Targeting histone demethylases as a potential cancer therapy (Review)

  • Authors:
    • Wenfei Diao
    • Jiabin Zheng
    • Yong Li
    • Junjiang Wang
    • Songhui Xu
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  • Published online on: July 7, 2022     https://doi.org/10.3892/ijo.2022.5393
  • Article Number: 103
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Abstract

Post‑translational modifications of histones by histone demethylases have an important role in the regulation of gene transcription and are implicated in cancers. Recently, the family of lysine (K)‑specific demethylase (KDM) proteins, referring to histone demethylases that dynamically regulate histone methylation, were indicated to be involved in various pathways related to cancer development. To date, numerous studies have been conducted to explore the effects of KDMs on cancer growth, metastasis and drug resistance, and a majority of KDMs have been indicated to be oncogenes in both leukemia and solid tumors. In addition, certain KDM inhibitors have been developed and have become the subject of clinical trials to explore their safety and efficacy in cancer therapy. However, most of them focus on hematopoietic malignancy. This review summarizes the effects of KDMs on tumor growth, drug resistance and the current status of KDM inhibitors in clinical trials.
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September-2022
Volume 61 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Diao W, Zheng J, Li Y, Wang J and Xu S: Targeting histone demethylases as a potential cancer therapy (Review). Int J Oncol 61: 103, 2022
APA
Diao, W., Zheng, J., Li, Y., Wang, J., & Xu, S. (2022). Targeting histone demethylases as a potential cancer therapy (Review). International Journal of Oncology, 61, 103. https://doi.org/10.3892/ijo.2022.5393
MLA
Diao, W., Zheng, J., Li, Y., Wang, J., Xu, S."Targeting histone demethylases as a potential cancer therapy (Review)". International Journal of Oncology 61.3 (2022): 103.
Chicago
Diao, W., Zheng, J., Li, Y., Wang, J., Xu, S."Targeting histone demethylases as a potential cancer therapy (Review)". International Journal of Oncology 61, no. 3 (2022): 103. https://doi.org/10.3892/ijo.2022.5393