Effects of exosomes on tumor immunomodulation and their potential clinical applications (Review)

  • Authors:
    • Man Li
    • Hongzhen Cai
    • Ruiyi Deng
    • Jin Cheng
    • Yanyan Shi
  • View Affiliations

  • Published online on: October 10, 2022     https://doi.org/10.3892/ijo.2022.5437
  • Article Number: 147
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Abstract

Exosomes are small extracellular vesicles containing proteins, nucleic acids and lipids, which can transmit information between cells, and can interfere with the epigenetic characteristics and functions of recipient cells. Tumor‑derived exosomes play a crucial role as communicators in the tumor microenvironment, and are involved in the occurrence and development of various tumors. The present review article summarizes the biogenesis of exosomes and their communication with local and remote cells, focusing on the function of tumor‑derived exosomes in the tumor microenvironment, including the promotion of angiogenesis, the induction of epithelial mesenchymal transformation, and the activation and inhibition of immune cells, as well as the effects of exosomes on the tumor microenvironment during microbial infections. Additionally, the effects of exosomes on tumor immunotherapy and the potential applications of exosomes as biomarkers, delivery vehicles and cancer vaccines in cancer diagnostics and therapeutics are discussed.
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December-2022
Volume 61 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Li M, Cai H, Deng R, Cheng J and Shi Y: Effects of exosomes on tumor immunomodulation and their potential clinical applications (Review). Int J Oncol 61: 147, 2022
APA
Li, M., Cai, H., Deng, R., Cheng, J., & Shi, Y. (2022). Effects of exosomes on tumor immunomodulation and their potential clinical applications (Review). International Journal of Oncology, 61, 147. https://doi.org/10.3892/ijo.2022.5437
MLA
Li, M., Cai, H., Deng, R., Cheng, J., Shi, Y."Effects of exosomes on tumor immunomodulation and their potential clinical applications (Review)". International Journal of Oncology 61.6 (2022): 147.
Chicago
Li, M., Cai, H., Deng, R., Cheng, J., Shi, Y."Effects of exosomes on tumor immunomodulation and their potential clinical applications (Review)". International Journal of Oncology 61, no. 6 (2022): 147. https://doi.org/10.3892/ijo.2022.5437