Open Access

Regulation of temozolomide resistance via lncRNAs: Clinical and biological properties of lncRNAs in gliomas (Review)

  • Authors:
    • Sui Li
    • Xiaofang Xie
    • Fu Peng
    • Junrong Du
    • Cheng Peng
  • View Affiliations

  • Published online on: July 5, 2022     https://doi.org/10.3892/ijo.2022.5391
  • Article Number: 101
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Gliomas are a primary types of intracranial malignancies and are characterized by a poor prognosis due to aggressive recurrence profiles. Temozolomide (TMZ) is an auxiliary alkylating agent that is extensively used in conjunction with surgical resection and forms the mainstay of clinical treatment strategies for gliomas. However, the frequent occurrence of TMZ resistance in clinical practice limits its therapeutic efficacy. Accumulating evidence has demonstrated that long non‑coding RNAs (lncRNAs) can play key and varied roles in glioma progression. lncRNAs have been reported to inhibit glioma progression by targeting various signaling pathways. In addition, the differential expression of lncRNAs has also been found to mediate the resistance of glioma to several chemotherapeutic agents, particularly to TMZ. The present review article therefore summarizes the findings of previous studies in an aim to report the significance and function of lncRNAs in regulating the chemoresistance of gliomas. The present review may provide further insight into the clinical treatment of gliomas.
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September-2022
Volume 61 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Li S, Xie X, Peng F, Du J and Peng C: Regulation of temozolomide resistance via lncRNAs: Clinical and biological properties of lncRNAs in gliomas (Review). Int J Oncol 61: 101, 2022
APA
Li, S., Xie, X., Peng, F., Du, J., & Peng, C. (2022). Regulation of temozolomide resistance via lncRNAs: Clinical and biological properties of lncRNAs in gliomas (Review). International Journal of Oncology, 61, 101. https://doi.org/10.3892/ijo.2022.5391
MLA
Li, S., Xie, X., Peng, F., Du, J., Peng, C."Regulation of temozolomide resistance via lncRNAs: Clinical and biological properties of lncRNAs in gliomas (Review)". International Journal of Oncology 61.3 (2022): 101.
Chicago
Li, S., Xie, X., Peng, F., Du, J., Peng, C."Regulation of temozolomide resistance via lncRNAs: Clinical and biological properties of lncRNAs in gliomas (Review)". International Journal of Oncology 61, no. 3 (2022): 101. https://doi.org/10.3892/ijo.2022.5391