|
1
|
Lingvay I, Cohen RV, Roux CWL and
Sumithran P: Obesity in adults. Lancet. 404:972–987. 2024.
View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Chandrasekaran P and Weiskirchen R: The
role of obesity in type 2 diabetes mellitus-an overview. Int J Mol
Sci. 25:18822024. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Koskinas KC, Van Craenenbroeck EM,
Antoniades C, Blüher M, Gorter TM, Hanssen H, Marx N, McDonagh TA,
Mingrone G, Rosengren A, et al: Obesity and cardiovascular disease:
An ESC clinical consensus statement. Eur Heart J. 45:4063–4098.
2024. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
King LK, March L and Anandacoomarasamy A:
Obesity & osteoarthritis. Indian J Med Res. 138:185–193.
2013.
|
|
5
|
GBD 2021 Adult BMI Collaborators: Global,
regional, and national prevalence of adult overweight and obesity,
1990-2021, with forecasts to 2050: A forecasting study for the
Global burden of disease study 2021. Lancet. 405:813–838. 2025.
View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Sung H, Ferlay J, Siegel RL, Laversanne M,
Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020:
GLOBOCAN estimates of incidence and mortality worldwide for 36
cancers in 185 countries. CA Cancer J Clin. 71:209–249.
2021.PubMed/NCBI
|
|
7
|
Wu Y, Zhou L, Zhang X, Yang X, Niedermann
G and Xue J: Psychological distress and eustress in cancer and
cancer treatment: Advances and perspectives. Sci Adv.
8:eabq79822022. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Early Breast Cancer Trialists'
Collaborative Group (EBCTCG); Darby S, McGale P, Correa C, Taylor
C, Arriagada R, Clarke M, Cutter D, Davies C, Ewertz M, et al:
Effect of radiotherapy after breast-conserving surgery on 10-year
recurrence and 15-year breast cancer death: Meta-analysis of
individual patient data for 10,801 women in 17 randomised trials.
Lancet. 378:1707–1716. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Teli BD and Behzadifar M, Beiranvand M,
Rezapour A, Ehsanzadeh SJ, Azari S, Bakhtiari A, Haghighatfard P,
Martini M, Saran M and Behzadifar M: The economic burden of breast
cancer in western Iran: A cross-sectional cost-of-illness study. J
Health Popul Nutr. 44:162025. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Xiong N, Wu H and Yu Z: Advancements and
challenges in triple-negative breast cancer: A comprehensive review
of therapeutic and diagnostic strategies. Front Oncol.
14:14054912024. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Hu JJ, Zhang QY and Yang ZC: The
correlation between obesity and the occurrence and development of
breast cancer. Eur J Med Res. 30:4192025. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Agnoli C, Grioni S, Sieri S, Sacerdote C,
Ricceri F, Tumino R, Frasca G, Pala V, Mattiello A, Chiodini P, et
al: Metabolic syndrome and breast cancer risk: A case-cohort study
nested in a multicentre italian cohort. PLoS One. 10:e01288912015.
View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Cozzo AJ, Fuller AM and Makowski L:
Contribution of adipose tissue to development of cancer. Compr
Physiol. 8:237–282. 2017. View Article : Google Scholar
|
|
14
|
Xu Q, Yu J, Jia G, Li Z and Xiong H:
Crocin attenuates NF-κB-mediated inflammation and proliferation in
breast cancer cells by down-regulating PRKCQ. Cytokine.
154:1558882022. View Article : Google Scholar
|
|
15
|
Chen EP and Smyth EM: COX-2 and
PGE2-dependent immunomodulation in breast cancer. Prostaglandins
Other Lipid Mediat. 96:14–20. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Sharma VR, Gupta GK and Sharma AK, Batra
N, Sharma DK, Joshi A and Sharma AK: PI3K/Akt/mTOR intracellular
pathway and breast cancer: Factors, mechanism and regulation. Curr
Pharm Des. 23:1633–1638. 2017. View Article : Google Scholar
|
|
17
|
Mohanty SS and Mohanty PK: Obesity as
potential breast cancer risk factor for postmenopausal women. Genes
Dis. 8:117–123. 2021. View Article : Google Scholar :
|
|
18
|
Neuhouser ML, Aragaki AK, Prentice RL,
Manson JE, Chlebowski R, Carty CL, Ochs-Balcom HM, Thomson CA, Caan
BJ, Tinker LF, et al: Overweight, obesity, and postmenopausal
invasive breast cancer risk: A secondary analysis of the women's
health initiative randomized clinical trials. JAMA Oncol.
1:611–621. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Kabat GC, Kim MY, Lee JS, Ho GY, Going SB,
Beebe-Dimmer J, Manson JE, Chlebowski RT and Rohan TE: Metabolic
obesity phenotypes and risk of breast cancer in postmenopausal
women. Cancer Epidemiol Biomarkers Prev. 26:1730–1735. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Picon-Ruiz M, Morata-Tarifa C,
Valle-Goffin JJ, Friedman ER and Slingerland JM: Obesity and
adverse breast cancer risk and outcome: Mechanistic insights and
strategies for intervention. CA Cancer J Clin. 67:378–397.
2017.PubMed/NCBI
|
|
21
|
Ladoire S, Dalban C, Roché H, Spielmann M,
Fumoleau P, Levy C, Martin AL, Ecarnot F, Bonnetain F and
Ghiringhelli F: Effect of obesity on disease-free and overall
survival in node-positive breast cancer patients in a large French
population: a pooled analysis of two randomised trials. Eur J
Cancer. 50:506–516. 2014. View Article : Google Scholar
|
|
22
|
Ligibel JA, Cirrincione CT, Liu M, Citron
M, Ingle JN, Gradishar W, Martino S, Sikov W, Michaelson R, Mardis
E, et al: Body mass index, PAM50 subtype, and outcomes in
node-positive breast cancer: CALGB 9741 (Alliance). J Natl Cancer
Inst. 107:djv1792015. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Iyengar NM, Arthur R, Manson JE,
Chlebowski RT, Kroenke CH, Peterson L, Cheng TD, Feliciano EC, Lane
D, Luo J, et al: Association of body fat and risk of breast cancer
in postmenopausal women with normal body mass index: A secondary
analysis of a randomized clinical trial and observational study.
JAMA Oncol. 5:155–163. 2019. View Article : Google Scholar :
|
|
24
|
Dias JA, Fredrikson GN, Ericson U,
Gullberg B, Hedblad B, Engström G, Borgquist S, Nilsson J and
Wirfält E: Low-grade inflammation, oxidative stress and risk of
invasive post-menopausal breast cancer-A nested case-control study
from the malmö diet and cancer cohort. PLoS One. 11:e01589592016.
View Article : Google Scholar
|
|
25
|
Chlebowski RT, Aragaki AK, Pan K, Simon
MS, Neuhouser ML, Haque R, Rohan TE, Wactawski-Wende J, Orchard TS,
Mortimer JE, et al: Breast cancer incidence and mortality by
metabolic syndrome and obesity: The women's health initiative.
Cancer. 130:3147–3156. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Widschwendter P, Friedl TW, Schwentner L,
DeGregorio N, Jaeger B, Schramm A, Bekes I, Deniz M, Lato K,
Weissenbacher T, et al: The influence of obesity on survival in
early, high-risk breast cancer: Results from the randomized SUCCESS
A trial. Breast Cancer Res. 17:1292015. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Gennari A, Amadori D, Scarpi E, Farolfi A,
Paradiso A, Mangia A, Biglia N, Gianni L, Tienghi A, Rocca A, et
al: Impact of body mass index (BMI) on the prognosis of high-risk
early breast cancer (EBC) patients treated with adjuvant
chemotherapy. Breast Cancer Res Treat. 159:79–86. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Biganzoli E, Desmedt C, Fornili M, de
Azambuja E, Cornez N, Ries F, Closon-Dejardin MT, Kerger J, Focan
C, Di Leo L, et al: Recurrence dynamics of breast cancer according
to baseline body mass index. Eur J Cancer. 87:10–20. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Lammers SWM, Geurts SME, van Hellemond
IEG, Swinkels ACP, Smorenburg CH, van der Sangen MJC, Kroep JR, de
Graaf H, Honkoop AH, Erdkamp FLG, et al: The prognostic and
predictive effect of body mass index in hormone receptor-positive
breast cancer. JNCI Cancer Spectr. 7:pkad0922023. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Tzschaschel M, Friedl TWP, Schochter F,
Schütze S, Polasik A, Fehm T, Pantel K, Schindlbeck C, Schneeweiss
A, Schreier J, et al: Association Between Obesity and Circulating
Tumor Cells in Early Breast Cancer Patients. Clin Breast Cancer.
23:e345–e353. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Tangalakis LL, Cortina CS, Son JD, Poirier
J and Madrigrano A: Obesity does not influence management of
advanced breast cancer in the elderly. Clin Breast Cancer.
19:197–199. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Bhan A and Mandal SS: LncRNA HOTAIR: A
master regulator of chromatin dynamics and cancer. Biochim Biophys
Acta. 1856:151–164. 2015.PubMed/NCBI
|
|
33
|
Zhang Y, Sano M, Shinmura K, Tamaki K,
Katsumata Y, Matsuhashi T, Morizane S, Ito H, Hishiki T, Endo J, et
al: 4-hydroxy-2-nonenal protects against cardiac
ischemia-reperfusion injury via the Nrf2-dependent pathway. J Mol
Cell Cardiol. 49:576–586. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Pizzimenti S, Toaldo C, Pettazzoni P,
Dianzani MU and Barrera G: The 'two-faced' effects of reactive
oxygen species and the lipid peroxidation product 4-hydroxynonenal
in the hallmarks of cancer. Cancers (Basel). 2:338–363. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Zhong H and Yin H: Role of lipid
peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: Focusing
on mitochondria. Redox Biol. 4:193–199. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Di Cosimo S, Porcu L, Agbor-Tarh D,
Cinieri S, Franzoi MA, De Santis MC, Saura C, Huober J, Fumagalli
D, Izquierdo M, et al: Effect of body mass index on response to
neo-adjuvant therapy in HER2-positive breast cancer: An exploratory
analysis of the NeoALTTO trial. Breast Cancer Res. 22:1152020.
View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Martel S, Lambertini M, Agbor-Tarh D,
Ponde NF, Gombos A, Paterson V, Hilbers F, Korde L, Manukyants A,
Dueck A, et al: Body mass index and weight change in patients with
HER2-positive early breast cancer: Exploratory analysis of the
ALTTO BIG 2-06 trial. J Natl Compr Canc Netw. 19:181–189. 2021.
View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Dauccia C, Alice Franzoi M, Martel S,
Agbor-Tarh D, Fielding S, Piccart M, Bines J, Loibl S, Di Cosimo S,
Vaz-Luis I, et al: Body mass index and weight changes in patients
with HER2-positive early breast cancer: A sub-analysis of the
APHINITY trial. Eur J Cancer. 223:1154892025. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Sedjo RL, Byers T, Ganz PA, Colditz GA,
Demark-Wahnefried W, Wolin KY, Azrad M and Rock CL: Weight gain
prior to entry into a weight-loss intervention study among
overweight and obese breast cancer survivors. J Cancer Surviv.
8:410–418. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Mutschler NS, Scholz C, Friedl TWP,
Zwingers T, Fasching PA, Beckmann MW, Fehm T, Mohrmann S, Salmen J,
Ziegler C, et al: Prognostic impact of weight change during
adjuvant chemotherapy in patients with high-risk early breast
cancer: Results from the ADEBAR study. Clin Breast Cancer.
18:175–183. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Goodwin PJ, Segal RJ, Vallis M, Ligibel
JA, Pond GR, Robidoux A, Blackburn GL, Findlay B, Gralow JR,
Mukherjee S, et al: Randomized trial of a telephone-based weight
loss intervention in postmenopausal women with breast cancer
receiving letrozole: The LISA trial. J Clin Oncol. 32:2231–2239.
2014. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Babatunde OA, Arp Adams S, Truman S, Sercy
EMSPH, Murphy AE, Khan SMSW, Hurley TGMS, Wirth MD, Choi SK,
Johnson HBA and Hebert ScD JR: The impact of a randomized dietary
and physical activity intervention on chronic inflammation among
obese African-American women. Women Health. 60:792–805. 2020.
View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Inglis JE, Kleckner AS, Lin PJ, Gilmore
NJ, Culakova E, VanderWoude AC, Mustian KM, Fernandez ID, Dunne RF,
Deutsch J and Peppone LJ: Excess body weight and cancer-related
fatigue, systemic inflammation, and serum lipids in breast cancer
survivors. Nutr Cancer. 73:1676–1686. 2021. View Article : Google Scholar
|
|
44
|
Kiecolt-Glaser JK, Renna M, Peng J,
Sheridan J, Lustberg M, Ramaswamy B, Wesolowski R, VanDeusen JB,
Williams NO, Sardesai SD, et al: Breast cancer survivors' typhoid
vaccine responses: Chemotherapy, obesity, and fitness make a
difference. Brain Behav Immun. 103:1–9. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Poggio F, Blondeaux E, Tagliamento M,
Perachino M, Nardin S, Conte B, Giuliano M, Arpino G, De Laurentiis
M, Gravina A, et al: Efficacy of adjuvant chemotherapy schedules
for breast cancer according to body mass index: results from the
phase III GIM2 trial. ESMO Open. 9:1036502024. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Biganzoli G, Isnaldi E, Richard F, Marano
G, Boracchi P, Maetens M, Floris G, Neven P, Jerusalem G, Munzone
E, et al: Prognostic relation of body mass index on extended
aromatase inhibition treatment in postmenopausal patients with
estrogen receptor positive breast cancer: A retrospective analysis
of the SOLE trial. Eur J Cancer. 222:1154382025. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Macis D, Bellerba F, Aristarco V,
Johansson H, Guerrieri-Gonzaga A, Lazzeroni M, Sestak I, Cuzick J,
DeCensi A, Bonanni B and Gandini S: A mediation analysis of obesity
and adiponectin association with postmenopausal breast cancer risk:
A nested cohort study in the International breast cancer
intervention study II (IBIS-II) prevention trial. Nutrients.
16:20982024. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Surmacz E: Obesity hormone leptin: A new
target in breast cancer? Breast Cancer Res. 9:3012007. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Zhou W, Guo S and Gonzalez-Perez RR:
Leptin pro-angiogenic signature in breast cancer is linked to IL-1
signalling. Br J Cancer. 104:128–137. 2011. View Article : Google Scholar :
|
|
50
|
Wang L, Tang C, Cao H, Li K, Pang X, Zhong
L, Dang W, Tang H, Huang Y, Wei L, et al: Activation of IL-8 via
PI3K/Akt-dependent pathway is involved in leptin-mediated
epithelial-mesenchymal transition in human breast cancer cells.
Cancer Biol Ther. 16:1220–1230. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Qi Y, Li R and Han M: Tumor-associated
macrophages induce epithelial-mesenchymal transition and promote
lung metastasis in breast cancer by activating the IL-6/STAT3/TGM2
axis. Int Immunopharmacol. 143(Pt 2): 1133872024. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Luan D, Dadpey B, Zaid J, Bridge-Comer PE,
DeLuca JH, Xia W, Castle J and Reilly SM: Adipocyte-Secreted IL-6
sensitizes macrophages to IL-4 signaling. Diabetes. 72:367–374.
2023. View Article : Google Scholar :
|
|
53
|
Zhou Y and Rui L: Leptin signaling and
leptin resistance. Front Med. 7:207–222. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Jiang M, Zhang K, Zhang Z, Zeng X, Huang
Z, Qin P, Xie Z, Cai X, Ashrafizadeh M, Tian Y and Wei R:
PI3K/AKT/mTOR axis in cancer: From pathogenesis to treatment.
MedComm (2020). 6:e702952025. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Kwon O, Kim KW and Kim MS: Leptin
signalling pathways in hypothalamic neurons. Cell Mol Life Sci.
73:1457–1477. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Zhang L, Wen K, Han X, Liu R and Qu Q:
Adiponectin mediates antiproliferative and apoptotic responses in
endometrial carcinoma by the AdipoRs/AMPK pathway. Gynecol Oncol.
137:311–320. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Herzig S and Shaw RJ: AMPK: Guardian of
metabolism and mitochondrial homeostasis. Nat Rev Mol Cell Biol.
19:121–135. 2018. View Article : Google Scholar :
|
|
58
|
Fosam A and Perry RJ: Current mechanisms
in obesity and tumor progression. Curr Opin Clin Nutr Metab Care.
23:395–403. 2020.PubMed/NCBI
|
|
59
|
Wang Y, Luo M, Wang F, Tong Y, Li L, Shu
Y, Qiao K, Zhang L, Yan G, Liu J, et al: AMPK induces degradation
of the transcriptional repressor PROX1 impairing branched amino
acid metabolism and tumourigenesis. Nat Commun. 13:72152022.
View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Tong Y, Xu S, Huang L and Chen C: Obesity
and insulin resistance: Pathophysiology and treatment. Drug Discov
Today. 27:822–830. 2022. View Article : Google Scholar
|
|
61
|
Hotamisligil GS, Peraldi P, Budavari A,
Ellis R, White MF and Spiegelman BM: IRS-1-mediated inhibition of
insulin receptor tyrosine kinase activity in TNF-alpha- and
obesity-induced insulin resistance. Science. 271:665–668. 1996.
View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Piro S, Anello M, Di Pietro C, Lizzio MN,
Patanè G, Rabuazzo AM, Vigneri R, Purrello M and Purrello F:
Chronic exposure to free fatty acids or high glucose induces
apoptosis in rat pancreatic islets: possible role of oxidative
stress. Metabolism. 51:1340–1347. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Lopez R, Arumugam A, Joseph R, Monga K,
Boopalan T, Agullo P, Gutierrez C, Nandy S, Subramani R, de la Rosa
JM and Lakshmanaswamy R: Hyperglycemia enhances the proliferation
of non-tumorigenic and malignant mammary epithelial cells through
increased leptin/IGF1R signaling and activation of AKT/mTOR. PLoS
One. 8:e797082013. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Bartella V, Cascio S, Fiorio E, Auriemma
A, Russo A and Surmacz E: Insulin-dependent leptin expression in
breast cancer cells. Cancer Res. 68:4919–4927. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Tiwari P, Blank A, Cui C, Schoenfelt KQ,
Zhou G, Xu Y, Khramtsova G, Olopade F, Shah AM, Khan SA, et al:
Metabolically activated adipose tissue macrophages link obesity to
triple-negative breast cancer. J Exp Med. 216:1345–1358. 2019.
View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Morris PG, Hudis CA, Giri D, Morrow M,
Falcone DJ, Zhou XK, Du B, Brogi E, Crawford CB, Kopelovich L, et
al: Inflammation and increased aromatase expression occur in the
breast tissue of obese women with breast cancer. Cancer Prev Res
(Phila). 4:1021–1029. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
67
|
Potolitsyna E, Hazell Pickering S, Germier
T, Collas P and Briand N: Long non-coding RNA HOTAIR regulates
cytoskeleton remodeling and lipid storage capacity during
adipogenesis. Sci Rep. 12:101572022. View Article : Google Scholar : PubMed/NCBI
|
|
68
|
Zhang J, Chen M, Zhai Y and Fu Y: HOTAIR
regulates lipopolysaccharide-induced inflammatory response in
hepatocytes. J Cell Physiol. 235:4247–4255. 2020. View Article : Google Scholar
|
|
69
|
Gupta RA, Shah N, Wang KC, Kim J, Horlings
HM, Wong DJ, Tsai MC, Hung T, Argani P, Rinn JL, et al: Long
non-coding RNA HOTAIR reprograms chromatin state to promote cancer
metastasis. Nature. 464:1071–1076. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
70
|
Kado T, Nawaz A, Takikawa A, Usui I and
Tobe K: Linkage of CD8(+) T cell exhaustion with high-fat
diet-induced tumourigenesis. Sci Rep. 9:122842019. View Article : Google Scholar : PubMed/NCBI
|
|
71
|
Ivanisevic T and Sewduth RN: Multi-Omics
integration for the design of novel therapies and the
identification of novel biomarkers. Proteomes. 11:342023.
View Article : Google Scholar : PubMed/NCBI
|
|
72
|
Pingili AK, Chaib M, Sipe LM, Miller EJ,
Teng B, Sharma R, Yarbro JR, Asemota S, Al Abdallah Q, Mims TS, et
al: Immune checkpoint blockade reprograms systemic immune landscape
and tumor microenvironment in obesity-associated breast cancer.
Cell Rep. 35:1092852021. View Article : Google Scholar : PubMed/NCBI
|
|
73
|
Wang Z, Aguilar EG, Luna JI, Dunai C,
Khuat LT, Le CT, Mirsoian A, Minnar CM, Stoffel KM, Sturgill IR, et
al: Paradoxical effects of obesity on T cell function during tumor
progression and PD-1 checkpoint blockade. Nat Med. 25:141–151.
2019. View Article : Google Scholar :
|
|
74
|
Danforth DN: The role of chronic
inflammation in the development of breast cancer. Cancers (Basel).
13:39182021. View Article : Google Scholar : PubMed/NCBI
|
|
75
|
Mao H, Zhao X and Sun SC: NF-κB in
inflammation and cancer. Cell Mol Immunol. 22:811–839. 2025.
View Article : Google Scholar : PubMed/NCBI
|
|
76
|
Andrijauskaite K and Wargovich MJ: Role of
natural products in breast cancer related symptomology: Targeting
chronic inflammation. Semin Cancer Biol. 80:370–378. 2022.
View Article : Google Scholar
|
|
77
|
Suman S, Sharma PK, Rai G, Mishra S, Arora
D, Gupta P and Shukla Y: Current perspectives of molecular pathways
involved in chronic inflammation-mediated breast cancer. Biochem
Biophys Res Commun. 472:401–409. 2016. View Article : Google Scholar
|
|
78
|
Greenlee H, Shi Z, Hibshoosh H, Giri DD,
Ahmed A, Williams S, Falcone DJ, Winston LA, Zhou XK, Hudis CA, et
al: Obesity-associated breast inflammation among hispanic/latina
breast cancer patients. Cancer Prev Res (Phila). 12:21–30. 2019.
View Article : Google Scholar
|
|
79
|
Xiao L, Xian M, Zhang C, Guo Q and Yi Q:
Lipid peroxidation of immune cells in cancer. Front Immunol.
14:13227462024. View Article : Google Scholar : PubMed/NCBI
|
|
80
|
Kubatka P, Bojkova B, Nosalova N, Huniadi
M, Samuel SM, Sreenesh B, Hrklova G, Kajo K, Hornak S, Cizkova D,
et al: Targeting the MAPK signaling pathway: Implications and
prospects of flavonoids in 3P medicine as modulators of cancer cell
plasticity and therapeutic resistance in breast cancer patients.
EPMA J. 16:437–463. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
81
|
Guo YJ, Pan WW, Liu SB, Shen ZF, Xu Y and
Hu LL: ERK/MAPK signalling pathway and tumorigenesis. Exp Ther Med.
19:1997–2007. 2020.PubMed/NCBI
|
|
82
|
Burotto M, Chiou VL, Lee JM and Kohn EC:
The MAPK pathway across different malignancies: A new perspective.
Cancer. 120:3446–3456. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
83
|
Pallathadka H, Khaleel AQ, Zwamel AH,
Malathi H, Sharma S, Rizaev JA, Mustafa YF, Pramanik A, Shuhata
Alubiady MH and Jawad MA: Multi-Drug resistance and breast cancer
progression via toll-like receptors (TLRs) signaling. Cell Biochem
Biophys. 82:3015–3030. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
84
|
Pálmai-Pallag T and Bachrati CZ:
Inflammation-induced DNA damage and damage-induced inflammation: A
vicious cycle. Microbes Infect. 16:822–832. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
85
|
Zhou J, Zhang L, Liu S, DeRubeis D and
Zhang D: Toll-like receptors in breast cancer immunity and
immunotherapy. Front Immunol. 15:14180252024. View Article : Google Scholar : PubMed/NCBI
|
|
86
|
Kanda H, Tateya S, Tamori Y, Kotani K,
Hiasa K, Kitazawa R, Kitazawa S, Miyachi H, Maeda S, Egashira K and
Kasuga M: MCP-1 contributes to macrophage infiltration into adipose
tissue, insulin resistance, and hepatic steatosis in obesity. J
Clin Invest. 116:1494–1505. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
87
|
Wang F, Yao T, Yang W, Wu P, Liu Y and
Yang B: Protocol to detect nucleotide-protein interaction in vitro
using a non-radio-active competitive electrophoretic mobility shift
assay. STAR Protoc. 3:1017302022. View Article : Google Scholar
|
|
88
|
Bowers LW, Doerstling SS, Shamsunder MG,
Lineberger CG, Rossi EL, Montgomery SA, Coleman MF, Gong W, Parker
JS, Howell A, et al: Reversing the genomic, epigenetic, and
triple-negative breast cancer-enhancing effects of obesity. Cancer
Prev Res (Phila). 15:581–594. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
89
|
Kong W, He L, Richards EJ, Challa S, Xu
CX, Permuth-Wey J, Lancaster JM, Coppola D, Sellers TA, Djeu JY and
Cheng JQ: Upregulation of miRNA-155 promotes tumour angiogenesis by
targeting VHL and is associated with poor prognosis and
triple-negative breast cancer. Oncogene. 33:679–689. 2014.
View Article : Google Scholar :
|
|
90
|
Sturgeon KM, Brown JC, Sears DD, Sarwer DB
and Schmitz KH: WISER survivor trial: combined effect of exercise
and weight loss interventions on inflammation in breast cancer
survivors. Med Sci Sports Exerc. 55:209–215. 2023. View Article : Google Scholar :
|
|
91
|
Holm JB, Baggesen E, Cronin-Fenton D,
Frystyk J, Bruun JM, Christiansen P and Borgquist S: Circulating
C-reactive protein levels as a prognostic biomarker in breast
cancer across body mass index groups. Sci Rep. 14:144862024.
View Article : Google Scholar : PubMed/NCBI
|
|
92
|
Mallya S, Gangadhar V, Aldrin SE, Acharya
M, Kabekkodu SP, Kolathur KK and Chakrabarty S: Insights into the
molecular and genetic role of obesity in breast cancer
pathogenesis. Cancer Biol Ther. 26:25013452025. View Article : Google Scholar : PubMed/NCBI
|
|
93
|
Aristokli N, Polycarpou I, Themistocleous
SC, Sophocleous D and Mamais I: Comparison of the diagnostic
performance of Magnetic Resonance Imaging (MRI), ultrasound and
mammography for detection of breast cancer based on tumor type,
breast density and patient's history: A review. Radiography (Lond).
28:848–856. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
94
|
Harborg S, Feldt M, Cronin-Fenton D,
Klintman M, Dalton SO, Rosendahl AH and Borgquist S: Obesity and
breast cancer prognosis: pre-diagnostic anthropometric measures in
relation to patient, tumor, and treatment characteristics. Cancer
Metab. 11:82023. View Article : Google Scholar : PubMed/NCBI
|
|
95
|
Laforest S, Ennour-Idrissi K, Ouellette G,
Gauthier MF, Michaud A, Durocher F, Tchernof A and Diorio C:
Associations between markers of mammary adipose tissue dysfunction
and breast cancer prognostic factors. Int J Obes (Lond).
45:195–205. 2021. View Article : Google Scholar
|
|
96
|
Coradini D: Adipokines, cell polarity
disruption and breast cancer. Aging (Albany NY). 13:22625–22626.
2021. View Article : Google Scholar : PubMed/NCBI
|
|
97
|
Zha JM, Zhang M, Wang T, Li HS, Ban QY,
Liu M, Jiang XX, Guo SY, Wang J, Zhou YR, et al: Association of
overweight and inflammatory indicators with breast cancer: A
cross-sectional study in Chinese women. Int J Womens Health.
16:783–795. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
98
|
Houssami N: Breast cancer screening at a
crossroads: Supplemental imaging for dense breasts. Lancet.
405:1887–1889. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
99
|
Thigpen D, Kappler A and Brem R: The role
of ultrasound in screening dense breasts-A review of the literature
and practical solutions for implementation. Diagnostics (Basel).
8:202018. View Article : Google Scholar : PubMed/NCBI
|
|
100
|
Robinson PJ, Bell RJ and Davis SR: Obesity
is associated with a poorer prognosis in women with hormone
receptor positive breast cancer. Maturitas. 79:279–286. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
101
|
Blair CK, Wiggins CL, Nibbe AM, Storlie
CB, Prossnitz ER, Royce M, Lomo LC and Hill DA: Obesity and
survival among a cohort of breast cancer patients is partially
mediated by tumor characteristics. NPJ Breast Cancer. 5:332019.
View Article : Google Scholar : PubMed/NCBI
|
|
102
|
Suzuki R, Saji S and Toi M: Impact of body
mass index on breast cancer in accordance with the life-stage of
women. Front Oncol. 2:1232012. View Article : Google Scholar : PubMed/NCBI
|
|
103
|
Bocian-Jastrzębska A, Malczewska-Herman A
and Kos-Kudła B: Role of leptin and adiponectin in carcinogenesis.
Cancers (Basel). 15:42502023. View Article : Google Scholar
|
|
104
|
Hillers-Ziemer LE, Kuziel G, Williams AE,
Moore BN and Arendt LM: Breast cancer microenvironment and obesity:
challenges for therapy. Cancer Metastasis Rev. 41:627–647. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
105
|
Demark-Wahnefried W, Colditz GA, Rock CL,
Sedjo RL, Liu J, Wolin KY, Krontiras H, Byers T, Pakiz B, Parker
BA, et al: Quality of life outcomes from the exercise and nutrition
enhance recovery and good health for you (ENERGY)-randomized weight
loss trial among breast cancer survivors. Breast Cancer Res Treat.
154:329–337. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
106
|
Rock CL, Flatt SW, Byers TE, Colditz GA,
Demark-Wahnefried W, Ganz PA, Wolin KY, Elias A, Krontiras H, Liu
J, et al: Results of the exercise and nutrition to enhance recovery
and good health for you (ENERGY) trial: A behavioral weight loss
intervention in overweight or obese breast cancer survivors. J Clin
Oncol. 33:3169–3176. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
107
|
Stolley M, Sheean P, Gerber B, Arroyo C,
Schiffer L, Banerjee A, Visotcky A, Fantuzzi G, Strahan D, Matthews
L, et al: Efficacy of a weight loss intervention for African
American breast cancer survivors. J Clin Oncol. 35:2820–2828. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
108
|
Befort CA, Klemp JR, Sullivan DK, Shireman
T, Diaz FJ, Schmitz K, Perri MG and Fabian C: Weight loss
maintenance strategies among rural breast cancer survivors: The
rural women connecting for better health trial. Obesity (Silver
Spring). 24:2070–2077. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
109
|
Courneya KS, McNeil J, O'Reilly R,
Morielli AR and Friedenreich CM: Dose-Response effects of aerobic
exercise on quality of life in postmenopausal women: Results from
the breast cancer and exercise trial in Alberta (BETA). Ann Behav
Med. 51:356–364. 2017. View Article : Google Scholar
|
|
110
|
Yam C, Esteva FJ, Patel MM, Raghavendra
AS, Ueno NT, Moulder SL, Hess KR, Shroff GS, Hodge S, Koenig KH, et
al: Efficacy and safety of the combination of metformin, everolimus
and exemestane in overweight and obese postmenopausal patients with
metastatic, hormone receptor-positive, HER2-negative breast cancer:
A phase II study. Invest New Drugs. 37:345–351. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
111
|
Patterson RE, Marinac CR, Natarajan L,
Hartman SJ, Cadmus-Bertram L, Flatt SW, Li H, Parker B,
Oratowski-Coleman J, Villaseñor A, et al: Recruitment strategies,
design, and participant characteristics in a trial of weight-loss
and metformin in breast cancer survivors. Contemp Clin Trials.
47:64–71. 2016. View Article : Google Scholar :
|
|
112
|
Sandhu N, Schetter SE, Liao J, Hartman TJ,
Richie JP, McGinley J, Thompson HJ, Prokopczyk B, DuBrock C,
Signori C, et al: Influence of obesity on breast density reduction
by omega-3 fatty acids: Evidence from a Randomized clinical trial.
Cancer Prev Res (Phila). 9:275–282. 2016. View Article : Google Scholar
|
|
113
|
Fabian CJ, Befort CA, Phillips TA,
Nydegger JL, Kreutzjans AL, Powers KR, Metheny T, Klemp JR, Carlson
SE, Sullivan DK, et al: Change in blood and benign breast
biomarkers in women undergoing a weight-loss intervention
randomized to high-dose ω-3 fatty acids versus placebo. Cancer Prev
Res (Phila). 14:893–904. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
114
|
Manni A, Richie JP, Schetter SE,
Calcagnotto A, Trushin N, Aliaga C and El-Bayoumy K: Stearoyl-CoA
desaturase-1, a novel target of omega-3 fatty acids for reducing
breast cancer risk in obese postmenopausal women. Eur J Clin Nutr.
71:762–765. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
115
|
D'Alonzo NJ, Qiu L, Sears DD, Chinchilli
V, Brown JC, Sarwer DB, Schmitz KH and Sturgeon KM: WISER survivor
trial: Combined effect of exercise and weight loss interventions on
insulin and insulin resistance in breast cancer survivors.
Nutrients. 13:31082021. View Article : Google Scholar : PubMed/NCBI
|
|
116
|
Bull CJ, Hazelwood E, Legge DN, Corbin LJ,
Richardson TG, Lee M, Yarmolinsky J, Smith-Byrne K, Hughes DA,
Johansson M, et al: Impact of weight loss on cancer-related
proteins in serum: results from a cluster randomised controlled
trial of individuals with type 2 diabetes. EBioMedicine.
100:1049772024. View Article : Google Scholar : PubMed/NCBI
|
|
117
|
Mastrolonardo EV, Llerena P, De Ravin E,
Nunes K, Kaki PC, Bridgham KM, Amin DR, Campbell DJ, Philips R,
Koeneman SH, et al: Improved survival with elevated BMI following
immune checkpoint inhibition across various solid tumor cancer
types. Cancer. 131:e357992025. View Article : Google Scholar : PubMed/NCBI
|
|
118
|
Goodwin PJ, Chen BE, Gelmon KA, Whelan TJ,
Ennis M, Lemieux J, Ligibel JA, Hershman DL, Mayer IA, Hobday TJ,
et al: Effect of metformin vs placebo on invasive disease-free
survival in patients with breast cancer: The MA.32 Randomized
clinical trial. JAMA. 327:1963–1973. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
119
|
Aminian A, Wilson R, Al-Kurd A, Tu C,
Milinovich A, Kroh M, Rosenthal RJ, Brethauer SA, Schauer PR,
Kattan MW, et al: Association of bariatric surgery with cancer risk
and mortality in adults with obesity. JAMA. 327:2423–2433. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
120
|
Wiggins T, Antonowicz SS and Markar SR:
Cancer risk following bariatric surgery-systematic review and
meta-analysis of National population-based cohort studies. Obes
Surg. 29:1031–1039. 2019. View Article : Google Scholar
|
|
121
|
Zhang K, Luo Y, Dai H and Deng Z: Effects
of bariatric surgery on cancer risk: Evidence from meta-analysis.
Obes Surg. 30:1265–1272. 2020. View Article : Google Scholar
|
|
122
|
Hao Y, Xiao J, Fu P, Yan L, Zhao X, Wu X,
Zhou M, Zhang X, Xu B, Li X, et al: Increases in BMI contribute to
worsening inflammatory biomarkers related to breast cancer risk in
women: a longitudinal study. Breast Cancer Res Treat. 202:117–127.
2023. View Article : Google Scholar : PubMed/NCBI
|
|
123
|
Motevalli M and Stanford FC: Personalized
lifestyle interventions for prevention and treatment of
obesity-related cancers: A call to action. Cancers (Basel).
17:12552025. View Article : Google Scholar : PubMed/NCBI
|
|
124
|
Gkrinia EMM and Belančić A: The mechanisms
of chronic inflammation in obesity and potential therapeutic
strategies: A narrative review. Curr Issues Mol Biol. 47:3572025.
View Article : Google Scholar : PubMed/NCBI
|
|
125
|
Chen Z, Li Z, Li H and Jiang Y:
Metabolomics: A promising diagnostic and therapeutic implement for
breast cancer. Onco Targets Ther. 12:6797–6811. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
126
|
Acevedo-Román A, Pagán-Zayas N,
Velázquez-Rivera LI, Torres-Ventura AC and Godoy-Vitorino F:
Insights into gut dysbiosis: Inflammatory diseases, obesity, and
restoration approaches. Int J Mol Sci. 25:97152024. View Article : Google Scholar : PubMed/NCBI
|
|
127
|
Jaye K, Chang D, Li CG and Bhuyan DJ: Gut
metabolites and breast cancer: The continuum of dysbiosis, breast
cancer risk, and potential breast cancer therapy. Int J Mol Sci.
23:94902022. View Article : Google Scholar : PubMed/NCBI
|
|
128
|
Thirunavukkarasan M, Wang C, Rao A, Hind
T, Teo YR, Siddiquee AA, Goghari MAI, Kumar AP and Herr DR:
Short-chain fatty acid receptors inhibit invasive phenotypes in
breast cancer cells. PLoS One. 12:e01863342017. View Article : Google Scholar : PubMed/NCBI
|