Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
April-2023 Volume 62 Issue 4

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2023 Volume 62 Issue 4

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

A disintegrin and metalloprotease 12 contributes to colorectal cancer metastasis by regulating epithelial‑mesenchymal transition

  • Authors:
    • Hyung-Hoon Oh
    • Young-Lan Park
    • Sun-Young Park
    • Young-Eun Joo
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, Chonnam National University Medical School, Gwangju 501‑757, Republic of Korea
    Copyright: © Oh et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 50
    |
    Published online on: March 1, 2023
       https://doi.org/10.3892/ijo.2023.5498
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

A disintegrin and metalloprotease 12 (ADAM12) and epithelial‑mesenchymal transition (EMT) are linked in the metastasis of various types of cancer. The present study aimed to assess the ability of ADAM12 to induce EMT and its potential as a therapeutic target for colorectal cancer (CRC). ADAM12 expression in CRC cell lines, CRC tissues and a mouse model of peritoneal metastasis was assessed. The effect of ADAM12 on CRC EMT and metastasis was investigated using ADAM12‑pcDNA6‑myc and ADAM12‑pGFP‑C‑shLenti constructs. ADAM12 overexpression enhanced the proliferation, migration, invasion and EMT of CRC cells. The phosphorylation levels of factors associated with the PI3K/Akt pathway were also increased by ADAM12 overexpression. The knockdown of ADAM12 reversed these effects. ADAM12 expression and the loss of E‑cadherin expression were significantly associated with poorer survival compared with other expression statuses of both proteins. In a mouse model of peritoneal metastasis, overexpression of ADAM12 induced increased tumor weight and peritoneal carcinomatosis index compared with that in the negative control group. Conversely, knockdown of ADAM12 reversed these effects. Furthermore, E‑cadherin expression was significantly decreased by overexpression of ADAM12 compared with in the negative control group. By contrast, E‑cadherin expression was increased by knockdown of ADAM12 compared with in the negative control group. ADAM12 overexpression contributed to CRC metastasis by regulating EMT. In addition, in the mouse model of peritoneal metastasis, ADAM12 knockdown exhibited strong anti‑metastatic action. Consequently, ADAM12 may be considered a therapeutic target for CRC metastasis.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Hossain MS, Karuniawati H, Jairoun AA, Urbi Z, Ooi DJ, John A, Lim YC, Kibria KMK, Mohiuddin AKM, Ming LC, et al: Colorectal cancer: A review of carcinogenesis, global epidemiology, current challenges, risk factors, preventive and treatment strategies. Cancers (Basel). 14:17322022. View Article : Google Scholar : PubMed/NCBI

3 

Sullivan BA, Noujaim M and Roper J: Cause, epidemiology, and histology of polyps and pathways to colorectal cancer. Gastrointest Endosc Clin N Am. 32:177–194. 2022. View Article : Google Scholar : PubMed/NCBI

4 

Mattiuzzi C, Sanchis-Gomar F and Lippi G: Concise update on colorectal cancer epidemiology. Ann Transl Med. 7:6092019. View Article : Google Scholar

5 

Van Cutsem E, Cervantes A, Adam R, Sobrero A, Van Krieken JH, Aderka D, Aguilar EA, Bardelli A, Benson A, Bodoky G, et al: ESMO consensus guidelines for the management of patients with metastatic colorectal cancer. Ann Oncol. 27:1386–1422. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Bijelic L, Ramos I and Goeré D: The landmark series: Surgical treatment of colorectal cancer peritoneal metastases. Ann Surg Oncol. 28:4140–4150. 2021. View Article : Google Scholar : PubMed/NCBI

7 

Sugarbaker PH: Prevention and treatment of peritoneal metastases: A comprehensive review. Indian J Surg Oncol. 10:3–23. 2019. View Article : Google Scholar : PubMed/NCBI

8 

Parikh MS, Johnson P, Romanes JP, Freitag HE, Spring ME, Garcia-Henriquez N and Monson JRT: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for colorectal peritoneal metastases: A systematic review. Dis Colon Rectum. 65:16–26. 2022. View Article : Google Scholar

9 

Kciuk M, Gielecińska A, Budzinska A, Mojzych M and Kontek R: Metastasis and MAPK Pathways. Int J Mol Sci. 23:38472022. View Article : Google Scholar : PubMed/NCBI

10 

LeBleu VS and Thiery JP: The continuing search for causality between epithelial-to-mesenchymal transition and the metastatic fitness of carcinoma cells. Cancer Res. 82:1467–1469. 2022. View Article : Google Scholar : PubMed/NCBI

11 

Banerjee S, Lo WC, Majumder P, Roy D, Ghorai M, Shaikh NK, Kant N, Shekhawat MS, Gadekar VS, Ghosh S, et al: Multiple roles for basement membrane proteins in cancer progression and EMT. Eur J Cell Biol. 101:1512202022. View Article : Google Scholar : PubMed/NCBI

12 

Han L, Wang S, Wei C, Fang Y, Huang S, Yin T, Xiong B and Yang C: Tumour microenvironment: A non-negligible driver for epithelial-mesenchymal transition in colorectal cancer. Expert Rev Mol Med. 23:e162021. View Article : Google Scholar : PubMed/NCBI

13 

Ni Q, Li M and Yu S: Research progress of epithelial-mesenchymal transition treatment and drug resistance in colorectal cancer. Technol Cancer Res Treat. 21:153303382210812192022. View Article : Google Scholar : PubMed/NCBI

14 

Zhang N, Ng AS, Cai S, Li Q, Yang L and Kerr D: Novel therapeutic strategies: Targeting epithelial-mesenchymal transition in colorectal cancer. Lancet Oncol. 22:e358–e368. 2021. View Article : Google Scholar : PubMed/NCBI

15 

Wolfsberg TG, Straight PD, Gerena RL, Huovila AP, Primakoff P, Myles DG and White JM: ADAM, a widely distributed and developmentally regulated gene family encoding membrane proteins with a disintegrin and metalloprotease domain. Dev Biol. 169:378–383. 1995. View Article : Google Scholar : PubMed/NCBI

16 

Edwards DR, Handsley MM and Pennington CJ: The ADAM metalloproteinases. Mol Aspects Med. 29:258–289. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Reiss K and Saftig P: The 'a disintegrin and metalloprotease' (ADAM) family of sheddases: Physiological and cellular functions. Semin Cell Dev Biol. 20:126–137. 2009. View Article : Google Scholar

18 

Ma B, Ma Q, Jin C, Wang X, Zhang G, Zhang H, Seeger H and Mueck AO: ADAM12 expression predicts clinical outcome in estrogen receptor-positive breast cancer. Int J Clin Exp Pathol. 8:13279–13283. 2015.

19 

Pan J, Huang Z, Zhang Y and Xu Y: ADAM12 as a clinical prognostic indicator associated with tumor immune infiltration in lung adenocarcinoma. DNA Cell Biol. 41:410–423. 2022. View Article : Google Scholar : PubMed/NCBI

20 

Zhu H, Jiang W, Zhu H, Hu J, Tang B, Zhou Z and He X: Elevation of ADAM12 facilitates tumor progression by enhancing metastasis and immune infiltration in gastric cancer. Int J Oncol. 60:512022. View Article : Google Scholar : PubMed/NCBI

21 

Du S, Sun L, Wang Y, Zhu W, Gao J, Pei W and Zhang Y: ADAM12 is an independent predictor of poor prognosis in liver cancer. Sci Rep. 12:66342022. View Article : Google Scholar : PubMed/NCBI

22 

Mendaza S, Ulazia-Garmendia A, Monreal-Santesteban I, Córdoba A, de Azúa YR, Aguiar B, Beloqui R, Armendáriz P, Arriola M, Martín-Sánchez E and Guerrero-Setas D: ADAM12 is a potential therapeutic target regulated by hypomethylation in triple-negative breast cancer. Int J Mol Sci. 21:9032020. View Article : Google Scholar : PubMed/NCBI

23 

Reiss K, Leitzke S, Seidel J, Sperrhacke M and Bhakdi S: Scramblases as regulators of proteolytic ADAM function. Membranes (Basel). 12:1852022. View Article : Google Scholar : PubMed/NCBI

24 

Zadka L, Kulus MJ and Piatek K: ADAM protein family-its role in tumorigenesis, mechanisms of chemoresistance and potential as diagnostic and prognostic factors. Neoplasma. 65:823–839. 2018. View Article : Google Scholar : PubMed/NCBI

25 

Kveiborg M, Albrechtsen R, Couchman JR and Wewer UM: Cellular roles of ADAM12 in health and disease. Int J Biochem Cell Biol. 40:1685–1702. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Jacobsen J and Wewer UM: Targeting ADAM12 in human disease: Head, body or tail? Curr Pharm Des. 15:2300–2310. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Nyren-Erickson EK, Jones JM, Srivastava DK and Mallik S: A disintegrin and metalloproteinase-12 (ADAM12): Function, roles in disease progression, and clinical implications. Biochim Biophys Acta. 1830:4445–4455. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Park YL, Park SY, Oh HH, Chung MW, Hong JY, Kim KY, Myung DS, Cho SB, Lee WS, Kim HS and Joo YE: A disintegrin and metalloprotease 12 promotes tumor progression by inhibiting apoptosis in human colorectal cancer. Cancers (Basel). 13:19272021. View Article : Google Scholar : PubMed/NCBI

29 

Huang Z, Lai H, Liao J, Cai J, Li B, Meng L, Wang W, Mo X and Qin H: Upregulation of ADAM12 is associated with a poor survival and immune cell infiltration in colon adenocarcinoma. Front Oncol. 11:7292302021. View Article : Google Scholar : PubMed/NCBI

30 

Ten Hoorn S, Waasdorp C, van Oijen MGH, Damhofer H, Trinh A, Zhao L, Smits LJH, Bootsma S, van Pelt GW, Mesker WE, et al: Serum-based measurements of stromal activation through ADAM12 associate with poor prognosis in colorectal cancer. BMC Cancer. 22:3942022. View Article : Google Scholar : PubMed/NCBI

31 

Mochizuki S, Ao T, Sugiura T, Yonemura K, Shiraishi T, Kajiwara Y, Okamoto K, Shinto E, Okada Y and Ueno H: Expression and function of a disintegrin and metalloproteinases in cancer-associated fibroblasts of colorectal cancer. Digestion. 101:18–24. 2020. View Article : Google Scholar

32 

Yao Y, Zhou Y, Su X, Dai L, Yu L, Deng H, Gou L and Yang J: Establishment and characterization of intraperitoneal xenograft models by co-injection of human tumor cells and extracellular matrix gel. Oncol Lett. 10:3450–3456. 2015. View Article : Google Scholar

33 

Bastiaenen VP, Klaver CEL, van der Heijden MCS, Nijman LE, Lecca MC, Tanis PJ, Lenos KJ and Vermeulen L: A mouse model for peritoneal metastases of colorectal origin recapitulates patient heterogeneity. Lab Invest. 100:1465–1474. 2020. View Article : Google Scholar : PubMed/NCBI

34 

Sugarbaker PH: Intraperitoneal chemotherapy and cytoreductive surgery for the prevention and treatment of peritoneal carcinomatosis and sarcomatosis. Semin Surg Oncol. 14:254–261. 1998. View Article : Google Scholar : PubMed/NCBI

35 

Klaver YL, Hendriks T, Lomme RM, Rutten HJ, Bleichrodt RP and de Hingh IH: Intraoperative hyperthermic intraperitoneal chemotherapy after cytoreductive surgery for peritoneal carcinomatosis in an experimental model. Br J Surg. 97:1874–1880. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Amin MB, Edge SB, Greene FL, Byrd DR, Brookland RK, Washington MK, Gershenwald JE, Compton CC, Hess KR, Sullivan DC, et al: AJCC Cancer Staging Manual. Springer International Publishing; 2018

37 

Chen N, Zhu X, Zhu Y, Shi J, Zhang J, Tang C and Chen J: The regulatory relationship and function of LncRNA FAM225A-miR-206-ADAM12 in gastric cancer. Am J Transl Res. 13:8632–8652. 2021.PubMed/NCBI

38 

Huang X and Xie X, Liu P, Yang L, Chen B, Song C, Tang H and Xie X: Adam12 and lnc015192 act as ceRNAs in breast cancer by regulating miR-34a. Oncogene. 37:6316–6326. 2018. View Article : Google Scholar : PubMed/NCBI

39 

Dekky B, Ruff M, Bonnier D, Legagneux V and Théret N: Proteomic screening identifies the zonula occludens protein ZO-1 as a new partner for ADAM12 in invadopodia-like structures. Oncotarget. 9:21366–21382. 2018. View Article : Google Scholar : PubMed/NCBI

40 

Wang J, Zhang Z, Li R, Mao F, Sun W, Chen J, Zhang H, Bartsch JW, Shu K and Lei T: ADAM12 induces EMT and promotes cell migration, invasion and proliferation in pituitary adenomas via EGFR/ERK signaling pathway. Biomed Pharmacother. 97:1066–1077. 2018. View Article : Google Scholar

41 

Eckert MA, Santiago-Medina M, Lwin TM, Kim J, Courtneidge SA and Yang J: ADAM12 induction by Twist1 promotes tumor invasion and metastasis via regulation of invadopodia and focal adhesions. J Cell Sci. 130:2036–2048. 2017.PubMed/NCBI

42 

Ruff M, Leyme A, Le Cann F, Bonnier D, Le Seyec J, Chesnel F, Fattet L, Rimokh R, Baffet G and Théret N: The disintegrin and metalloprotease ADAM12 is associated with TGF-β-induced epithelial to mesenchymal transition. PLoS One. 10:e01391792015. View Article : Google Scholar

43 

Li H, Duhachek-Muggy S, Dubnicka S and Zolkiewska A: Metalloproteinase-disintegrin ADAM12 is associated with a breast tumor-initiating cell phenotype. Breast Cancer Res Treat. 139:691–703. 2013. View Article : Google Scholar : PubMed/NCBI

44 

Guan X: Cancer metastases: Challenges and opportunities. Acta Pharm Sin B. 5:402–418. 2015. View Article : Google Scholar : PubMed/NCBI

45 

Neophytou CM, Panagi M, Stylianopoulos T and Papageorgis P: The role of tumor microenvironment in cancer metastasis: Molecular mechanisms and therapeutic opportunities. Cancers (Basel). 13:20532021. View Article : Google Scholar : PubMed/NCBI

46 

Henke E, Nandigama R and Ergün S: Extracellular matrix in the tumor microenvironment and its impact on cancer therapy. Front Mol Biosci. 6:1602019. View Article : Google Scholar

47 

Popova NV and Jücker M: The functional role of extracellular matrix proteins in cancer. Cancers (Basel). 14:2382022. View Article : Google Scholar : PubMed/NCBI

48 

Devergne O, Sun GH and Schüpbach T: Stratum, a homolog of the human GEF Mss4, partnered with Rab8, controls the basal restriction of basement membrane proteins in epithelial cells. Cell Rep. 18:1831–1839. 2017. View Article : Google Scholar : PubMed/NCBI

49 

Horejs CM: Basement membrane fragments in the context of the epithelial-to-mesenchymal transition. Eur J Cell Biol. 95:427–440. 2016. View Article : Google Scholar : PubMed/NCBI

50 

Liao Z, Tan ZW, Zhu P and Tan NS: Cancer-associated fibroblasts in tumor microenvironment-Accomplices in tumor malignancy. Cell Immunol. 343:1037292019. View Article : Google Scholar

51 

Deng S, Leong HC, Datta A, Gopal V, Kumar AP and Yap CT: PI3K/AKT signaling tips the balance of cytoskeletal forces for cancer progression. Cancers (Basel). 14:16522022. View Article : Google Scholar : PubMed/NCBI

52 

Peng Y, Wang Y, Zhou C, Mei W and Zeng C: PI3K/Akt/mTOR pathway and its role in cancer therapeutics: Are we making headway? Front Oncol. 12:8191282022. View Article : Google Scholar : PubMed/NCBI

53 

Di Blasio L, Gagliardi PA, Puliafito A and Primo L: Serine/Threonine kinase 3-phosphoinositide-dependent protein kinase-1 (PDK1) as a key regulator of cell migration and cancer dissemination. Cancers (Basel). 9:252017. View Article : Google Scholar : PubMed/NCBI

54 

Gagliardi PA, Puliafito A and Primo L: PDK1: At the crossroad of cancer signaling pathways. Semin Cancer Biol. 48:27–35. 2018. View Article : Google Scholar

55 

Lin J, Song T, Li C and Mao W: GSK-3β in DNA repair, apoptosis, and resistance of chemotherapy, radiotherapy of cancer. Biochim Biophys Acta Mol Cell Res. 1867:1186592020. View Article : Google Scholar

56 

Nagini S, Sophia J and Mishra R: Glycogen synthase kinases: Moonlighting proteins with theranostic potential in cancer. Semin Cancer Biol. 56:25–36. 2019. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Oh H, Park Y, Park S and Joo Y: A disintegrin and metalloprotease 12 contributes to colorectal cancer metastasis by regulating epithelial‑mesenchymal transition. Int J Oncol 62: 50, 2023.
APA
Oh, H., Park, Y., Park, S., & Joo, Y. (2023). A disintegrin and metalloprotease 12 contributes to colorectal cancer metastasis by regulating epithelial‑mesenchymal transition. International Journal of Oncology, 62, 50. https://doi.org/10.3892/ijo.2023.5498
MLA
Oh, H., Park, Y., Park, S., Joo, Y."A disintegrin and metalloprotease 12 contributes to colorectal cancer metastasis by regulating epithelial‑mesenchymal transition". International Journal of Oncology 62.4 (2023): 50.
Chicago
Oh, H., Park, Y., Park, S., Joo, Y."A disintegrin and metalloprotease 12 contributes to colorectal cancer metastasis by regulating epithelial‑mesenchymal transition". International Journal of Oncology 62, no. 4 (2023): 50. https://doi.org/10.3892/ijo.2023.5498
Copy and paste a formatted citation
x
Spandidos Publications style
Oh H, Park Y, Park S and Joo Y: A disintegrin and metalloprotease 12 contributes to colorectal cancer metastasis by regulating epithelial‑mesenchymal transition. Int J Oncol 62: 50, 2023.
APA
Oh, H., Park, Y., Park, S., & Joo, Y. (2023). A disintegrin and metalloprotease 12 contributes to colorectal cancer metastasis by regulating epithelial‑mesenchymal transition. International Journal of Oncology, 62, 50. https://doi.org/10.3892/ijo.2023.5498
MLA
Oh, H., Park, Y., Park, S., Joo, Y."A disintegrin and metalloprotease 12 contributes to colorectal cancer metastasis by regulating epithelial‑mesenchymal transition". International Journal of Oncology 62.4 (2023): 50.
Chicago
Oh, H., Park, Y., Park, S., Joo, Y."A disintegrin and metalloprotease 12 contributes to colorectal cancer metastasis by regulating epithelial‑mesenchymal transition". International Journal of Oncology 62, no. 4 (2023): 50. https://doi.org/10.3892/ijo.2023.5498
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team