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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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January 2003 Volume 22 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2003 Volume 22 Issue 1

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Article

Expression of the anti-apoptotic gene survivin in myelodysplastic syndrome

  • Authors:
    • Adel Badran
    • Akira Yoshida
    • Yuji Wano
    • Masato Mutoh
    • Shin Imamura
    • Taro Yamashita
    • Hiroshi Tsutani
    • Manabu Inuzuka
    • Takanori Ueda

  • View Affiliations / Copyright

    Affiliations: First Department of Internal Medicine, Fukui Medical University, Matsuoka, Fukui 910-1193, Japan
  • Pages: 59-64
    |
    Published online on: January 1, 2003
       https://doi.org/10.3892/ijo.22.1.59
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Abstract

Survivin is a member of the inhibitor of apoptosis protein (IAPs) family and considered to play a pivotal role in oncogenesis. We present the first report of survivin expression profile in myelodysplastic syndrome (MDS). Expression of survivin messenger RNA was evaluated by semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) in patients with MDS and acute myeloid leukemia (AML). Eleven out of 12 patients with refractory anemia (RA) (91.6%), and all 3 patients with refractory anemia with excess blasts in transformation (RAEBt) (100%), were positive for survivin expression with the majority of cases showing abundant levels of the survivin transcript. On the other hand, expression of survivin was undetectable in the 4 patients with chronic myelomonocytic leukemia (CMMoL). The level and frequency of survivin expression in patients with refractory anemia were compared to those in patients with AML. Out of 12 patients with de novo AML, 5 patients (41.7%) showed detectable levels of survivin expression. Abundant survivin expression in RA was also confirmed by immunohistochemistry. In contrast, survivin was almost absent in two cases with aplastic anemia. We propose that high levels of survivin expression can serve as a reliable diagnostic marker of RA in MDS.

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Copy and paste a formatted citation
Spandidos Publications style
Badran A, Yoshida A, Wano Y, Mutoh M, Imamura S, Yamashita T, Tsutani H, Inuzuka M and Ueda T: Expression of the anti-apoptotic gene survivin in myelodysplastic syndrome. Int J Oncol 22: 59-64, 2003.
APA
Badran, A., Yoshida, A., Wano, Y., Mutoh, M., Imamura, S., Yamashita, T. ... Ueda, T. (2003). Expression of the anti-apoptotic gene survivin in myelodysplastic syndrome. International Journal of Oncology, 22, 59-64. https://doi.org/10.3892/ijo.22.1.59
MLA
Badran, A., Yoshida, A., Wano, Y., Mutoh, M., Imamura, S., Yamashita, T., Tsutani, H., Inuzuka, M., Ueda, T."Expression of the anti-apoptotic gene survivin in myelodysplastic syndrome". International Journal of Oncology 22.1 (2003): 59-64.
Chicago
Badran, A., Yoshida, A., Wano, Y., Mutoh, M., Imamura, S., Yamashita, T., Tsutani, H., Inuzuka, M., Ueda, T."Expression of the anti-apoptotic gene survivin in myelodysplastic syndrome". International Journal of Oncology 22, no. 1 (2003): 59-64. https://doi.org/10.3892/ijo.22.1.59
Copy and paste a formatted citation
x
Spandidos Publications style
Badran A, Yoshida A, Wano Y, Mutoh M, Imamura S, Yamashita T, Tsutani H, Inuzuka M and Ueda T: Expression of the anti-apoptotic gene survivin in myelodysplastic syndrome. Int J Oncol 22: 59-64, 2003.
APA
Badran, A., Yoshida, A., Wano, Y., Mutoh, M., Imamura, S., Yamashita, T. ... Ueda, T. (2003). Expression of the anti-apoptotic gene survivin in myelodysplastic syndrome. International Journal of Oncology, 22, 59-64. https://doi.org/10.3892/ijo.22.1.59
MLA
Badran, A., Yoshida, A., Wano, Y., Mutoh, M., Imamura, S., Yamashita, T., Tsutani, H., Inuzuka, M., Ueda, T."Expression of the anti-apoptotic gene survivin in myelodysplastic syndrome". International Journal of Oncology 22.1 (2003): 59-64.
Chicago
Badran, A., Yoshida, A., Wano, Y., Mutoh, M., Imamura, S., Yamashita, T., Tsutani, H., Inuzuka, M., Ueda, T."Expression of the anti-apoptotic gene survivin in myelodysplastic syndrome". International Journal of Oncology 22, no. 1 (2003): 59-64. https://doi.org/10.3892/ijo.22.1.59
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