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RBM15‑mediating MDR1 mRNA m6A methylation regulated by the TGF‑β signaling pathway in paclitaxel‑resistant ovarian cancer

  • Authors:
    • Jia Yuan
    • Wencai Guan
    • Xin Li
    • Fanchen Wang
    • Huiqiang Liu
    • Guoxiong Xu
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    Affiliations: Research Center for Clinical Medicine, Jinshan Hospital, Fudan University, Shanghai 201508, P.R. China
    Copyright: © Yuan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 112
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    Published online on: August 11, 2023
       https://doi.org/10.3892/ijo.2023.5560
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Abstract

Ovarian cancer (OC) lacks effective biomarkers for diagnosis at an early stage and often develops chemoresistance after the initial treatment at an advanced stage. RNA‑binding motif protein 15 (RBM15) is an RNA m6A methylation mediator that serves an oncogenic role in some cancers. However, the function and molecular mechanisms of RBM15 in ovarian tumorigenesis and chemoresistance remain to be elucidated. The present study identified the overexpression of RBM15 in OC tissues and paclitaxel (PTX)‑resistant cells using reverse transcription‑quantitative (q)PCR, western blotting and immunohistochemistry. Clinical data analyses showed that high expression of RBM15 was associated with poor prognosis in patients with OC. Overexpression of RBM15 led to an increase in cell viability and colony formation and a decrease in cell sensitivity to PTX and apoptosis, whereas the knockdown of RBM15 resulted in the inhibition of cell viability and colony formation in vitro and tumor formation in vivo and increased cell apoptosis and sensitivity to PTX in a time‑ and dose‑dependent manner. Furthermore, RBM15 knockdown reduced the spheroid formation of PTX‑resistant OC cells. Silencing of RBM15 decreased multidrug resistance 1 (MDR1) mRNA m6A methylation detected by the methylated RNA immunoprecipitation‑qPCR assay and downregulated the expression of a chemo‑drug efflux pump MDR1 at the mRNA and protein levels. Finally, RBM15 expression was suppressed by the activation of the TGF‑β signaling pathway. Thus, the findings revealed a TGF‑β/RBM15/MDR1 regulatory mechanism. Targeting RBM15 may provide a novel therapeutic strategy for the treatment of PTX‑resistant OC.
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1 

Siegel RL, Miller KD, Fuchs HE and Jemal A: Cancer statistics, 2022. CA Cancer J Clin. 72:7–33. 2022. View Article : Google Scholar : PubMed/NCBI

2 

Lheureux S, Braunstein M and Oza AM: Epithelial ovarian cancer: Evolution of management in the era of precision medicine. CA Cancer J Clin. 69:280–304. 2019.PubMed/NCBI

3 

Lheureux S, Gourley C, Vergote I and Oza AM: Epithelial ovarian cancer. Lancet. 393:1240–1253. 2019. View Article : Google Scholar : PubMed/NCBI

4 

Ramos A, Sadeghi S and Tabatabaeian H: Battling chemoresistance in cancer: Root causes and strategies to uproot them. Int J Mol Sci. 22:94512021. View Article : Google Scholar : PubMed/NCBI

5 

Hrycyna CA: Molecular genetic analysis and biochemical characterization of mammalian P-glycoproteins involved in multidrug resistance. Semin Cell Dev Biol. 12:247–256. 2001. View Article : Google Scholar : PubMed/NCBI

6 

Ahmed N, Escalona R, Leung D, Chan E and Kannourakis G: Tumour microenvironment and metabolic plasticity in cancer and cancer stem cells: Perspectives on metabolic and immune regulatory signatures in chemoresistant ovarian cancer stem cells. Semin Cancer Biol. 53:265–281. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Wang F, Zhang L, Liu J, Zhang J and Xu G: Highly expressed STAT1 contributes to the suppression of stemness properties in human paclitaxel-resistant ovarian cancer cells. Aging (Albany NY). 12:11042–11060. 2020. View Article : Google Scholar : PubMed/NCBI

8 

Foster R, Buckanovich RJ and Rueda BR: Ovarian cancer stem cells: Working towards the root of stemness. Cancer Lett. 338:147–157. 2013. View Article : Google Scholar

9 

Garson K and Vanderhyden BC: Epithelial ovarian cancer stem cells: Underlying complexity of a simple paradigm. Reproduction. 149:R59–R70. 2015. View Article : Google Scholar

10 

Gerardo-Ramirez M, Keggenhoff FL, Giam V, Becker D, Groth M, Hartmann N, Straub BK, Morrison H, Galle PR, Marquardt JU, et al: CD44 contributes to the regulation of MDR1 protein and doxorubicin chemoresistance in osteosarcoma. Int J Mol Sci. 23:86162022. View Article : Google Scholar : PubMed/NCBI

11 

Zaccara S, Ries RJ and Jaffrey SR: Reading, writing and erasing mRNA methylation. Nat Rev Mol Cell Biol. 20:608–624. 2019. View Article : Google Scholar

12 

Lan Q, Liu PY, Bell JL, Wang JY, Hüttelmaier S, Zhang XD, Zhang L and Liu T: The emerging roles of RNA m6A methylation and demethylation as critical regulators of tumorigenesis, drug sensitivity, and resistance. Cancer Res. 81:3431–3440. 2021. View Article : Google Scholar : PubMed/NCBI

13 

Hiriart E, Gruffat H, Buisson M, Mikaelian I, Keppler S, Meresse P, Mercher T, Bernard OA, Sergeant A and Manet E: Interaction of the Epstein-Barr virus mRNA export factor EB2 with human Spen proteins SHARP, OTT1, and a novel member of the family, OTT3, links Spen proteins with splicing regulation and mRNA export. J Biol Chem. 280:36935–36945. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Yang Y, Hsu PJ, Chen YS and Yang YG: Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism. Cell Res. 28:616–624. 2018. View Article : Google Scholar :

15 

Yang F, Liu Y, Xiao J, Li B, Chen Y, Hu A, Zeng J, Liu Z and Liu H: Circ-CTNNB1 drives aerobic glycolysis and osteosarcoma progression via m6A modification through interacting with RBM15. Cell Prolif. 56:e133442023. View Article : Google Scholar

16 

Wang X, Tian L, Li Y, Wang J, Yan B, Yang L, Li Q, Zhao R, Liu M, Wang P and Sun Y: RBM15 facilitates laryngeal squamous cell carcinoma progression by regulating TMBIM6 stability through IGF2BP3 dependent. J Exp Clin Cancer Res. 40:802021. View Article : Google Scholar : PubMed/NCBI

17 

Zhao Z, Ju Q, Ji J, Li Y and Zhao Y: N6-methyladenosine methylation regulator RBM15 is a potential prognostic biomarker and promotes cell proliferation in pancreatic adenocarcinoma. Front Mol Biosci. 9:8428332022. View Article : Google Scholar : PubMed/NCBI

18 

Wang H, Zhao X and Lu Z: m6A RNA methylation regulators act as potential prognostic biomarkers in lung adenocarcinoma. Front Genet. 12:6222332021. View Article : Google Scholar

19 

Jang KH, Heras CR and Lee G: m6A in the signal transduction network. Mol Cells. 45:435–443. 2022. View Article : Google Scholar : PubMed/NCBI

20 

Kwok AL, Wong OG, Wong ES, Tsun OK, Chan KK and Cheung AN: Caution over use of ES2 as a model of ovarian clear cell carcinoma. J Clin Pathol. 67:921–922. 2014. View Article : Google Scholar

21 

Zhang J, Guan W, Xu X, Wang F, Li X and Xu G: A novel homeostatic loop of sorcin drives paclitaxel-resistance and malignant progression via Smad4/ZEB1/miR-142-5p in human ovarian cancer. Oncogene. 40:4906–4918. 2021. View Article : Google Scholar : PubMed/NCBI

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

23 

Zhang L, Zhou D, Guan W, Ren W, Sun W, Shi J, Lin Q, Zhang J, Qiao T, Ye Y, et al: Pyridoxine 5'-phosphate oxidase is a novel therapeutic target and regulated by the TGF-β signalling pathway in epithelial ovarian cancer. Cell Death Dis. 8:32142017. View Article : Google Scholar

24 

Edgar R, Domrachev M and Lash AE: Gene expression omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res. 30:207–210. 2002. View Article : Google Scholar :

25 

Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W and Smyth GK: limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43:e472015. View Article : Google Scholar : PubMed/NCBI

26 

Chandrashekar DS, Bashel B, Balasubramanya SAH, Creighton CJ, Ponce-Rodriguez I, Chakravarthi BVSK and Varambally S: UALCAN: A portal for facilitating tumor subgroup gene expression and survival analyses. Neoplasia. 19:649–658. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Yu G, Wang LG, Han Y and He QY: clusterProfiler: An R package for comparing biological themes among gene clusters. OMICS. 16:284–287. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Gyorffy B, Lánczky A and Szállási Z: Implementing an online tool for genome-wide validation of survival-associated biomarkers in ovarian-cancer using microarray data from 1287 patients. Endocr Relat Cancer. 19:197–208. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Tang Z, Li C, Kang B, Gao G, Li C and Zhang Z: GEPIA: A web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 45(W1): W98–W102. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Geeleher P, Cox N and Huang RS: pRRophetic: An R package for prediction of clinical chemotherapeutic response from tumor gene expression levels. PLoS One. 9:e1074682014. View Article : Google Scholar : PubMed/NCBI

31 

Zhou Y, Zeng P, Li YH, Zhang Z and Cui Q: SRAMP: Prediction of mammalian N6-methyladenosine (m6A) sites based on sequence-derived features. Nucleic Acids Res. 44:e912016. View Article : Google Scholar : PubMed/NCBI

32 

Castro-Mondragon JA, Riudavets-Puig R, Rauluseviciute I, Lemma RB, Turchi L, Blanc-Mathieu R, Lucas J, Boddie P, Khan A, Manosalva Pérez N, et al: JASPAR 2022: The 9th release of the open-access database of transcription factor binding profiles. Nucleic Acids Res. 50(D1): D165–D173. 2022. View Article : Google Scholar :

33 

Bowen NJ, Walker LD, Matyunina LV, Logani S, Totten KA, Benigno BB and McDonald JF: Gene expression profiling supports the hypothesis that human ovarian surface epithelia are multipotent and capable of serving as ovarian cancer initiating cells. BMC Med Genomics. 2:712009. View Article : Google Scholar : PubMed/NCBI

34 

Yoshihara K, Tajima A, Komata D, Yamamoto T, Kodama S, Fujiwara H, Suzuki M, Onishi Y, Hatae M, Sueyoshi K, et al: Gene expression profiling of advanced-stage serous ovarian cancers distinguishes novel subclasses and implicates ZEB2 in tumor progression and prognosis. Cancer Sci. 100:1421–1428. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Dong H, Zhang H, Mao X, Liu S, Xu W and Zhang Y: RBM15 promates the proliferation, migration and invasion of pancreatic cancer cell lines. Cancers (Basel). 15:10842023. View Article : Google Scholar : PubMed/NCBI

36 

Zeng X, Chen K, Li L, Tian J, Ruan W, Hu Z, Peng D and Chen Z: Epigenetic activation of RBM15 promotes clear cell renal cell carcinoma growth, metastasis and macrophage infiltration by regulating the m6A modification of CXCL11. Free Radic Biol Med. 184:135–147. 2022. View Article : Google Scholar : PubMed/NCBI

37 

Ayob AZ and Ramasamy TS: Cancer stem cells as key drivers of tumour progression. J Biomed Sci. 25:202018. View Article : Google Scholar : PubMed/NCBI

38 

Abdullah LN and Chow EKH: Mechanisms of chemoresistance in cancer stem cells. Clin Transl Med. 2:32013. View Article : Google Scholar : PubMed/NCBI

39 

Elzarkaa AA, Sabaa BE, Abdelkhalik D, Mansour H, Melis M, Shaalan W, Farouk M, Malik E and Soliman AA: Clinical relevance of CD44 surface expression in advanced stage serous epithelial ovarian cancer: A prospective study. J Cancer Res Clin Oncol. 142:949–958. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Gao Y, Foster R, Yang X, Feng Y, Shen JK, Mankin HJ, Hornicek FJ, Amiji MM and Duan Z: Up-regulation of CD44 in the development of metastasis, recurrence and drug resistance of ovarian cancer. Oncotarget. 6:9313–9326. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Cai X, Chen Y, Man D, Yang B, Feng X, Zhang D, Chen J and Wu J: RBM15 promotes hepatocellular carcinoma progression by regulating N6-methyladenosine modification of YES1 mRNA in an IGF2BP1-dependent manner. Cell Death Discov. 7:3152021. View Article : Google Scholar : PubMed/NCBI

42 

Fang J, Wu X, He J, Zhang H, Chen X, Zhang H, Novakovic B, Qi H and Yu X: RBM15 suppresses hepatic insulin sensitivity of offspring of gestational diabetes mellitus mice via m6A-mediated regulation of CLDN4. Mol Med. 29:232023. View Article : Google Scholar : PubMed/NCBI

43 

Takara K, Sakaeda T and Okumura K: An update on overcoming MDR1-mediated multidrug resistance in cancer chemotherapy. Curr Pharm Des. 12:273–286. 2006. View Article : Google Scholar : PubMed/NCBI

44 

Huang W, Yang S, Cheng YS, Sima N, Sun W, Shen M, Braisted JC, Lu W and Zheng W: Terfenadine resensitizes doxorubicin activity in drug-resistant ovarian cancer cells via an inhibition of CaMKII/CREB1 mediated ABCB1 expression. Front Oncol. 12:10684432022. View Article : Google Scholar : PubMed/NCBI

45 

Su S, Sun X, Zhang Q, Zhang Z and Chen J: CCL20 promotes ovarian cancer chemotherapy resistance by regulating ABCB1 expression. Cell Struct Funct. 44:21–28. 2019. View Article : Google Scholar : PubMed/NCBI

46 

Vaidyanathan A, Sawers L, Gannon AL, Chakravarty P, Scott AL, Bray SE, Ferguson MJ and Smith G: ABCB1 (MDR1) induction defines a common resistance mechanism in paclitaxeland olaparib-resistant ovarian cancer cells. Br J Cancer. 115:431–441. 2016. View Article : Google Scholar : PubMed/NCBI

47 

Wang T, Kong S, Tao M and Ju S: The potential role of RNA N6-methyladenosine in Cancer progression. Mol Cancer. 19:882020. View Article : Google Scholar : PubMed/NCBI

48 

Ikushima H and Miyazono K: TGFbeta signalling: A complex web in cancer progression. Nat Rev Cancer. 10:415–424. 2010. View Article : Google Scholar : PubMed/NCBI

49 

Katsuno Y, Meyer DS, Zhang Z, Shokat KM, Akhurst RJ, Miyazono K and Derynck R: Chronic TGF-β exposure drives stabilized EMT, tumor stemness, and cancer drug resistance with vulnerability to bitopic mTOR inhibition. Sci Signal. 12:eaau85442019. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Yuan J, Guan W, Li X, Wang F, Liu H and Xu G: RBM15‑mediating MDR1 mRNA m<sup>6</sup>A methylation regulated by the TGF‑β signaling pathway in paclitaxel‑resistant ovarian cancer. Int J Oncol 63: 112, 2023.
APA
Yuan, J., Guan, W., Li, X., Wang, F., Liu, H., & Xu, G. (2023). RBM15‑mediating MDR1 mRNA m<sup>6</sup>A methylation regulated by the TGF‑β signaling pathway in paclitaxel‑resistant ovarian cancer. International Journal of Oncology, 63, 112. https://doi.org/10.3892/ijo.2023.5560
MLA
Yuan, J., Guan, W., Li, X., Wang, F., Liu, H., Xu, G."RBM15‑mediating MDR1 mRNA m<sup>6</sup>A methylation regulated by the TGF‑β signaling pathway in paclitaxel‑resistant ovarian cancer". International Journal of Oncology 63.4 (2023): 112.
Chicago
Yuan, J., Guan, W., Li, X., Wang, F., Liu, H., Xu, G."RBM15‑mediating MDR1 mRNA m<sup>6</sup>A methylation regulated by the TGF‑β signaling pathway in paclitaxel‑resistant ovarian cancer". International Journal of Oncology 63, no. 4 (2023): 112. https://doi.org/10.3892/ijo.2023.5560
Copy and paste a formatted citation
x
Spandidos Publications style
Yuan J, Guan W, Li X, Wang F, Liu H and Xu G: RBM15‑mediating MDR1 mRNA m<sup>6</sup>A methylation regulated by the TGF‑β signaling pathway in paclitaxel‑resistant ovarian cancer. Int J Oncol 63: 112, 2023.
APA
Yuan, J., Guan, W., Li, X., Wang, F., Liu, H., & Xu, G. (2023). RBM15‑mediating MDR1 mRNA m<sup>6</sup>A methylation regulated by the TGF‑β signaling pathway in paclitaxel‑resistant ovarian cancer. International Journal of Oncology, 63, 112. https://doi.org/10.3892/ijo.2023.5560
MLA
Yuan, J., Guan, W., Li, X., Wang, F., Liu, H., Xu, G."RBM15‑mediating MDR1 mRNA m<sup>6</sup>A methylation regulated by the TGF‑β signaling pathway in paclitaxel‑resistant ovarian cancer". International Journal of Oncology 63.4 (2023): 112.
Chicago
Yuan, J., Guan, W., Li, X., Wang, F., Liu, H., Xu, G."RBM15‑mediating MDR1 mRNA m<sup>6</sup>A methylation regulated by the TGF‑β signaling pathway in paclitaxel‑resistant ovarian cancer". International Journal of Oncology 63, no. 4 (2023): 112. https://doi.org/10.3892/ijo.2023.5560
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