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Article Open Access

A novel ferroptosis‑related gene signature for overall survival prediction and immune infiltration in patients with breast cancer

  • Authors:
    • Yan Zhang
    • Yiran Liang
    • Yajie Wang
    • Fangzhou Ye
    • Xiaoli Kong
    • Qifeng Yang
  • View Affiliations / Copyright

    Affiliations: Department of Breast Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 148
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    Published online on: October 12, 2022
       https://doi.org/10.3892/ijo.2022.5438
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Abstract

Breast cancer is the most prevalent type of cancer among women worldwide. The heterogeneous nature of breast cancer poses a serious challenge for prognostic prediction and individualized therapies. Recently, ferroptosis, an iron‑dependent form of programmed cell death, has been reported to serve a significant role in the regulation of the biological behavior of tumors. Several studies have revealed the prognostic significance of the ferroptosis‑related gene (FRG) model; however, additional efforts are required to elucidate the details. Moreover, genes that modulate ferroptosis may be promising candidate bioindicators in cancer therapy. The present study systematically assessed the expression profiles of FRGs to reveal the relationship between FRGs and the prognostic features of patients with breast cancer based on data obtained from the Gene Expression Omnibus and Molecular Taxonomy of Breast Cancer International Consortium. Using a non‑negative matrix factorization clustering method, patients with breast cancer were classified into two sub‑groups (cluster 1 and cluster 2) based on the expression of FRGs. Furthermore, Cox regression, and least absolute shrinkage and selection operator methods were used to construct a risk score formula comprised of nine genes, which stratified patients with breast cancer into two risk groups. Patients belonging to the high‑risk group exhibited significantly shorter overall survival (OS) time compared with patients in the low‑risk group. The prognostic value of this signature was further verified in the training and validation cohorts. The results for univariate and multivariate Cox regression analyses indicated that risk score acted as an independent predictor for OS. Subsequently, a nomogram was constructed. Receiver operating characteristic analysis further confirmed that the resulting nomogram exhibited powerful discriminatory ability. Functional analysis revealed that the immune environment differed notably between the two groups and indicated an association between ferroptosis and breast cancer proliferation, migration and drug resistance. Taken together, the present study demonstrated that FRGs were significantly associated with breast cancer progression, and thus could be used as novel biomarkers for prognostic prediction and individualized treatment of patients with breast cancer.
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View References

1 

Radenkovic S, Konjevic G, Isakovic A, Stevanovic P, Gopcevic K and Jurisic V: HER2-positive breast cancer patients: Correlation between mammographic and pathological findings. Radiat Prot Dosimetry. 162:125–128. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Tao Z, Shi A, Lu C, Song T, Zhang Z and Zhao J: Breast cancer: Epidemiology and etiology. Cell Biochem Biophys. 72:333–338. 2015. View Article : Google Scholar

4 

Feng Y, Spezia M, Huang S, Yuan C, Zeng Z, Zhang L, Ji X, Liu W, Huang B, Luo W, et al: Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis. Genes Dis. 5:77–106. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Radenkovic S, Konjevic G, Gavrilovic D, Stojanovic-Rundic S, Plesinac-Karapandzic V, Stevanovic P and Jurisic V: pSTAT3 expression associated with survival and mammographic density of breast cancer patients. Pathol Res Pract. 215:366–372. 2019. View Article : Google Scholar : PubMed/NCBI

6 

Chen F, Han B, Meng Y, Han Y, Liu B, Zhang B, Chang Y, Cao P, Fan Y and Tan K: Ceruloplasmin correlates with immune infiltration and serves as a prognostic biomarker in breast cancer. Aging (Albany NY). 13:20438–20467. 2021. View Article : Google Scholar

7 

Lee SY, Ju MK, Jeon HM, Jeong EK, Lee YJ, Kim CH, Park HG, Han SI and Kang HS: Regulation of tumor progression by programmed necrosis. Oxid Med Cell Longev. 2018:35374712018. View Article : Google Scholar : PubMed/NCBI

8 

Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, et al: Ferroptosis: An iron-dependent form of nonapoptotic cell death. Cell. 149:1060–1072. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Seibt TM, Proneth B and Conrad M: Role of GPX4 in ferroptosis and its pharmacological implication. Free Radic Biol Med. 133:144–152. 2019. View Article : Google Scholar

10 

Yuan H, Li X, Zhang X, Kang R and Tang D: CISD1 inhibits ferroptosis by protection against mitochondrial lipid peroxidation. Biochem Biophys Res Commun. 478:838–844. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Dodson M, Castro-Portuguez R and Zhang DD: NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis. Redox Biol. 23:1011072019. View Article : Google Scholar : PubMed/NCBI

12 

Ooko E, Saeed ME, Kadioglu O, Sarvi S, Colak M, Elmasaoudi K, Janah R, Greten HJ and Efferth T: Artemisinin derivatives induce iron-dependent cell death (ferroptosis) in tumor cells. Phytomedicine. 22:1045–1054. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Wu ZH, Tang Y, Yu H and Li HD: The role of ferroptosis in breast cancer patients: A comprehensive analysis. Cell Death Discov. 7:932021. View Article : Google Scholar : PubMed/NCBI

14 

Wang D, Wei G, Ma J, Cheng S, Jia L, Song X, Zhang M, Ju M, Wang L, Zhao L, et al: Identification of the prognostic value of ferroptosis-related gene signature in breast cancer patients. BMC Cancer. 21:6452021. View Article : Google Scholar : PubMed/NCBI

15 

Sato M, Kusumi R, Hamashima S, Kobayashi S, Sasaki S, Komiyama Y, Izumikawa T, Conrad M, Bannai S and Sato H: The ferroptosis inducer erastin irreversibly inhibits system xc- and synergizes with cisplatin to increase cisplatin's cytotoxicity in cancer cells. Sci Rep. 8:9682018. View Article : Google Scholar

16 

Guo J, Xu B, Han Q, Zhou H, Xia Y, Gong C, Dai X, Li Z and Wu G: Ferroptosis: A novel anti-tumor action for cisplatin. Cancer Res Treat. 50:445–460. 2018. View Article : Google Scholar :

17 

Li Z, Chen L, Chen C, Zhou Y, Hu D, Yang J, Chen Y, Zhuo W, Mao M, Zhang X, et al: Targeting ferroptosis in breast cancer. Biomark Res. 8:582020. View Article : Google Scholar : PubMed/NCBI

18 

Xie Y, Xiao Y, Liu Y, Lu X, Wang Z, Sun S, Liu L, Tang X, Xiao H and Liu H: Construction of a novel radiosensitivity- and ferroptosis-associated gene signature for prognosis prediction in gliomas. J Cancer. 13:2683–2693. 2022. View Article : Google Scholar : PubMed/NCBI

19 

Yue Z, Sun J and Shi L: Construction and validation of a 6-Ferroptosis related gene signature for prognosis and immune landscape prediction in melanoma. Front Genet. 13:8875422022. View Article : Google Scholar : PubMed/NCBI

20 

Xing XL, Liu Y, Liu J, Zhou H, Zhang H, Zuo Q, Bu P, Duan T, Zhou Y and Xiao Z: Comprehensive analysis of ferroptosis- and immune-related signatures to improve the prognosis and diagnosis of kidney renal clear cell carcinoma. Front Immunol. 13:8513122022. View Article : Google Scholar : PubMed/NCBI

21 

Sui S, Xu S and Pang D: Emerging role of ferroptosis in breast cancer: New dawn for overcoming tumor progression. Pharmacol Ther. 232:1079922022. View Article : Google Scholar

22 

Wu M, Zhang X, Zhang W, Chiou YS, Qian W, Liu X, Zhang M, Yan H, Li S, Li T, et al: Cancer stem cell regulated phenotypic plasticity protects metastasized cancer cells from ferroptosis. Nat Commun. 13:13712022. View Article : Google Scholar : PubMed/NCBI

23 

Konjevic GM, Vuletić AM, Mirjacic Martinovic KM, Larsen AK and Jurisic VB: The role of cytokines in the regulation of NK cells in the tumor environment. Cytokine. 117:30–40. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Jurisic V: Multiomic analysis of cytokines in immuno-oncology. Expert Rev Proteomics. 17:663–674. 2020. View Article : Google Scholar : PubMed/NCBI

25 

Ni S, Yuan Y, Kuang Y and Li X: Iron metabolism and immune regulation. Front Immunol. 13:8162822022. View Article : Google Scholar : PubMed/NCBI

26 

Ganz T and Nemeth E: Iron homeostasis in host defence and inflammation. Nat Rev Immunol. 15:500–510. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Wang W, Green M, Choi JE, Gijon M, Kennedy PD, Johnson JK, Liao P, Lang X, Kryczek I, Sell A, et al: CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy. Nature. 569:270–274. 2019. View Article : Google Scholar : PubMed/NCBI

28 

Kao KJ, Chang KM, Hsu HC and Huang AT: Correlation of microarray-based breast cancer molecular subtypes and clinical outcomes: Implications for treatment optimization. BMC Cancer. 11:1432011. View Article : Google Scholar : PubMed/NCBI

29 

Curtis C, Shah SP, Chin SF, Turashvili G, Rueda OM, Dunning MJ, Speed D, Lynch AG, Samarajiwa S, Yuan Y, et al: The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups. Nature. 486:346–352. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Wu Q, Tang X, Zhu W, Li Q, Zhang X and Li H: The potential prognostic role of oligosaccharide-binding fold-containing protein 2A (OBFC2A) in triple-negative breast cancer. Front Oncol. 11:7514302021. View Article : Google Scholar : PubMed/NCBI

31 

Zhuo S, Chen Z, Yang Y, Zhang J, Tang J and Yang K: Clinical and biological significances of a ferroptosis-related gene signature in glioma. Front Oncol. 10:5908612020. View Article : Google Scholar : PubMed/NCBI

32 

Tang R, Hua J, Xu J, Liang C, Meng Q, Liu J, Zhang B, Yu X and Shi S: The role of ferroptosis regulators in the prognosis, immune activity and gemcitabine resistance of pancreatic cancer. Ann Transl Med. 8:13472020. View Article : Google Scholar : PubMed/NCBI

33 

R Core Team: 2012, R: A language and environment for statistical computing. R Foundation for Statistical Computing; Vienna, Austria: ISBN: 3-900051-07-0URL http://www.R-project.org/.

34 

Gaujoux R and Seoighe C: A flexible R package for nonnegative matrix factorization. BMC Bioinformatics. 11:3672010. View Article : Google Scholar : PubMed/NCBI

35 

Brunet JP, Tamayo P, Golub TR and Mesirov JP: Metagenes and molecular pattern discovery using matrix factorization. Proc Natl Acad Sci USA. 101:4164–4169. 2004. View Article : Google Scholar : PubMed/NCBI

36 

Friedman J, Hastie T and Tibshirani R: Regularization paths for generalized linear models via coordinate descent. J Stat Softw. 33:1–22. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Yoshihara K, Shahmoradgoli M, Martinez E, Vegesna R, Kim H, Torres-Garcia W, Trevino V, Shen H, Laird PW, Levine DA, et al: Inferring tumour purity and stromal and immune cell admixture from expression data. Nat Commun. 4:26122013. View Article : Google Scholar : PubMed/NCBI

38 

Becht E, Giraldo NA, Lacroix L, Buttard B, Elarouci N, Petitprez F, Selves J, Laurent-Puig P, Sautes-Fridman C, Fridman WH, et al: Estimating the population abundance of tissue-infiltrating immune and stromal cell populations using gene expression. Genome Biol. 17:2182016. View Article : Google Scholar

39 

Rooney MS, Shukla SA, Wu CJ, Getz G and Hacohen N: Molecular and genetic properties of tumors associated with local immune cytolytic activity. Cell. 160:48–61. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Roh W, Chen PL, Reuben A, Spencer CN, Prieto PA, Miller JP, Gopalakrishnan V, Wang F, Cooper ZA, Reddy SM, et al: Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance. Sci Transl Med. 9:eaah35602017. View Article : Google Scholar : PubMed/NCBI

41 

Reinhold WC, Sunshine M, Liu H, Varma S, Kohn KW, Morris J, Doroshow J and Pommier Y: CellMiner: A web-based suite of genomic and pharmacologic tools to explore transcript and drug patterns in the NCI-60 cell line set. Cancer Res. 72:3499–3511. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W and Smyth GK: limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43:e472015. View Article : Google Scholar : PubMed/NCBI

43 

Vickers AJ, Cronin AM, Elkin EB and Gonen M: Extensions to decision curve analysis, a novel method for evaluating diagnostic tests, prediction models and molecular markers. BMC Med Inform Decis Mak. 8:532008. View Article : Google Scholar : PubMed/NCBI

44 

Michielin O, Lalani AK, Robert C, Sharma P and Peters S: Defining unique clinical hallmarks for immune checkpoint inhibitor-based therapies. J Immunother Cancer. 10:e0030242022. View Article : Google Scholar : PubMed/NCBI

45 

Hubert P, Roncarati P, Demoulin S, Pilard C, Ancion M, Reynders C, Lerho T, Bruyere D, Lebeau A, Radermecker C, et al: Extracellular HMGB1 blockade inhibits tumor growth through profoundly remodeling immune microenvironment and enhances checkpoint inhibitor-based immunotherapy. J Immunother Cancer. 9:e0019662021. View Article : Google Scholar : PubMed/NCBI

46 

Yang C, Huang X, Liu Z, Qin W and Wang C: Metabolism-associated molecular classification of hepatocellular carcinoma. Mol Oncol. 14:896–913. 2020. View Article : Google Scholar : PubMed/NCBI

47 

Wang M, Mao C, Ouyang L, Liu Y, Lai W, Liu N, Shi Y, Chen L, Xiao D, Yu F, et al: Long noncoding RNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competing endogenous RNA. Cell Death Differ. 26:2329–2343. 2019. View Article : Google Scholar : PubMed/NCBI

48 

Gai C, Yu M, Li Z, Wang Y, Ding D, Zheng J, Lv S, Zhang W and Li W: Acetaminophen sensitizing erastin-induced ferroptosis via modulation of Nrf2/heme oxygenase-1 signaling pathway in non-small-cell lung cancer. J Cell Physiol. 235:3329–3339. 2020. View Article : Google Scholar

49 

Cui Z, Fu Y, Yang Z, Gao Z, Feng H, Zhou M, Zhang L and Chen C: Comprehensive analysis of a ferroptosis pattern and associated prognostic signature in acute myeloid leukemia. Front Pharmacol. 13:8663252022. View Article : Google Scholar : PubMed/NCBI

50 

Wang Y, Yang J, Chen S, Wang W and Teng L: Identification and validation of a prognostic signature for thyroid cancer based on ferroptosis-related genes. Genes (Basel). 13:9972022. View Article : Google Scholar

51 

Fan R, Chen Y, Nechuta S, Cai H, Gu K, Shi L, Bao P, Shyr Y, Shu XO and Ye F: Prediction models for breast cancer prognosis among Asian women. Cancer. 127:1758–1769. 2021. View Article : Google Scholar : PubMed/NCBI

52 

Yang YF, Lee YC, Wang YY, Wang CH, Hou MF and Yuan SF: YWHAE promotes proliferation, metastasis, and chemoresistance in breast cancer cells. Kaohsiung J Med Sci. 35:408–416. 2019.PubMed/NCBI

53 

Liu T, Jiang L, Tavana O and Gu W: The Deubiquitylase OTUB1 mediates ferroptosis via stabilization of SLC7A11. Cancer Res. 79:1913–1924. 2019. View Article : Google Scholar : PubMed/NCBI

54 

Zou Y, Palte MJ, Deik AA, Li H, Eaton JK, Wang W, Tseng YY, Deasy R, Kost-Alimova M, Dančík V, et al: A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis. Nat Commun. 10:16172019. View Article : Google Scholar : PubMed/NCBI

55 

Lang X, Green MD, Wang W, Yu J, Choi JE, Jiang L, Liao P, Zhou J, Zhang Q, Dow A, et al: Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11. Cancer Discov. 9:1673–1685. 2019. View Article : Google Scholar : PubMed/NCBI

56 

Lee YH, Kim HS, Kim JS, Yu MK, Cho SD, Jeon JG and Yi HK: C-myb regulates autophagy for pulp vitality in glucose oxidative stress. J Dent Res. 95:430–438. 2016. View Article : Google Scholar

57 

Minekura H, Kang MJ, Inagaki Y, Suzuki H, Sato H, Fujino T and Yamamoto TT: Genomic organization and transcription units of the human acyl-CoA synthetase 3 gene. Gene. 278:185–192. 2001. View Article : Google Scholar : PubMed/NCBI

58 

Hao S, Yu J, He W, Huang Q, Zhao Y, Liang B, Zhang S, Wen Z, Dong S, Rao J, et al: Cysteine dioxygenase 1 mediates erastin-induced ferroptosis in human gastric cancer cells. Neoplasia. 19:1022–1032. 2017. View Article : Google Scholar : PubMed/NCBI

59 

Alfarsi LH, El Ansari R, Masisi BK, Parks R, Mohammed OJ, Ellis IO, Rakha EA and Green AR: Integrated analysis of key differentially expressed genes identifies DBN1 as a predictive marker of response to endocrine therapy in luminal breast cancer. Cancers (Basel). 12:15492020. View Article : Google Scholar

60 

Wang X, Fu Y, Chen X, Ye J, Lü B, Ye F, Lü W and Xie X: The expressions of bHLH gene HES1 and HES5 in advanced ovarian serous adenocarcinomas and their prognostic significance: A retrospective clinical study. J Cancer Res Clin Oncol. 136:989–996. 2010. View Article : Google Scholar : PubMed/NCBI

61 

Konishi J, Kawaguchi KS, Vo H, Haruki N, Gonzalez A, Carbone DP and Dang TP: Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers. Cancer Res. 67:8051–8057. 2007. View Article : Google Scholar : PubMed/NCBI

62 

Li X, Cao Y, Li M and Jin F: Upregulation of HES1 promotes cell proliferation and invasion in breast cancer as a prognosis marker and therapy target via the AKT pathway and emt process. J Cancer. 9:757–766. 2018. View Article : Google Scholar : PubMed/NCBI

63 

Li X, Li Y, Du X, Wang X, Guan S, Cao Y, Jin F and Li F: HES1 promotes breast cancer stem cells by elevating slug in triple-negative breast cancer. Int J Biol Sci. 17:247–258. 2021. View Article : Google Scholar : PubMed/NCBI

64 

Sun X, Ou Z, Xie M, Kang R, Fan Y, Niu X, Wang H, Cao L and Tang D: HSPB1 as a novel regulator of ferroptotic cancer cell death. Oncogene. 34:5617–5625. 2015. View Article : Google Scholar : PubMed/NCBI

65 

Jiang XP, Elliott RL and Head JF: Manipulation of iron transporter genes results in the suppression of human and mouse mammary adenocarcinomas. Anticancer Res. 30:759–765. 2010.PubMed/NCBI

66 

Emens LA: Breast cancer immunotherapy: Facts and hopes. Clin Cancer Res. 24:511–520. 2018. View Article : Google Scholar :

67 

Dunn GP, Bruce AT, Ikeda H, Old LJ and Schreiber RD: Cancer immunoediting: From immunosurveillance to tumor escape. Nat Immunol. 3:991–998. 2002. View Article : Google Scholar : PubMed/NCBI

68 

Jia M, Qin D, Zhao C, Chai L, Yu Z, Wang W, Tong L, Lv L, Wang Y, Rehwinkel J, et al: Redox homeostasis maintained by GPX4 facilitates STING activation. Nat Immunol. 21:727–735. 2020. View Article : Google Scholar : PubMed/NCBI

69 

Maldonado EN and Lemasters JJ: Warburg revisited: Regulation of mitochondrial metabolism by voltage-dependent anion channels in cancer cells. J Pharmacol Exp Ther. 342:637–641. 2012. View Article : Google Scholar : PubMed/NCBI

70 

Yagoda N, von Rechenberg M, Zaganjor E, Bauer AJ, Yang WS, Fridman DJ, Wolpaw AJ, Smukste I, Peltier JM, Boniface JJ, et al: RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels. Nature. 447:864–868. 2007. View Article : Google Scholar : PubMed/NCBI

71 

Ponde NF, Zardavas D and Piccart M: Progress in adjuvant systemic therapy for breast cancer. Nat Rev Clin Oncol. 16:27–44. 2019. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Liang Y, Wang Y, Ye F, Kong X and Yang Q: A novel ferroptosis‑related gene signature for overall survival prediction and immune infiltration in patients with breast cancer. Int J Oncol 61: 148, 2022.
APA
Zhang, Y., Liang, Y., Wang, Y., Ye, F., Kong, X., & Yang, Q. (2022). A novel ferroptosis‑related gene signature for overall survival prediction and immune infiltration in patients with breast cancer. International Journal of Oncology, 61, 148. https://doi.org/10.3892/ijo.2022.5438
MLA
Zhang, Y., Liang, Y., Wang, Y., Ye, F., Kong, X., Yang, Q."A novel ferroptosis‑related gene signature for overall survival prediction and immune infiltration in patients with breast cancer". International Journal of Oncology 61.6 (2022): 148.
Chicago
Zhang, Y., Liang, Y., Wang, Y., Ye, F., Kong, X., Yang, Q."A novel ferroptosis‑related gene signature for overall survival prediction and immune infiltration in patients with breast cancer". International Journal of Oncology 61, no. 6 (2022): 148. https://doi.org/10.3892/ijo.2022.5438
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Liang Y, Wang Y, Ye F, Kong X and Yang Q: A novel ferroptosis‑related gene signature for overall survival prediction and immune infiltration in patients with breast cancer. Int J Oncol 61: 148, 2022.
APA
Zhang, Y., Liang, Y., Wang, Y., Ye, F., Kong, X., & Yang, Q. (2022). A novel ferroptosis‑related gene signature for overall survival prediction and immune infiltration in patients with breast cancer. International Journal of Oncology, 61, 148. https://doi.org/10.3892/ijo.2022.5438
MLA
Zhang, Y., Liang, Y., Wang, Y., Ye, F., Kong, X., Yang, Q."A novel ferroptosis‑related gene signature for overall survival prediction and immune infiltration in patients with breast cancer". International Journal of Oncology 61.6 (2022): 148.
Chicago
Zhang, Y., Liang, Y., Wang, Y., Ye, F., Kong, X., Yang, Q."A novel ferroptosis‑related gene signature for overall survival prediction and immune infiltration in patients with breast cancer". International Journal of Oncology 61, no. 6 (2022): 148. https://doi.org/10.3892/ijo.2022.5438
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