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International Journal of Oncology
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Review

Presence and prospects of exosomal circRNAs in cancer (Review)

  • Authors:
    • Junjie Cui
    • Jiaqi Wang
    • Lianyu Liu
    • Changwen Zou
    • Ying Zhao
    • Zhenyu Xue
    • Xiaoxiong Sun
    • Tao Jiang
    • Jun Song
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R. China, Department of Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400010, P.R. China, Department of General Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R. China
  • Article Number: 47
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    Published online on: February 28, 2023
       https://doi.org/10.3892/ijo.2023.5495
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Abstract

Exosomes are nanoscale extracellular vesicles secreted by parent cells and they are present in most bodily fluids, are able to carry active substances through intercellular transport and mediate communication between different cells, in particular those active in cancer. Circular RNAs (circRNAs) are novel noncoding RNAs expressed in most eukaryotic cells and are involved in various physiological and pathological processes, particularly in the occurrence and progression of cancer. Numerous studies have indicated a close relationship between circRNAs and exosomes. Exosomal circRNAs (exo‑circRNAs) are a type of circRNA enriched in exosomes that may participate in the progression of cancer. Based on this, exo‑circRNAs may have an important role in malignant behavioral manifestations of cancer and hold great promise in the diagnosis and treatment of cancer. The present review gives an introduction to the origin and functions of exosomes and circRNAs and elaborates on the mechanisms of exo‑circRNAs in cancer progression. The biological functions of exo‑circRNAs in tumorigenesis, development and drug resistance, as well as their role as predictive biomarkers, were discussed.
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Copy and paste a formatted citation
Spandidos Publications style
Cui J, Wang J, Liu L, Zou C, Zhao Y, Xue Z, Sun X, Jiang T and Song J: Presence and prospects of exosomal circRNAs in cancer (Review). Int J Oncol 62: 47, 2023.
APA
Cui, J., Wang, J., Liu, L., Zou, C., Zhao, Y., Xue, Z. ... Song, J. (2023). Presence and prospects of exosomal circRNAs in cancer (Review). International Journal of Oncology, 62, 47. https://doi.org/10.3892/ijo.2023.5495
MLA
Cui, J., Wang, J., Liu, L., Zou, C., Zhao, Y., Xue, Z., Sun, X., Jiang, T., Song, J."Presence and prospects of exosomal circRNAs in cancer (Review)". International Journal of Oncology 62.4 (2023): 47.
Chicago
Cui, J., Wang, J., Liu, L., Zou, C., Zhao, Y., Xue, Z., Sun, X., Jiang, T., Song, J."Presence and prospects of exosomal circRNAs in cancer (Review)". International Journal of Oncology 62, no. 4 (2023): 47. https://doi.org/10.3892/ijo.2023.5495
Copy and paste a formatted citation
x
Spandidos Publications style
Cui J, Wang J, Liu L, Zou C, Zhao Y, Xue Z, Sun X, Jiang T and Song J: Presence and prospects of exosomal circRNAs in cancer (Review). Int J Oncol 62: 47, 2023.
APA
Cui, J., Wang, J., Liu, L., Zou, C., Zhao, Y., Xue, Z. ... Song, J. (2023). Presence and prospects of exosomal circRNAs in cancer (Review). International Journal of Oncology, 62, 47. https://doi.org/10.3892/ijo.2023.5495
MLA
Cui, J., Wang, J., Liu, L., Zou, C., Zhao, Y., Xue, Z., Sun, X., Jiang, T., Song, J."Presence and prospects of exosomal circRNAs in cancer (Review)". International Journal of Oncology 62.4 (2023): 47.
Chicago
Cui, J., Wang, J., Liu, L., Zou, C., Zhao, Y., Xue, Z., Sun, X., Jiang, T., Song, J."Presence and prospects of exosomal circRNAs in cancer (Review)". International Journal of Oncology 62, no. 4 (2023): 47. https://doi.org/10.3892/ijo.2023.5495
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