Open Access

RNA m6A methylation regulators in endometrial cancer (Review)

  • Authors:
    • Siyi Shen
    • Jialu Guo
    • Nengyuan Lv
    • Qianying Chen
    • Jinyi Tong
  • View Affiliations

  • Published online on: November 1, 2022     https://doi.org/10.3892/ijo.2022.5445
  • Article Number: 155
  • Copyright: © Shen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

As one of the three major malignant tumor types of the female reproductive system, endometrial cancer (EC) is the most prevalent gynecologic cancer in developed countries. In recent years, the incidence of EC has increased worldwide, threatening the health and well‑being of women. Recent research has indicated that the expression of multiple N6‑methyladenosine (m6A) regulators is up‑ or downregulated in EC and that abnormalities in m6A methylation and the expression of associated regulators are critical to the pathogenesis and progression of EC. m6A is the most abundant internal modification of mRNA. Several studies have demonstrated a close association between the development and progression of malignant tumors and the epigenetic phenomenon of m6A methylation. In the present study, the current status of research on m6A methylation in EC was reviewed. The mechanisms of methyltransferase, demethylase and m6A binding protein in regulating the development and progression of EC by modifying mRNA were introduced. The related research results will provide novel methods and approaches for the prevention and treatment of EC.
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December-2022
Volume 61 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Shen S, Guo J, Lv N, Chen Q and Tong J: RNA m6A methylation regulators in endometrial cancer (Review). Int J Oncol 61: 155, 2022
APA
Shen, S., Guo, J., Lv, N., Chen, Q., & Tong, J. (2022). RNA m6A methylation regulators in endometrial cancer (Review). International Journal of Oncology, 61, 155. https://doi.org/10.3892/ijo.2022.5445
MLA
Shen, S., Guo, J., Lv, N., Chen, Q., Tong, J."RNA m6A methylation regulators in endometrial cancer (Review)". International Journal of Oncology 61.6 (2022): 155.
Chicago
Shen, S., Guo, J., Lv, N., Chen, Q., Tong, J."RNA m6A methylation regulators in endometrial cancer (Review)". International Journal of Oncology 61, no. 6 (2022): 155. https://doi.org/10.3892/ijo.2022.5445