Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
November-2022 Volume 61 Issue 5

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2022 Volume 61 Issue 5

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data1.pdf
    • Supplementary_Data2.pdf
Article Open Access

GSTO1 confers drug resistance in HCT‑116 colon cancer cells through an interaction with TNFαIP3/A20

  • Authors:
    • Souren Paul
    • Monika Bhardwaj
    • Sun Chul Kang
  • View Affiliations / Copyright

    Affiliations: The Hormel Institute, University of Minnesota, Austin, MN 55912, USA, Department of Biotechnology, Daegu University, Kyoungsan, Kyoungbook 38453, Republic of Korea
    Copyright: © Paul et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 136
    |
    Published online on: September 21, 2022
       https://doi.org/10.3892/ijo.2022.5426
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to decipher the mechanism of glutathione‑S‑transferase Ω‑1 (GSTO1)‑induced drug resistance in colon cancer cells. Cisplatin is used widely as a therapeutic drug in cancer, but colon cancer is the most susceptible to acquired drug resistance. Autophagy is recognized as one of the contributors to drug resistance in cancers. Phase II detoxifying enzymes, such as GSTO1, serve important roles in autophagy‑apoptosis cross talk. The present study revealed a novel interaction between GSTO1 and TNFα‑induced protein 3/zinc‑finger protein A20 (TNFαIP3/A20) as a prime target for cisplatin sensitization in drug‑resistant cells. GSTO1 and ATP‑binding cassette subfamily B member 1 (ABCB1) were both expressed at higher levels in multidrug‑resistant (MDR) HCT‑116 cells compared with the wild‑type (WT) HCT‑116 cells, suggesting they may serve vital roles in multidrug resistance. MDR cells showed autophagy induction, which is dependent on calcium signaling‑dependent endoplasmic stress. In WT cells, the mitochondria‑dependent pathway leads to apoptosis, which was not observed in MDR cells. The MDR conditions were mimicked by transfecting WT cells with the GSTO1‑activation CRISPR plasmid, which induced autophagy. Similarly, MDR cells with GSTO1‑knockdown (KD) CRISPR/Cas9 transfection showed reduced autophagy with increased apoptosis. These data revealed a potentially important role of GSTO1 in drug resistance. A GSTO1 pull‑down assay detected TNFαIP3/A20 as a binding partner in MDR cells. The data suggested that the expression of TNFαIP3/A20 may be dependent on GSTO1 expression in MDR cells. Targeting either GSTO1 or TNFαIP3/A20 by CRISPR/Cas9 sensitized the MDR cells to cisplatin. GSTO1 and TNFαIP3/A20 dual‑KD cells were more sensitive to cisplatin compared with single‑gene KD cells. These data highlight the importance of the GSTO1‑TNFαIP3/A20 interaction during drug resistance.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Wang X, Zhang H and Chen X: Drug resistance and combating drug resistance in cancer. Cancer Drug Resist. 2:141–160. 2019.PubMed/NCBI

2 

Bukowski K, Kciuk M and Kontek R: Mechanisms of multidrug resistance in cancer chemotherapy1. Int J Mol Sci. 21:32332020. View Article : Google Scholar

3 

Köberle B and Schoch S: Platinum complexes in colorectal cancer and other solid tumors. Cancers (Basel). 13:20732021. View Article : Google Scholar

4 

Mele L, Del Vecchio V, Liccardo D, Prisco C, Schwerdtfeger M, Robinson N, Desiderio V, Tirino V, Papaccio G and La Noce M: The role of autophagy in resistance to targeted therapies. Cancer Treat Rev. 88:1020432020. View Article : Google Scholar : PubMed/NCBI

5 

Dang DT, Chen F, Kohli M, Rago C, Cummins JM and Dang LH: Glutathione S-transferase pi1 promotes tumorigenicity in HCT116 human colon cancer cells. Cancer Res. 65:9485–9494. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Ogino S, Konishi H, Ichikawa D, Matsubara D, Shoda K, Arita T, Kosuga T, Komatsu S, Shiozaki A, Okamoto K, et al: Glutathione S-transferase Pi 1 is a valuable predictor for cancer drug resistance in esophageal squamous cell carcinoma. Cancer Sci. 110:795–804. 2019. View Article : Google Scholar

7 

Su F, Hu X, Jia W, Gong C, Song E and Hamar P: Glutathion S transferase pi indicates chemotherapy resistance in breast cancer. J Surg Res. 113:102–108. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Board PG, Coggan M, Chelvanayagam G, Easteal S, Jermiin LS, Schulte GK, Danley DE, Hoth LR, Griffor MC, Kamath AV, et al: Identification, characterization, and crystal structure of the omega class glutathione transferases. J Biol Chem. 275:24798–24806. 2000. View Article : Google Scholar : PubMed/NCBI

9 

Paul S, Jakhar R, Bha rdwaj M and Kang SC: Glutathione-S-transferase omega 1 (GSTO11) acts as mediator of signaling pathways involved in aflatoxin B1-induced apoptosis-autophagy crosstalk in macrophages. Free Radic Biol Med. 89:1218–1230. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Lu H, Chen I, Shimoda LA, Park Y, Zhang C, Tran L, Zhang H and Semenza GL: Erratum: Chemotherapy-induced Ca2+ release stimulates breast cancer stem cell enrichment. Cell Rep. 18:1946–1957. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Yan XD, Pan LY, Yuan Y, Lang JH and Mao N: Identification of platinum-resistance associated proteins through proteomic analysis of human ovarian cancer cells and their platinum-resistant sublines. J Proteome Res. 6:772–780. 2007. View Article : Google Scholar : PubMed/NCBI

12 

De Boussac H, Kassambara A, Machura A, Chemlal D, Gourzones C, Requirand G, Robert N, Vincent L, Herbaux C, Bruyer A and Moreaux J: Genomic characterization of in vitro acquired-resistance to proteasome inhibitors. Blood. 138(Suppl 1): S26512021. View Article : Google Scholar

13 

Mowers EE, Sharifi MN and Macleod KF: Autophagy in cancer metastasis. Oncogene. 36:1619–1630. 2017. View Article : Google Scholar :

14 

Cao W, Wei W, Zhan Z, Xie D, Xie Y and Xiao Q: Regulation of drug resistance and metastasis of gastric cancer cells via the microRNA647-ANK2 axis. Int J Mol Med. 41:1958–1966. 2018.PubMed/NCBI

15 

Malek E, Jagannathan S and Driscoll JJ: Correlation of long non-coding RNA expression with metastasis, drug resistance and clinical outcome in cancer. Oncotarget. 5:8027–8038. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Bhardwaj M, Cho HJ, Paul S, Jakhar R, Khan I, Lee SJ, Kim BY, Krishnan M, Khaket TP, Lee HG and Kang SC: Vitexin induces apoptosis by suppressing autophagy in multi-drug resistant colorectal cancer cells. Oncotarget. 9:3278–3291. 2017. View Article : Google Scholar

17 

Wang J, Seebacher N, Shi H, Kan Q and Duan Z: Novel strategies to prevent the development of multidrug resistance (MDR) in cancer. Oncotarget. 8:84559–84571. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Galluzzi L, Senovilla L, Vitale I, Michels J, Martins I, Kepp O, Castedo M and Kroemer G: Molecular mechanisms of cisplatin resistance. Novel strategies to prevent the development of multidrug resistance (MDR) in cancer. Oncogene. 31:1869–1883. 2012. View Article : Google Scholar

19 

Siddik ZH: Cisplatin: Mode of cytotoxic action and molecular basis of resistance. Oncogene. 22:7265–7279. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Florea AM and Büsselberg D: Cisplatin as an anti-tumor drug: Cellular mechanisms of activity, drug resistance and induced side effects. Cancers (Basel). 3:1351–1371. 2011. View Article : Google Scholar

21 

Chen Y, Zhang W, Guo X, Ren J and Gao A: The crosstalk between autophagy and apoptosis was mediated by phosphorylation of Bcl-2 and beclin1 in benzene-induced hematotoxicity. Cell Death Dis. 10:7722019. View Article : Google Scholar : PubMed/NCBI

22 

Daugas E, Susin SA, Zamzami N, Ferri KF, Irinopoulou T, Larochette N, Prévost MC, Leber B, Andrews D, Penninger J and Kroemer G: Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis. FASEB J. 14:729–739. 2000. View Article : Google Scholar : PubMed/NCBI

23 

Koo MS, Kwon YG, Park JH, Choi WJ, Billiar TR and Kim YM: Signaling and function of caspase and c-Jun N-terminal kinase in cisplatin-induced apoptosis. Mol Cells. 13:194–201. 2002.PubMed/NCBI

24 

Lin Y, Jiang M, Chen W, Zhao T and Wei Y: Cancer and ER stress: Mutual crosstalk between autophagy, oxidative stress and inflammatory response. Biomed Pharmacother. 118:1092492019. View Article : Google Scholar : PubMed/NCBI

25 

Bertero E and Maack C: Calcium signaling and reactive oxygen species in mitochondria. Circ Res. 122:1460–1478. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Sukumaran P, Nascimento Da Conceicao V, Sun Y, Ahamad N, Saraiva LR, Selvaraj S and Singh BB: Calcium signaling regulates autophagy and apoptosis. Cells. 10:21252021. View Article : Google Scholar : PubMed/NCBI

27 

Bertero E and Maack C: Calcium signaling and reactive oxygen species in mitochondria. Circ Res. 122:1460–1478. 2018. View Article : Google Scholar : PubMed/NCBI

28 

Carreras-Sureda A, Pihán P and Hetz C: Calcium signaling at the endoplasmic reticulum: Fine-tuning stress responses. Cell Calcium. 70:2018. View Article : Google Scholar

29 

Huang R, Hui Z, Wei S, Li D, Li W, Daping W and Alahdal M: IRE1 signaling regulates chondrocyte apoptosis and death fate in the osteoarthritis. J Cell Physiol. 237:118–127. 2022. View Article : Google Scholar :

30 

Hu H, Tian M, Ding C and Yu S: The C/EBP homologous protein (CHOP) transcription factor functions in endoplasmic reticulum stress-induced apoptosis and microbial infection. Front Immunol. 9:30832019. View Article : Google Scholar : PubMed/NCBI

31 

Jiang Q, Li F, Shi K, Wu P, An J, Yang Y and Xu C: Involvement of p38 in signal switching from autophagy to apoptosis via the PERK/eIF2α/ATF4 axis in selenite-treated NB4 cells. Cell Death Dis. 5:e12702014. View Article : Google Scholar

32 

Lumley EC, Osborn AR, Scott JE, Scholl AG, Mercado V, McMahan YT, Coffman ZG and Brewster JL: Moderate endoplasmic reticulum stress activates a PERK and p38-dependent apoptosis. Cell Stress Chaperones. 22:43–54. 2017. View Article : Google Scholar :

33 

Xu Y, Sun Q, Yuan F, Dong H, Zhang H, Geng R, Qi Y, Xiong X, Chen Q and Liu B: RND2 attenuates apoptosis and autophagy in glioblastoma cells by targeting the p38 MAPK signalling pathway. J Exp Clin Cancer Res. 39:1742020. View Article : Google Scholar : PubMed/NCBI

34 

Koromilas AE: M(en)TORship lessons on life and death by the integrated stress response. Biochim Biophys Acta Gen Subj. 1863:644–649. 2019. View Article : Google Scholar

35 

Pljesa-Ercegovac M, Savic-Radojevic A, Matic M, Coric V, Djukic T, Radic T and Simic T: Glutathione transferases: Potential targets to overcome chemoresistance in solid tumors. Int J Mol Sci. 19:37852018. View Article : Google Scholar

36 

Guo C, Fordjour FK, Tsai SJ, Morrell JC and Gould SJ: Choice of selectable marker affects recombinant protein expression in cells and exosomes. J Biol Chem. 297:1008382021. View Article : Google Scholar : PubMed/NCBI

37 

Jiang W, Yan Y, Chen M, Luo G, Hao J, Pan J, Hu S, Guo P, Li W, Wang R, et al: Aspirin enhances the sensitivity of colon cancer cells to cisplatin by abrogating the binding of NF-κB to the COX-2 promoter. Aging (Albany NY). 12:611–627. 2020. View Article : Google Scholar

38 

Kleih M, Böpple K, Dong M, Gaißler A, Heine S, Olayioye MA, Aulitzky WE and Essmann F: Direct impact of cisplatin on mitochondria induces ROS production that dictates cell fate of ovarian cancer cells. Cell Death Dis. 10:8512019. View Article : Google Scholar : PubMed/NCBI

39 

Zhang W, Wang Z, Cai G and Huang P: Downregulation of circ_0071589 suppresses cisplatin resistance in colorectal cancer by regulating the MiR-526b-3p/KLF12 axis. Cancer Manag Res. 13:2717–2731. 2021. View Article : Google Scholar : PubMed/NCBI

40 

Sun M, He L, Fan Z, Tang R and Du J: Effective treatment of drug-resistant lung cancer via a nanogel capable of reactivating cisplatin and enhancing early apoptosis. Biomaterials. 257:1202522020. View Article : Google Scholar : PubMed/NCBI

41 

Sun X, Wang S, Gai J, Guan J, Li J, Li Y, Zhao J, Zhao C, Fu L and Li Q: SIRT5 promotes cisplatin resistance in ovarian cancer by suppressing DNA damage in a ROS-dependent manner via regulation of the Nrf2/HO-1 pathway. Front Oncol. 9:7542019. View Article : Google Scholar : PubMed/NCBI

42 

Zhang YK, Wang YJ, Lei ZN, Zhang GN, Zhang XY, Wang DS, Al Rihani SB, Shukla S, Ambudkar SV, Kaddoumi A, et al: Regorafenib antagonizes BCRP-mediated multidrug resistance in colon cancer. Cancer Lett. 442:104–112. 2019. View Article : Google Scholar

43 

Uozaki H, Horiuchi H, Ishida T, Iijima T, Imamura T and Machinami R: Overexpression of resistance-related proteins (metallothioneins, glutathione-S-transferase pi, heat shock protein 27, and lung resistance-related protein) in osteosarcoma: Relationship with poor prognosis. Cancer. 79:2336–2344. 1997. View Article : Google Scholar : PubMed/NCBI

44 

Singh RR and Reindl KM: Glutathione S-transferases in cancer. Antioxidants (Basel). 10:7012021. View Article : Google Scholar

45 

Guo Y, Chang C, Huang R, Liu B, Bao L and Liu W: AP1 is essential for generation of autophagosomes from the trans-Golgi network. J Cell Sci. 125:1706–1715. 2012.PubMed/NCBI

46 

Chen P, Liu XQ, Lin X, Gao LY, Zhang S and Huang X: Targeting YTHDF1 effectively re-sensitizes cisplatin-resistant colon cancer cells by modulating GLS-mediated glutamine metabolism. Mol Ther Oncolytics. 20:228–239. 2021. View Article : Google Scholar : PubMed/NCBI

47 

Dong X, Yang Y, Zhou Y, Bi X, Zhao N, Zhang Z, Li L, Hang Q, Zhang R, Chen D, et al: Glutathione S-transferases P1 protects breast cancer cell from adriamycin-induced cell death through promoting autophagy. Cell Death Differ. 26:2086–2099. 2019. View Article : Google Scholar : PubMed/NCBI

48 

Abbasi A, Forsberg K and Bischof F: The role of the ubiquitin-editing enzyme A20 in diseases of the central nervous system and other pathological processes. Front Mol Neurosci. 8:212015. View Article : Google Scholar : PubMed/NCBI

49 

Das T, Chen Z, Hendriks RW and Kool M: A20/tumor necrosis factor α-induced protein 3 in immune cells controls development of autoinflammation and autoimmunity: Lessons from mouse models. Front Immunol. 9:1042018. View Article : Google Scholar

50 

Yang C, Zang W, Tang Z, Ji Y, Xu R, Yang Y, Luo A, Hu B, Zhang Z, Liu Z and Zheng X: A20/TNFAIP3 regulates the DNA damage response and mediates tumor cell resistance to DNA-damaging therapy. Cancer Res. 78:1069–1082. 2018. View Article : Google Scholar

51 

Vendrell JA, Ghayad S, Ben-Larbi S, Dumontet C, Mechti N and Cohen PA: A20/TNFAIP3, a new estrogen-regulated gene that confers tamoxifen resistance in breast cancer cells. Oncogene. 26:4656–4667. 2007. View Article : Google Scholar : PubMed/NCBI

52 

Matsuzawa Y, Oshima S, Takahara M, Maeyashiki C, Nemoto Y, Kobayashi M, Nibe Y, Nozaki K, Nagaishi T, Okamoto R, et al: TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy. Autophagy. 11:1052–1062. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Paul S, Bhardwaj M and Kang SC: GSTO1 confers drug resistance in HCT‑116 colon cancer cells through an interaction with TNFαIP3/A20. Int J Oncol 61: 136, 2022.
APA
Paul, S., Bhardwaj, M., & Kang, S.C. (2022). GSTO1 confers drug resistance in HCT‑116 colon cancer cells through an interaction with TNFαIP3/A20. International Journal of Oncology, 61, 136. https://doi.org/10.3892/ijo.2022.5426
MLA
Paul, S., Bhardwaj, M., Kang, S. C."GSTO1 confers drug resistance in HCT‑116 colon cancer cells through an interaction with TNFαIP3/A20". International Journal of Oncology 61.5 (2022): 136.
Chicago
Paul, S., Bhardwaj, M., Kang, S. C."GSTO1 confers drug resistance in HCT‑116 colon cancer cells through an interaction with TNFαIP3/A20". International Journal of Oncology 61, no. 5 (2022): 136. https://doi.org/10.3892/ijo.2022.5426
Copy and paste a formatted citation
x
Spandidos Publications style
Paul S, Bhardwaj M and Kang SC: GSTO1 confers drug resistance in HCT‑116 colon cancer cells through an interaction with TNFαIP3/A20. Int J Oncol 61: 136, 2022.
APA
Paul, S., Bhardwaj, M., & Kang, S.C. (2022). GSTO1 confers drug resistance in HCT‑116 colon cancer cells through an interaction with TNFαIP3/A20. International Journal of Oncology, 61, 136. https://doi.org/10.3892/ijo.2022.5426
MLA
Paul, S., Bhardwaj, M., Kang, S. C."GSTO1 confers drug resistance in HCT‑116 colon cancer cells through an interaction with TNFαIP3/A20". International Journal of Oncology 61.5 (2022): 136.
Chicago
Paul, S., Bhardwaj, M., Kang, S. C."GSTO1 confers drug resistance in HCT‑116 colon cancer cells through an interaction with TNFαIP3/A20". International Journal of Oncology 61, no. 5 (2022): 136. https://doi.org/10.3892/ijo.2022.5426
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team