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International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.
International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.
Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.
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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.
Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.
Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.
International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.
Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.
Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.
Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.
An International Open Access Journal Devoted to General Medicine.
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Jänne PA, Baik C, Su WC, Johnson ML, Hayashi H, Nishio M, Kim DW, Koczywas M, Gold KA, Steuer CE, et al: Efficacy and safety of patritumab deruxtecan (HER3-DXd) in EGFR inhibitor-resistant, EGFR-Mutated Non-small cell lung cancer. Cancer Discov. 12:74–89. 2022. View Article : Google Scholar | |
|
Jordan EJ, Kim HR, Arcila ME, Barron D, Chakravarty D, Gao J, Chang MT, Ni A, Kundra R, Jonsson P, et al: Prospective comprehensive molecular characterization of lung adenocarcinomas for efficient patient matching to approved and emerging therapies. Cancer Discov. 7:596–609. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Xu K, Wang H, Li S, Zhao L, Liu X, Liu Y, Ye L, Liu X, Li L and He Y: Changing profile of lung cancer clinical characteristics in China: Over 8-year population-based study. Chin Med J Pulm Crit Care Med. 1:188–194. 2023. View Article : Google Scholar | |
|
Passaro A, Jänne PA, Mok T and Peters S: Overcoming therapy resistance in EGFR-mutant lung cancer. Nat Cancer. 2:377–391. 2021. View Article : Google Scholar | |
|
Westover D, Zugazagoitia J, Cho BC, Lovly CM and Paz-Ares L: Mechanisms of acquired resistance to first- and second-generation EGFR tyrosine kinase inhibitors. Ann Oncol. 29(suppl 1): i10–i19. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Tian X, Gu T, Lee MH and Dong Z: Challenge and countermeasures for EGFR targeted therapy in non-small cell lung cancer. Biochim Biophys Acta Rev Cancer. 1877:1886452022. View Article : Google Scholar | |
|
Rotow J and Bivona TG: Understanding and targeting resistance mechanisms in NSCLC. Nat Rev Cancer. 17:637–658. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Han J, Wang Y, Zhong L, Zhou H, Yu M, Li Y, Lu Y, Wang Y and Zhu J: T790M mutation in stage Iv EGFR-mutated NSCLC patient with acquired resistance reverted to original 19Del mutation after administration of a series of precision treatments: a case report. Precis Clin Med. 1:129–133. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Sun SY: Taking early preventive interventions to manage the challenging issue of acquired resistance to third-generation EGFR inhibitors. Chin Med J Pulm Crit Care Med. 1:3–10. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Liu J, Zhang Y, Liu K, Shi J, Yan M, Xu J, Liu Y and Zhang S: Cross-talk between cancer-associated fibroblasts and dormant cancer cells: Current status and promising therapeutic potential. Cancer Cell Int. 26:242025. View Article : Google Scholar : PubMed/NCBI | |
|
Rahal Z, El Darzi R, Moghaddam SJ, Cascone T and Kadara H: Tumour and microenvironment crosstalk in NSCLC progression and response to therapy. Nat Rev Clin Oncol. 22:463–482. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Spranger S and Gajewski TF: Impact of oncogenic pathways on evasion of antitumour immune responses. Nat Rev Cancer. 18:139–147. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
de visser KE and Joyce JA: The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth. Cancer Cell. 41:374–403. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Hou J, Karin M and Sun B: Targeting cancer-promoting inflammation-have anti-inflammatory therapies come of age? Nat Rev Clin Oncol. 18:261–279. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Fisher DT, Appenheimer MM and Evans SS: The two faces of IL-6 in the tumor microenvironment. Semin Immunol. 26:38–47. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Abulaiti A, Shintani Y, Funaki S, Nakagiri T, Inoue M, Sawabata N, Minami M and Okumura M: Interaction between non-small-cell lung cancer cells and fibroblasts via enhancement of TGF-β signaling by IL-6. Lung Cancer. 82:204–213. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Song Z, Lin Y, Ye X, Feng C, Lu Y, Yang G and Dong C: Expression of IL-1α and IL-6 is associated with progression and prognosis of human cervical cancer. Med Sci Monit. 22:4475–4481. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Ma Y, Ren Y, Dai ZJ, Wu CJ, Ji YH and Xu J: IL-6, IL-8 and TNF-alpha levels correlate with disease stage in breast cancer patients. Adv Clin Exp Med. 26:421–426. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Feng L, Qi Q, Wang P, Chen H, Chen Z, Meng Z and Liu L: Serum levels of IL-6, IL-8, and IL-10 are indicators of prognosis in pancreatic cancer. J Int Med Res. 46:5228–5236. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Liang B, Li L, Miao R, Wang J, Chen Y, Li Z, Zou X and Zhou M: Expression of interleukin-6 and integrin ανβ6 in colon cancer: Association with clinical outcomes and prognostic implications. Cancer Invest. 37:174–184. 2019. View Article : Google Scholar | |
|
Tsai MS, Chen WC, Lu CH and Chen MF: The prognosis of head and neck squamous cell carcinoma related to immunosuppressive tumor microenvironment regulated by IL-6 signaling. Oral Oncol. 91:47–55. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Kaur S, Bansal Y, Kumar R and Bansal G: A panoramic review of IL-6: Structure, pathophysiological roles and inhibitors. Bioorg Med Chem. 28:1153272020. View Article : Google Scholar : PubMed/NCBI | |
|
Rose-John S, Jenkins BJ, Garbers C, Moll JM and Scheller J: Targeting IL-6 trans-signalling: Past, present and future prospects. Nat Rev Immunol. 23:666–681. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Yao X, Huang J, Zhong H, Shen N, Faggioni R, Fung M and Yao Y: Targeting interleukin-6 in inflammatory autoimmune diseases and cancers. Pharmacol Ther. 141:125–139. 2014. View Article : Google Scholar | |
|
Nozawa H, Chiu C and Hanahan D: Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multi-stage carcinogenesis. Proc Natl Acad Sci USA. 1032006. | |
|
Walter M, Liang S, Ghosh S, Hornsby PJ and Li R: Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells. Oncogene. 28:2745–2755. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Nagasaki T, Hara M, Nakanishi H, Takahashi H, Sato M and Takeyama H: Interleukin-6 released by colon cancer-associated fibroblasts is critical for tumour angiogenesis: Anti-interleukin-6 receptor antibody suppressed angiogenesis and inhibited tumour-stroma interaction. Br J Cancer. 110:469–478. 2014. View Article : Google Scholar | |
|
Kumari N, Dwarakanath BS, Das A and Bhatt AN: Role of interleukin-6 in cancer progression and therapeutic resistance. Tumour Biol. 37:11553–11572. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Wolf J, Waetzig GH, Chalaris A, Reinheimer TM, Wege H, Rose-John S and Garbers C: Different soluble forms of the interleukin-6 family signal transducer gp130 fine-tune the blockade of interleukin-6 trans-signaling. J Biol Chem. 291:16186–16196. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Scheller J, Chalaris A, Schmidt-Arras D and Rose-John S: The pro- and anti-inflammatory properties of the cytokine interleukin-6. Biochim Biophys Acta. 1813:878–888. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Orange ST, Leslie J, Ross M, Mann DA and Wackerhage H: The exercise IL-6 enigma in cancer. Trends Endocrinol Metab. 34:749–763. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Arnold P, Lückstädt W, Li W, Boll I, Lokau J, Garbers C, Lucius R, Rose-John S and Becker-Pauly C: Joint reconstituted signaling of the IL-6 receptor via extracellular vesicles. Cells. 9:13072020. View Article : Google Scholar : PubMed/NCBI | |
|
Heink S, Yogev N, Garbers C, Herwerth M, Aly L, Gasperi C, Husterer V, Croxford AL, Möller-Hackbarth K, Bartsch HS, et al: Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells. Nat Immunol. 18:74–85. 2017. View Article : Google Scholar : | |
|
Schaper F and Rose-John S: Interleukin-6: Biology, signaling and strategies of blockade. Cytokine Growth Factor Rev. 26:475–487. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Hu X, Li J, Fu M, Zhao X and Wang W: The JAK/STAT signaling pathway: From bench to clinic. Signal Transduct Target Ther. 6:4022021. View Article : Google Scholar : PubMed/NCBI | |
|
Chen RY, Yen CJ, Liu YW, Guo CG, Weng CY, Lai CH, Wang JM, Lin YJ and Hung LY: CPAP promotes angiogenesis and metastasis by enhancing STAT3 activity. Cell Death Differ. 27:1259–1273. 2020. View Article : Google Scholar : | |
|
Chen H, Zhou W, Bian A, Zhang Q, Miao Y, Yin X, Ye J, Xu S, Ti C, Sun Z, et al: Selectively targeting STAT3 using a small molecule inhibitor is a potential therapeutic strategy for pancreatic cancer. Clin Cancer Res. 29:815–830. 2023. View Article : Google Scholar | |
|
McGuire JJ, Frieling JS, Lo CH, Li T, Muhammad A, Lawrence HR, Lawrence NJ, Cook LM and Lynch CC: Mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer. Nat Commun. 12:7232021. View Article : Google Scholar : PubMed/NCBI | |
|
Hong C, Schubert M, Tijhuis AE, Requesens M, Roorda M, van den Brink A, Ruiz LA, Bakker PL, van der Sluis T, Pieters W, et al: cGAS-STING drives the IL-6-dependent survival of chromosomally instable cancers. Nature. 607:366–373. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Wong GL, Manore SG, Doheny DL and Lo HW: STAT family of transcription factors in breast cancer: Pathogenesis and therapeutic opportunities and challenges. Semin Cancer Biol. 86(Pt 3): 84–106. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Huynh J, Chand A, Gough D and Ernst M: Therapeutically exploiting STAT3 activity in cancer-using tissue repair as a road map. Nat Rev Cancer. 19:82–96. 2019. View Article : Google Scholar | |
|
Wang R, Du TT, Liu WQ, Liu YC, Yang YD, Hu JP, Ji M, Yang BB, Li L and Chen XG: Discovery, optimization, and evaluation of novel N-(Benzimidazol-5-yl)-1,3,4-thiadiazol-2-amine analogues as potent STAT3 inhibitors for cancer treatment. J Med Chem. 66:12373–12395. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Tamura T, Kato Y, Ohashi K, Ninomiya K, Makimoto G, Gotoda H, Kubo T, Ichihara E, Tanaka T, Ichimura K, et al: Potential influence of interleukin-6 on the therapeutic effect of gefitinib in patients with advanced non-small cell lung cancer harbouring EGFR mutations. Biochem Biophys Res Commun. 495:360–367. 2018. View Article : Google Scholar | |
|
Li L, Li Z, Lu C, Li J, Zhang K, Lin C, Tang X, Liu Z, Zhang Y, Han R, et al: Ibrutinib reverses IL-6-induced osimertinib resistance through inhibition of Laminin α5/FAK signaling. Commun Biol. 5:1552022. View Article : Google Scholar | |
|
Hsu HS, Lin JH, Hsu TW, Su K, Wang CW, Yang KY, Chiou SH and Hung SC: Mesenchymal stem cells enhance lung cancer initiation through activation of IL-6/JAK2/STAT3 pathway. Lung Cancer. 75:167–177. 2012. View Article : Google Scholar | |
|
Xie C, Liang C, Wang R, Yi K, Zhou X, Li X, Chen Y, Miao D, Zhong C and Zhu J: Resveratrol suppresses lung cancer by targeting cancer stem-like cells and regulating tumor microenvironment. J Nutr Biochem. 112:1092112023. View Article : Google Scholar | |
|
Thuya WL, Cao Y, Ho PC, Wong AL, Wang L, Zhou J, Nicot C and Goh BC: Insights into IL-6/JAK/STAT3 signaling in the tumor microenvironment: Implications for cancer therapy. Cytokine Growth Factor Rev. 85:26–42. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Soler MF, Abaurrea A, Azcoaga P, Araujo AM and Caffarel MM: New perspectives in cancer immunotherapy: Targeting IL-6 cytokine family. J Immunother Cancer. 11:e0075302023. View Article : Google Scholar : PubMed/NCBI | |
|
Chen SF, Zhang ZY and Zhang JL: Matrine increases the inhibitory effects of afatinib on H1975 cells via the IL-6/JAK1/STAT3 signaling pathway. Mol Med Rep. 16:2733–2739. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Yuquan B, Hexiao T, Laiyi W, Gaofeng P, Xuefeng Z, Ming X, Yanhong W, Li Z and Jinping Z: Interaction between epidermal growth factor receptor and interleukin-6 receptor in NSCLC progression. J Cell Biochem. 120:872–881. 2019. View Article : Google Scholar | |
|
Wang J, Wang Y, Zheng C, Hou K, Zhang T, Qu X, Liu Y, Kang J, Hu X and Che X: Tyrosine kinase inhibitor-induced IL-6/STAT3 activation decreases sensitivity of EGFR-mutant non-small cell lung cancer to icotinib. Cell Biol Int. 42:1292–1299. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Liu C, Yang L, Xu H, Zheng S, Wang Z, Wang S, Yang Y, Zhang S, Feng X, Sun N, et al: Systematic analysis of IL-6 as a predictive biomarker and desensitizer of immunotherapy responses in patients with non-small cell lung cancer. BMC Med. 20:1872022. View Article : Google Scholar : PubMed/NCBI | |
|
Looyenga BD, Hutchings D, Cherni I, Kingsley C, Weiss GJ and Mackeigan JP: STAT3 is activated by JAK2 independent of key oncogenic driver mutations in non-small cell lung carcinoma. PLoS One. 7:e308202012. View Article : Google Scholar : PubMed/NCBI | |
|
Pine SR, Mechanic LE, Enewold L, Chaturvedi AK, Katki HA, Zheng YL, Bowman ED, Engels EA, Caporaso NE and Harris CC: Increased levels of circulating interleukin 6, interleukin 8, C-reactive protein, and risk of lung cancer. J Natl Cancer Inst. 103:1112–1122. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Silva EM, Mariano VS, Pastrez PRA, Pinto MC, Castro AG, Syrjanen KJ and Longatto-Filho A: High systemic IL-6 is associated with worse prognosis in patients with non-small cell lung cancer. PLoS One. 12:e01811252017. View Article : Google Scholar : PubMed/NCBI | |
|
Jones SA and Jenkins BJ: Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer. Nat Rev Immunol. 18:773–789. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Islas-vazquez L, Prado-Garcia H, Aguilar-Cazares D, Meneses-Flores M, Galicia-velasco M, Romero-Garcia S, Camacho-Mendoza C and Lopez-Gonzalez JS: LAP TGF-Beta Subset of CD4(+)CD25(+)CD127(-) Treg cells is increased and overexpresses LAP TGF-Beta in lung adenocarcinoma patients. Biomed Res Int. 2015:4309432015. View Article : Google Scholar : PubMed/NCBI | |
|
Brooks GD, McLeod L, Alhayyani S, Miller A, Russell PA, Ferlin W, Rose-John S, Ruwanpura S and Jenkins BJ: IL6 Trans-signaling promotes KRAS-driven lung carcinogenesis. Cancer Res. 76:866–876. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Ujiie H, Tomida M, Akiyama H, Nakajima Y, Okada D, Yoshino N, Takiguchi Y and Tanzawa H: Serum hepatocyte growth factor and interleukin-6 are effective prognostic markers for non-small cell lung cancer. Anticancer Res. 32:3251–3258. 2012.PubMed/NCBI | |
|
Liao C, Yu Z, Guo W, Liu Q, Wu Y, Li Y and Bai L: Prognostic value of circulating inflammatory factors in non-small cell lung cancer: A systematic review and meta-analysis. Cancer Biomark. 14:469–481. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Sheng J, Fang W, Liu X, Xing S, Zhan J, Ma Y, Huang Y, Zhou N, Zhao H and Zhang L: Impact of gefitinib in early stage treatment on circulating cytokines and lymphocytes for patients with advanced non-small cell lung cancer. Onco Targets Ther. 10:1101–1110. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Jia Y, Li X, Zhao C, Jiang T, Zhao S, Zhang L, Liu X, Shi J, Qiao M, Luo J, et al: Impact of serum vascular endothelial growth factor and interleukin-6 on treatment response to epidermal growth factor receptor tyrosine kinase inhibitors in patients with non-small-cell lung cancer. Lung Cancer. 125:22–28. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Komi DEA and Redegeld FA: Role of mast cells in shaping the tumor microenvironment. Clin Rev Allergy Immunol. 58:313–325. 2020. View Article : Google Scholar : | |
|
Nilsson MB, Sun H, Diao L, Tong P, Liu D, Li L, Fan Y, Poteete A, Lim SO, Howells K, et al: Stress hormones promote EGFR inhibitor resistance in NSCLC: Implications for combinations with β-blockers. Sci Transl Med. 9:eaao43072017. View Article : Google Scholar | |
|
Jia Y, Li X, Zhao C, Jiang T, Zhao S, Zhang L, Liu X, Shi J, Qiao M, Luo J, et al: Impact of serum vascular endothelial growth factor and interleukin-6 on treatment response to epidermal growth factor receptor tyrosine kinase inhibitors in patients with non-small-cell lung cancer. Lung Cancer. 125:22–28. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Oh YT, Chen Z, Wang D, Ramalingam SS and Sun SY: Induction of IL6/STAT3-dependent TRAIL expression that contributes to the therapeutic efficacy of osimertinib in EGFR mutant NSCLC cells. Oncogene. 44:2315–2327. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Kim SM, Kwon OJ, Hong YK, Kim JH, Solca F, Ha SJ, Soo RA, Christensen JG, Lee JH and Cho BC: Activation of IL-6R/JAK1/STAT3 signaling induces de novo resistance to irreversible EGFR inhibitors in non-small cell lung cancer with T790M resistance mutation. Mol Cancer Ther. 11:2254–2264. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Yao Z, Fenoglio S, Gao DC, Camiolo M, Stiles B, Lindsted T, Schlederer M, Johns C, Altorki N, Mittal V, et al: TGF-beta IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer. Proc Natl Acad Sci USA. 107:15535–15540. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Liang Q, Gong M, Zou JH, Luo MY, Jiang LL, Wang C, Shen NX, Zhang MC, Xu L, Lei HM, et al: A phosphoglycerate mutase 1 allosteric inhibitor overcomes drug resistance to EGFR-targeted therapy via disrupting IL-6/JAK2/STAT3 signaling pathway in lung adenocarcinoma. Drug Resist Updat. 68:1009572023. View Article : Google Scholar : PubMed/NCBI | |
|
Lee HJ, Zhuang G, Cao Y, Du P, Kim HJ and Settleman J: Drug resistance via feedback activation of Stat3 in oncogene-addicted cancer cells. Cancer Cell. 26:207–221. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Li L, Han R, Xiao H, Lin C, Wang Y, Liu H, Li K, Chen H, Sun F, Yang Z, et al: Metformin sensitizes EGFR-TKI-resistant human lung cancer cells in vitro and in vivo through inhibition of IL-6 signaling and EMT reversal. Clin Cancer Res. 20:2714–2726. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Zheng X, Lu G, Yao Y and Gu W: An Autocrine IL-6/IGF-1R loop mediates EMT and promotes tumor growth in non-small cell lung cancer. Int J Biol Sci. 15:1882–1891. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Shi Q, Godschalk RWL and van Schooten FJ: Inflammation and the chemical carcinogen benzo[a]pyrene: Partners in crime. Mutat Res Rev Mutat Res. 774:12–24. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Klammer H, Mladenov E, Li F and Iliakis G: Bystander effects as manifestation of intercellular communication of DNA damage and of the cellular oxidative status. Cancer Lett. 356:58–71. 2015. View Article : Google Scholar | |
|
Maynard A, McCoach CE, Rotow JK, Harris L, Haderk F, Kerr DL, Yu EA, Schenk EL, Tan W, Zee A, et al: Therapy-induced evolution of human lung cancer revealed by single-cell RNA sequencing. Cell. 182:1232–1251.e22. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Isomoto K, Haratani K, Hayashi H, Shimizu S, Tomida S, Niwa T, Yokoyama T, Fukuda Y, Chiba Y, Kato R, et al: Impact of EGFR-TKI treatment on the tumor immune microenvironment in EGFR mutation-positive non-small cell lung cancer. Clin Cancer Res. 26:2037–2046. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Tsukamoto H, Nishikata R, Senju S and Nishimura Y: Myeloid-derived suppressor cells attenuate TH1 development through IL-6 production to promote tumor progression. Cancer Immunol Res. 1:64–76. 2013. View Article : Google Scholar | |
|
Tsukamoto H, Fujieda K, Senju S, Ikeda T, Oshiumi H and Nishimura Y: Immune-suppressive effects of interleukin-6 on T-cell-mediated anti-tumor immunity. Cancer Sci. 109:523–530. 2018. View Article : Google Scholar : | |
|
Ohno Y, Kitamura H, Takahashi N, Ohtake J, Kaneumi S, Sumida K, Homma S, Kawamura H, Minagawa N, Shibasaki S and Taketomi A: IL-6 down-regulates HLA class II expression and IL-12 production of human dendritic cells to impair activation of antigen-specific CD4(+) T cells. Cancer Immunol Immunother. 65:193–204. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Huseni MA, Wang L, Klementowicz JE, Yuen K, Breart B, Orr C, Liu LF, Li Y, Gupta V, Li C, et al: CD8+ T cell-intrinsic IL-6 signaling promotes resistance to anti-PD-L1 immunotherapy. Cell Rep Med. 4:1008782023. View Article : Google Scholar | |
|
Patel SA, Nilsson MB, Yang Y, Le X, Tran HT, Elamin YY, Yu X, Zhang F, Poteete A, Ren X, et al: IL6 mediates suppression of T- and NK-cell function in EMT-associated TKI-resistant EGFR-mutant NSCLC. Clin Cancer Res. 29:1292–1304. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Kuo IY, Yang YE, Yang PS, Tsai YJ, Tzeng HT, Cheng HC, Kuo WT, Su WC, Chang CP and Wang YC: Converged Rab37/IL-6 trafficking and STAT3/PD-1 transcription axes elicit an immunosuppressive lung tumor microenvironment. Theranostics. 11:7029–7044. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang N, Zeng Y, Du W, Zhu J, Shen D, Liu Z and Huang JA: The EGFR pathway is involved in the regulation of PD-L1 expression via the IL-6/JAK/STAT3 signaling pathway in EGFR-mutated non-small cell lung cancer. Int J Oncol. 49:1360–1368. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Kang M, Park C, Kim SH, Yoon SW, Suh KJ, Kim YJ, Ock CY, Kim M, Keam B, Kim TM, et al: Programmed death-ligand 1 expression level as a predictor of EGFR tyrosine kinase inhibitor efficacy in lung adenocarcinoma. Transl Lung Cancer Res. 10:699–711. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Li J, Xu J, Yan X, Jin K, Li W and Zhang R: Targeting interleukin-6 (IL-6) sensitizes Anti-PD-L1 treatment in a colorectal cancer preclinical model. Med Sci Monit. 24:5501–5508. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Fan K, Yang C, Fan Z, Huang Q, Zhang Y, Cheng H, Jin K, Lu Y, Wang Z, Luo G, et al: MUC16 C terminal-induced secretion of tumor-derived IL-6 contributes to tumor-associated treg enrichment in pancreatic cancer. Cancer Lett. 418:167–175. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Hu G, Cheng P, Pan J, Wang S, Ding Q, Jiang Z, Cheng L, Shao X, Huang L and Huang J: An IL6-adenosine positive feedback loop between CD73+ γδTregs and CAFs promotes tumor progression in human breast cancer. Cancer Immunol Res. 8:1273–1286. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Salazar Y, Zheng X, Brunn D, Raifer H, Picard F, Zhang Y, Winter H, Guenther S, Weigert A, Weigmann B, et al: Microenvironmental Th9 and Th17 lymphocytes induce metastatic spreading in lung cancer. J Clin Invest. 130:3560–3575. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Kim HY, Jhun JY, Cho ML, Choi JY, Byun JK, Kim EK, Yoon SK, Bae SH, Chung BH and Yang CW: Interleukin-6 upregulates Th17 response via mTOR/STAT3 pathway in acute-on-chronic hepatitis B liver failure. J Gastroenterol. 49:1264–1273. 2014. View Article : Google Scholar | |
|
Zheng Y, Sun L, Jiang T, Zhang D, He D and Nie H: TNFα promotes Th17 cell differentiation through IL-6 and IL-1β produced by monocytes in rheumatoid arthritis. J Immunol Res. 2014:3853522014. View Article : Google Scholar | |
|
Tsukamoto H, Fujieda K, Hirayama M, Ikeda T, Yuno A, Matsumura K, Fukuma D, Araki K, Mizuta H, Nakayama H, et al: Soluble IL6R expressed by myeloid cells reduces tumor-specific Th1 differentiation and drives tumor progression. Cancer Res. 77:2279–2291. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Wu J, Gao FX, Wang C, Qin M, Han F, Xu T, Hu Z, Long Y, He XM, Deng X, et al: IL-6 and IL-8 secreted by tumour cells impair the function of NK cells via the STAT3 pathway in oesophageal squamous cell carcinoma. J Exp Clin Cancer Res. 38:3212019. View Article : Google Scholar : PubMed/NCBI | |
|
Gotthardt D, Putz EM, Straka E, Kudweis P, Biaggio M, Poli V, Strobl B, Müller M and Sexl V: Loss of STAT3 in murine NK cells enhances NK cell-dependent tumor surveillance. Blood. 124:2370–2379. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Kalluri R and Zeisberg M: Fibroblasts in cancer. Nat Rev Cancer. 6:392–401. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Karagiannis GS, Poutahidis T, Erdman SE, Kirsch R, Riddell RH and Diamandis EP: Cancer-associated fibroblasts drive the progression of metastasis through both paracrine and mechanical pressure on cancer tissue. Mol Cancer Res. 10:1403–1418. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Meador CB and Hata AN: Acquired resistance to targeted therapies in NSCLC: Updates and evolving insights. Pharmacol Ther. 210:1075222020. View Article : Google Scholar : PubMed/NCBI | |
|
Mikubo M, Inoue Y, Liu G and Tsao MS: Mechanism of drug tolerant persister cancer cells: The landscape and clinical implication for therapy. J Thorac Oncol. 16:1798–1809. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Bullock E, Rozyczko A, Shabbir S, Tsoupi I, Young AIJ, Travnickova J, Gómez-Cuadrado L, Mabruk Z, Carrasco G, Morrow E, et al: Cancer-associated fibroblast driven paracrine IL-6/STAT3 signaling promotes migration and dissemination in invasive lobular carcinoma. Breast Cancer Res. 27:1212025. View Article : Google Scholar : PubMed/NCBI | |
|
Tan J, Zhu L, Shi J, Zhang J, Kuang J, Guo Q, Zhu X, Chen Y, Zhou C and Gao X: Evaluation of drug resistance for EGFR-TKIs in lung cancer via multicellular lung-on-a-chip. Eur J Pharm Sci. 199:1068052024. View Article : Google Scholar : PubMed/NCBI | |
|
Ishiguro Y, Ishiguro H and Miyamoto H: Epidermal growth factor receptor tyrosine kinase inhibition up-regulates interleukin-6 in cancer cells and induces subsequent development of interstitial pneumonia. Oncotarget. 4:550–559. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Ochi K, Suzawa K, Thu YM, Takatsu F, Tsudaka S, Zhu Y, Nakata K, Takeda T, Shien K, Yamamoto H, et al: Drug repositioning of tranilast to sensitize a cancer therapy by targeting cancer-associated fibroblast. Cancer Sci. 113:3428–3436. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Shien K, Papadimitrakopoulou vA, Ruder D, Behrens C, Shen L, Kalhor N, Song J, Lee JJ, Wang J, Tang X, et al: JAK1/STAT3 activation through a proinflammatory cytokine pathway leads to resistance to molecularly targeted therapy in non-small cell lung cancer. Mol Cancer Ther. 16:2234–2245. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Mantovani A, Marchesi F, Malesci A, Laghi L and Allavena P: Tumour-associated macrophages as treatment targets in oncology. Nat Rev Clin Oncol. 14:399–416. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Xiang X, Wang J, Lu D and Xu X: Targeting tumor-associated macrophages to synergize tumor immunotherapy. Signal Transduct Target Ther. 6:752021. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang B, Zhang Y, Zhao J, Wang Z, Wu T, Ou W, Wang J, Yang B, Zhao Y, Rao Z and Gao J: M2-polarized macrophages contribute to the decreased sensitivity of EGFR-TKIs treatment in patients with advanced lung adenocarcinoma. Med Oncol. 31:1272014. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou J, Qu Z, Sun F, Han L, Li L, Yan S, Stabile LP, Chen LF, Siegfried JM and Xiao G: Myeloid STAT3 promotes lung tumorigenesis by transforming tumor immunosurveillance into tumor-promoting inflammation. Cancer Immunol Res. 5:257–268. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Hu Z, Sui Q, Jin X, Shan G, Huang Y, Yi Y, Zeng D, Zhao M, Zhan C, Wang Q, et al: IL6-STAT3-C/EBPβ-IL6 positive feedback loop in tumor-associated macrophages promotes the EMT and metastasis of lung adenocarcinoma. J Exp Clin Cancer Res. 43:632024. View Article : Google Scholar | |
|
Lin G, Lin L, Chen X, Chen L, Yang J, Chen Y, Qian D, Zeng Y and Xu Y: PPAR-γ/NF-kB/AQP3 axis in M2 macrophage orchestrates lung adenocarcinoma progression by upregulating IL-6. Cell Death Dis. 15:5322024. View Article : Google Scholar | |
|
Chen S, Lu K, Hou Y, You Z, Shu C, Wei X, Wu T, Shi N, Zhang G, Wu J, et al: YY1 complex in M2 macrophage promotes prostate cancer progression by upregulating IL-6. J Immunother Cancer. 11:e0060202023. View Article : Google Scholar : PubMed/NCBI | |
|
Che D, Zhang S, Jing Z, Shang L, Jin S, Liu F, Shen J, Li Y, Hu J, Meng Q and Yu Y: Macrophages induce EMT to promote invasion of lung cancer cells through the IL-6-mediated COX-2/PGE2/β-catenin signalling pathway. Mol Immunol. 90:197–210. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Wu Y, Yi M, Niu M, Mei Q and Wu K: Myeloid-derived suppressor cells: An emerging target for anticancer immunotherapy. Mol Cancer. 21:1842022. View Article : Google Scholar : PubMed/NCBI | |
|
Tang J, Liu X, Gong Y, Zhu J, Huang M, Ding Z, Yu M, Tie Y, Li Q and Wang Y: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) impact on immune microenvironment in non-small cell lung cancer (NSCLC). J Clin Oncol. 36(15_Suppl): e211542018. View Article : Google Scholar | |
|
Yang Z, Guo J, Weng L, Tang W, Jin S and Ma W: Myeloid-derived suppressor cells-new and exciting players in lung cancer. J Hematol Oncol. 13:102020. View Article : Google Scholar : PubMed/NCBI | |
|
vasquez-Dunddel D, Pan F, Zeng Q, Gorbounov M, Albesiano E, Fu J, Blosser RL, Tam AJ, Bruno T, Zhang H, et al: STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients. J Clin Invest. 123:1580–1589. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Altorki NK, Markowitz GJ, Gao D, Port JL, Saxena A, Stiles B, McGraw T and Mittal V: The lung microenvironment: An important regulator of tumour growth and metastasis. Nat Rev Cancer. 19:9–31. 2019. View Article : Google Scholar : | |
|
Neo SY, Tong L, Chong J, Liu Y, Jing X, Oliveira MMS, Chen Y, Chen Z, Lee K, Burduli N, et al: Tumor-associated NK cells drive MDSC-mediated tumor immune tolerance through the IL-6/STAT3 axis. Sci Transl Med. 16:eadi29522024. View Article : Google Scholar : PubMed/NCBI | |
|
Gabrilovich DI and Nagaraj S: Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol. 9:162–174. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Condamine T and Gabrilovich DI: Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function. Trends Immunol. 32:19–25. 2011. View Article : Google Scholar | |
|
Weber R, Groth C, Lasser S, Arkhypov I, Petrova V, Altevogt P, Utikal J and Umansky V: IL-6 as a major regulator of MDSC activity and possible target for cancer immunotherapy. Cell Immunol. 359:1042542021. View Article : Google Scholar | |
|
Jeong H, Koh J, Kim S, Yim J, Song SG, Kim H, Li Y, Lee SH, Chung YK, Kim H, et al: Cell-intrinsic PD-L1 signaling drives immunosuppression by myeloid-derived suppressor cells through IL-6/jak/Stat3 in PD-L1-high lung cancer. J Immunother Cancer. 13:e0106122025. View Article : Google Scholar : PubMed/NCBI | |
|
Weber R, Riester Z, Hüser L, Sticht C, Siebenmorgen A, Groth C, Hu X, Altevogt P, Utikal JS and Umansky V: IL-6 regulates CCR5 expression and immunosuppressive capacity of MDSC in murine melanoma. J Immunother Cancer. 8:e0009492020. View Article : Google Scholar : PubMed/NCBI | |
|
Song L, Rawal B, Nemeth JA and Haura EB: JAK1 activates STAT3 activity in non-small-cell lung cancer cells and IL-6 neutralizing antibodies can suppress JAK1-STAT3 signaling. Mol Cancer Ther. 10:481–494. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Yang Y, Wang W, Chang H, Han Z, Yu X and Zhang T: Reciprocal regulation of miR-206 and IL-6/STAT3 pathway mediates IL6-induced gefitinib resistance in EGFR-mutant lung cancer cells. J Cell Mol Med. 23:7331–7341. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Murakami T, Takigawa N, Ninomiya T, Ochi N, Yasugi M, Honda Y, Kubo T, Ichihara E, Hotta K, Tanimoto M and Kiura K: Effect of AZD1480 in an epidermal growth factor receptor-driven lung cancer model. Lung Cancer. 83:30–36. 2014. View Article : Google Scholar | |
|
Padda SK, Reckamp KL, Koczywas M, Neal JW, Kawashima J, Kong S, Huang DB, Kowalski M and Wakelee HA: A phase 1b study of erlotinib and momelotinib for the treatment of EGFR-mutated, tyrosine kinase inhibitor-naive metastatic non-small cell lung cancer. Cancer Chemother Pharmacol. 89:105–115. 2022. View Article : Google Scholar : | |
|
Hong D, Kurzrock R, Kim Y, Woessner R, Younes A, Nemunaitis J, Fowler N, Zhou T, Schmidt J, Jo M, et al: AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer. Sci Transl Med. 7:314ra1852015. View Article : Google Scholar : PubMed/NCBI | |
|
Nan J, Du Y, Chen X, Bai Q, Wang Y, Zhang X, Zhu N, Zhang J, Hou J, Wang Q and Yang J: TPCA-1 is a direct dual inhibitor of STAT3 and NF-κB and regresses mutant EGFR-Associated human non-small cell lung cancers. Mol Cancer Ther. 13:617–629. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Chiu HC, Chou DL, Huang CT, Lin WH, Lien TW, Yen KJ and Hsu JT: Suppression of Stat3 activity sensitizes gefitinib-resistant non small cell lung cancer cells. Biochem Pharmacol. 81:1263–1270. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Hedvat M, Huszar D, Herrmann A, Gozgit JM, Schroeder A, Sheehy A, Buettner R, Proia D, Kowolik CM, Xin H, et al: The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors. Cancer Cell. 16:487–497. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Xin H, Herrmann A, Reckamp K, Zhang W, Pal S, Hedvat M, Zhang C, Liang W, Scuto A, Weng S, et al: Antiangiogenic and antimetastatic activity of JAK inhibitor AZD1480. Cancer Res. 71:6601–6610. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Li R, Huang Y and Lin J: Distinct effects of general anesthetics on lung metastasis mediated by IL-6/JAK/STAT3 pathway in mouse models. Nat Commun. 11:6422020. View Article : Google Scholar : PubMed/NCBI | |
|
Cao W, Liu Y, Zhang R, Zhang B, Wang T, Zhu X, Mei L, Chen H, Zhang H, Ming P and Huang L: Homoharringtonine induces apoptosis and inhibits STAT3 via IL-6/JAK1/STAT3 signal pathway in Gefitinib-resistant lung cancer cells. Sci Rep. 5:84772015. View Article : Google Scholar : PubMed/NCBI | |
|
Lou W, Chen Y, Zhu KY, Deng H, Wu T and Wang J: Polyphyllin I overcomes EMT-associated resistance to erlotinib in lung cancer cells via IL-6/STAT3 pathway inhibition. Biol Pharm Bull. 40:1306–1313. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Shi Y, Gao W, Lytle NK, Huang P, Yuan X, Dann AM, Ridinger-Saison M, DelGiorno KE, Antal CE, Liang G, et al: Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. Nature. 569:131–135. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Ernst M and Putoczki TL: Molecular pathways: IL11 as a tumor-promoting cytokine-translational implications for cancers. Clin Cancer Res. 20:5579–5588. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Kang S, Narazaki M, Metwally H and Kishimoto T: Historical overview of the interleukin-6 family cytokine. J Exp Med. 217:e201903472020. View Article : Google Scholar : PubMed/NCBI | |
|
Zhao K, Lu Y, Chen Y, Cheng J and Zhang W: Dual inhibition of MAPK and JAK2/STAT3 pathways is critical for the treatment of BRAF mutant melanoma. Mol Ther Oncolytics. 18:100–108. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Huang B, Lang X and Li X: The role of IL-6/JAK2/STAT3 signaling pathway in cancers. Front Oncol. 12:10231772022. View Article : Google Scholar : | |
|
Reck M, Rodríguez-Abreu D, Robinson AG, Hui R, Csőszi T, Fülöp A, Gottfried M, Peled N, Tafreshi A, Cuffe S, et al: Updated analysis of KEYNOTE-024: Pembrolizumab versus platinum-based chemotherapy for advanced non-small-cell lung cancer with PD-L1 tumor proportion score of 50% or greater. J Clin Oncol. 37:537–546. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Luo W, Wang Z, Zhang T, Yang L, Xian J, Li Y and Li W: Immunotherapy in non-small cell lung cancer: Rationale, recent advances and future perspectives. Precis Clin Med. 4:258–270. 2021. View Article : Google Scholar | |
|
Hayashi H, Sugawara S, Fukuda Y, Fujimoto D, Miura S, Ota K, Ozawa Y, Hara S, Tanizaki J, Azuma K, et al: A randomized phase II study comparing nivolumab with carboplatin-pemetrexed for EGFR-mutated NSCLC with resistance to EGFR tyrosine kinase inhibitors (WJOG8515L). Clin Cancer Res. 28:893–902. 2022. View Article : Google Scholar | |
|
Mok T, Nakagawa K, Park K, Ohe Y, Girard N, Kim HR, Wu YL, Gainor J, Lee SH, Chiu CH, et al: Nivolumab plus chemotherapy in epidermal growth factor receptor-mutated metastatic non-small-cell lung cancer after disease progression on epidermal growth factor receptor tyrosine kinase inhibitors: Final results of CheckMate 722. J Clin Oncol. 42:1252–1264. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Yang JC, Lee DH, Lee JS, Fan Y, de Marinis F, Iwama E, Inoue T, Rodríguez-Cid J, Zhang L, Yang CT, et al: Phase III KEYNOTE-789 study of pemetrexed and platinum with or without pembrolizumab for tyrosine kinase inhibitor-resistant, EGFR-mutant, metastatic nonsquamous non-small cell lung cancer. J Clin Oncol. 42:4029–4039. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Yu H, Kortylewski M and Pardoll D: Crosstalk between cancer and immune cells: Role of STAT3 in the tumour microenvironment. Nat Rev Immunol. 7:41–51. 2007. View Article : Google Scholar | |
|
Iwata-Kajihara T, Sumimoto H, Kawamura N, Ueda R, Takahashi T, Mizuguchi H, Miyagishi M, Takeda K and Kawakami Y: Enhanced cancer immunotherapy using STAT3-depleted dendritic cells with high Th1-inducing ability and resistance to cancer cell-derived inhibitory factors. J Immunol. 187:27–36. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Hossain DM, Dos Santos C, Zhang Q, Kozlowska A, Liu H, Gao C, Moreira D, Swiderski P, Jozwiak A, Kline J, et al: Leukemia cell-targeted STAT3 silencing and TLR9 triggering generate systemic antitumor immunity. Blood. 123:15–25. 2014. View Article : Google Scholar | |
|
Yu H, Pardoll D and Jove R: STATs in cancer inflammation and immunity: A leading role for STAT3. Nat Rev Cancer. 9:798–809. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Kortylewski M, Kujawski M, Wang T, Wei S, Zhang S, Pilon-Thomas S, Niu G, Kay H, Mulé J, Kerr WG, et al: Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity. Nat Med. 11:1314–1321. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Tan DSW, Felip E, de Castro G, Solomon BJ, Greystoke A, Cho BC, Cobo M, Kim TM, Ganguly S, Carcereny E, et al: Canakinumab versus placebo in combination with first-line pembrolizumab plus chemotherapy for advanced non-small-cell lung cancer: Results from the CANOPY-1 trial. J Clin Oncol. 42:192–204. 2024. View Article : Google Scholar | |
|
Zhang W, Liu Y, Yan Z, Yang H, Sun W, Yao Y, Chen Y and Jiang R: IL-6 promotes PD-L1 expression in monocytes and macrophages by decreasing protein tyrosine phosphatase receptor type O expression in human hepatocellular carcinoma. J Immunother Cancer. 8:e0002852020. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou J, Lu X, Zhu H, Ding N, Zhang Y, Xu X, Gao L, Zhou J, Song Y and Hu J: Resistance to immune checkpoint inhibitors in advanced lung cancer: Clinical characteristics, potential prognostic factors and next strategy. Front Immunol. 14:10890262023. View Article : Google Scholar : PubMed/NCBI | |
|
Tsukamoto H, Fujieda K, Miyashita A, Fukushima S, Ikeda T, Kubo Y, Senju S, Ihn H, Nishimura Y and Oshiumi H: Combined blockade of IL6 and PD-1/PD-L1 signaling abrogates mutual regulation of their immunosuppressive effects in the tumor microenvironment. Cancer Res. 78:5011–5022. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Mace TA, Shakya R, Pitarresi JR, Swanson B, McQuinn CW, Loftus S, Nordquist E, Cruz-Monserrate Z, Yu L, Young G, et al: IL-6 and PD-L1 antibody blockade combination therapy reduces tumour progression in murine models of pancreatic cancer. Gut. 67:320–332. 2018. View Article : Google Scholar | |
|
Jin W: Role of JAK/STAT3 signaling in the regulation of metastasis, the transition of cancer stem cells, and chemoresistance of cancer by epithelial-mesenchymal transition. Cells. 9:2172020. View Article : Google Scholar : PubMed/NCBI | |
|
Danlos FX, Texier M, Job B, Mouraud S, Cassard L, Baldini C, varga A, Yurchenko AA, Rabeau A, Champiat S, et al: Genomic instability and protumoral inflammation are associated with primary resistance to anti-PD-1 + antiangiogenesis in malignant pleural mesothelioma. Cancer Discov. 13:858–879. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Yokota H, Sato K, Sakamoto S, Okuda Y, Takeda M, Akamine Y, Nakayama K and Miura M: Influence of interleukin-6 on the pharmacokinetics and pharmacodynamics of osimertinib in patients with non-small cell lung cancer. Cancer Chemother Pharmacol. 95:492025. View Article : Google Scholar : PubMed/NCBI | |
|
Martin FJ, Amode MR, Aneja A, Austine-Orimoloye O, Azov AG, Barnes I, Becker A, Bennett R, Berry A, Bhai J, et al: Ensembl 2023. Nucleic Acids Res. 51:D933–D941. 2023. View Article : Google Scholar : | |
|
Xie Y, Li H, Luo X, Li H, Gao Q, Zhang L, Teng Y, Zhao Q, Zuo Z and Ren J: IBS 2.0: An upgraded illustrator for the visualization of biological sequences. Nucleic Acids Res. 50(W1): W420–W426. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Fang Z, Ran H, Zhang Y, Chen C, Lin P, Zhang X and Wu M: AlphaFold 3: An unprecedent opportunity for fundamental research and drug development. Precis Clin Med. 8:pbaf0152025. View Article : Google Scholar : PubMed/NCBI |