Roles of m<sup>6</sup>A modification in oral cancer (Review)

Liu,Huimin; Wang,Yinyu; Xue,Tianyi; Yang,Zhijing; Kan,Shaoning; Hao,Ming; Gao,Yang; Wang,Dongxu; Liu,Weiwei

doi:10.3892/ijo.2022.5453

Roles of m⁶A modification in oral cancer (Review)

Authors:
- Huimin Liu
- Yinyu Wang
- Tianyi Xue
- Zhijing Yang
- Shaoning Kan
- Ming Hao
- Yang Gao
- Dongxu Wang
- Weiwei Liu
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Affiliations: Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Jilin University, Changchun, Jilin 130021, P.R. China, Baicheng Medical College, Baicheng, Jilin 137000, P.R. China, Laboratory Animal Center, College of Animal Science, Jilin University, Changchun, Jilin 130062, P.R. China, Center of Implant Dentistry, Stomatological Hospital of Southern Medical University, Guangzhou, Guangdong 510280, P.R. China
Published online on: November 11, 2022 https://doi.org/10.3892/ijo.2022.5453
Article Number: 5
Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Oral cancer is one of the highly malignant tumors with poor prognosis. The pathogenic mechanisms of oral cancer have remained to be fully elucidated and this brings significant challenges to the treatment. RNA modification is a common intracellular chemical modification that has been related to various pathological processes, such as blood diseases, immune system diseases and cancer. As the most common and abundant RNA modification in eukaryotic mRNA, N⁶‑methyladenosine (m⁶A) modification has a crucial role in several cancers, including oral cancer. m⁶A modification directly affects gene expression levels and regulates various physiological and pathological processes. It has been demonstrated that m⁶A modification may affect the proliferation, migration and invasion of oral cancer cells by regulating the level of m⁶A modification. In the present review, the effects of m⁶A modification on the proliferation and death of oral cancer cells, as well as the occurrence and development of oral cancer, were analyzed in order to provide a new target for treatment. Furthermore, the roles of m⁶A modification in chemotherapy resistance and potential immunotherapy were analyzed and new treatment ideas were provided.

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