Antiproliferative effect of chlorophyllin derived from a traditional Chinese medicine Bombyx mori excreta on human breast cancer MCF-7 cells

  • Authors:
    • Lawrence Chi-Ming Chiu
    • Carrie K.-L. Kong
    • Vincent E.C. Ooi
  • View Affiliations

  • Published online on: September 1, 2003     https://doi.org/10.3892/ijo.23.3.729
  • Pages: 729-735
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Abstract

Chlorophyllin (CHL) is the sodium-copper salts of chlorophyll derivatives. In this study, the CHL was derived from a traditional Chinese medicine, the Bombyx mori excreta. The CHL, at concentrations 25-400 µg/ml, reduced the proliferation of HL-60, K-562, S-180, and MCF-7 cells by 8.2-95.7% after 72 h of incubation. The CHL also accumulated G2/M cells and induced apoptosis in the MCF-7 cells. Furthermore, the breast carcinoma cells exhibited lower cyclin D1 and cyclin E levels but higher cyclin B1 level after incubation with the CHL showing that these cyclin changes may be important for the antiproliferative effect of the CHL.

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September 2003
Volume 23 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Chiu LC, Kong CK and Ooi VE: Antiproliferative effect of chlorophyllin derived from a traditional Chinese medicine Bombyx mori excreta on human breast cancer MCF-7 cells. Int J Oncol 23: 729-735, 2003
APA
Chiu, L.C., Kong, C.K., & Ooi, V.E. (2003). Antiproliferative effect of chlorophyllin derived from a traditional Chinese medicine Bombyx mori excreta on human breast cancer MCF-7 cells. International Journal of Oncology, 23, 729-735. https://doi.org/10.3892/ijo.23.3.729
MLA
Chiu, L. C., Kong, C. K., Ooi, V. E."Antiproliferative effect of chlorophyllin derived from a traditional Chinese medicine Bombyx mori excreta on human breast cancer MCF-7 cells". International Journal of Oncology 23.3 (2003): 729-735.
Chicago
Chiu, L. C., Kong, C. K., Ooi, V. E."Antiproliferative effect of chlorophyllin derived from a traditional Chinese medicine Bombyx mori excreta on human breast cancer MCF-7 cells". International Journal of Oncology 23, no. 3 (2003): 729-735. https://doi.org/10.3892/ijo.23.3.729