|
1
|
Guven DC, Ahmed J, Stephen B and Naing A:
IGF-1R inhibitors in cancer: A review of available evidence and
future outlook. Crit Rev Oncol Hematol. 214:1048092025. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Gui R, Li W, Li Z, Wang H, Wu Y, Jiao W,
Zhao G, Shen Y, Wang L, Zhang J, et al: Effects and potential
mechanisms of IGF1/IGF1R in the liver fibrosis: A review. Int J
Biol Macromol. 251:1262632023. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Robertson DM, Zhu M and Wu YC: Cellular
distribution of the IGF-1R in corneal epithelial cells. Exp Eye
Res. 94:179–186. 2012. View Article : Google Scholar
|
|
4
|
Martin A, Fernandez MC, Miraglia S, Venara
M, Clement F, Papendieck P, De Matteo E and Pennisi PA: Brachyury
and IGF1R: Potential opposing roles in pediatric thyroid nodular
pathology. J Endocrinol Invest. 48:2643–2655. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Truong T and Silkiss RZ: The role of
insulin-like growth factor-1 and its receptor in the eye: A review
and implications for IGF-1R inhibition. Ophthalmic Plast Reconstr
Surg. 39:4–12. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Nieto Guil AF, Oksdath M, Weiss LA, Grassi
DJ, Sosa LJ, Nieto M and Quiroga S: IGF-1 receptor regulates
dynamic changes in neuronal polarity during cerebral cortical
migration. Sci Rep. 7:77032017. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Ngo MT, Jeng HY, Kuo YC, Diony Nanda J,
Brahmadhi A, Ling TY, Chang TS and Huang YH: The role of IGF/IGF-1R
signaling in hepatocellular carcinomas: Stemness-related properties
and drug resistance. Int J Mol Sci. 22:19312021. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Liu G, Zhu M, Zhang M and Pan F: Emerging
role of IGF-1 in prostate cancer: A promising biomarker and
therapeutic target. Cancers (Basel). 15:12872023. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Weiwei Z, Ya X, Wenwen W, Jia J, Jing B,
Ruitao Z, Chunfang W and Ruixia G: IGF-1R anti-idiotypic antibody
antagonist exhibited anti-ovarian cancer bioactivity and reduced
cisplatin resistance. Hum Cell. 34:1197–1214. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Ben Elhadj M, Goucha A, Fourati A, Adouni
O, Dhambri S, Hsairi M, El May MV and Mokni Baizig N: The
prognostic significance of IGF-1R and the predictive risk value of
circulating IGF-1 in tunisian patients with laryngeal carcinoma.
Cancer Invest. 38:289–299. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Guo C, Zhang M, Qian J, Li P and Guo L:
Oncogenic long noncoding RNA Linc01287 promotes IGF1R expression by
sponging miR-98 in breast cancer. Crit Rev Eukaryot Gene Expr.
32:31–44. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Zhang Y, Gao C, Cao F, Wu Y, Chen S, Han
X, Mo J, Qiu Z, Fan W, Zhou P and Shen L: Pan-cancer analysis of
IGF-1 and IGF-1R as potential prognostic biomarkers and
immunotherapy targets. Front Oncol. 11:7553412021. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Liu F, Ye S, Zhao L and Niu Q: The role of
IGF/IGF-1R signaling in the regulation of cancer stem cells. Clin
Transl Oncol. 26:2924–2934. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Rieger L and O'Connor R: Controlled
signaling-insulin-like growth factor receptor endocytosis and
presence at intracellular compartments. Front Endocrinol
(Lausanne). 11:6200132021. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Peloso Maia ML, Albuquerque RM, do Carmo
Silva SD, Lima CX, Costa Diniz PH and Vieira Teixeira Vidigal P:
Immunohistochemical expression of insulin-like growth factor-1
receptor and its association with clinicopathological parameters in
hepatocellular carcinoma. Oncology. 102:494–502. 2024. View Article : Google Scholar :
|
|
16
|
Soni UK, Jenny L and Hegde RS: IGF-1R
targeting in cancer-does sub-cellular localization matter? J Exp
Clin Cancer Res. 42:2732023. View Article : Google Scholar
|
|
17
|
Grice DM, Vetter I, Faddy HM, Kenny PA,
Roberts-Thomson SJ and Monteith GR: Golgi calcium pump secretory
pathway calcium ATPase 1 (SPCA1) is a key regulator of insulin-like
growth factor receptor (IGF1R) processing in the basal-like breast
cancer cell line MDA-MB-231. J Biol Chem. 285:37458–37466. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Rieger L, O'Shea S, Godsmark G, Stanicka
J, Kelly G and O'Connor R: IGF-1 receptor activity in the Golgi of
migratory cancer cells depends on adhesion-dependent
phosphorylation of Tyr(1250) and Tyr(1251). Sci Signal.
13:eaba31762020. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Crudden C and Girnita L: The tale of a
tail: The secret behind IGF-1R's oncogenic power. Sci Signal.
13:eabb78872020. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Werner H, Sarfstein R and Laron Z: The
role of nuclear insulin and IGF1 receptors in metabolism and
cancer. Biomolecules. 11:5312021. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Amin HM, Morani AC, Daw NC,
Lamhamedi-Cherradi SE, Subbiah V, Menegaz BA, Vishwamitra D,
Eskandari G, George B, Benjamin RS, et al: IGF-1R/mTOR targeted
therapy for ewing sarcoma: A meta-analysis of five IGF-1R-related
trials matched to proteomic and radiologic predictive biomarkers.
Cancers (Basel). 12:17682020. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Batishchev OV, Kuzmina NV, Mozhaev AA,
Goryashchenko AS, Mileshina ED, Orsa AN, Bocharov EV, Deyev IE and
Petrenko AG: Activity-dependent conformational transitions of the
insulin receptor-related receptor. J Biol Chem. 296:1005342021.
View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Ferguson KM, Hu C and Lemmon MA: Insulin
and epidermal growth factor receptor family members share parallel
activation mechanisms. Protein Sci. 29:1331–1344. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Sheff J, Wang P, Xu P, Arbour M, Masson L,
van Faassen H, Hussack G, Kemmerich K, Brunette E, Stanimirovic D,
et al: Defining the epitope of a blood-brain barrier crossing
single domain antibody specific for the type 1 insulin-like growth
factor receptor. Sci Rep. 11:42842021. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Wang C, Liu S, Wu Q, Cheng Y, Feng T, Song
J, Yang R, Geng H, Lu G, Wang S and Hao L: Porcine IGF-1R
synonymous mutations in the intracellular domain affect cell
proliferation and alter kinase activity. Int J Biol Macromol.
152:147–153. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Bano N, Hossain MM, Bhat AQ, Ayaz MO,
Kumari M, Sandhu P, Akhter Y and Dar MJ: Analyzing structural
differences between insulin receptor (IR) and IGF1R for designing
small molecule allosteric inhibitors of IGF1R as novel anti-cancer
agents. Growth Horm IGF Res. 55:1013432020. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Mills JV, Osher E, Rieunier G, Mills IG
and Macaulay VM: IGF-1R nuclear import and recruitment to chromatin
involves both alpha and beta subunits. Discov Oncol. 12:132021.
View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Khan N, Althobiti M, Chinnadurai RK,
Alharbi S and Kumar R: Evolutionary sequences and structural
information-driven reconstruction of new insulin-like growth
factor-I peptide variants. Curr Mol Med. 25:652–661. 2025.
View Article : Google Scholar
|
|
29
|
Salvi R, Kumar C, Brahmbhatt K, Subedi R,
Idicula-Thomas S, Madan T and Biswas B: N-Linked glycosylation in
chinese hamster ovary cells is critical for insulin-like growth
factor 1 signaling. Int J Mol Sci. 23:149522022. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Vivian J, Rao AA, Nothaft FA, Ketchum C,
Armstrong J, Novak A, Pfeil J, Narkizian J, Deran AD,
Musselman-Brown A, et al: Toil enables reproducible, open source,
big biomedical data analyses. Nat Biotechnol. 35:314–316. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Cheng H, Dodge J, Mehl E, Liu S, Poulin N,
van de Rijn M and Nielsen TO: Validation of immature adipogenic
status and identification of prognostic biomarkers in myxoid
liposarcoma using tissue microarrays. Hum Pathol. 40:1244–1251.
2009. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Li F, Wang X, Zhang J, Zhang J, Jing X,
Jiang Q, Zhou J, Cao L, Peng H, Tong D and Huang C: RBM8A, a new
target of TEAD4, promotes breast cancer progression by regulating
IGF1R and IRS-2. J Transl Med. 22:8232024. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Zhang J, Chen B, Li H, Wang Y, Liu X, Wong
KY, Chan WN, Chan AK, Cheung AH, Leung KT, et al: Cancer-associated
fibroblasts potentiate colorectal cancer progression by crosstalk
of the IGF2-IGF1R and Hippo-YAP1 signaling pathways. J Pathol.
259:205–219. 2023. View Article : Google Scholar
|
|
34
|
Huang YK, Kang WM, Ma ZQ, Liu YQ, Zhou L
and Yu JC: NUCKS1 promotes gastric cancer cell aggressiveness by
upregulating IGF-1R and subsequently activating the PI3K/Akt/mTOR
signaling pathway. Carcinogenesis. 40:370–379. 2019. View Article : Google Scholar
|
|
35
|
Jassi C, Kuo WW, Chang YC, Wang TF, Li CC,
Ho TJ, Hsieh DJ, Kuo CH, Chen MC and Huang CY: Aloin and CPT-11
combination activates miRNA-133b and downregulates
IGF1R-PI3K/AKT/mTOR and MEK/ERK pathways to inhibit colorectal
cancer progression. Biomed Pharmacother. 169:1159112023. View Article : Google Scholar
|
|
36
|
Zhou Y, Deng Y, Wang J, Yan Z, Wei Q, Ye
J, Zhang J, He TC and Qiao M: Effect of antibiotic monensin on cell
proliferation and IGF1R signaling pathway in human colorectal
cancer cells. Ann Med. 55:954–964. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Yang B, Li G, Wang S, Zheng Y, Zhang J,
Pan B, Wang N and Wang Z: Tumor-associated macrophages/C-X-C motif
chemokine ligand 1 promotes breast cancer autophagy-mediated
chemoresistance via IGF1R/STAT3/HMGB1 signaling. Cell Death Dis.
15:7432024. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Zhu S, Soutto M, Chen Z, Blanca Piazuelo
M, Kay Washington M, Belkhiri A, Zaika A, Peng D and El-Rifai W:
Activation of IGF1R by DARPP-32 promotes STAT3 signaling in gastric
cancer cells. Oncogene. 38:5805–5816. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Chen C, Gupta P, Parashar D, Nair GG,
George J, Geethadevi A, Wang W, Tsaih SW, Bradley W, Ramchandran R,
et al: ERBB3-induced furin promotes the progression and metastasis
of ovarian cancer via the IGF1R/STAT3 signaling axis. Oncogene.
39:2921–2933. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Yang C, Zhang Y, Segar N, Huang C, Zeng P,
Tan X, Mao L, Chen Z, Haglund F, Larsson O, et al: Nuclear IGF1R
interacts with NuMA and regulates 53BP1-dependent DNA double-strand
break repair in colorectal cancer. Oncol Rep. 46:1682021.
View Article : Google Scholar
|
|
41
|
Li L, Zhang Z, Huang N, Ren J, Qin Y and
Luo Y: IGF1R activates FOXP3-β-catenin signaling to promote breast
cancer development. Breast Cancer Res Treat. 211:467–478. 2025.
View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Guo C, Chu H, Gong Z, Zhang B, Li C, Chen
J and Huang L: HOXB13 promotes gastric cancer cell migration and
invasion via IGF-1R upregulation and subsequent activation of
PI3K/AKT/mTOR signaling pathway. Life Sci. 278:1195222021.
View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Chen WJ, Tsai JH, Hsu LS, Lin CL, Hong HM
and Pan MH: Quercetin blocks the aggressive phenotype of
triple-negative breast cancer by inhibiting IGF1/IGF1R-mediated EMT
program. J Food Drug Anal. 29:98–112. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Li W, Huang C, Qiu L, Tang Y, Zhang X,
Zhang L, Zhao H, Miyagishi M, Kasim V and Wu S: p52-ZER6/IGF1R axis
maintains cancer stem cell population to promote cancer progression
by enhancing pro-survival mitophagy. Oncogene. 43:2115–2131. 2024.
View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Zhang R, Li L and Yu J: Lactate-induced
IGF1R protein lactylation promotes proliferation and metabolic
reprogramming of lung cancer cells. Open Life Sci. 19:202208742024.
View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Zhang M, Li Z and Liu X: MiR-98-5p/IGF2
axis influence herceptin sensitivity through IGF1R/HER2 heterodimer
formation and AKT/mTOR signal pathway in HER2 positive breast
cancer. Asian Pac J Cancer Prev. 22:3693–3703. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Jassi C, Kuo WW, Chang YC, Wang TF, Ho TJ,
Hsieh DJ, Kuo CH, Chen MC, Li CC and Huang CY: MicroRNA-376a-3p
sensitizes CPT-11-resistant colorectal cancer by enhancing
apoptosis and reversing the epithelial-to-mesenchymal transition
(EMT) through the IGF1R/PI3K/AKT pathway. Transl Oncol.
50:1021252024. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Catalano R, Giardino E, Treppiedi D,
Mangili F, Morelli V, Elli FM, Serban AL, Luconi M, Mannelli M,
Spada A, et al: The cytoskeleton actin binding protein filamin A
impairs both IGF2 mitogenic effects and the efficacy of IGF1R
inhibitors in adrenocortical cancer cells. Cancer Lett. 497:77–88.
2021. View Article : Google Scholar
|
|
49
|
Shin GC, Lee HM, Kim N, Seo SU, Kim KP and
Kim KH: PRKCSH contributes to TNFSF resistance by extending IGF1R
half-life and activation in lung cancer. Exp Mol Med. 56:192–209.
2024. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Xie Q, Chu Y, Yuan W, Li Y, Li K, Wu X,
Liu X, Xu R, Cui S and Qu X: Activation of insulin-like growth
factor-1 receptor (IGF-1R) promotes growth of colorectal cancer
through triggering the MEX3A-mediated degradation of RIG-I. Acta
Pharm Sin B. 13:2963–2975. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Liu Z, Meng D, Wang J, Cao H, Feng P, Wu
S, Wang N, Dang C, Hou P and Xia P: GASP1 enhances malignant
phenotypes of breast cancer cells and decreases their response to
paclitaxel by forming a vicious cycle with IGF1/IGF1R signaling
pathway. Cell Death Dis. 13:7512022. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Santos Fortes Dos Reis VM, Ramos FM, de
Oliveira HL, Machado FD, Hartke S, Machado-Weber A, Germeyer A,
Strowitzki T, Kliemann LM, von Eye Corleta H, et al: Effects of
metformin treatment against endometrial cancer cells cultured in
vitro or grafted into female balb/C nude mice: Insights into cell
response and IGF-1R and PI3K/AKT/mTOR signaling pathways. Cell
Biochem Biophys. 83:5227–5245. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Kuo YC, Chen CL, Lee KL, Wang HF, Drew VJ,
Lan PC, Ho YS and Huang YH: Nicotine-driven enhancement of tumor
malignancy in triple-negative breast cancer via additive regulation
of CHRNA9 and IGF1R. J Pathol. 266:230–245. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Deo AN, Thorat R, Dhadve AC, De A, Rekhi B
and Ray P: IGF1R-α6 integrin-S100A4 network governs the
organ-specific metastasis of chemoresistant epithelial ovarian
cancer cells. Biochim Biophys Acta Mol Basis Dis. 1868:1662822022.
View Article : Google Scholar
|
|
55
|
Noyan S and Gur Dedeoglu B:
miR-770-5p-induced cellular switch to sensitize trastuzumab
resistant breast cancer cells targeting HER2/EGFR/IGF1R
bidirectional crosstalk. Turk J Biol. 48:153–162. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Bustamante-Marin X, Devlin KL, McDonell
SB, Dave O, Merlino JL, Grindstaff EJ, Ho AN, Rezeli ET, Coleman MF
and Hursting SD: Regulation of IGF1R by MicroRNA-15b contributes to
the anticancer effects of calorie restriction in a murine C3-TAg
model of triple-negative breast cancer. Cancers (Basel).
15:43202023. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Jiang S, Chen H, He K and Wang J: Human
bone marrow mesenchymal stem cells-derived exosomes attenuated
prostate cancer progression via the miR-99b-5p/IGF1R axis.
Bioengineered. 13:2004–2016. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Han B, Xu K, Feng D, Bai Y, Liu Y, Zhang Y
and Zhou L: miR-144 inhibits the IGF1R-ERK1/2 signaling pathway via
NUDCD1 to suppress the proliferation and metastasis of colorectal
cancer cells: A study based on bioinformatics and in vitro and in
vivo verification. J Cancer Res Clin Oncol. 148:1903–1918. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Zhang H, Zheng XD, Zeng XH, Li L and Zhou
Q: miR-520b Inhibits IGF-1R to increase doxorubicin sensitivity and
promote cell apoptosis in breast cancer. Yakugaku Zasshi.
141:415–426. 2021. View Article : Google Scholar
|
|
60
|
Han L: miR-99a inhibits proliferation and
migration of cervical cancer cells by targeting IGF1R. J BUON 2021.
26:1782–1788. 2021.
|
|
61
|
Bai R, Dou K, Wu Y, Ma Y and Sun J: The
NF-ĸB modulated miR-194-5p/IGF1R/PPFIBP axis is crucial for the
tumorigenesis of ovarian cancer. J Cancer. 11:3433–3445. 2020.
View Article : Google Scholar
|
|
62
|
Hsu XR, Wu JE, Wu YY, Hsiao SY, Liang JL,
Wu YJ, Tung CH, Huang MF, Lin MS, Yang PC, et al: Exosomal long
noncoding RNA MLETA1 promotes tumor progression and metastasis by
regulating the miR-186-5p/EGFR and miR-497-5p/IGF1R axes in
non-small cell lung cancer. J Exp Clin Cancer Res. 42:2832023.
View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Golestan S, Soltani BM, Jafarzadeh M,
Ghaemi Z and Nafisi N: LINC02381 suppresses cell proliferation and
promotes apoptosis via attenuating IGF1R/PI3K/AKT signaling pathway
in breast cancer. Funct Integr Genomics. 23:402023. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Zhou L, Li H, Sun T, Wen X, Niu C, Li M,
Li W, Hoffman AR, Hu JF and Cui J: HULC targets the IGF1R-PI3K-AKT
axis in trans to promote breast cancer metastasis and cisplatin
resistance. Cancer Lett. 548:2158612022. View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Zhang L, Cai Y, Tian C, Li Y, Ma K, Gao X,
Liu L, Jiang Y, Wen W and Ma Z: LncRNA Opa interacting protein
5-antisense RNA 1 (OIP5-AS1) promotes the migration, invasion and
epithelial-mesenchymal transition (EMT) through targeting
miR-147a/insulin-like growth factor 1 receptor (IGF1R) pathway in
cervical cancer tissues and cell model. J Obstet Gynaecol Res.
48:1222–1232. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Liu Y, Peng H, Shen Y, Da R, Tian A and
Guo X: Downregulation of long noncoding RNA myocardial infarction
associated transcript suppresses cell proliferation, migration,
invasion, and glycolysis by regulation of miR-488-3p/IGF1R pathway
in colorectal cancer. Cancer Biother Radiopharm. 37:927–938.
2022.
|
|
67
|
Xie Q, Zhao S, Kang R and Wang X: lncRNA
SNHG11 facilitates prostate cancer progression through the
upregulation of IGF-1R expression and by sponging miR-184. Int J
Mol Med. 48:1822021. View Article : Google Scholar
|
|
68
|
Liu B, Jiang HY, Yuan T, Zhou WD, Xiang
ZD, Jiang QQ and Wu DL: Long Non-coding RNA AFAP1-AS1 facilitates
prostate cancer progression by regulating miR-15b/IGF1R axis. Curr
Pharm Des. 27:4261–4269. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
69
|
Capik O, Sanli F, Kurt A, Ceylan O, Suer
I, Kaya M, Ittmann M and Karatas OF: CASC11 promotes aggressiveness
of prostate cancer cells through miR-145/IGF1R axis. Prostate
Cancer Prostatic Dis. 24:891–902. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
70
|
Zhang M, Lin B, Liu Y, Huang T, Chen M,
Lian D, Deng S and Zhuang C: LINC00324 affects non-small cell lung
cancer cell proliferation and invasion through regulation of the
miR-139-5p/IGF1R axis. Mol Cell Biochem. 473:193–202. 2020.
View Article : Google Scholar : PubMed/NCBI
|
|
71
|
Ma Z, Cai Y, Zhang L, Tian C and Lyu L:
LINC00319 promotes cervical cancer progression via targeting
miR-147a/IGF1R pathway. Cancer Biother Radiopharm. Jul 9–2020.Epub
ahead of print.
|
|
72
|
Du P, Liu F, Liu Y, Shao M, Li X and Qin
G: Linc00210 enhances the malignancy of thyroid cancer cells by
modulating miR-195-5p/IGF1R/Akt axis. J Cell Physiol.
235:1001–1012. 2020. View Article : Google Scholar
|
|
73
|
Cui Y, Xie M and Zhang Z: LINC00958
involves in bladder cancer through sponging miR-378a-3p to Elevate
IGF1R. Cancer Biother Radiopharm. 35:776–788. 2020.PubMed/NCBI
|
|
74
|
Zhang R, Hao S, Yang L, Xie J, Chen S and
Gu G: LINC00339 promotes cell proliferation and metastasis in
pancreatic cancer via miR-497-5p/IGF1R axis. J BUON. 24:729–738.
2019.PubMed/NCBI
|
|
75
|
Zhang X, Fang F, Zhang J, Zhang S, Li H,
Li B, Zhong Y and Zhen P: Circ_0006174 upregulates IGF1R to enhance
radioresistance and tumorigenesis in colorectal cancer via miR-940
suppression. Appl Biochem Biotechnol. 197:497–517. 2025. View Article : Google Scholar
|
|
76
|
Tang YF, Liu ZH, Zhang LY, Shi SH, Xu S,
Ma JA, Hu CH and Zou FW: circ_PPAPDC1A promotes Osimertinib
resistance by sponging the miR-30a-3p/IGF1R pathway in non-small
cell lung cancer (NSCLC). Mol Cancer. 23:912024. View Article : Google Scholar
|
|
77
|
Gao S, Zhang X, Bai W, Wang J and Jiang B:
Circ-IGF1R affects the progression of colorectal cancer by
activating the miR-362-5p/HMGB3-Mediated Wnt/β-catenin signal
pathway. Biochem Genet. 61:1210–1229. 2023. View Article : Google Scholar
|
|
78
|
Hua J, Wang X, Ma L, Li J, Cao G, Zhang S
and Lin W: CircVAPA promotes small cell lung cancer progression by
modulating the miR-377-3p and miR-494-3p/IGF1R/AKT axis. Mol
Cancer. 21:1232022. View Article : Google Scholar : PubMed/NCBI
|
|
79
|
Wang P, Sun Y, Yang Y, Chen Y and Liu H:
Circ_0067835 knockdown enhances the radiosensitivity of colorectal
cancer by miR-296-5p/IGF1R axis. Onco Targets Ther. 14:491–502.
2021. View Article : Google Scholar : PubMed/NCBI
|
|
80
|
Liu X, Zhou L, Chen Y, Jiang X and Jiang
J: CircRNF13 promotes the malignant progression of pancreatic
cancer through targeting miR-139-5p/IGF1R axis. J Oncol.
2021:69450462021. View Article : Google Scholar : PubMed/NCBI
|
|
81
|
Wang Y, Yin L and Sun X: CircRNA
I_circ_0002577 accelerates endometrial cancer progression through
activating IGF1R/PI3K/Akt pathway. J Exp Clin Cancer Res.
39:1692020. View Article : Google Scholar
|
|
82
|
Liu P, Zou Y, Li X, Yang A, Ye F, Zhang J,
Wei W and Kong Y: circGNB1 facilitates triple-negative breast
cancer progression by regulating miR-141-5p-IGF1R axis. Front
Genet. 11:1932020. View Article : Google Scholar : PubMed/NCBI
|
|
83
|
Wang X, Song Z, Meng Q, Xia S, Wang C and
Huang X: Circular RNA circ_0006089 regulates the IGF1R expression
by targeting miR-143-3p to promote gastric cancer proliferation,
migration and invasion. Cell Cycle. 1–14. 2022.Epub ahead of print.
View Article : Google Scholar : PubMed/NCBI
|
|
84
|
Dam DHM, Jelsma SA, Yu JM, Liu H, Kong B
and Paller AS: Flotillin and AP2A1/2 Promote IGF-1 receptor
association with clathrin and internalization in primary human
keratinocytes. J Invest Dermatol. 140:1743–1752 e4. 2020.
View Article : Google Scholar : PubMed/NCBI
|
|
85
|
Kwon H, Choi M, Ahn Y, Jang D and Pak Y:
Flotillin-1 palmitoylation turnover by APT-1 and ZDHHC-19 promotes
cervical cancer progression by suppressing IGF-1 receptor
desensitization and proteostasis. Cancer Gene Ther. 30:302–312.
2023. View Article : Google Scholar
|
|
86
|
Xiu M, Huan X, Ou Y, Ying S and Wang J:
The basic route of nuclear-targeted transport of IGF-1/IGF-1R and
potential biological functions in intestinal epithelial cells. Cell
Prolif. 54:e130302021. View Article : Google Scholar : PubMed/NCBI
|
|
87
|
Crudden C, Song D, Cismas S, Trocme E,
Pasca S, Calin GA, Girnita A and Girnita L: Below the surface:
IGF-1R therapeutic targeting and its endocytic journey. Cells.
8:12232019. View Article : Google Scholar : PubMed/NCBI
|
|
88
|
Chen X, Pang Z, Wang Y, Zhu L, Liu J and
Du J: Cezanne contributes to cancer progression by playing a key
role in the deubiquitination of IGF-1R. Am J Cancer Res.
10:4342–4356. 2020.
|
|
89
|
Packham S, Warsito D, Lin Y, Sadi S,
Karlsson R, Sehat B and Larsson O: Nuclear translocation of IGF-1R
via p150(Glued) and an importin-β/RanBP2-dependent pathway in
cancer cells. Oncogene. 34:2227–2238. 2015. View Article : Google Scholar
|
|
90
|
Sehat B, Tofigh A, Lin Y, Trocme E,
Liljedahl U, Lagergren J and Larsson O: SUMOylation mediates the
nuclear translocation and signaling of the IGF-1 receptor. Sci
Signal. 3:ra102010. View Article : Google Scholar : PubMed/NCBI
|
|
91
|
Gulec Taskiran AE, Husnugil HH, Soltani
ZE, Oral G, Menemenli NS, Hampel C, Huebner K, Erlenbach-Wuensch K,
Sheraj I, Schneider-Stock R, et al: Post-transcriptional regulation
of Rab7a in lysosomal positioning and drug resistance in
nutrient-limited cancer cells. Traffic. 25:e129562024. View Article : Google Scholar : PubMed/NCBI
|
|
92
|
Wong WH, Liu SZ, Li ASR, Liu X, Manolson
MF and Zirngibl RA: Evidence for Rab7b and its splice isoforms
having distinct biological functions from Rab7a. Int J Mol Sci.
26:26102025. View Article : Google Scholar : PubMed/NCBI
|
|
93
|
Hewawasam NV, Lhaf F, Taylor HA, Viloria
K, Austin A, King A, Jones P, Jones L, Turner MD and Hill NJ:
Modulation of Rab7a-mediated growth factor receptor trafficking
inhibits islet beta cell apoptosis and autophagy under conditions
of metabolic stress. Sci Rep. 10:157412020. View Article : Google Scholar : PubMed/NCBI
|
|
94
|
McDermott N, O'Shea S, Rieger L, Cox OT
and O'Connor R: beta(1)-integrin controls IGF-1R internalization
and intracellular signaling. J Biol Chem. 301:1080212025.
View Article : Google Scholar
|
|
95
|
Guglielmi V, Lam D and D'Angelo MA:
Nucleoporin Nup358 drives the differentiation of myeloid-biased
multipotent progenitors by modulating HDAC3 nuclear translocation.
Sci Adv. 10:eadn89632024. View Article : Google Scholar : PubMed/NCBI
|
|
96
|
Guo Y, Tao T, Wu T, Hou J and Lin W:
Nucleoporin Nup98 is an essential factor for ipo4 dependent protein
import. J Cell Biochem. 125:e305732024. View Article : Google Scholar : PubMed/NCBI
|
|
97
|
Artico LL, Laranjeira ABA, Campos LW,
Correa JR, Zenatti PP, Carvalheira JBC, Brambilla SR, Nowill AE,
Brandalise SR and Yunes JA: Physiologic IGFBP7 levels prolong IGF1R
activation in acute lymphoblastic leukemia. Blood Adv. 5:3633–3646.
2021. View Article : Google Scholar : PubMed/NCBI
|
|
98
|
Chakraborty S, Bhat AM, Mushtaq I, Luan H,
Kalluchi A, Mirza S, Storck MD, Chaturvedi N, Lopez-Guerrero JA,
Llombart-Bosch A, et al: EHD1-dependent traffic of IGF-1 receptor
to the cell surface is essential for Ewing sarcoma tumorigenesis
and metastasis. Commun Biol. 6:7582023. View Article : Google Scholar : PubMed/NCBI
|
|
99
|
Zong R, Chen X, Feng J and Xu S: IGF-1R
depletion sensitizes colon cancer cell lines to radiotherapy.
Cancer Biomark. 32:199–206. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
100
|
Ko JC, Syu JJ, Chen JC, Wang TJ, Chang PY,
Chen CY, Jian YT, Jian YJ and Lin YW: Resveratrol enhances
etoposide-induced cytotoxicity through down-regulating ERK1/2 and
AKT-Mediated X-ray repair cross-complement group 1 (XRCC1) protein
expression in human non-small-cell lung cancer cells. Basic Clin
Pharmacol Toxicol. 117:383–391. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
101
|
Toulany M, Dittmann K, Fehrenbacher B,
Schaller M, Baumann M and Rodemann HP: PI3K-Akt signaling regulates
basal, but MAP-kinase signaling regulates radiation-induced XRCC1
expression in human tumor cells in vitro. DNA Repair (Amst).
7:1746–1756. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
102
|
Deng H, Lin Y, Badin M, Vasilcanu D,
Stromberg T, Jernberg-Wiklund H, Sehat B and Larsson O:
Over-accumulation of nuclear IGF-1 receptor in tumor cells requires
elevated expression of the receptor and the SUMO-conjugating enzyme
Ubc9. Biochem Biophys Res Commun. 404:667–671. 2011. View Article : Google Scholar
|
|
103
|
Li J, Yin Q, Xuan N, Gan Q, Liu C, Zhang
Q, Yang M and Yang C: LYSMD proteins promote activation of
Rab32-family GTPases for lysosome-related organelle biogenesis. J
Cell Biol. 223:e2024020162024. View Article : Google Scholar : PubMed/NCBI
|
|
104
|
Haga K and Fukuda M: Comprehensive
knockout analysis of the RAB family small GTPases reveals an
overlapping role of RAB2 and RAB14 in autophagosome maturation.
Autophagy. 21:21–36. 2025. View Article : Google Scholar :
|
|
105
|
Matsumoto N, Sekiya M, Sun-Wada GH, Wada Y
and Nakanishi-Matsui M: The lysosomal V-ATPase a3 subunit is
involved in localization of Mon1-Ccz1, the GEF for Rab7, to
secretory lysosomes in osteoclasts. Sci Rep. 12:84552022.
View Article : Google Scholar : PubMed/NCBI
|
|
106
|
Wang X, Wang Y, Lei P, Qu X, Qi R, Chen D
and Chang Y: IGFBP5 regulates fibrocartilage differentiation and
cartilage injury induced by T-2 toxin via blocking IGF-1/IGF-1R
signalling. Rheumatology (Oxford). 64:4051–4060. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
107
|
Peng SW, Ngo MT, Kuo YC, Teng MH, Guo CL,
Lai HC, Chang TS and Huang YH: Niclosamide revitalizes sorafenib
through insulin-like growth factor 1 receptor (IGF-1R)/stemness and
metabolic changes in hepatocellular carcinoma. Cancers (Basel).
15:9312023. View Article : Google Scholar : PubMed/NCBI
|
|
108
|
Stuard WL, Titone R and Robertson DM: The
IGF/Insulin-IGFBP axis in corneal development, wound healing, and
disease. Front Endocrinol (Lausanne). 11:242020. View Article : Google Scholar : PubMed/NCBI
|
|
109
|
Zeng B, Liu L, Liao X and Zhang C:
Cardiomyocyte protective effects of thyroid hormone during
hypoxia/reoxygenation injury through activating of IGF-1-mediated
PI3K/Akt signalling. J Cell Mol Med. 25:3205–3215. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
110
|
Icard P, Coquerel A, Wu Z, Gligorov J,
Fuks D, Fournel L, Lincet H and Simula L: Understanding the central
role of citrate in the metabolism of cancer cells and tumors: An
update. Int J Mol Sci. 22:65872021. View Article : Google Scholar : PubMed/NCBI
|
|
111
|
Mafi S, Mansoori B, Taeb S, Sadeghi H,
Abbasi R, Cho WC and Rostamzadeh D: mTOR-Mediated Regulation of
Immune Responses in Cancer and Tumor Microenvironment. Front
Immunol. 12:7741032022. View Article : Google Scholar : PubMed/NCBI
|
|
112
|
Nwabo Kamdje AH, Seke Etet PF, Kipanyula
MJ, Vecchio L, Tagne Simo R, Njamnshi AK, Lukong KE and Mimche PN:
Insulin-like growth factor-1 signaling in the tumor
microenvironment: Carcinogenesis, cancer drug resistance, and
therapeutic potential. Front Endocrinol (Lausanne). 13:9273902022.
View Article : Google Scholar : PubMed/NCBI
|
|
113
|
Stefani C, Miricescu D, Stanescu-Spinu II,
Nica RI, Greabu M, Totan AR and Jinga M: Growth factors,
PI3K/AKT/mTOR and MAPK signaling pathways in colorectal cancer
pathogenesis: Where are we now? Int J Mol Sci. 22:102602021.
View Article : Google Scholar : PubMed/NCBI
|
|
114
|
Zhu E, Liu Y, Xie S, Hou J, Yang X, Xu M,
Yang F, Li Z, Zhu B and Zha H: IGF2-IGF1R signaling inhibition
delays the growth of IGF2-high colorectal cancer by modulating
MDSCs. Biochem Biophys Res Commun. 746:1512302025. View Article : Google Scholar : PubMed/NCBI
|
|
115
|
Wan M, Mei J, Cai Y, Zhou J, Xue N, Jiang
Y, Zhang Y, Huang J and Zhu Y: Targeting IGF1R overcomes armored
and cold tumor microenvironment and boosts immune checkpoint
blockade in triple-negative breast cancer. Adv Sci (Weinh).
12:e013412025. View Article : Google Scholar : PubMed/NCBI
|
|
116
|
Somri-Gannam L, Meisel-Sharon S,
Hantisteanu S, Bar-Noy T, Sigal E, Groisman G, Hallak M, Werner H
and Bruchim I: IGF1R inhibition and PD-1 blockade improve
anti-tumor immune response in epithelial ovarian cancer. Front
Oncol. 14:14104472024. View Article : Google Scholar : PubMed/NCBI
|
|
117
|
Heitzeneder S, Sotillo E, Shern JF,
Sindiri S, Xu P, Jones R, Pollak M, Noer PR, Lorette J, Fazli L, et
al: Pregnancy-associated plasma protein-A (PAPP-A) in ewing
sarcoma: Role in tumor growth and immune evasion. J Natl Cancer
Inst. 111:970–982. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
118
|
Alfaro-Arnedo E, Lopez IP, Pineiro-Hermida
S, Canalejo M, Gotera C, Sola JJ, Roncero A, Peces-Barba G,
Ruiz-Martinez C and Pichel JG: IGF1R acts as a cancer-promoting
factor in the tumor microenvironment facilitating lung metastasis
implantation and progression. Oncogene. 41:3625–3639. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
119
|
Hanzelmann S, Castelo R and Guinney J:
GSVA: Gene set variation analysis for microarray and RNA-seq data.
BMC Bioinformatics. 14:72013. View Article : Google Scholar : PubMed/NCBI
|
|
120
|
Bindea G, Mlecnik B, Tosolini M,
Kirilovsky A, Waldner M, Obenauf AC, Angell H, Fredriksen T,
Lafontaine L, Berger A, et al: Spatiotemporal dynamics of
intratumoral immune cells reveal the immune landscape in human
cancer. Immunity. 39:782–795. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
121
|
Kang J, Guo Z, Zhang H, Guo R, Zhu X and
Guo X: Dual inhibition of EGFR and IGF-1R signaling leads to
enhanced antitumor efficacy against esophageal squamous cancer. Int
J Mol Sci. 23:103822022. View Article : Google Scholar : PubMed/NCBI
|
|
122
|
Kumar S and Chaudhri S: Recent update on
IGF-1/IGF-1R signaling axis as a promising therapeutic target for
triple-negative breast cancer. Pathol Res Pract. 263:1556202024.
View Article : Google Scholar : PubMed/NCBI
|
|
123
|
Zhao Q and Shen J: Insulin-like growth
factor-neutralizing antibodies for cancer therapy. J Leukoc Biol.
117:qiaf1222025. View Article : Google Scholar : PubMed/NCBI
|
|
124
|
Shen HT, Chien PJ, Sheu GT, Wang BY and
Chang WW: Reciprocal regulation between B lymphoma Mo-MLV insertion
region 1 homolog and type I insulin-like growth factor receptor in
pemetrexed-resistant lung cancer cells. Tzu Chi Med J. 37:285–292.
2025. View Article : Google Scholar : PubMed/NCBI
|
|
125
|
Cao D, Lei Y, Ye Z, Zhao L, Wang H, Zhang
J, He F, Huang L, Shi D, Liu Q, et al: Blockade of IGF/IGF-1R
signaling axis with soluble IGF-1R mutants suppresses the cell
proliferation and tumor growth of human osteosarcoma. Am J Cancer
Res. 10:3248–3266. 2020.PubMed/NCBI
|
|
126
|
Yang K, Hu Y, Feng Y, Li K, Zhu Z, Liu S,
Lin Y and Yu B: IGF-1R mediates crosstalk between nasopharyngeal
carcinoma cells and osteoclasts and promotes tumor bone metastasis.
J Exp Clin Cancer Res. 43:462024. View Article : Google Scholar : PubMed/NCBI
|
|
127
|
Liu Y, Yu S, Xu T, Bodenko V, Orlova A,
Oroujeni M, Rinne SS, Tolmachev V, Vorobyeva A and Graslund T:
Preclinical evaluation of a new format of (68)Ga- and
(111)In-labeled affibody molecule Z(IGF-1R:4551) for the
Visualization of IGF-1R expression in malignant tumors using PET
and SPECT. Pharmaceutics. 14:14752022. View Article : Google Scholar : PubMed/NCBI
|
|
128
|
Choi JH and Park JY: Insulin-like growth
factor-1 receptor targeted fluorescent imaging for gallbladder
cancer in orthotopic mouse models. Gut Liver. 16:606–612. 2022.
View Article : Google Scholar :
|
|
129
|
Molina ER, Chim LK, Lamhamedi-Cherradi SE,
Mohiuddin S, McCall D, Cuglievan B, Krishnan S, Porter RW, Ingram
DR, Wang WL, et al: Correlation of nuclear pIGF-1R/IGF-1R and
YAP/TAZ in a tissue microarray with outcomes in osteosarcoma
patients. Oncotarget. 13:521–533. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
130
|
Gennari A, Foca F, Zamarchi R, Rocca A,
Amadori D, De Censi A, Bologna A, Cavanna L, Gianni L, Scaltriti L,
et al: Insulin-like growth factor-1 receptor (IGF-1R) expression on
circulating tumor cells (CTCs) and metastatic breast cancer
outcome: Results from the TransMYME trial. Breast Cancer Res Treat.
181:61–68. 2020. View Article : Google Scholar : PubMed/NCBI
|