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Review

Effects of exosomes on tumor immunomodulation and their potential clinical applications (Review)

  • Authors:
    • Man Li
    • Hongzhen Cai
    • Ruiyi Deng
    • Jin Cheng
    • Yanyan Shi
  • View Affiliations / Copyright

    Affiliations: Peking University Third Hospital, Research Center of Clinical Epidemiology, Beijing 100191, P.R. China, Peking University Third Hospital, Department of Sports Medicine, Institute of Sports Medicine of Peking University, Beijing Key Laboratory of Sports Injuries, Beijing 100191, P.R. China
  • Article Number: 147
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    Published online on: October 10, 2022
       https://doi.org/10.3892/ijo.2022.5437
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Abstract

Exosomes are small extracellular vesicles containing proteins, nucleic acids and lipids, which can transmit information between cells, and can interfere with the epigenetic characteristics and functions of recipient cells. Tumor‑derived exosomes play a crucial role as communicators in the tumor microenvironment, and are involved in the occurrence and development of various tumors. The present review article summarizes the biogenesis of exosomes and their communication with local and remote cells, focusing on the function of tumor‑derived exosomes in the tumor microenvironment, including the promotion of angiogenesis, the induction of epithelial mesenchymal transformation, and the activation and inhibition of immune cells, as well as the effects of exosomes on the tumor microenvironment during microbial infections. Additionally, the effects of exosomes on tumor immunotherapy and the potential applications of exosomes as biomarkers, delivery vehicles and cancer vaccines in cancer diagnostics and therapeutics are discussed.
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Copy and paste a formatted citation
Spandidos Publications style
Li M, Cai H, Deng R, Cheng J and Shi Y: Effects of exosomes on tumor immunomodulation and their potential clinical applications (Review). Int J Oncol 61: 147, 2022.
APA
Li, M., Cai, H., Deng, R., Cheng, J., & Shi, Y. (2022). Effects of exosomes on tumor immunomodulation and their potential clinical applications (Review). International Journal of Oncology, 61, 147. https://doi.org/10.3892/ijo.2022.5437
MLA
Li, M., Cai, H., Deng, R., Cheng, J., Shi, Y."Effects of exosomes on tumor immunomodulation and their potential clinical applications (Review)". International Journal of Oncology 61.6 (2022): 147.
Chicago
Li, M., Cai, H., Deng, R., Cheng, J., Shi, Y."Effects of exosomes on tumor immunomodulation and their potential clinical applications (Review)". International Journal of Oncology 61, no. 6 (2022): 147. https://doi.org/10.3892/ijo.2022.5437
Copy and paste a formatted citation
x
Spandidos Publications style
Li M, Cai H, Deng R, Cheng J and Shi Y: Effects of exosomes on tumor immunomodulation and their potential clinical applications (Review). Int J Oncol 61: 147, 2022.
APA
Li, M., Cai, H., Deng, R., Cheng, J., & Shi, Y. (2022). Effects of exosomes on tumor immunomodulation and their potential clinical applications (Review). International Journal of Oncology, 61, 147. https://doi.org/10.3892/ijo.2022.5437
MLA
Li, M., Cai, H., Deng, R., Cheng, J., Shi, Y."Effects of exosomes on tumor immunomodulation and their potential clinical applications (Review)". International Journal of Oncology 61.6 (2022): 147.
Chicago
Li, M., Cai, H., Deng, R., Cheng, J., Shi, Y."Effects of exosomes on tumor immunomodulation and their potential clinical applications (Review)". International Journal of Oncology 61, no. 6 (2022): 147. https://doi.org/10.3892/ijo.2022.5437
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