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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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January 2003 Volume 22 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2003 Volume 22 Issue 1

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Article

Expression of angiogenic factors including VEGFs and the effects of hypoxia and thalidomide on human myeloma cells

  • Authors:
    • Kenichiro Yata
    • Takemi Otsuki
    • Junichi Kurebayashi
    • Masako Uno
    • Tomohiro Fujii
    • Yoshihito Yawata
    • Akiko Takata
    • Fuminori Hyodoh
    • Takashi Sugihara

  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, Division of Hematology, Kawasaki Medical School, Okayama 701-0192, Japan
  • Pages: 165-173
    |
    Published online on: January 1, 2003
       https://doi.org/10.3892/ijo.22.1.165
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Abstract

Angiogenic factors are major causes of tumor progression in hematological malignancies, particularly multiple myeloma, as well as solid tumors. The introduction of thalidomide as an anti-angiogenic agent in myeloma treatment has demonstrated the importance of angiogenic factors in the progression of myeloma. However, the direct effects of angiogenic factors, particularly VEGFs, hypoxia, and thalidomide, on myeloma cells are not been documented. In this study, we demonstrate increased expression and production levels of VEGF in myeloma compared to non-myelomatous hematological lines, resistance to hypoxia and enhancement of VEGF-A production by hypoxia in myeloma, and direct growth inhibition of myeloma cells due to apoptosis and G1 arrest caused by TNFα upregulation induced by thalidomide. These findings may encourage the clinical use of anti-angiogenic agents for their cytostatic effects and the prevention of progression.

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Copy and paste a formatted citation
Spandidos Publications style
Yata K, Otsuki T, Kurebayashi J, Uno M, Fujii T, Yawata Y, Takata A, Hyodoh F and Sugihara T: Expression of angiogenic factors including VEGFs and the effects of hypoxia and thalidomide on human myeloma cells. Int J Oncol 22: 165-173, 2003.
APA
Yata, K., Otsuki, T., Kurebayashi, J., Uno, M., Fujii, T., Yawata, Y. ... Sugihara, T. (2003). Expression of angiogenic factors including VEGFs and the effects of hypoxia and thalidomide on human myeloma cells. International Journal of Oncology, 22, 165-173. https://doi.org/10.3892/ijo.22.1.165
MLA
Yata, K., Otsuki, T., Kurebayashi, J., Uno, M., Fujii, T., Yawata, Y., Takata, A., Hyodoh, F., Sugihara, T."Expression of angiogenic factors including VEGFs and the effects of hypoxia and thalidomide on human myeloma cells". International Journal of Oncology 22.1 (2003): 165-173.
Chicago
Yata, K., Otsuki, T., Kurebayashi, J., Uno, M., Fujii, T., Yawata, Y., Takata, A., Hyodoh, F., Sugihara, T."Expression of angiogenic factors including VEGFs and the effects of hypoxia and thalidomide on human myeloma cells". International Journal of Oncology 22, no. 1 (2003): 165-173. https://doi.org/10.3892/ijo.22.1.165
Copy and paste a formatted citation
x
Spandidos Publications style
Yata K, Otsuki T, Kurebayashi J, Uno M, Fujii T, Yawata Y, Takata A, Hyodoh F and Sugihara T: Expression of angiogenic factors including VEGFs and the effects of hypoxia and thalidomide on human myeloma cells. Int J Oncol 22: 165-173, 2003.
APA
Yata, K., Otsuki, T., Kurebayashi, J., Uno, M., Fujii, T., Yawata, Y. ... Sugihara, T. (2003). Expression of angiogenic factors including VEGFs and the effects of hypoxia and thalidomide on human myeloma cells. International Journal of Oncology, 22, 165-173. https://doi.org/10.3892/ijo.22.1.165
MLA
Yata, K., Otsuki, T., Kurebayashi, J., Uno, M., Fujii, T., Yawata, Y., Takata, A., Hyodoh, F., Sugihara, T."Expression of angiogenic factors including VEGFs and the effects of hypoxia and thalidomide on human myeloma cells". International Journal of Oncology 22.1 (2003): 165-173.
Chicago
Yata, K., Otsuki, T., Kurebayashi, J., Uno, M., Fujii, T., Yawata, Y., Takata, A., Hyodoh, F., Sugihara, T."Expression of angiogenic factors including VEGFs and the effects of hypoxia and thalidomide on human myeloma cells". International Journal of Oncology 22, no. 1 (2003): 165-173. https://doi.org/10.3892/ijo.22.1.165
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