kang HM, Korbel JO, Marchini JL, McCarthy S, McVean GA and Abecasis GR: A global reference for human genetic variation. Nature. 526:68–74. 2015. View Article : Google Scholar : PubMed/NCBI

60 

Kircher M, Witten DM, Jain P, O'Roak BJ, Cooper GM and Shendure J: A general framework for estimating the relative pathogenicity of human genetic variants. Nat Genet. 46:310–315. 2014. View Article : Google Scholar : PubMed/NCBI

61 

Ng PC and Henikoff S: SIFT: Predicting amino acid changes that affect protein function. Nucleic Acids Res. 31:3812–3814. 2003. View Article : Google Scholar : PubMed/NCBI

62 

McNulty SN, Parikh BA, Duncavage EJ, Heusel JW and Pfeifer JD: Optimization of population frequency cutoffs for filtering common germline polymorphisms from tumor-only next-generation sequencing data. J Mol Diagn. 21:903–912. 2019. View Article : Google Scholar : PubMed/NCBI

63 

Sukhai MA, Misyura M, Thomas M, Garg S, Zhang T, Stickle N, Virtanen C, Bedard PL, Siu LL, Smets T, et al: Somatic tumor variant filtration strategies to optimize tumor-only molecular profiling using targeted next-generation sequencing panels. J Mol Diagn. 21:261–273. 2019. View Article : Google Scholar

64 

Hiltemann S, Jenster G, Trapman J, van der Spek P and Stubbs A: Discriminating somatic and germline mutations in tumor DNA samples without matching normals. Genome Res. 25:1382–1390. 2015. View Article : Google Scholar : PubMed/NCBI

65 

Teer JK, Zhang Y, Chen L, Welsh EA, Cress WD, Eschrich SA and Berglund AE: Evaluating somatic tumor mutation detection without matched normal samples. Hum Genomics. 11:222017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Nian R, Jiang H, Zhao J, Hou W, Zhang H, Ma J, Lv P, Jiang L, Wang Y, Xu Y, Xu Y, et al: Differences in actionable genomic alterations between brain metastases and non‑brain metastases in patients with non‑small cell lung cancer. Int J Oncol 61: 100, 2022.
APA
Nian, R., Jiang, H., Zhao, J., Hou, W., Zhang, H., Ma, J. ... Li, W. (2022). Differences in actionable genomic alterations between brain metastases and non‑brain metastases in patients with non‑small cell lung cancer. International Journal of Oncology, 61, 100. https://doi.org/10.3892/ijo.2022.5390
MLA
Nian, R., Jiang, H., Zhao, J., Hou, W., Zhang, H., Ma, J., Lv, P., Jiang, L., Wang, Y., Xu, Y., Wu, S., Lou, J., Li, W."Differences in actionable genomic alterations between brain metastases and non‑brain metastases in patients with non‑small cell lung cancer". International Journal of Oncology 61.3 (2022): 100.
Chicago
Nian, R., Jiang, H., Zhao, J., Hou, W., Zhang, H., Ma, J., Lv, P., Jiang, L., Wang, Y., Xu, Y., Wu, S., Lou, J., Li, W."Differences in actionable genomic alterations between brain metastases and non‑brain metastases in patients with non‑small cell lung cancer". International Journal of Oncology 61, no. 3 (2022): 100. https://doi.org/10.3892/ijo.2022.5390
Copy and paste a formatted citation
x
Spandidos Publications style
Nian R, Jiang H, Zhao J, Hou W, Zhang H, Ma J, Lv P, Jiang L, Wang Y, Xu Y, Xu Y, et al: Differences in actionable genomic alterations between brain metastases and non‑brain metastases in patients with non‑small cell lung cancer. Int J Oncol 61: 100, 2022.
APA
Nian, R., Jiang, H., Zhao, J., Hou, W., Zhang, H., Ma, J. ... Li, W. (2022). Differences in actionable genomic alterations between brain metastases and non‑brain metastases in patients with non‑small cell lung cancer. International Journal of Oncology, 61, 100. https://doi.org/10.3892/ijo.2022.5390
MLA
Nian, R., Jiang, H., Zhao, J., Hou, W., Zhang, H., Ma, J., Lv, P., Jiang, L., Wang, Y., Xu, Y., Wu, S., Lou, J., Li, W."Differences in actionable genomic alterations between brain metastases and non‑brain metastases in patients with non‑small cell lung cancer". International Journal of Oncology 61.3 (2022): 100.
Chicago
Nian, R., Jiang, H., Zhao, J., Hou, W., Zhang, H., Ma, J., Lv, P., Jiang, L., Wang, Y., Xu, Y., Wu, S., Lou, J., Li, W."Differences in actionable genomic alterations between brain metastases and non‑brain metastases in patients with non‑small cell lung cancer". International Journal of Oncology 61, no. 3 (2022): 100. https://doi.org/10.3892/ijo.2022.5390
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