Open Access

Long non‑coding RNA 01614 hyperactivates WNT/β‑catenin signaling to promote pancreatic cancer progression by suppressing GSK‑3β

  • Authors:
    • Long-Jiang Chen
    • Lun Wu
    • Wei Wang
    • Lu-Lu Zhai
    • Feng Xiang
    • Wei-Bo Li
    • Zhi-Gang Tang
  • View Affiliations

  • Published online on: August 4, 2022     https://doi.org/10.3892/ijo.2022.5406
  • Article Number: 116
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Pancreatic cancer (PC) is a lethal type of cancer for which effective therapies are limited. Long non‑coding RNAs (lncRNAs) represent a critical type of regulator category, mediating the tumorigenesis and development of various tumor types, including PC. However, the expression patterns and functions of numerous lncRNAs in PC remain poorly understood. In the present study, linc01614 was identified as a PC‑related lncRNA. linc01614 was notably upregulated in PC tissues and cell lines and was associated with the poor disease‑free survival of patients with PC according to the analysis of The Cancer Genome Atlas‑derived datasets. Functionally, linc01614 knockdown suppressed PC cell proliferation, migration and invasion in vitro, and inhibited tumor proliferation in vitro and in vivo. Mechanistically, linc01614 overexpression stabilized the level of β‑catenin protein to hyperactivate the WNT/β‑catenin signaling pathway in PC cells. Further analyses revealed that linc01614 bound to GSK‑3β and perturbed the interaction between GSK‑3β and AXIN1, thereby preventing the formation of the β‑catenin degradation complex and reducing the degradation of β‑catenin. In summary, the present findings reveal that linc01614 may function as an oncogene and promote the progression of PC and may thus be considered as a potential therapeutic target in the future.

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October-2022
Volume 61 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Chen L, Wu L, Wang W, Zhai L, Xiang F, Li W and Tang Z: Long non‑coding RNA 01614 hyperactivates WNT/β‑catenin signaling to promote pancreatic cancer progression by suppressing GSK‑3β. Int J Oncol 61: 116, 2022
APA
Chen, L., Wu, L., Wang, W., Zhai, L., Xiang, F., Li, W., & Tang, Z. (2022). Long non‑coding RNA 01614 hyperactivates WNT/β‑catenin signaling to promote pancreatic cancer progression by suppressing GSK‑3β. International Journal of Oncology, 61, 116. https://doi.org/10.3892/ijo.2022.5406
MLA
Chen, L., Wu, L., Wang, W., Zhai, L., Xiang, F., Li, W., Tang, Z."Long non‑coding RNA 01614 hyperactivates WNT/β‑catenin signaling to promote pancreatic cancer progression by suppressing GSK‑3β". International Journal of Oncology 61.4 (2022): 116.
Chicago
Chen, L., Wu, L., Wang, W., Zhai, L., Xiang, F., Li, W., Tang, Z."Long non‑coding RNA 01614 hyperactivates WNT/β‑catenin signaling to promote pancreatic cancer progression by suppressing GSK‑3β". International Journal of Oncology 61, no. 4 (2022): 116. https://doi.org/10.3892/ijo.2022.5406