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VIM‑AS1 promotes proliferation and drives enzalutamide resistance in prostate cancer via IGF2BP2‑mediated HMGCS1 mRNA stabilization

  • Authors:
    • Sheng-Jia Shi
    • Dong-Hui Han
    • Jing-Liang Zhang
    • Yu Li
    • An-Gang Yang
    • Rui Zhang
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Cancer Biology, Department of Immunology, Air Force Medical University, Xi'an, Shaanxi 710032, P.R. China, Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, Shaanxi 710069, P.R. China
    Copyright: © Shi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 34
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    Published online on: January 30, 2023
       https://doi.org/10.3892/ijo.2023.5482
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Abstract

VIM‑AS1, a cancer‑specific long non‑coding RNA, has been recognized as a pivotal regulator in multiple types of cancer. However, the role of VIM‑AS1 in the proliferation and resistance to anti‑androgen therapy of LNCaP and C4‑2 prostate cancer cells remains to be determined. In the current study, gain‑and‑loss experiments were used to investigate the effects of VIM‑AS on the proliferation and anti‑androgen therapy of LNCaP and C4‑2 cells. RNA sequencing, RNA pulldown and RNA immunoprecipitation were used to elucidate the underlying mechanism of VIM‑AS1 driving prostate progression. It was demonstrated that VIM‑AS1 was upregulated in C4‑2 cells, an established castration‑resistant prostate cancer (CRPC) cell line, compared with in LNCaP cells, an established hormone‑sensitive prostate cancer cell line. The present study further demonstrated that VIM‑AS1 was positively associated with the clinical stage of prostate cancer. Functionally, overexpression of VIM‑AS1 decreased the sensitivity to enzalutamide treatment and enhanced the proliferation of LNCaP cells in vitro, whereas knockdown of VIM‑AS1 increased the sensitivity to enzalutamide treatment and reduced the proliferation of C4‑2 cells in vitro and in vivo. Mechanistically, 3‑hydroxy‑3‑methylglutaryl‑CoA synthase 1 (HMGCS1) was identified as one of the direct downstream targets of VIM‑AS1, and VIM‑AS1 promoted HMGCS1 expression by enhancing HMGCS1 mRNA stability through a VIM‑AS1/insulin like growth factor 2 mRNA binding protein 2 (IGF2BP2)/HMGCS1 RNA‑protein complex. Rescue assays indicated that knockdown of HMGCS1 expression ameliorated the increase in proliferation and enzalutamide resistance of prostate cancer cells induced by VIM‑AS1 overexpression. Overall, the present study determined the roles and mechanism of the VIM‑AS1/IGF2BP2/HMGCS1 axis in regulating proliferation and enzalutamide sensitivity of prostate cancer cells and suggested that VIM‑AS1 may serve as a novel therapeutic target for the treatment of patients with CRPC.
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View References

1 

Siegel RL, Miller KD, Fuchs HE and Jemal A: Cancer statistics, 2022. CA Cancer J Clin. 72:7–33. 2022. View Article : Google Scholar

2 

Xia C, Dong X, Li H, Cao M, Sun D, He S, Yang F, Yan X, Zhang S, Li N and Chen W: Cancer statistics in China and United States, 2022: Profiles, trends, and determinants. Chin Med J (Engl). 135:584–590. 2022. View Article : Google Scholar : PubMed/NCBI

3 

Desai K, McManus JM and Sharifi N: Hormonal therapy for prostate cancer. Endocr Rev. 42:354–373. 2021. View Article : Google Scholar

4 

Teo MY, Rathkopf DE and Kantoff P: Treatment of advanced prostate cancer. Annu Rev Med. 70:479–499. 2019. View Article : Google Scholar : PubMed/NCBI

5 

Lin SR, Mokgautsi N and Liu YN: Ras and Wnt interaction contribute in prostate cancer bone metastasis. Molecules. 25:23802020. View Article : Google Scholar :

6 

Tan YT, Lin JF, Li T, Li JJ, Xu RH and Ju HQ: LncRNA-mediated posttranslational modifications and reprogramming of energy metabolism in cancer. Cancer Commun (Lond). 41:109–120. 2021. View Article : Google Scholar

7 

Li S, Xie X, Peng F, Du J and Peng C: Regulation of temozolomide resistance via lncRNAs: Clinical and biological properties of lncRNAs in gliomas (Review). Int J Oncol. 61:1012022. View Article : Google Scholar

8 

Yang G, Wu Y, Wan R, Sang H, Liu H and Huang W: The role of noncoding RNAs in the regulation, diagnosis, prognosis and treatment of osteosarcoma (Review). Int J Oncol. 59:692021. View Article : Google Scholar

9 

Lv Y, Wang Z, Zhao K, Zhang G, Huang S and Zhao Y: Role of noncoding RNAs in cholangiocarcinoma (Review). Int J Oncol. 57:7–20. 2020.PubMed/NCBI

10 

Sun X, Xin S, Zhang Y, Jin L, Liu X, Zhang J, Mei W, Zhang B, Ma W and Ye L: Long noncoding RNA CASC11 interacts with YBX1 to promote prostate cancer progression by suppressing the p53 pathway. Int J Oncol. 61:1102022. View Article : Google Scholar

11 

Chen C, Tang X, Liu Y, Zhu J and Liu J: Induction/reversal of drug resistance in gastric cancer by non-coding RNAs (Review). Int J Oncol. 54:1511–1524. 2019.

12 

Chen LJ, Wu L, Wang W, Zhai LL, Xiang F, Li WB and Tang ZG: Long non-coding 01614 hyperactivates WNT/β-catenin signaling to promote pancreatic cancer progression by suppressing GSK-3β. Int J Oncol. 61:1162022. View Article : Google Scholar

13 

Zhang M, Wu L, Wang X and Chen J: LncKRT16P6 promotes tongue squamous cell carcinoma progression by sponging miR-3180 and regulating GATAD2A expression. Int J Oncol. 61:1112022. View Article : Google Scholar :

14 

Xie H, Zhao J, Wan J, Zhao J, Wang Q, Yang X, Yang W, Lin P and Yu X: Long noncoding RNA AC245100.4 promotes prostate cancer tumorigenesis via the microRNA1455p/RBBP5 axis. Oncol Rep. 45:619–629. 2021. View Article : Google Scholar : PubMed/NCBI

15 

Huo W, Qi F and Wang K: Long noncoding RNA BCYRN1 promotes prostate cancer progression via elevation of HDAC11. Oncol Rep. 44:1233–1245. 2020. View Article : Google Scholar : PubMed/NCBI

16 

Wang L, Han S, Jin G, Zhou X, Li M, Ying X, Wang L, Wu H and Zhu Q: Linc00963: A novel, long non-coding RNA involved in the transition of prostate cancer from androgen-dependence to androgen-independence. Int J Oncol. 44:2041–2049. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Bai M, He C, Shi S, Wang M, Ma J, Yang P, Dong Y, Mou X and Han S: Linc00963 promote cell proliferation and tumor growth in castration-resistant prostate cancer by modulating miR-655/TRIM24 axis. Front Oncol. 11:6369652021. View Article : Google Scholar : PubMed/NCBI

18 

Hu CY, Wu KY, Lin TY and Chen CC: The crosstalk of long non-coding RNA and MicroRNA in castration-resistant and neuroendocrine prostate cancer: Their interaction and clinical importance. Int J Mol Sci. 23:3922021. View Article : Google Scholar

19 

Zhang Y, Zhang J, Liang S, Lang G, Liu G, Liu P and Deng X: Long non-coding RNA VIM-AS1 promotes prostate cancer growth and invasion by regulating epithelial-mesenchymal transition. J BUON. 24:2090–2098. 2019.PubMed/NCBI

20 

Yin H, Zhang X, Yang P, Zhang X, Peng Y, Li D, Yu Y, Wang Y, Zhang J, Ding X, et al: RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming. Nat Commun. 12:13942021. View Article : Google Scholar : PubMed/NCBI

21 

Sun J, Xiong Y, Jiang K, Xin B, Jiang T, Wei R, Zou Y, Tan H, Jiang T, Yang A, et al: Hypoxia-sensitive long noncoding RNA CASC15 promotes lung tumorigenesis by regulating the SOX4/beta-catenin axis. J Exp Clin Cancer Res. 40:122021. View Article : Google Scholar

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

23 

Feng T, Wei D, Zhao J, Li Q, Guo P, Yang X, Li M, Jiang Y and Luo Y: Construction of enzalutamide-resistant cell model of prostate cancer and preliminary screening of potential drug-resistant genes. Exp Bio Med (Maywood). 15:1776–1787. 2021. View Article : Google Scholar

24 

Chen S, Zhou Y, Chen Y and Gu J: fastp: An ultra-fast all-in-one FASTQ preprocessor. Bioinformatics. 34:i884–i890. 2018. View Article : Google Scholar :

25 

Kim D, Langmead B and Salzberg SL: HISAT: A fast spliced aligner with low memory requirements. Nat Methods. 12:357–360. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Liao Y, Smyth GK and Shi W: featureCounts: An efficient general purpose program for assigning sequence reads to genomic features. Bioinformatics. 30:923–930. 2014. View Article : Google Scholar

27 

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al: Gene ontology: Tool for the unification of biology. The gene ontology consortium. Nat Genet. 25:25–29. 2000. View Article : Google Scholar : PubMed/NCBI

28 

The Gene Ontology Consortium: The gene ontology resource: 20 years and still GOing strong. Nucleic Acids Res. 47:D330–D338. 2019. View Article : Google Scholar :

29 

Kanehisa M: Post-Genome Informatics. Oxford University Press; New York, NY: 2000

30 

Cai C, Wang H, He HH, Chen S, He L, Ma F, Mucci L, Wang Q, Fiore C, Sowalsky AG, et al: ERG induces androgen receptor-mediated regulation of SOX9 in prostate cancer. J Clin Invest. 123:1109–1122. 2013. View Article : Google Scholar :

31 

Zhou C, Wang Z, Cao Y and Zhao L: Pan-cancer analysis reveals the oncogenic role of 3-hydroxy-3-methylglutaryl-CoA synthase 1. Cancer Rep (Hoboken). 5:e15622021.

32 

Yang M, Gallo-Ebert C, Hayward M, Liu W, McDonough V and Nickels JT Jr: Human insulin growth factor 2 mRNA binding protein 2 increases MicroRNA 33a/b inhibition of liver ABCA1 expression and alters low-density apolipoprotein levels in mice. Mol Cell Biol. 40:e00058–e00020. 2020. View Article : Google Scholar :

33 

Xu K, Dai X, Wu J and Wen K: N(6)-methyladenosine (m(6)A) reader IGF2BP2 stabilizes HK2 stability to accelerate the Warburg effect of oral squamous cell carcinoma progression. J Cancer Res Clin Oncol. 148:3375–3384. 2022. View Article : Google Scholar

34 

Xu Q, Chen K and Meng J: WHISTLE: A functionally annotated high-accuracy map of human m(6)a epitranscriptome. Methods Mol Biol. 2284:519–529. 2021. View Article : Google Scholar

35 

Zhang Y, Huang YX, Wang DL, Yang B, Yan HY, Lin LH, Li Y, Chen J, Xie LM, Huang YS, et al: LncRNA DSCAM-AS1 interacts with YBX1 to promote cancer progression by forming a positive feedback loop that activates FOXA1 transcription network. Theranostics. 10:10823–10837. 2020. View Article : Google Scholar :

36 

Wen S, Wei Y, Zen C, Xiong W, Niu Y and Zhao Y: Long non-coding RNA NEAT1 promotes bone metastasis of prostate cancer through N6-methyladenosine. Mol Cancer. 19:1712020. View Article : Google Scholar :

37 

Ghildiyal R, Sawant M, Renganathan A, Mahajan K, Kim EH, Luo J, Dang HX, Maher CA, Feng FY and Mahajan NP: Loss of long noncoding RNA NXTAR in prostate cancer augments androgen receptor expression and enzalutamide resistance. Cancer Res. 82:155–168. 2022. View Article : Google Scholar

38 

Sun F, Wu K, Yao Z, Mu X, Zheng Z, Sun M, Wang Y, Liu Z and Zhu Y: Long noncoding RNA LINC00963 induces NOP2 expression by sponging tumor suppressor miR-542-3p to promote metastasis in prostate cancer. Aging (Albany NY). 12:11500–11516. 2020. View Article : Google Scholar

39 

Zhao H, Dong H, Wang P and Zhu H: Long non-coding RNA SNHG17 enhances the aggressiveness of C4-2 human prostate cancer cells in association with β-catenin signaling. Oncol Lett. 21:4722021. View Article : Google Scholar

40 

Bai M, Lei Y, Wang M, Ma J, Yang P, Mou X, Dong Y and Han S: Long Non-coding RNA SNHG17 promotes cell proliferation and invasion in castration-resistant prostate cancer by targeting the miR-144/CD51 Axis. Front Genet. 11:2742020. View Article : Google Scholar

41 

Jin Y, Cui Z, Li X, Jin X and Peng J: Upregulation of long non-coding RNA PlncRNA-1 promotes proliferation and induces epithelial-mesenchymal transition in prostate cancer. Oncotarget. 8:26090–26099. 2017. View Article : Google Scholar

42 

Cui Z, Gao H, Yan N, Dai Y, Wang H, Wang M, Wang J, Zhang D, Sun P, Qi T, et al: LncRNA PlncRNA-1 accelerates the progression of prostate cancer by regulating PTEN/Akt axis. Aging (Albany NY). 13:12113–12128. 2021. View Article : Google Scholar

43 

Shi SJ, Zhang X, Han DH, Yang F, LI Y and Wang LJ: Long non-coding RNA VIM-AS1 promote proliferation and invasion of castrition-resistant prostate cancer C4-2 cells. Chin J Cell Mol Imm. 36:1083–1088. 2020.

44 

Gobel A, Riffel RM, Hofbauer LC and Rachner TD: The mevalonate pathway in breast cancer biology. Cancer Lett. 542:2157612022. View Article : Google Scholar

45 

Laka K, Makgoo L and Mbita Z: Cholesterol-lowering phytochemicals: Targeting the mevalonate pathway for anticancer interventions. Front Genet. 13:8416392022. View Article : Google Scholar

46 

Wang IH, Huang TT, Chen JL, Chu LW, Ping YH, Hsu KW, Huang KH, Fang WL, Lee HC, Chen CF, et al: Mevalonate pathway enzyme HMGCS1 contributes to gastric cancer progression. Cancers (Basel). 12:10882020. View Article : Google Scholar

47 

Yao W, Jiao Y, Zhou Y and Luo X: KLF13 suppresses the proliferation and growth of colorectal cancer cells through transcriptionally inhibiting HMGCS1-mediated cholesterol biosynthesis. Cell Biosci. 10:762020. View Article : Google Scholar : PubMed/NCBI

48 

Walsh CA, Akrap N, Garre E, Magnusson Y, Harrison H, Andersson D, Jonasson E, Rafnsdottir S, Choudhry H, Buffa F, et al: The mevalonate precursor enzyme HMGCS1 is a novel marker and key mediator of cancer stem cell enrichment in luminal and basal models of breast cancer. PLoS One. 15:e02361872020. View Article : Google Scholar : PubMed/NCBI

49 

Ashida S, Kawada C and Inoue K: Stromal regulation of prostate cancer cell growth by mevalonate pathway enzymes HMGCS1 and HMGCR. Oncol Lett. 14:6533–6542. 2017.PubMed/NCBI

50 

Cheng Y, Meng Y, Li S, Cao D, Ben S, Qin C, Hua L and Cheng G: Genetic variants in the cholesterol biosynthesis pathway genes and risk of prostate cancer. Gene. 774:1454322021. View Article : Google Scholar

51 

Xue ST, Zheng B, Cao SQ, Ding JC, Hu GS, Liu W and Chen C: Long non-coding RNA LINC00680 functions as a ceRNA to promote esophageal squamous cell carcinoma progression through the miR-423-5p/PAK6 axis. Mol Cancer. 21:692022. View Article : Google Scholar :

52 

Lang C, Yin C, Lin K, Li Y, Yang Q, Wu Z, Du H, Ren D, Dai Y and Peng X: m(6) A modification of lncRNA PCAT6 promotes bone metastasis in prostate cancer through IGF2BP2-mediated IGF1R mRNA stabilization. Clin Transl Med. 11. pp. e4262021, View Article : Google Scholar

53 

Chen X, Xie R, Gu P, Huang M, Han J, Dong W, Xie W, Wang B, He W, Zhong G, et al: Long noncoding RNA LBCS inhibits self-renewal and chemoresistance of bladder cancer stem cells through epigenetic silencing of SOX2. Clin Cancer Res. 25:1389–1403. 2019. View Article : Google Scholar

54 

Li S, Wu Q, Liu J and Zhong Y: Identification of Two m6A Readers YTHDF1 and IGF2BP2 as immune biomarkers in head and neck squamous cell carcinoma. Front Genet. 13:9036342022. View Article : Google Scholar

55 

Zhang Z, Xing Y, Gao W, Yang L, Shi J, Song W and Li T: N(6)-methyladenosine (m(6)A) reader IGF2BP2 promotes gastric cancer progression via targeting SIRT1. Bioengineered. 13:11541–11550. 2022. View Article : Google Scholar

56 

Yao B, Zhang Q, Yang Z, An F, Nie H, Wang H, Yang C, Sun J, Chen K, Zhou J, et al: CircEZH2/miR-133b/IGF2BP2 aggravates colorectal cancer progression via enhancing the stability of m(6) A-modified CREB1 mRNA. Mol Cancer. 21:1402022. View Article : Google Scholar

57 

Liu Y, Shi M, He X, Cao Y, Liu P, Li F, Zou S, Wen C, Zhan Q, Xu Z, et al: LncRNA-PACERR induces pro-tumour macrophages via interacting with miR-671-3p and m6A-reader IGF2BP2 in pancreatic ductal adenocarcinoma. J Hematol Oncol. 15:522022. View Article : Google Scholar

58 

Han L, Lei G, Chen Z, Zhang Y, Huang C and Chen W: IGF2BP2 regulates MALAT1 by serving as an N6-methyladenosine reader to promote NSCLC proliferation. Front Mol Biosci. 8:7800892021. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Shi S, Han D, Zhang J, Li Y, Yang A and Zhang R: VIM‑AS1 promotes proliferation and drives enzalutamide resistance in prostate cancer via IGF2BP2‑mediated HMGCS1 mRNA stabilization. Int J Oncol 62: 34, 2023.
APA
Shi, S., Han, D., Zhang, J., Li, Y., Yang, A., & Zhang, R. (2023). VIM‑AS1 promotes proliferation and drives enzalutamide resistance in prostate cancer via IGF2BP2‑mediated HMGCS1 mRNA stabilization. International Journal of Oncology, 62, 34. https://doi.org/10.3892/ijo.2023.5482
MLA
Shi, S., Han, D., Zhang, J., Li, Y., Yang, A., Zhang, R."VIM‑AS1 promotes proliferation and drives enzalutamide resistance in prostate cancer via IGF2BP2‑mediated HMGCS1 mRNA stabilization". International Journal of Oncology 62.3 (2023): 34.
Chicago
Shi, S., Han, D., Zhang, J., Li, Y., Yang, A., Zhang, R."VIM‑AS1 promotes proliferation and drives enzalutamide resistance in prostate cancer via IGF2BP2‑mediated HMGCS1 mRNA stabilization". International Journal of Oncology 62, no. 3 (2023): 34. https://doi.org/10.3892/ijo.2023.5482
Copy and paste a formatted citation
x
Spandidos Publications style
Shi S, Han D, Zhang J, Li Y, Yang A and Zhang R: VIM‑AS1 promotes proliferation and drives enzalutamide resistance in prostate cancer via IGF2BP2‑mediated HMGCS1 mRNA stabilization. Int J Oncol 62: 34, 2023.
APA
Shi, S., Han, D., Zhang, J., Li, Y., Yang, A., & Zhang, R. (2023). VIM‑AS1 promotes proliferation and drives enzalutamide resistance in prostate cancer via IGF2BP2‑mediated HMGCS1 mRNA stabilization. International Journal of Oncology, 62, 34. https://doi.org/10.3892/ijo.2023.5482
MLA
Shi, S., Han, D., Zhang, J., Li, Y., Yang, A., Zhang, R."VIM‑AS1 promotes proliferation and drives enzalutamide resistance in prostate cancer via IGF2BP2‑mediated HMGCS1 mRNA stabilization". International Journal of Oncology 62.3 (2023): 34.
Chicago
Shi, S., Han, D., Zhang, J., Li, Y., Yang, A., Zhang, R."VIM‑AS1 promotes proliferation and drives enzalutamide resistance in prostate cancer via IGF2BP2‑mediated HMGCS1 mRNA stabilization". International Journal of Oncology 62, no. 3 (2023): 34. https://doi.org/10.3892/ijo.2023.5482
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