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Review Open Access

Glioma‑neuronal interactions in tumor progression: Mechanism, therapeutic strategies and perspectives (Review)

  • Authors:
    • Tianzhen Hua
    • Huanxiao Shi
    • Mengmei Zhu
    • Chao Chen
    • Yandong Su
    • Shengjia Wen
    • Xu Zhang
    • Juxiang Chen
    • Qilin Huang
    • Hongxiang Wang
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Changhai Hospital, Naval Medical University, Shanghai 200433, P.R. China, Department of Neurosurgery, General Hospital of Central Theater Command of Chinese People's Liberation Army, Wuhan, Hubei 430070, P.R. China
    Copyright: © Hua et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 104
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    Published online on: July 11, 2022
       https://doi.org/10.3892/ijo.2022.5394
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Abstract

An increasing body of evidence has become available to reveal the synaptic and functional integration of glioma into the brain network, facilitating tumor progression. The novel discovery of glioma‑neuronal interactions has fundamentally challenged our understanding of this refractory disease. The present review aimed to provide an overview of how the neuronal activities function through synapses, neurotransmitters, ion channels, gap junctions, tumor microtubes and neuronal molecules to establish communications with glioma, as well as a simplified explanation of the reciprocal effects of crosstalk on neuronal pathophysiology. In addition, the current state of therapeutic avenues targeting critical factors involved in glioma‑euronal interactions is discussed and an overview of clinical trial data for further investigation is provided. Finally, newly emerging technologies, including immunomodulation, a neural stem cell‑based delivery system, optogenetics techniques and co‑culture of neuron organoids and glioma, are proposed, which may pave a way towards gaining deeper insight into both the mechanisms associated with neuron‑ and glioma‑communicating networks and the development of therapeutic strategies to target this currently lethal brain tumor.
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Copy and paste a formatted citation
Spandidos Publications style
Hua T, Shi H, Zhu M, Chen C, Su Y, Wen S, Zhang X, Chen J, Huang Q, Wang H, Wang H, et al: Glioma‑neuronal interactions in tumor progression: Mechanism, therapeutic strategies and perspectives (Review). Int J Oncol 61: 104, 2022.
APA
Hua, T., Shi, H., Zhu, M., Chen, C., Su, Y., Wen, S. ... Wang, H. (2022). Glioma‑neuronal interactions in tumor progression: Mechanism, therapeutic strategies and perspectives (Review). International Journal of Oncology, 61, 104. https://doi.org/10.3892/ijo.2022.5394
MLA
Hua, T., Shi, H., Zhu, M., Chen, C., Su, Y., Wen, S., Zhang, X., Chen, J., Huang, Q., Wang, H."Glioma‑neuronal interactions in tumor progression: Mechanism, therapeutic strategies and perspectives (Review)". International Journal of Oncology 61.3 (2022): 104.
Chicago
Hua, T., Shi, H., Zhu, M., Chen, C., Su, Y., Wen, S., Zhang, X., Chen, J., Huang, Q., Wang, H."Glioma‑neuronal interactions in tumor progression: Mechanism, therapeutic strategies and perspectives (Review)". International Journal of Oncology 61, no. 3 (2022): 104. https://doi.org/10.3892/ijo.2022.5394
Copy and paste a formatted citation
x
Spandidos Publications style
Hua T, Shi H, Zhu M, Chen C, Su Y, Wen S, Zhang X, Chen J, Huang Q, Wang H, Wang H, et al: Glioma‑neuronal interactions in tumor progression: Mechanism, therapeutic strategies and perspectives (Review). Int J Oncol 61: 104, 2022.
APA
Hua, T., Shi, H., Zhu, M., Chen, C., Su, Y., Wen, S. ... Wang, H. (2022). Glioma‑neuronal interactions in tumor progression: Mechanism, therapeutic strategies and perspectives (Review). International Journal of Oncology, 61, 104. https://doi.org/10.3892/ijo.2022.5394
MLA
Hua, T., Shi, H., Zhu, M., Chen, C., Su, Y., Wen, S., Zhang, X., Chen, J., Huang, Q., Wang, H."Glioma‑neuronal interactions in tumor progression: Mechanism, therapeutic strategies and perspectives (Review)". International Journal of Oncology 61.3 (2022): 104.
Chicago
Hua, T., Shi, H., Zhu, M., Chen, C., Su, Y., Wen, S., Zhang, X., Chen, J., Huang, Q., Wang, H."Glioma‑neuronal interactions in tumor progression: Mechanism, therapeutic strategies and perspectives (Review)". International Journal of Oncology 61, no. 3 (2022): 104. https://doi.org/10.3892/ijo.2022.5394
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