Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
November-2022 Volume 61 Issue 5

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2022 Volume 61 Issue 5

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Eupalinolide A induces autophagy via the ROS/ERK signaling pathway in hepatocellular carcinoma cells in vitro and in vivo

  • Authors:
    • Yonghui Zhang
    • Feng Dong
    • Zhihao Cao
    • Tingting Wang
    • Lian Pan
    • Wujing Luo
    • Wenxuan Ding
    • Jiaxin Li
    • Lishan Jin
    • Huan Liu
    • Haoyang Zhang
    • Jinage Mu
    • Meiyue Han
    • Yong Wei
    • Xuesong Deng
    • Dan Liu
    • Po Hao
    • Gang Zeng
    • Yi Pang
    • Guiyuan Liu
    • Changlin Zhen
  • View Affiliations / Copyright

    Affiliations: Chongqing Key Laboratory of Development and Utilization of Genuine Medicinal Materials in Three Gorges Reservoir Area, Chongqing Three Gorges Medical College, Chongqing 404120, P.R. China, Key Laboratory of Intelligent Information Processing and Control, College of Electronic and Information Engineering, Chongqing Three Gorges University, Chongqing 404110, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 131
    |
    Published online on: September 15, 2022
       https://doi.org/10.3892/ijo.2022.5421
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Hepatocellular carcinoma is the most common primary malignancy of the liver. The current systemic drugs used to treat hepatocellular carcinoma result in low overall survival time. It has therefore been suggested that new small‑molecule drugs should be developed for treating hepatocellular carcinoma. Eupatorium lindleyanum DC. (EL) has been used to treat numerous diseases, particularly respiratory diseases; however, to the best of our knowledge, studies have not yet fully elucidated the effect of EL on hepatocellular carcinoma. In the present study, the effect of eupalinolide A (EA), one of the extracts of EL, was evaluated on tumor growth in a xenograft model of human hepatocellular carcinoma cells, and on the proliferation and migration of hepatocellular carcinoma cell lines. Cell cycle progression and the type of cell death were then evaluated using the Cell Counting Kit 8 assay, flow cytometry, electron microscopy and western blotting. EA significantly inhibited cell proliferation and migration by arresting the cell cycle at the G1 phase and inducing autophagy in hepatocellular carcinoma cells. EA‑induced autophagy was mediated by reactive oxygen species (ROS) and ERK signaling activation. Specific inhibitors of ROS, autophagy and ERK inhibited EA‑induced cell death and migration. In conclusion, the present study revealed that EA may inhibit the proliferation and migration of hepatocellular carcinoma cells, highlighting its potential as a promising antitumor compound for treating hepatocellular carcinoma.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

View References

1 

Zheng RS, Zhang SW, Zeng HM, Wang SM, Sun KX, Chen R, Li L, Wei WQ and He J: Cancer incidence and mortality in China, 2016. J Nat Cancer Cent. 2:1–9. 2022. View Article : Google Scholar

2 

Forner A, Reig M and Bruix J: Hepatocellular carcinoma. Lancet. 391:1301–1314. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Liu CY, Chen KF and Chen PJ: Treatment of liver cancer. Cold Spring Harb Perspect Med. 5:a0215352015. View Article : Google Scholar : PubMed/NCBI

4 

Chen S, Cao Q, Wen W and Wang H: Targeted therapy for hepatocellular carcinoma: Challenges and opportunities. Cancer Lett. 460:1–9. 2019. View Article : Google Scholar : PubMed/NCBI

5 

Llovet JM, Montal R, Sia D and Finn RS: Molecular therapies and precision medicine for hepatocellular carcinoma. Nat Rev Clin Oncol. 15:599–616. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Li Y, Gao ZH and Qu XJ: The adverse effects of sorafenib in patients with advanced cancers. Basic Clin Pharmacol Toxicol. 116:216–221. 2015. View Article : Google Scholar

7 

Heo YA and Syed YY: Regorafenib: A review in hepatocellular carcinoma. Drugs. 78:951–958. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Wang X, Ma S, Lai F, Wang Y and Lou C: Traditional applications, phytochemistry, and pharmacological activities of Eupatorium lindleyanum DC.: A comprehensive review. Front Pharmacol. 8:5771242020. View Article : Google Scholar

9 

Chi D: Study on the antihypertensive effects of water decoction of Eupatorium lindleyanum on spontaneously hypertensive rats and corresponding mechanism. China Pharm. 27:3502–3504. 2016.

10 

Lou C, Chen Y, Zhang J, Yang B and Zhao H: Eupalinolide J suppresses the growth of triple-negative breast cancer cells via targeting STAT3 signaling pathway. Front Pharmacol. 10:10712019. View Article : Google Scholar :

11 

Peng Y, Dou J, Huang F and Qian D: Antiviral effects of Fufang Yemazhui capsule in vitro and in vivo. Chin Tradit Pat Med. 30:650–654. 2008.

12 

Chen WY, Qin J, He HX, Li Q, Wang KJ and Zhou YD: Effects of lindley eupatorium herb total flavonoid on blood lipid metabolism in experimental hyperlipidemic rats. J Third Mil Med Univ. 31:1589–1591. 2009.

13 

Cu CJ, Ren HL and Wu TW: Study on the chemical constituents and antipyretic action of Eupatorium lindleyanum DC. Nat Prod Res Dev. 5:816–821. 2015.

14 

Wang J, Wu M, Zheng D, Zhang H, Lv Y, Zhang L, Tan HS, Zhou H, Lao YZ and Xu HX: Garcinol inhibits esophageal cancer metastasis by suppressing the p300 and TGF-β1 signaling pathways. Acta Pharmacol Sin. 41:82–92. 2020. View Article : Google Scholar

15 

Zhang YH, Pan LH, Pang Y, Yang JX, Lv MJ, Liu F, Qu XF, Chen XX, Gong HJ, Liu D and Wei Y: GDF11/BMP11 as a novel tumor marker for liver cancer. Exp Ther Med. 15:3495–3500. 2018.PubMed/NCBI

16 

Yue SR, Tan YY, Zhang L, Zhang BJ, Jiang FY, Ji G, Liu BC and Wang RR: Gynostemma pentaphyllum polysaccharides ameliorate non-alcoholic steatohepatitis in mice associated with gut microbiota and the TLR2/NLRP3 pathway. Front Endocrinol (Lausanne). 13:8850392022. View Article : Google Scholar

17 

Anders S and Huber W: Differential expression analysis for sequence count data. Genome Biol. 11:R1062010. View Article : Google Scholar : PubMed/NCBI

18 

Yu G, Wang LG, Han Y and He QY: clusterProfiler: An R package for comparing biological themes among gene clusters. OMICS. 16:284–287. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Zhang Y, Li M, Li L, Qian G, Wang Y, Chen Z, Liu J, Fang C, Huang F, Guo D, et al: β-arrestin 2 as an activator of cGAS-STING signaling and target of viral immune evasion. Nat Commun. 11:60002020. View Article : Google Scholar

20 

Wang Y, Qian G, Zhu L, Zhao Z, Liu Y, Han W, Zhang X, Zhang Y, Xiong T, Zeng H, et al: HIV-1 Vif suppresses antiviral immunity by targeting STING. Cell Mol Immunol. 19:108–121. 2022. View Article : Google Scholar

21 

Piñero F, Dirchwolf M and Pessôa MG: Biomarkers in hepatocellular carcinoma: Diagnosis, prognosis and treatment response assessment. Cells. 9:13702020. View Article : Google Scholar :

22 

Yang B, Zhao Y, Lou C and Zhao H: Eupalinolide O, a novel sesquiterpene lactone from Eupatorium lindleyanum DC., induces cell cycle arrest and apoptosis in human MDA-MB-468 breast cancer cells. Oncol Rep. 36:2807–2813. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Yang B, Shen JW, Zhou DH, Zhao YP, Wang WQ, Zhu Y and Zhao HJ: Precise discovery of a STAT3 inhibitor from Eupatorium lindleyanum and evaluation of its activity of anti-triple-negative breast cancer. Nat Prod Res. 33:477–485. 2019. View Article : Google Scholar

24 

Bekki Y, Von Ahrens D, Takahashi H, Schwartz M and Gunasekaran G: Recurrent intrahepatic cholangiocarcinoma-review. Front Oncol. 11:7768632021. View Article : Google Scholar

25 

Nijkamp MM, Span PN, Hoogsteen IJ, van der Kogel AJ, Kaanders JH and Bussink J: Expression of E-cadherin and vimentin correlates with metastasis formation in head and neck squamous cell carcinoma patients. Radiother Oncol. 99:344–348. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Alenzi FQ: Links between apoptosis, proliferation and the cell cycle. Br J Biomed Sci. 61:99–102. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Johansson M and Persson JL: Cancer therapy: Targeting cell cycle regulators. Anticancer Agents Med Chem. 8:723–731. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Honda R, Lowe ED, Dubinina E, Skamnaki V, Cook A, Brown NR and Johnson LN: The structure of cyclin E1/CDK2: Implications for CDK2 activation and CDK2-independent roles. EMBO J. 24:452–463. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Su Z, Yang Z, Xu Y, Chen Y and Yu Q: Apoptosis, autophagy, necroptosis, and cancer metastasis. Mol Cancer. 14:482015. View Article : Google Scholar : PubMed/NCBI

30 

Denicourt C and Dowdy SF: Medicine. Targeting apoptotic pathways in cancer cells. Science. 305:1411–1413. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Amaravadi RK and Thompson CB: The roles of therapy-induced autophagy and necrosis in cancer treatment. Clin Cancer Res. 13:7271–7279. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Li X, He S and Ma B: Autophagy and autophagy-related proteins in cancer. Mol Cancer. 19:122020. View Article : Google Scholar : PubMed/NCBI

33 

Poillet-Perez L, Despouy G, Delage-Mourroux R and Boyer-Guittaut M: Interplay between ROS and autophagy in cancer cells, from tumor initiation to cancer therapy. Redox Biol. 4:184–192. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Park HS, Han JH, Park JW, Lee DH, Jang KW, Lee M, Heo KS and Myung CS: Sodium propionate exerts anticancer effect in mice bearing breast cancer cell xenograft by regulating JAK2/STAT3/ROS/p38 MAPK signaling. Acta Pharmacol Sin. 42:1311–1323. 2021. View Article : Google Scholar :

35 

He C, Lu S, Wang XZ, Wang CC, Wang L, Liang SP, Luo TF, Wang ZC, Piao MH, Chi GF and Ge PF: FOXO3a protects glioma cells against temozolomide-induced DNA double strand breaks via promotion of BNIP3-mediated mitophagy. Acta Pharmacol Sin. 42:1324–1337. 2021. View Article : Google Scholar : PubMed/NCBI

36 

Schieber M and Chandel NS: ROS function in redox signaling and oxidative stress. Curr Biol. 24:E453–R462. 2014. View Article : Google Scholar

37 

Delire B and Stärkel P: The Ras/MAPK pathway and hepatocarcinoma: Pathogenesis and therapeutic implications. Eur J Clin Invest. 45:609–623. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Zhou SL, Zhou ZJ, Hu ZQ, Huang XW, Wang Z, Chen EB, Fan J, Cao Y, Dai Z and Zhou J: Tumor-associated neutrophils recruit macrophages and T-regulatory cells to promote progression of hepatocellular carcinoma and resistance to sorafenib. Gastroenterology. 150:1646–1658.e17. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Wu F, Yang LY, Li YF, Ou DP, Chen DP and Fan C: Novel role for epidermal growth factor-like domain 7 in metastasis of human hepatocellular carcinoma. Hepatology. 50:1839–1850. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Zhang YS, Shen Q and Li J: Traditional Chinese medicine targeting apoptotic mechanisms for esophageal cancer therapy. Acta Pharmacol Sin. 37:295–302. 2016. View Article : Google Scholar :

41 

Liu Y, Yang S, Wang K, Lu J, Bao X, Wang R, Qiu Y, Wang T and Yu H: Cellular senescence and cancer: Focusing on traditional Chinese medicine and natural products. Cell Prolif. 53:e128942020. View Article : Google Scholar : PubMed/NCBI

42 

Yamaguchi H, Wyckoff J and Condeelis J: Cell migration in tumors. Curr Opin Cell Biol. 17:559–564. 2005. View Article : Google Scholar : PubMed/NCBI

43 

Chaffer CL, San Juan BP, Lim E and Weinberg RA: EMT, cell plasticity and metastasis. Cancer Metastasis Rev. 35:645–654. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Mendonsa AM, Na TY and Gumbiner BM: E-cadherin in contact inhibition and cancer. Oncogene. 37:4769–4780. 2018. View Article : Google Scholar : PubMed/NCBI

45 

Satelli A and Li S: Vimentin in cancer and its potential as a molecular target for cancer therapy. Cell Mol Life Sci. 68:3033–3046. 2011. View Article : Google Scholar : PubMed/NCBI

46 

Suski JM, Braun M, Strmiska V and Sicinski P: Targeting cell-cycle machinery in cancer. Cancer Cell. 39:759–778. 2021. View Article : Google Scholar : PubMed/NCBI

47 

Camplejohn RS: A critical review of the use of vincristine (VCR) as a tumour cell synchronizing agent in cancer therapy. Cell Tissue Kinet. 13:327–335. 1980.PubMed/NCBI

48 

Kumar A, Sharma PR and Mondhe DM: Potential anticancer role of colchicine-based derivatives: An overview. Anticancer Drugs. 28:250–262. 2017. View Article : Google Scholar

49 

Chen TK, Tang MS, Jiang CX and Zeng BX: Effect of vincristine on proliferation and apoptosis of human gastric cancer BGC cells and its mechanism. Chin Tradit Herb Drugs. 46:72015.

50 

Pfeffer CM and Singh ATK: Apoptosis: A target for anticancer therapy. Int J Mol Sci. 19:4482018. View Article : Google Scholar :

51 

Karsch-Bluman A, Feiglin A, Arbib E, Stern T, Shoval H, Schwob O, Berger M and Benny O: Tissue necrosis and its role in cancer progression. Oncogene. 38:1920–1935. 2019. View Article : Google Scholar

52 

Azad MB, Chen Y and Gibson SB: Regulation of autophagy by reactive oxygen species (ROS): Implications for cancer progression and treatment. Antioxid Redox Signal. 11:777–790. 2009. View Article : Google Scholar

53 

Gibson SB: A matter of balance between life and death: Targeting reactive oxygen species (ROS)-induced autophagy for cancer therapy. Autophagy. 6:835–837. 2010. View Article : Google Scholar : PubMed/NCBI

54 

Yang ZJ, Chee CE, Huang S and Sinicrope FA: The role of autophagy in cancer: Therapeutic implications. Mol Cancer Ther. 10:1533–1541. 2011. View Article : Google Scholar : PubMed/NCBI

55 

Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H, Øvervatn A, Bjørkøy G and Johansen T: p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem. 282:24131–2445. 2007. View Article : Google Scholar : PubMed/NCBI

56 

Pyo JO, Yoo SM, Ahn HH, Nah J, Hong SH, Kam TI, Jung S and Jung YK: Overexpression of Atg5 in mice activates autophagy and extends lifespan. Nat Commun. 4:23002013. View Article : Google Scholar : PubMed/NCBI

57 

Mizushima N, Levine B, Cuervo AM and Klionsky DJ: Autophagy fights disease through cellular self-digestion. Nature. 451:1069–1075. 2008. View Article : Google Scholar : PubMed/NCBI

58 

Moloney JN and Cotter TG: ROS signalling in the biology of cancer. Semin Cell Dev Biol. 80:50–64. 2018. View Article : Google Scholar

59 

Liu Y and Fan D: Ginsenoside Rg5 induces G2/M phase arrest, apoptosis and autophagy via regulating ROS-mediated MAPK pathways against human gastric cancer. Biochem Pharmacol. 168:285–304. 2019. View Article : Google Scholar : PubMed/NCBI

60 

Fan J, Ren D, Wang J, Liu X, Zhang H, Wu M and Yang G: Bruceine D induces lung cancer cell apoptosis and autophagy via the ROS/MAPK signaling pathway in vitro and in vivo. Cell Death Dis. 11:1262020. View Article : Google Scholar : PubMed/NCBI

61 

Wu Z, Xu X, Dai L, Wang Y, Yang B, Zhao H and Lou C: Eupalinolide J induces apoptosis, cell cycle arrest, mitochondrial membrane potential disruption and DNA damage in human prostate cancer cells. J Toxicol Sci. 45:15–23. 2020. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Dong F, Cao Z, Wang T, Pan L, Luo W, Ding W, Li J, Jin L, Liu H, Liu H, et al: Eupalinolide A induces autophagy via the ROS/ERK signaling pathway in hepatocellular carcinoma cells <em>in vitro</em> and <em>in vivo</em>. Int J Oncol 61: 131, 2022.
APA
Zhang, Y., Dong, F., Cao, Z., Wang, T., Pan, L., Luo, W. ... Zhen, C. (2022). Eupalinolide A induces autophagy via the ROS/ERK signaling pathway in hepatocellular carcinoma cells <em>in vitro</em> and <em>in vivo</em>. International Journal of Oncology, 61, 131. https://doi.org/10.3892/ijo.2022.5421
MLA
Zhang, Y., Dong, F., Cao, Z., Wang, T., Pan, L., Luo, W., Ding, W., Li, J., Jin, L., Liu, H., Zhang, H., Mu, J., Han, M., Wei, Y., Deng, X., Liu, D., Hao, P., Zeng, G., Pang, Y., Liu, G., Zhen, C."Eupalinolide A induces autophagy via the ROS/ERK signaling pathway in hepatocellular carcinoma cells <em>in vitro</em> and <em>in vivo</em>". International Journal of Oncology 61.5 (2022): 131.
Chicago
Zhang, Y., Dong, F., Cao, Z., Wang, T., Pan, L., Luo, W., Ding, W., Li, J., Jin, L., Liu, H., Zhang, H., Mu, J., Han, M., Wei, Y., Deng, X., Liu, D., Hao, P., Zeng, G., Pang, Y., Liu, G., Zhen, C."Eupalinolide A induces autophagy via the ROS/ERK signaling pathway in hepatocellular carcinoma cells <em>in vitro</em> and <em>in vivo</em>". International Journal of Oncology 61, no. 5 (2022): 131. https://doi.org/10.3892/ijo.2022.5421
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Dong F, Cao Z, Wang T, Pan L, Luo W, Ding W, Li J, Jin L, Liu H, Liu H, et al: Eupalinolide A induces autophagy via the ROS/ERK signaling pathway in hepatocellular carcinoma cells <em>in vitro</em> and <em>in vivo</em>. Int J Oncol 61: 131, 2022.
APA
Zhang, Y., Dong, F., Cao, Z., Wang, T., Pan, L., Luo, W. ... Zhen, C. (2022). Eupalinolide A induces autophagy via the ROS/ERK signaling pathway in hepatocellular carcinoma cells <em>in vitro</em> and <em>in vivo</em>. International Journal of Oncology, 61, 131. https://doi.org/10.3892/ijo.2022.5421
MLA
Zhang, Y., Dong, F., Cao, Z., Wang, T., Pan, L., Luo, W., Ding, W., Li, J., Jin, L., Liu, H., Zhang, H., Mu, J., Han, M., Wei, Y., Deng, X., Liu, D., Hao, P., Zeng, G., Pang, Y., Liu, G., Zhen, C."Eupalinolide A induces autophagy via the ROS/ERK signaling pathway in hepatocellular carcinoma cells <em>in vitro</em> and <em>in vivo</em>". International Journal of Oncology 61.5 (2022): 131.
Chicago
Zhang, Y., Dong, F., Cao, Z., Wang, T., Pan, L., Luo, W., Ding, W., Li, J., Jin, L., Liu, H., Zhang, H., Mu, J., Han, M., Wei, Y., Deng, X., Liu, D., Hao, P., Zeng, G., Pang, Y., Liu, G., Zhen, C."Eupalinolide A induces autophagy via the ROS/ERK signaling pathway in hepatocellular carcinoma cells <em>in vitro</em> and <em>in vivo</em>". International Journal of Oncology 61, no. 5 (2022): 131. https://doi.org/10.3892/ijo.2022.5421
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team