You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.
I agree
International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.
International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.
Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.
Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.
Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.
Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.
Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.
International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.
Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.
Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.
Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.
An International Open Access Journal Devoted to General Medicine.
![]() |
![]() |
![]() |
|
Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I and Jemal A: Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 74:229–263. 2024.PubMed/NCBI | |
|
Li X, Wang J, Ma Y, Wang S, Yu X, Niu K, Yan P, Wu D, Song J, Kou Y, et al: Burden and trends of early-onset gastric cancer in the 11 BRICS countries (2025 expansion): 1990-2021 with projections to 2035. BMC Cancer. 25:14782025. View Article : Google Scholar : PubMed/NCBI | |
|
Luzko I, Moreira L and Bornschein J: Screening for and surveillance of premalignant conditions of the stomach. Best Pract Res Clin Gastroenterol. 75:1019782025. View Article : Google Scholar : PubMed/NCBI | |
|
Ko MT, Fung A, Kumar A, McArdle A and Alexandre L: Post-endoscopy upper gastrointestinal cancer: Emerging data and opportunities to improve early detection. Best Pract Res Clin Gastroenterol. 75:1020032025. View Article : Google Scholar : PubMed/NCBI | |
|
Luo D, Zhou J, Ruan S, Zhang B, Zhu H, Que Y, Ying S, Li X, Hu Y and Song Z: Overcoming immunotherapy resistance in gastric cancer: insights into mechanisms and emerging strategies. Cell Death Dis. 16:752025. View Article : Google Scholar : PubMed/NCBI | |
|
Sun Q, Li S, Lou J, Wang X and Xu X: Recent advances in tumour microenvironment impact immunotherapy resistance in gastric cancer. Crit Rev Oncol Hematol. 215:1048372025. View Article : Google Scholar : PubMed/NCBI | |
|
Vander Heiden MG, Cantley LC and Hompson CB: Understanding the Warburg effect: The metabolic requirements of cell proliferation. Science. 324:1029–1033. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Schiliro C and Firestein BL: Mechanisms of metabolic reprogramming in cancer cells supporting enhanced growth and proliferation. Cells. 10:10562021. View Article : Google Scholar : PubMed/NCBI | |
|
Warburg O: On the origin of cancer cells. Science. 123:309–314. 1956. View Article : Google Scholar : PubMed/NCBI | |
|
Cai H, Zhang F, Xu F and Yang C: Metabolic reprogramming and therapeutic targeting in non-small cell lung cancer: Emerging insights beyond the Warburg effect. Front Oncol. 15:15642262025. View Article : Google Scholar : PubMed/NCBI | |
|
Marei HE: Epigenetic regulators in cancer therapy and progression. NPJ Precis Oncol. 9:2062025. View Article : Google Scholar : PubMed/NCBI | |
|
Toden S, Zumwalt TJ and Goel A: Non-coding RNAs and potential therapeutic targeting in cancer. Biochim Biophys Acta Rev Cancer. 1875:1884912021. View Article : Google Scholar | |
|
Saw PE, Xu X, Chen J and Song E: Non-coding RNAs: The new central dogma of cancer biology. Sci China Life Sci. 64:22–50. 2021. View Article : Google Scholar | |
|
Xie S, Chang Y, Jin H, Yang F, Xu Y, Yan X, Lin A, Shu Q and Zhou T: Non-coding RNAs in gastric cancer. Cancer Lett. 493:55–70. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Li J, Sun D, Pu W, Wang J and Peng Y: Circular RNAs in cancer: Biogenesis, function, and clinical significance. Trends Cancer. 6:319–336. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Xia L, Song M, Sun M, Wang F and Yang C: Circular RNAs as biomarkers for cancer. Adv Exp Med Biol. 1087:171–187. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Pandey PR, Munk R, Kundu G, De S, Abdelmohsen K and Gorospe M: Methods for analysis of circular RNAs. Wiley Interdiscip Rev RNA. 11:e15662020. View Article : Google Scholar | |
|
Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, et al: Circular RNAs are a large class of animal RNAs with regulatory potency. Nature. 495:333–338. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
He AT, Liu J, Li F and Yang BB: Targeting circular RNAs as a therapeutic approach: Current strategies and challenges. Signal Transduct Target Ther. 6:1852021. View Article : Google Scholar : PubMed/NCBI | |
|
Lee K, Ku J, Ku D and Kim Y: Inverted Alu repeats: Friends or foes in the human transcriptome. Exp Mol Med. 56:1250–1262. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Jeck WR, Sorrentino JA, Wang K, Slevin MK, Burd CE, Liu J, Marzluff WF and Sharpless NE: Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA. 19:141–157. 2013. View Article : Google Scholar : | |
|
Wang S, Sun Z, Lei Z and Zhang H: RNA-binding proteins and cancer metastasis. Semin Cancer Biol. 86:748–768. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Galarneau A and Richard S: Target RNA motif and target mRNAs of the Quaking STAR protein. Nat Struct Mol Biol. 12:691–698. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Conn SJ, Pillman KA, Toubia J, Conn VM, Salmanidis M, Phillips CA, Roslan S, Schreiber AW, Gregory PA and Goodall GJ: The RNA binding protein quaking regulates formation of circRNAs. Cell. 160:1125–1134. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Hong H, An O, Chan THM, Ng VHE, Kwok HS, Lin JS, Qi L, Han J, Tay DJT, Tang SJ, et al: Bidirectional regulation of adenosine-to-inosine (A-to-I) RNA editing by DEAH box helicase 9 (DHX9) in cancer. Nucleic Acids Res. 46:7953–7969. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Ivanov A, Memczak S, Wyler E, Torti F, Porath HT, Orejuela MR, Piechotta M, Levanon EY, Landthaler M, Dieterich C and Rajewsky N: Analysis of intron sequences reveals hallmarks of circular RNA biogenesis in animals. Cell Rep. 10:170–177. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Warburg O: On respiratory impairment in cancer cells. Science. 124:269–270. 1956. View Article : Google Scholar : PubMed/NCBI | |
|
Ciccarone F and Ciriolo MR: Reprogrammed mitochondria: A central hub of cancer cell metabolism. Biochem Soc Trans. 52:1305–1315. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Zhan H, Pal DS, Borleis J, Deng Y, Long Y, Janetopoulos C, Huang CH and Devreotes PN: Self-organizing glycolytic waves tune cellular metabolic states and fuel cancer progression. Nat Commun. 16:55632025. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang H, Liu S, Fu S, Zhao Q, Wang Y, Yuan Y and Zhang C: Novel insight into the Warburg effect: Sweet temptation. Crit Rev Oncol Hematol. 214:1048442025. View Article : Google Scholar : PubMed/NCBI | |
|
Qu J, Li P and Sun Z: Histone lactylation regulates cancer progression by reshaping the tumor microenvironment. Front Immunol. 14:12843442023. View Article : Google Scholar : PubMed/NCBI | |
|
Pavlova NN, Zhu J and Thompson CB: The hallmarks of cancer metabolism: Still emerging. Cell Metab. 34:355–377. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Barba I, Carrillo-Bosch L and Seoane J: Targeting the Warburg effect in cancer: Where do we stand? Int J Mol Sci. 25:31422024. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Q, Li M, Chen C, Xu L, Fu Y, Xu J, Shu C, Wang B, Wang Z, Chen C, et al: Glucose homeostasis controls N-acetyltransferase 10-mediated ac4C modification of HK2 to drive gastric tumorigenesis. Theranostics. 15:2428–2450. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Bian X, Jiang H, Meng Y, Li YP, Fang J and Lu Z: Regulation of gene expression by glycolytic and gluconeogenic enzymes. Trends Cell Biol. 32:786–799. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Campos M and Albrecht LV: Hitting the sweet spot: How glucose metabolism is orchestrated in space and time by phosphofructokinase-1. Cancers (Basel). 16:162023. View Article : Google Scholar | |
|
Zhang Z, Han S, Ouyang S, Zeng Z, Liu Z, Sun J and Kang W: PDK4 constitutes a novel prognostic biomarker and therapeutic target in gastric cancer. Diagnostics (Basel). 12:11012022. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang R, Mao G, Tang Y, Li C, Gao Y, Nie W, Song T, Liu S, Zhang P, Tao K and Li W: Inhibition of glycolysis enhances the efficacy of immunotherapy via PDK-mediated upregulation of PD-L1. Cancer Immunol Immunother. 73:1512024. View Article : Google Scholar : PubMed/NCBI | |
|
Zhu S, Guo Y, Zhang X, Liu H, Yin M, Chen X and Peng C: Pyruvate kinase M2 (PKM2) in cancer and cancer therapeutics. Cancer Lett. 503:240–248. 2021. View Article : Google Scholar | |
|
Zhang Z, Deng X, Liu Y, Liu Y, Sun L and Chen F: PKM2, function and expression and regulation. Cell Biosci. 9:522019. View Article : Google Scholar : PubMed/NCBI | |
|
Röhrig F and Schulze A: The multifaceted roles of fatty acid synthesis in cancer. Nat Rev Cancer. 16:732–749. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Houten SM and Wanders RJ: A general introduction to the biochemistry of mitochondrial fatty acid β-oxidation. J Inherit Metab Dis. 33:469–477. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Jin HR, Wang J, Wang ZJ, Xi MJ, Xia BH, Deng K and Yang JL: Lipid metabolic reprogramming in tumor microenvironment: From mechanisms to therapeutics. J Hematol Oncol. 16:1032023. View Article : Google Scholar : PubMed/NCBI | |
|
Li C, Zhang L, Qiu Z, Deng W and Wang W: Key molecules of fatty acid metabolism in gastric cancer. Biomolecules. 12:7062022. View Article : Google Scholar : PubMed/NCBI | |
|
Guerrero-Rodríguez SL, Mata-Cruz C, Pérez-Tapia SM and Velasco-Velázquez MA: Role of CD36 in cancer progression, stemness, and targeting. Front Cell Dev Biol. 10:10790762022. View Article : Google Scholar : PubMed/NCBI | |
|
Hao J, Wang J, Guo H, Zhao Y, Sun H, Li Y, Lai X, Zhao N, Wang X, Xie C, et al: CD36 facilitates fatty acid uptake by dynamic palmitoylation-regulated endocytosis. Nat Commun. 11:47652020. View Article : Google Scholar : PubMed/NCBI | |
|
Jiang M, Wu N, Xu B, Chu Y, Li X, Su S, Chen D, Li W, Shi Y, Gao X, et al: Fatty acid-induced CD36 expression via O-GlcNAcylation drives gastric cancer metastasis. Theranostics. 9:5359–5373. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Severin M, Hansen RK, Rolver MG, Hels T, Maeda K, Pardo LA and Pedersen SF: Tumor acidosis supports cancer cell lipid uptake via a rapid transporter-independent mechanism. J Cell Sci. 138:jcs2636882025. View Article : Google Scholar : PubMed/NCBI | |
|
Schlaepfer IR and Joshi M: CPT1A-mediated fat oxidation, mechanisms, and therapeutic potential. Endocrinology. 161:bqz0462020. View Article : Google Scholar : PubMed/NCBI | |
|
Pereyra AS, Rajan A, Ferreira CR and Ellis JM: Loss of muscle carnitine palmitoyltransferase 2 prevents diet-induced obesity and insulin resistance despite long-chain acylcarnitine accumulation. Cell Rep. 33:1083742020. View Article : Google Scholar : PubMed/NCBI | |
|
Wang C, Zhang C, Li X, Shen J, Xu Y, Shi H, Mu X, Pan J, Zhao T, Li M, et al: CPT1A-mediated succinylation of S100A10 increases human gastric cancer invasion. J Cell Mol Med. 23:293–305. 2019. View Article : Google Scholar : | |
|
Wang M, Yu W, Cao X, Gu H, Huang J, Wu C, Wang L, Sha X, Shen B, Wang T, et al: Exosomal CD44 transmits lymph node metastatic capacity between gastric cancer cells via YAP-CPT1A-mediated FAO reprogramming. Front Oncol. 12:8601752022. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Y, Lu JH, Wang F, Wang YN, He MM, Wu QN, Lu YX, Yu HE, Chen ZH, Zhao Q, et al: Inhibition of fatty acid catabolism augments the efficacy of oxaliplatin-based chemotherapy in gastrointestinal cancers. Cancer Lett. 473:74–89. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Ma G, Zhang Z, Li P, Zhang Z, Zeng M, Liang Z, Li D, Wang L, Chen Y, Liang Y and Niu H: Reprogramming of glutamine metabolism and its impact on immune response in the tumor microenvironment. Cell Commun Signal. 20:1142022. View Article : Google Scholar : PubMed/NCBI | |
|
Lieu EL, Nguyen T, Rhyne S and Kim J: Amino acids in cancer. Exp Mol Med. 52:15–30. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Wang B, Pei J, Xu S, Liu J and Yu J: A glutamine tug-of-war between cancer and immune cells: Recent advances in unraveling the ongoing battle. J Exp Clin Cancer Res. 43:742024. View Article : Google Scholar : PubMed/NCBI | |
|
Zou W, Han Z, Wang Z and Liu Q: Targeting glutamine metabolism as a potential target for cancer treatment. J Exp Clin Cancer Res. 44:1802025. View Article : Google Scholar : PubMed/NCBI | |
|
Ying M, You D, Zhu X, Cai L, Zeng S and Hu X: Lactate and glutamine support NADPH generation in cancer cells under glucose deprived conditions. Redox Biol. 46:1020652021. View Article : Google Scholar : PubMed/NCBI | |
|
Lu YX, Ju HQ, Liu ZX, Chen DL, Wang Y, Zhao Q, Wu QN, Zeng ZL, Qiu HB, Hu PS, et al: ME1 regulates NADPH homeostasis to promote gastric cancer growth and metastasis. Cancer Res. 78:1972–1985. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Yu JC, Jiang ZM and Li DM: Glutamine: A precursor of glutathione and its effect on liver. World J Gastroenterol. 5:143–146. 1999. View Article : Google Scholar | |
|
Jiang B, Zhang J, Zhao G, Liu M, Hu J, Lin F, Wang J, Zhao W, Ma H, Zhang C, et al: Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis. Mol Cell. 82:1821–1835.e6. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Jaune-Pons E and Vasseur S: Role of amino acids in regulation of ROS balance in cancer. Arch Biochem Biophys. 689:1084382020. View Article : Google Scholar : PubMed/NCBI | |
|
Byun JK, Park M, Lee S, Yun JW, Lee J, Kim JS, Cho SJ, Jeon HJ, Lee IK, Choi YK and Park KG: Inhibition of glutamine utilization synergizes with immune checkpoint inhibitor to promote antitumor immunity. Mol Cell. 80:592–606.e8. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Caforio M, Sorino C, Iacovelli S, Fanciulli M, Locatelli F and Folgiero V: Recent advances in searching c-Myc transcriptional cofactors during tumorigenesis. J Exp Clin Cancer Res. 37:2392018. View Article : Google Scholar : PubMed/NCBI | |
|
Gao P, Tchernyshyov I, Chang TC, Lee YS, Kita K, Ochi T, Zeller KI, De Marzo AM, Van Eyk JE, Mendell JT and Dang CV: c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature. 458:762–765. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Xu E, Ji B, Jin K and Chen Y: Branched-chain amino acids catabolism and cancer progression: Focus on therapeutic interventions. Front Oncol. 13:12206382023. View Article : Google Scholar : PubMed/NCBI | |
|
Peng H, Wang Y and Luo W: Multifaceted role of branched-chain amino acid metabolism in cancer. Oncogene. 39:6747–6756. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Yang D, Liu H, Cai Y, Lu K, Zhong X, Xing S, Song W, Zhang Y, Ye L, Zhu X, et al: Branched-chain amino acid catabolism breaks glutamine addiction to sustain hepatocellular carcinoma progression. Cell Rep. 41:1116912022. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang L and Han J: Branched-chain amino acid transaminase 1 (BCAT1) promotes the growth of breast cancer cells through improving mTOR-mediated mitochondrial biogenesis and function. Biochem Biophys Res Commun. 486:224–231. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Kami K, Fujimori T, Sato H, Sato M, Yamamoto H, Ohashi Y, Sugiyama N, Ishihama Y, Onozuka H, Ochiai A, et al: Metabolomic profiling of lung and prostate tumor tissues by capillary electrophoresis time-of-flight mass spectrometry. Metabolomics. 9:444–453. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Yu L, Bao S, Zhu F, Xu Y, Liu Y, Jiang R, Yang C, Cao F, Chen W and Li P: Association between branched-chain amino acid levels and gastric cancer risk: Large-scale prospective cohort study. Front Nutr. 11:14798002024. View Article : Google Scholar : PubMed/NCBI | |
|
Lane AN and Fan TWM: Regulation of mammalian nucleotide metabolism and biosynthesis. Nucleic Acids Res. 43:2466–2485. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Feng Q, Zhang W, Peng Y, Zhao C, Ren J and Qu X: Precise targeting one-carbon metabolism for potent cancer therapy and metastasis suppression. Small. 21:e046312025. View Article : Google Scholar : PubMed/NCBI | |
|
Malvi P, Bugide S, Dutta R, Reddi KK, Edwards YJK, Singh K, Gupta R and Wajapeyee N: PDE7A inhibition suppresses triple-negative breast cancer by attenuating de novo pyrimidine biosynthesis. Cell Rep Med. 6:1023562025. View Article : Google Scholar : PubMed/NCBI | |
|
Mullen NJ and Singh PK: Nucleotide metabolism: A pan-cancer metabolic dependency. Nat Rev Cancer. 23:275–294. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Tran DH, Kim D, Kesavan R, Brown H, Dey T, Soflaee MH, Vu HS, Tasdogan A, Guo J, Bezwada D, et al: De novo and salvage purine synthesis pathways across tissues and tumors. Cell. 187:3602–3618.e20. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Yoon BK, Kim H, Oh TG, Oh SK, Jo S, Kim M, Chun KH, Hwang N, Lee S, Jin S, et al: PHGDH preserves one-carbon cycle to confer metabolic plasticity in chemoresistant gastric cancer during nutrient stress. Proc Natl Acad Sci USA. 120:e22178261202023. View Article : Google Scholar : PubMed/NCBI | |
|
Feng X, Ma D, Zhao J, Song Y, Zhu Y, Zhou Q, Ma F, Liu X, Zhong M, Liu Y, et al: UHMK1 promotes gastric cancer progression through reprogramming nucleotide metabolism. EMBO J. 39:e1025412020. View Article : Google Scholar : PubMed/NCBI | |
|
Shi DD, Savani MR, Abdullah KG and McBrayer SK: Emerging roles of nucleotide metabolism in cancer. Trends Cancer. 9:624–635. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Møller SH, Mellergaard M, Madsen M, Bermejo AV, Jepsen SD, Hansen MH, Høgh RI, Aldana BI, Desler C, Rasmussen LJ, et al: Cytoplasmic citrate flux modulates the immune stimulatory NKG2D ligand MICA in cancer cells. Front Immunol. 11:19682020. View Article : Google Scholar : PubMed/NCBI | |
|
Ferrari de Andrade L, Tay RE, Pan D, Luoma AM, Ito Y, Badrinath S, Tsoucas D, Franz B, May KF Jr, Harvey CJ, et al: Antibody-mediated inhibition of MICA and MICB shedding promotes NK cell-driven tumor immunity. Science. 359:1537–1542. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Chen S and Wang Z: Integration of mult-omics and nucleotide metabolism reprogramming signature analysis reveals gastric cancer immunological and prognostic features. Cancer Cell Int. 24:2122024. View Article : Google Scholar : PubMed/NCBI | |
|
Losenkova K, Zuccarini M, Karikoski M, Laurila J, Boison D, Jalkanen S and Yegutkin GG: Compartmentalization of adenosine metabolism in cancer cells and its modulation during acute hypoxia. J Cell Sci. 133:jcs2414632020. View Article : Google Scholar : PubMed/NCBI | |
|
Antonioli L, Fornai M, Blandizzi C, Pacher P and Haskó G: Adenosine signaling and the immune system: When a lot could be too much. Immunol Lett. 205:9–15. 2019. View Article : Google Scholar | |
|
Haskó G, Linden J, Cronstein B and Pacher P: Adenosine receptors: Therapeutic aspects for inflammatory and immune diseases. Nat Rev Drug Discov. 7:759–770. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Wang M, Zhao X, Hou S, Wu Z and Yin HY: Purinergic receptors in dendritic cells. J Inflamm Res. 18:13423–13432. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Pisignano G, Michael DC, Visal TH, Pirlog R, Ladomery M and Calin GA: Going circular: History, present, and future of circRNAs in cancer. Oncogene. 42:2783–2800. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Shahpari M, Hashemi M, Younesirad T, Hasanzadeh A, Mosanne MM and Ahmadifard M: The functional roles of competitive endogenous RNA (ceRNA) networks in apoptosis in human cancers: The circRNA/miRNA/mRNA regulatory axis and cell signaling pathways. Heliyon. 10:e370892024. View Article : Google Scholar : PubMed/NCBI | |
|
Li H, Cao B, Zhao R, Li T, Xu X, Cui H, Deng H, Gao J and Wei B: circDNMT1 promotes malignant progression of gastric cancer through targeting miR-576-3p/hypoxia inducible factor-1 alpha axis. Front Oncol. 12:8171922022. View Article : Google Scholar : PubMed/NCBI | |
|
Fang X, Bai Y, Zhang L and Ding S: Silencing circSLAMF6 represses cell glycolysis, migration, and invasion by regulating the miR-204-5p/MYH9 axis in gastric cancer under hypoxia. Biosci Rep. 40:BSR202012752020. View Article : Google Scholar : PubMed/NCBI | |
|
Shen J and Zhu W: Research advances in the role of gastric cancer-derived mesenchymal stem cells in tumor progression (review). Int J Mol Med. 47:455–462. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Wang L, Wu C, Xu J, Gong Z, Cao X, Huang J, Dong H, Zhu W, Huang F, Zhou C and Wang M: GC-MSC-derived circ_0024107 promotes gastric cancer cell lymphatic metastasis via fatty acid oxidation metabolic reprogramming mediated by the miR-5572/6855-5p/CPT1A axis. Oncol Rep. 50:1382023. View Article : Google Scholar | |
|
Li F, Zhang L and Sun Q: CircAKT3 promotes cell proliferation, survival and glutamine metabolism of gastric cancer by activating SLC1A5 expression via targeting miR-515-5p. Histol Histopathol. 37:227–241. 2022. | |
|
Ye B, Yu S, Wang J and Ren Y: CircB3GNTL1 and miR-598 regulation effects on proliferation, apoptosis, and glutaminolysis in gastric cancer cells. Cell Mol Biol (Noisy-le-grand). 66:18–23. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Li J, Zhang G and Wu G: Effect of paeonol on proliferation, apoptosis, migration, invasion and glutamine of gastric cancer cells via circSFMBT2/miR-665 axis. Cell Mol Biol (Noisy-le-grand). 66:33–40. 2020. View Article : Google Scholar | |
|
Xu X, Wang S, Wang H, Pan C, Yang W and Yu J: Hsa_circ_0008434 regulates USP9X expression by sponging miR-6838-5p to promote gastric cancer growth, migration and invasion. BMC Cancer. 21:12892021. View Article : Google Scholar : PubMed/NCBI | |
|
Kim GW, Cha M, Ong HTM, Yoo J, Jeon YH, Lee SW, Oh SY, Kang MJ, Kim Y and Kwon SH: HDAC6 and USP9X control glutamine metabolism by stabilizing GS to promote glioblastoma tumorigenesis. Adv Sci (Weinh). 12:e25015532025. View Article : Google Scholar : PubMed/NCBI | |
|
Li L, Wei C, Xie Y, Su Y, Liu C, Qiu G, Liu W, Liang Y, Zhao X, Huang D and Wu D: Expanded insights into the mechanisms of RNA-binding protein regulation of circRNA generation and function in cancer biology and therapy. Genes Dis. 12:1013832024. View Article : Google Scholar | |
|
Ji C, Zhu J, Hou X, Zhou C, Zhao J, Zheng X and Tang Y: PTBP1 and cancer: From RNA regulation to therapeutic potential. J Cell Mol Med. 29:e706752025. View Article : Google Scholar : PubMed/NCBI | |
|
Qian L, Wang L, Chen H, Wang S, Hou Y, Xu L, Xia Y, Xu M and Huang X: Hsa_circ_0001756 drives gastric cancer glycolysis by increasing the expression and stability of PGK1 mRNA. Front Immunol. 16:15112472025. View Article : Google Scholar : PubMed/NCBI | |
|
Sun Q, Xing X, Wang H, Wan K, Fan R, Liu C, Wang Y, Wu W, Wang Y and Wang R: SCD1 is the critical signaling hub to mediate metabolic diseases: Mechanism and the development of its inhibitors. Biomed Pharmacother. 170:1155862024. View Article : Google Scholar | |
|
Lin Z, Zhong C, Shi M, Long Q, Jing L, Yu Y, Chou J, Chen M, Lan M and Long F: Circular RNA TFRC/SCD1 mRNA interaction regulates ferroptosis and metastasis in gastric cancer. Cell Death Dis. 16:4362025. View Article : Google Scholar : PubMed/NCBI | |
|
Cellarier E, Durando X, Vasson MP, Farges MC, Demiden A, Maurizis JC, Madelmont JC and Chollet P: Methionine dependency and cancer treatment. Cancer Treat Rev. 29:489–499. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Li F, Liu P, Mi W, Li L, Anderson NM, Lesner NP, Burrows M, Plesset J, Majer A, Wang G, et al: Blocking methionine catabolism induces senescence and confers vulnerability to GSK3 inhibition in liver cancer. Nat Cancer. 5:131–146. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Xin L, Zou YH, Liu CX, Lu H, Fan LJ, Xu HS, Zhou Q, Liu J, Yue ZQ and Gan JH: Methionine restriction promotes cisplatin sensitivity of gastric cancer resistant cells by down-regulating circ-CDK13 level. Exp Cell Res. 443:1143152024. View Article : Google Scholar : PubMed/NCBI | |
|
Xu AG, Li SG, Liu JH and Gan AH: Function of apoptosis and expression of the proteins Bcl-2, p53 and C-myc in the development of gastric cancer. World J Gastroenterol. 7:403–406. 2001. View Article : Google Scholar | |
|
Calcagno DQ, Leal MF, Assumpcao PP, Smith MAC and Burbano RR: MYC and gastric adenocarcinoma carcinogenesis. World J Gastroenterol. 14:5962–5968. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Cunningham JT, Moreno MV, Lodi A, Ronen SM and Ruggero D: Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer. Cell. 157:1088–1103. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Yu T, Ran L, Zhao H, Yin P, Li W, Lin J, Mao H, Cai D, Ma Q, Pan X, et al: Circular RNA circ-TNPO3 suppresses metastasis of GC by acting as a protein decoy for IGF2BP3 to regulate the expression of MYC and SNAIL. Mol Ther Nucleic Acids. 26:649–664. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Li H, Jiao W, Song J, Wang J, Chen G, Li D, Wang X, Bao B, Du X, Cheng Y, et al: circ-hnRNPU inhibits NONO-mediated c-Myc transactivation and mRNA stabilization essential for glycosylation and cancer progression. J Exp Clin Cancer Res. 42:3132023. View Article : Google Scholar : PubMed/NCBI | |
|
Lei M, Zheng G, Ning Q, Zheng J and Dong D: Translation and functional roles of circular RNAs in human cancer. Mol Cancer. 19:302020. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang M, Zhao K, Xu X, Yang Y, Yan S, Wei P, Liu H, Xu J, Xiao F, Zhou H, et al: A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma. Nat Commun. 9:44752018. View Article : Google Scholar : PubMed/NCBI | |
|
Jiang R, Li P, Meng E, Cheng X, Wu X and Wu H: Hsa_Circ_0008035 drives immune evasion of gastric cancer via promoting EXT1-mediated nuclear translocation of PKM2. Transl Oncol. 48:1020042024. View Article : Google Scholar : PubMed/NCBI | |
|
Lu L, Guo G, Guo J, Li H, Chen K, Chen Y, Li Q, Li Q, Diao Y, Sun M, et al: A novel protein encoded by circUBE2G1 suppresses glycolysis in gastric cancer through binding to ENO1. Cell Death Discov. 11:3502025. View Article : Google Scholar : PubMed/NCBI | |
|
Liu YY, Zhang YY, Ran LY, Huang B, Ren JW, Ma Q, Pan XJ, Yang FF, Liang C, Wang XL, et al: A novel protein FNDC3B-267aa encoded by circ0003692 inhibits gastric cancer metastasis via promoting proteasomal degradation of c-Myc. J Transl Med. 22:5072024. View Article : Google Scholar : PubMed/NCBI | |
|
Xiong L, Liu HS, Zhou C, Yang X, Huang L, Jie HQ, Zeng ZW, Zheng XB, Li WX, Liu ZZ, et al: A novel protein encoded by circINSIG1 reprograms cholesterol metabolism by promoting the ubiquitin-dependent degradation of INSIG1 in colorectal cancer. Mol Cancer. 22:722023. View Article : Google Scholar : PubMed/NCBI | |
|
Gao X, Sun Z, Liu X, Luo J, Liang X, Wang H, Zhou J, Yang C, Wang T and Li J: 127aa encoded by circSpdyA promotes FA synthesis and NK cell repression in breast cancers. Cell Death Differ. 32:416–433. 2025. View Article : Google Scholar : | |
|
Wang J, Wang X, Yang C, Li Q, Li D, Du X, Cheng Y, Tian M, Zheng L and Tong Q: circE2F1-encoded peptide inhibits circadian machinery essential for nucleotide biosynthesis and tumor progression via repressing SPIB/E2F1 axis. Int J Biol Macromol. 280:1356982024. View Article : Google Scholar : PubMed/NCBI | |
|
Hu H, Tang J, Wang H, Guo X, Tu C and Li Z: The crosstalk between alternative splicing and circular RNA in cancer: Pathogenic insights and therapeutic implications. Cell Mol Biol Lett. 29:1422024. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou C, Molinie B, Daneshvar K, Pondick JV, Wang J, Van Wittenberghe N, Xing Y, Giallourakis CC and Mullen AC: Genome-wide maps of m6A circRNAs identify widespread and cell-type-specific methylation patterns that are distinct from mRNAs. Cell Rep. 20:2262–2276. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Yi Q, Liao Y and Sun W, Li J, Yang D, Shang H and Sun W: m6A modification of non-coding RNA: Mechanisms, functions and potential values in human diseases (review). Int J Mol Med. 56:1642025. View Article : Google Scholar | |
|
An Y and Duan H: The role of m6A RNA methylation in cancer metabolism. Mol Cancer. 21:142022. View Article : Google Scholar : PubMed/NCBI | |
|
Wang T, Kong S, Tao M and Ju S: The potential role of RNA N6-methyladenosine in cancer progression. Mol Cancer. 19:882020. View Article : Google Scholar : PubMed/NCBI | |
|
Yang Y, Fan X, Mao M, Song X, Wu P, Zhang Y, Jin Y, Yang Y, Chen LL, Wang Y, et al: Extensive translation of circular RNAs driven by N6-methyladenosine. Cell Res. 27:626–641. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Zeng K, Peng J, Xing Y, Zhang L, Zeng P, Li W, Zhang W, Pan Z, Zhou C and Lin J: A positive feedback circuit driven by m6A-modified circular RNA facilitates colorectal cancer liver metastasis. Mol Cancer. 22:2022023. View Article : Google Scholar | |
|
Shan Z and Liu Y: Harnessing glycolysis in gastric cancer: Molecular targets, therapeutic strategies, and clinical horizons. Front Immunol. 16:16289372025. View Article : Google Scholar : PubMed/NCBI | |
|
Jia G, Fu Y, Zhao X, Dai Q, Zheng G, Yang Y, Yi C, Lindahl T, Pan T, Yang YG and He C: N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat Chem Biol. 7:885–887. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Wu X, Fang Y, Gu Y, Shen H, Xu Y, Xu T, Shi R, Xu D, Zhang J, Leng K, et al: Fat mass and obesity-associated protein (FTO) mediated m6A modification of circFAM192A promoted gastric cancer proliferation by suppressing SLC7A5 decay. Mol Biomed. 5:112024. View Article : Google Scholar | |
|
Liu J and Fang X: Regulation of hsa_circ_0112136 by m6A demethylase FTO can enhance the malignancy of gastric cancer via the regulation of the PI3K/AKT/mTOR pathway. Biotechnol Appl Biochem. 71:1316–1328. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Villa E, Ali ES, Sahu U and Ben-Sahra I: Cancer cells tune the signaling pathways to empower de novo synthesis of nucleotides. Cancers (Basel). 11:6882019. View Article : Google Scholar : PubMed/NCBI | |
|
Shi J, Mui S, Yan Y, Liu S, Wen K, He C, Li H, Liao H, Tao M, Wen J, et al: m6A-modified circRAPGEF1 interaction with IGF2BP3 promotes hepatocellular carcinoma progression via reprogramming aspartate metabolism. Adv Sci (Weinh). 12:e038512025. View Article : Google Scholar | |
|
Necula L, Matei L, Dragu D, Neagu AI, Mambet C, Nedeianu S, Bleotu C, Diaconu CC and Chivu-Economescu M: Recent advances in gastric cancer early diagnosis. World J Gastroenterol. 25:2029–2044. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Ott JJ, Ullrich A and Miller AB: The importance of early symptom recognition in the context of early detection and cancer survival. Eur J Cancer. 45:2743–2748. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Hazelton WD and Luebeck EG: Biomarker-based early cancer detection: Is it achievable? Sci Transl Med. 3:109fs92011. View Article : Google Scholar : PubMed/NCBI | |
|
Jacobson BC, Bhatt A, Greer KB, Lee LS, Park WG, Sauer BG and Shami VM: ACG clinical guideline: Diagnosis and management of gastrointestinal subepithelial lesions. Am J Gastroenterol. 118:46–58. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Feng F, Tian Y, Xu G, Liu Z, Liu S, Zheng G, Guo M, Lian X, Fan D and Zhang H: Diagnostic and prognostic value of CEA, CA19-9, AFP and CA125 for early gastric cancer. BMC Cancer. 17:7372017. View Article : Google Scholar : PubMed/NCBI | |
|
Smyth EC, Nilsson M, Grabsch HI, van Grieken NC and Lordick F: Gastric cancer. Lancet. 396:635–648. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang HD, Jiang LH, Sun DW, Hou JC and Ji ZL: CircRNA: A novel type of biomarker for cancer. Breast Cancer. 25:1–7. 2018. View Article : Google Scholar | |
|
Reis-das-Mercês L, Vinasco-Sandoval T, Pompeu R, Ramos AC, Anaissi AKM, Demachki S, de Assumpção PP, Vidal AF, Ribeiro-Dos-Santos  and Magalhães L: CircRNAs as potential blood biomarkers and key elements in regulatory networks in gastric cancer. Int J Mol Sci. 23:6502022. View Article : Google Scholar : PubMed/NCBI | |
|
Li T, Shao Y, Fu L, Xie Y, Zhu L, Sun W, Yu R, Xiao B and Guo J: Plasma circular RNA profiling of patients with gastric cancer and their droplet digital RT-PCR detection. J Mol Med (Berl). 96:85–96. 2018. View Article : Google Scholar | |
|
Yang X, Xia J, Peng C and Cai W: Expression of plasma exosomal circLPAR1 in patients with gastric cancer and its clinical application value. Am J Cancer Res. 13:4269–4276. 2023.PubMed/NCBI | |
|
Rao M, Zhu Y, Qi L, Hu F and Gao P: Circular RNA profiling in plasma exosomes from patients with gastric cancer. Oncol Lett. 20:2199–2208. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Huang M, He YR, Liang LC, Huang Q and Zhu ZQ: Circular RNA hsa_circ_0000745 may serve as a diagnostic marker for gastric cancer. World J Gastroenterol. 23:6330–6338. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Chen S, Li T, Zhao Q, Xiao B and Guo J: Using circular RNA hsa_circ_0000190 as a new biomarker in the diagnosis of gastric cancer. Clin Chim Acta. 466:167–171. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Zhao Q, Chen S, Li T, Xiao B and Zhang X: Clinical values of circular RNA 0000181 in the screening of gastric cancer. J Clin Lab Anal. 32:e223332018. View Article : Google Scholar | |
|
Ma Y, Li Z, Ma D, Guo J and Sun W: Hsa_circ_0003195 as a biomarker for diagnosis and prognosis of gastric cancer. Int J Clin Oncol. 27:354–361. 2022. View Article : Google Scholar | |
|
Ma S, Kong S, Gu X, Xu Y, Tao M, Shen L, Shen X and Ju S: As a biomarker for gastric cancer, circPTPN22 regulates the progression of gastric cancer through the EMT pathway. Cancer Cell Int. 21:442021. View Article : Google Scholar : PubMed/NCBI | |
|
Shao Y, Yu X, Hu M, Yan J, Miao M, Ye G and Guo J: Acting mechanism and clinical significance of hsa_circ_0005927 in the invasion and metastasis of gastric cancer. J Cancer. 15:4081–4094. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Shao Y, Tao X, Lu R, Zhang H, Ge J, Xiao B, Ye G and Guo J: Hsa_circ_0065149 is an indicator for early gastric cancer screening and prognosis prediction. Pathol Oncol Res. 26:1475–1482. 2020. View Article : Google Scholar | |
|
Li WH, Song YC, Zhang H, Zhou ZJ, Xie X, Zeng QN, Guo K, Wang T, Xia P and Chang DM: Decreased expression of Hsa_circ_00001649 in gastric cancer and its clinical significance. Dis Markers. 2017:45876982017. View Article : Google Scholar : PubMed/NCBI | |
|
Fang R, Yuan W, Mao C, Cao J, Chen H, Shi X and Cong H: Human circular RNA hsa_circ_0000231 clinical diagnostic effectiveness as a new tumor marker in gastric cancer. Cancer Rep (Hoboken). 7:e20812024.PubMed/NCBI | |
|
Ma S, Yao Y, Xu Y, Zou M, Zhou M, Abudushalamu G, Chen Y, Cai S, Zhang C and Wu G: Comprehensive evaluation of serum circHAS2 as a novel diagnostic and prognostic biomarker for gastric cancer. Mol Carcinog. 63:94–105. 2024. View Article : Google Scholar | |
|
Yuan W, Fang R, Mao C, Chen H, Tai B and Cong H: Serum circular RNA hsa_circ_0000702 as a novel biomarker for diagnosis of gastric cancer. J Clin Lab Anal. 37:e248422023. View Article : Google Scholar : PubMed/NCBI | |
|
Zang X, Wang R, Wang Z, Qiu S, Zhang F, Zhou L, Shen Y, Qian H, Xu W and Jiang J: Exosomal circ50547 as a potential marker and promotor of gastric cancer progression via miR-217/HNF1B axis. Transl Oncol. 45:1019692024. View Article : Google Scholar : PubMed/NCBI | |
|
Huang XJ, Wang Y, Wang HT, Liang ZF, Ji C, Li XX, Zhang LL, Ji RB, Xu WR, Jin JH and Qian H: Exosomal hsa_circ_000200 as a potential biomarker and metastasis enhancer of gastric cancer via miR-4659a/b-3p/HBEGF axis. Cancer Cell Int. 23:1512023. View Article : Google Scholar : PubMed/NCBI | |
|
Gareev I, Ahmad A, Wang J, Beilerli A, Ilyasova T, Sufianov A and Beylerli O: Gastric juice non-coding RNAs as potential biomarkers for gastric cancer. Front Physiol. 14:11795822023. View Article : Google Scholar : PubMed/NCBI | |
|
Shao Y, Li J, Lu R, Li T, Yang Y, Xiao B and Guo J: Global circular RNA expression profile of human gastric cancer and its clinical significance. Cancer Med. 6:1173–1180. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Arnaiz E, Sole C, Manterola L, Iparraguirre L, Otaegui D and Lawrie CH: CircRNAs and cancer: Biomarkers and master regulators. Semin Cancer Biol. 58:90–99. 2019. View Article : Google Scholar | |
|
Roy S, Kanda M, Nomura S, Zhu Z, Toiyama Y, Taketomi A, Goldenring J, Baba H, Kodera Y and Goel A: Diagnostic efficacy of circular RNAs as noninvasive, liquid biopsy biomarkers for early detection of gastric cancer. Mol Cancer. 21:422022. View Article : Google Scholar : PubMed/NCBI | |
|
Xu J, Liu Y, Zhang J, Yang S, Li T, Huang H, Liu Q, Wang H, Cao L, An Z, et al: Single-droplet dual-target quantification of circRNA biomarkers for colorectal cancer screening. Adv Sci (Weinh). 12:e061592025. View Article : Google Scholar : PubMed/NCBI | |
|
Yang L, Wilusz JE and Chen LL: Biogenesis and regulatory roles of circular RNAs. Annu Rev Cell Dev Biol. 38:263–289. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Szabo L and Salzman J: Detecting circular RNAs: Bioinformatic and experimental challenges. Nat Rev Genet. 17:679–692. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Porwal O, Visht S and Muhammed RA: Circular RNAs as biomarkers and targets in ovarian cancer. Clin Chim Acta. 582:1208022026. View Article : Google Scholar | |
|
Guria A, Sharma P, Srikakulam N, Baby A, Natesan S and Pandi G: Cost-effective transcriptome-wide profiling of circular RNAs by the improved-tdMDA-NGS method. Front Mol Biosci. 9:8863662022. View Article : Google Scholar : PubMed/NCBI | |
|
Saadh MJ, Ahmed HH, Kareem RA, Bishoyi AK, Roopashree R, Shit D, Arya R, Joshi KK, Sameer HN, Yaseen A, et al: The hidden messengers: Tumor microenvironment-derived exosomal ceRNAs in gastric cancer progression. Pathol Res Pract. 269:1559052025. View Article : Google Scholar : PubMed/NCBI | |
|
Ferda J, Ferdová E, Vítovec M, Glanc D and Mírka H: The imaging of the hypoxic microenvironment in tumorous tissue using PET/CT and PET/MRI. Eur J Radiol. 154:1104582022. View Article : Google Scholar : PubMed/NCBI | |
|
Zandieh MA, Farahani MH, Rajabi R, Avval ST, Karimi K, Rahmanian P, Razzazan M, Javanshir S, Mirzaei S, Paskeh MDA, et al: Epigenetic regulation of autophagy by non-coding RNAs in gastrointestinal tumors: Biological functions and therapeutic perspectives. Pharmacol Res. 187:1065822023. View Article : Google Scholar | |
|
Barati T, Mirzaei Z, Abarghooi Kahaki F and Afkhami H: Regulatory roles of ncRNAs in gastric cancer progression: A comprehensive insight into key signaling pathways. Med Oncol. 42:3092025. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Y, Jiang Y, Xu L, Qu C, Zhang L, Xiao X, Chen W, Li K, Liang Q and Wu H: circ-NRIP1 promotes glycolysis and tumor progression by regulating miR-186-5p/MYH9 axis in gastric cancer. Cancer Manag Res. 12:5945–5956. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Xu G, Li M, Wu J, Qin C, Tao Y and He H: Circular RNA circNRIP1 sponges microRNA-138-5p to maintain hypoxia-induced resistance to 5-fluorouracil through HIF-1α-dependent glucose metabolism in gastric carcinoma. Cancer Manag Res. 12:2789–2802. 2020. View Article : Google Scholar | |
|
Cordani M, Dando I, Ambrosini G and González-Menéndez P: Signaling, cancer cell plasticity, and intratumor heterogeneity. Cell Commun Signal. 22:2552024. View Article : Google Scholar : PubMed/NCBI | |
|
Golestanifar A, Zakeri M, Gohari-Lasaki S, Khedri H and Saberiyan M: Combined bulk and single-cell transcriptomic analysis reveals cell-type-specific inflammatory crosstalk in pancreatic cancer. Clin Exp Med. 25:2632025. View Article : Google Scholar : PubMed/NCBI | |
|
Li Y, Xu Q, Wu D and Chen G: Exploring additional valuable information from single-cell RNA-Seq data. Front Cell Dev Biol. 8:5930072020. View Article : Google Scholar : PubMed/NCBI | |
|
Aquino-Jarquin G: CircRNA knockdown based on antisense strategies. Drug Discov Today. 29:1040662024. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou Y, Zhang Q, Liao B, Qiu X, Hu S and Xu Q: circ_0006089 promotes gastric cancer growth, metastasis, glycolysis, and angiogenesis by regulating miR-361-3p/TGFB1. Cancer Sci. 113:2044–2055. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Jiang SF and Li RR: hsa_circ_0067514 suppresses gastric cancer progression and glycolysis via miR-654-3p/LATS2 axis. Neoplasma. 69:1079–1091. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Shen X, Zhu X, Hu P, Ji T, Qin Y and Zhu J: Knockdown circZNF131 inhibits cell progression and glycolysis in gastric cancer through miR-186-5p/PFKFB2 axis. Biochem Genet. 60:1567–1584. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Yang X, Li D, Sun Y, Yi L, Chen Q and Lai Y: CircFLNA facilitates gastric cancer cell proliferation and glycolysis via regulating SOX5 by sponging miR-1200. Arab J Gastroenterol. 25:369–377. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Y, Cao B, Zhao R, Li H, Wei B and Dai G: Knockdown of circBFAR inhibits proliferation and glycolysis in gastric cancer by sponging miR-513a-3p/hexokinase 2 axis. Biochem Biophys Res Commun. 560:80–86. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Zheng X, Shao J, Qian J and Liu S: circRPS19 affects HK2-mediated aerobic glycolysis and cell viability via the miR-125a-5p/USP7 pathway in gastric cancer. Int J Oncol. 63:982023. View Article : Google Scholar | |
|
Chen L, Chi K, Xiang H and Yang Y: Circ_0032821 facilitates gastric cancer cell proliferation, migration, invasion and glycolysis by regulating MiR-1236-3p/HMGB1 axis. Cancer Manag Res. 12:9965–9976. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Liu J, Li J, Su Y, Ma Z, Yu S and He Y: Circ_0009910 serves as miR-361-3p sponge to promote the proliferation, metastasis, and glycolysis of gastric cancer via regulating SNRPA. Biochem Genet. 60:1809–1824. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Zheng X, Xiao H, Liu X, Huang T and Deng C: Exosomal circKIAA1797 regulates cell progression and glycolysis by targeting miR-4429/PBX3 pathway in gastric cancer. Biochem Genet. 62:1762–1778. 2024. View Article : Google Scholar | |
|
Zhao X, Tian Z and Liu L: circATP2B1 promotes aerobic glycolysis in gastric cancer cells through regulation of the miR-326 gene cluster. Front Oncol. 11:6286242021. View Article : Google Scholar : PubMed/NCBI | |
|
Chen W and Ji Y: CircC6orf132 facilitates proliferation, migration, invasion, and glycolysis of gastric cancer cells under hypoxia by acting on the miR-873-5p/PRKAA1 axis. Front Genet. 12:6363922021. View Article : Google Scholar : PubMed/NCBI | |
|
Yang J, Zhang X, Cao J, Xu P, Chen Z, Wang S, Li B, Zhang L, Xie L, Fang L and Xu Z: Circular RNA UBE2Q2 promotes malignant progression of gastric cancer by regulating signal transducer and activator of transcription 3-mediated autophagy and glycolysis. Cell Death Dis. 12:9102021. View Article : Google Scholar : PubMed/NCBI | |
|
Liu J, Liu H, Zeng Q, Xu P, Liu M and Yang N: Circular RNA circ-MAT2B facilitates glycolysis and growth of gastric cancer through regulating the miR-515-5p/HIF-1α axis. Cancer Cell Int. 20:1712020. View Article : Google Scholar | |
|
Ou W, Tan R, Zhai J, Sun L, Quan Z, Huang X, Xu F, Xu Q and Zhou C: Silencing circ_0043256 inhibited CoCl2-induced proliferation, migration, and aerobic glycolysis in gastric cancer cells. Sci Rep. 15:1712025. View Article : Google Scholar : PubMed/NCBI | |
|
Lu Y, Cheng J, Cai W, Zhuo H, Wu G and Cai J: Inhibition of circRNA circVPS33B reduces warburg effect and tumor growth through regulating the miR-873-5p/HNRNPK axis in infiltrative gastric cancer. Onco Targets Ther. 14:3095–3108. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Qu J, Yang J, Chen M, Wei R and Tian J: CircFLNA acts as a sponge of miR-646 to facilitate the proliferation, metastasis, glycolysis, and apoptosis inhibition of gastric cancer by targeting PFKFB2. Cancer Manag Res. 12:8093–8103. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Lan ZZ, Sun FH, Chen C, Niu L, Shi JD and Zhang WY: CircPRDM5 inhibits the proliferation, migration, invasion, and glucose metabolism of gastric cancer cells by reducing GCNT4 expression in a miR-485-3p-dependent manner. Kaohsiung J Med Sci. 40:231–243. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Lu J, Zhou Y, Chen Z, Jiang H, Li J and Dou G: Circ_0000419 acts as a tumor suppressor in gastric cancer development via regulating miR-300/RGMB axis. Int J Clin Oncol. 28:1475–1485. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Wu G, Zhang A, Yang Y and Wu D: Circ-RNF111 aggravates the malignancy of gastric cancer through miR-876-3p-dependent regulation of KLF12. World J Surg Oncol. 19:2592021. View Article : Google Scholar : PubMed/NCBI | |
|
Ji Z, Diao W and Shang J: Circular RNA circ_0000592 elevates ANXA4 expression via sponging miR-1179 to facilitate tumor progression in gastric cancer. Anticancer Drugs. 33:e644–e654. 2022. View Article : Google Scholar | |
|
Pu Z, Xu M, Yuan X, Xie H and Zhao J: Circular RNA circCUL3 accelerates the warburg effect progression of gastric cancer through regulating the STAT3/HK2 axis. Mol Ther Nucleic Acids. 22:310–318. 2020. View Article : Google Scholar : PubMed/NCBI |